A new practicable and precise functional protein C evaluation test is based on the activation of protein C by a snake venom activator and determination of PC activity by its property to prolong the ...aPTT in a clotting assay (VK = 1.9% and 4% for intra- and interassay variance respectively). In 40 healthy controls there was a good correlation (r = 0.74) between the functional and immunological (ELISA) evaluation. In 123 patients with both evaluation methods but more pronounced with the measurement of the protein C activity a significant protein C deficiency was found in the patient groups with disseminated solid tumors, inflammatory diseases and myocardial infarction. Besides detection of hereditary PC deficiency Type II (generation of functionally abnormal PC) the functional assay profits by recording PC inhibitor complexes and otherwise dysfunctional PC in DIC. Thus, in patients with hematological neoplasias, only protein C activity was significantly decreases. Decrease of PC activity was more pronounced compared to PC Ag in liver disease indicating synthesis of functionally deficient PC, and in oral anticoagulant treatment due to detection of PIVKA-PC.
A non-specific vulvo-vagino-gingival syndrome Pheiffer, K F; Ould, G; Hoffmeister, B ...
Revue de stomatologie et de chirurgie maxillo-faciale,
1988, Letnik:
89, Številka:
2
Journal Article
The case of a 29 year-old patient is reported who initially complained about gingivitis and one year later developed a colpitis. After two years the patient was admitted to our hospital where ...inflammatory erosive changes of the gingiva, the vagina and the vulva were seen. Neither laboratory parameters nor histological results allowed an exact diagnosis of these findings. Also a Lichen ruber erosive had been excluded by the microscopic findings of a gingival and vaginal biopsy. Thus, the diagnosis of a non-specific vulvo-vagino-gingival syndrome was established, whereby antiphlogistic treatment with corticosteroids led to an improvement of the patient's symptoms.
The effect of probenecid on the pharmacokinetics of phenprocoumon (PPC) given as a single oral or intravenous dose, on the vitamin-K-dependent protein-C-antigen, and on the pharmacokinetics of ...antipyrine and 6 beta-hydroxycortisol was determined in 14 healthy volunteers. Probenecid caused a 75% decrease in urinary excretion of PPC and PPC-glucuronide and shortened the plasma half-life of PPC significantly (by about 35%). The results after oral and intravenous administration of PPC did not differ significantly. Plasma protein-C-antigen concentrations following intravenous PPC were significantly increased by probenecid. The plasma half-life of antipyrine after 7 days of probenecid therapy was significantly diminished. Accordingly, urinary excretion of 6 beta-hydroxycortisol was significantly increased. These data appear for the first time to reveal enzyme-inducing properties of probenecid, which may be responsible for the shortening of PPC plasma half-life when probenecid is given simultaneously. In addition, the influence of probenecid on plasma protein-C-antigen concentrations may indicate further effects of probenecid on liver metabolism.
The PS 185 experiment at LEAR/CERN studies strangeness production in antiproton-proton collisions in flight. Exclusive final states containing pairs of antihyperons and hyperons have been analysed. ...The data have been used to investigate strange quark production dynamics. New data at the highest energies available at LEAR extend the existing data set for the Λ¯Λ channel. Preliminary data from a new threshold scan are available. For the Σ¯
0Λ+cc channel first spin correlation data have been extracted. First preliminary differential cross section data from the Σ¯
−Σ
− channel are also presented.
PDF
