Platinum-based chemotherapies, such as cisplatin, play a large role in cancer treatment. The development of resistance and treatment toxicity creates substantial barriers to disease control, yet. To ...enhance the therapeutic index of cisplatin-based chemotherapy, it is imperative to circumvent resistance and toxicity while optimizing tumor sensitization. One of the primary mechanisms by which cancer cells develop resistance to cisplatin is through upregulation of DNA repair pathways. In this review, we discuss the DNA damage response in the context of cisplatin-induced DNA damage. We describe the proteins involved in the pathways and their roles in resistance development. Common biomarkers for cisplatin resistance and their utilization to improve patient risk stratification and treatment personalization are addressed. Finally, we discuss some of the current treatments and future strategies to circumvent the development of cisplatin resistance.
Abstract
The K2 mission of the Kepler Space Telescope allowed the observations of light curves of small solar system bodies throughout the whole solar system. In this paper, we present the results of ...a collection of K2 trans-Neptunian object observations between campaigns C03 (2014 November–2015 February) and C19 (2018 August–September), which includes 66 targets. Due to the faintness of our targets, the detectability rate of a light-curve period is ∼56%, notably lower than in the case of other small-body populations, like Hildas or Jovian Trojans. We managed to obtain light-curve periods with an acceptable confidence for 37 targets; the majority of these cases are new identifications. We were able to give light-curve amplitude upper limits for the other 29 targets. Several of the newly detected light-curve periods are longer than ∼24 hr, in many cases close to ∼80 hr; i.e., these targets are slow rotators. This relative abundance of slowly rotating objects is similar to that observed among Hildas, Jovian Trojans, and Centaurs in the K2 mission, as well as among main belt asteroids measured with the TESS space telescope. Trans-Neptunian objects show notably higher light-curve amplitudes at large (
D
≳ 300 km) sizes than found among large main belt asteroids, in contrast to the general expectation that due to their lower compressive strength, they reach hydrostatic equilibrium at smaller sizes than their inner solar system counterparts.
Temporal activity differences facilitate species’ coexistence by reducing interspecific competition. Such patterns can be studied via diel activity analysis, but obtaining data in cryptic mammals is ...difficult. We investigated the annual and diel activity pattern of such a small mammal, the endangered Hungarian birch mouse (
Sicista trizona trizona
), in its only known habitat. We employ trail cameras for the first time to reveal the diel and annual activity of a sminthid species. Data acquisition included the spring and summer seasons between 2019 and 2022 and was extended to detect the activity overlaps with other common coexisting rodents and shrews. The diel activity results rely on 581 detections of
S. trizona
over 5670 trap-nights of camera trap deployment characterising also activity pattern of the small mammal community in this Central European grassland ecosystem.
S. trizona
was not recorded during the day but was active at dawn and night, and in comparison with other coexisting species, its activity level was high. The presumed cold sensitivity was not confirmed as we detected activity at −6 °C. Diel activity peaked in early May in the mating season. Although the diel activity pattern of co-occurring small mammal species was also nocturnal, activity overlaps were relatively high suggesting that temporal niche partitioning is limited within the habitat. Our work provides the first insight into temporal overlaps within a small mammal community in a natural European grassland, moreover, also the first documented research on the activity pattern of a sminthid in its natural habitat.
We analyze albedo data obtained using the Herschel Space Observatory that reveal the existence of two distinct types of surface among midsized trans-Neptunian objects. A color-albedo diagram shows ...two large clusters of objects, one redder and higher albedo and another darker and more neutrally colored. Crucially, all objects in our sample located in dynamically stable orbits within the classical Kuiper Belt region and beyond are confined to the bright red group, implying a compositional link. Those objects are believed to have formed further from the Sun than the dark neutral bodies. This color-albedo separation is evidence for a compositional discontinuity in the young solar system.
Abstract
Various properties of Jovian Trojan asteroids such as composition, rotation periods, and photometric amplitudes, or the rate of binarity in the population, can provide information and ...constraints on the evolution of the group and of the solar system itself. Here we present new photometric properties of 45 Jovian Trojans from the K2 mission of the Kepler space telescope, and present phase-folded light curves for 44 targets, including (11351) Leucus, one of the targets of the Lucy mission. We extend our sample to 101 asteroids with previous K2 Trojan measurements, then compare their combined amplitude and frequency distributions to other ground-based and space data. We show that there is a dichotomy in the periods of Trojans with a separation at ∼100 hr. We find that 25% of the sample are slow rotators (
P
≥ 30 hr), an excess that can be attributed to binary objects. We also show that 32 systems can be classified as potential detached binary systems. Finally, we calculate density and rotation constraints for the asteroids. Both the spin barrier and fits to strengthless ellipsoid models indicate low densities and thus compositions similar to populations of comets and trans-Neptunian objects throughout the sample. This supports the scenario of outer solar system origin for Jovian Trojans.
Hilda asteroids orbit at the outer edge, or just outside of the Main Belt, occupying the 2:3 mean motion resonance with Jupiter. It is known that the group shows a mixed taxonomy that suggests the ...mixed origin of Hilda members, having migrated to the current orbit both from the outer Main Belt and from the Trojans swarms. But there are still few observations for comparative studies to help us understand the Hilda group in deeper detail. We identified 125 individual light curves of Hilda asteroids observed by the K2 mission. We found that despite of the mixed taxonomies, the Hilda group highly resembles the Trojans in the distribution of rotation periods and amplitudes, and even the LR group (mostly C- and X-type) Hildas follow this rule. Contrary to the Main Belt, the Hilda group lacks the very fast rotators. The ratio of extremely slow rotators (P > 100 hr) is a surprising 18%, which is unique in the solar system. The occurrence rate of asteroids with multiple periods (4%) and asteroids with three maxima in the light curves (5%) can be signs of a high rate of binarity, which we can estimate as 25% within the Hilda group.
Polygraph tests have been used for many years as a means of detecting deception, but their accuracy has been the subject of much debate. In recent years, researchers have explored the use of neural ...networks in polygraph scoring to improve the accuracy of deception detection. The purpose of this scoping review is to offer a comprehensive overview of the existing research on the subject of neural network applications in scoring polygraph tests. A total of 57 relevant papers were identified and analyzed for this review. The papers were examined for their research focus, methodology, results, and conclusions. The scoping review found that neural networks have shown promise in improving the accuracy of polygraph tests, with some studies reporting significant improvements over traditional methods. However, further research is needed to validate these findings and to determine the most effective ways of integrating neural networks into polygraph testing. The scoping review concludes with a discussion of the current state of the field and suggestions for future research directions.
ABSTRACT We present the first comprehensive thermal and rotational analysis of the second most distant trans-Neptunian object (TNOs) (225088) 2007 OR10. We combined optical light curves provided by ...the Kepler Space Telescope-K2 extended mission and thermal infrared data provided by the Herschel Space Observatory. We found that (225088) 2007 OR10 is likely to be larger and darker than derived by earlier studies: we obtained a diameter of d = 1535 − 225 + 75 km which places (225088) 2007 OR10 in the biggest top three TNOs. The corresponding visual geometric albedo is p V = 0.089 − 0.009 + 0.031 . The light-curve analysis revealed a slow rotation rate of Prot = 44.81 0.37 hr, superseded by very few objects. The most likely light-curve solution is double-peaked with a slight asymmetry; however, we cannot safely rule out the possibility of having a rotation period of Prot = 22.40 0.18 hr, which corresponds to a single-peaked solution. Due to the size and slow rotation, the shape of the object should be a MacLaurin ellipsoid, so the light variation should be caused by surface inhomogeneities. Its newly derived larger diameter also implies larger surface gravity and a more likely retention of volatiles-CH4, CO, and N2-on the surface.
This article aims to examine the relationship between job crafting activities and employees' readiness to change. Confirmatory factor analysis and hierarchical regression analysis were conducted on a ...representative sample of 500 employees. Sampling was carried out in a European country in a period strongly affected by COVID-19 to isolate the five dimensions of job crafting and their separate effects on employees' readiness to change. The findings show that the five dimensions of job crafting can be distinguished from each other and that they have differential effects on employees' readiness to change. Extending task crafting shows a positive relationship with employees' readiness to change while reducing task crafting showed no significant relationship. Surprisingly extending and reducing relationship crafting showed no significant relationship with readiness to change. Cognitive crafting was found to be significantly positively related to the dependent variable. This research contributes to the development of job crafting theory by providing empirical support that job crafting can be associated with readiness to change but that this relationship may vary across its dimensions. The results may also provide important conclusions for change leaders and HR professionals.
In this paper, we present the Small Bodies: Near and Far Infrared Database, an easy-to-use tool intended to facilitate the modelling of thermal emission of small bodies of the Solar System. Our ...database collects measurements of thermal emissions for small Solar System targets that are otherwise available in scattered sources and provides a complete description of the data, including all information necessary to perform direct scientific analyses and without the need to access additional external resources. This public database contains representative data of asteroid observations of large surveys (e.g. AKARI, IRAS, and WISE) as well as a collection of small body observations of infrared space telescopes (e.g. the
Herschel
Space Observatory) and provides a web interface to access this data. We also provide an example for the direct application of the database and show how it can be used to estimate the thermal inertia of specific populations, e.g. asteroids within a given size range. We show how different scalings of thermal inertia with heliocentric distance (i.e. temperature) may affect our interpretation of the data and discuss why the widely-used radiative conductivity exponent (
α
= –3/4) might not be adequate in general, as suggested in previous studies.
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