This study explored the association between parental fear of hypoglycemia, anxiety, and subjective well-being in parents of children and adolescents with type 1 diabetes. A total of 120 mothers and ...79 fathers participated. Mothers’ and fathers’ fear of hypoglycemia was significantly associated with anxiety and negative affect as well as with worse glycemic control in child. Paired-samples t-test showed that mothers were more involved in diabetes management and reported more fear and anxiety compared to fathers, but they did not differ in worries about hypoglycemia. The findings suggest screening for fear of hypoglycemia and subjective well-being in all parents regardless of whether their child experienced severe hypoglycemia.
Purpose
To determine the impact of advanced hybrid closed - loop (AHCL) insulin delivery on quality of life, metabolic control and time in range (TIR) in youth with type 1 diabetes mellitus (T1DM).
...Methods
Twenty-four children and adolescents with T1DM (14 female) aged of 10 to 18 years participated in the study. Mixed methods study design was implemented. Quantitative part of the study was conducted as a longitudinal crossover study with data collection before and at the end of AHCL use. Qualitative data were obtained with modeled interviews of four focus groups before and the end of the period. Clinical data were collected from the electronic medical records.
Results
The use of AHCL significantly improved the quality of life in terms of decreased fear of hypoglycemia (p<0.001), decrease in diabetes-related emotional distress (p<0.001), and increased wellbeing (p=0.003). The mean A1C decreased from 8.55 ± 1.34% (69.9 ± 12.3 mmol/mol) to 7.73 ± 0.42 (61.1 ± 2.2 mmol/mol) (p=0.002) at the end of the study. Mean TIR was 68.22% (± 13.89) before and 78.26 (± 6.29) % (p<0.001) at the end of the study.
Conclusion
The use of advanced hybrid closed loop significantly improved the quality of life and metabolic control in children and adolescents with T1DM.
The etymology of laz Klemencic, Simona
Slovenski jezik (Slovenska akademija znanosti in umetnosti. Znanstvenoraziskovalni center),
2015, Letnik:
10
Journal Article
Recenzirano
Odprti dostop
Proto-Slavic *lazъ, *lězti, *loza, and *lěsъ are explained as derived from the Proto-Indo-European root *leg’ ‛wind, bend’ through a closer look at the two origins of Proto-Slavic *lazъ and *lazь ...‛(fallow) field or meadow created in place of a cut or burned forest’ and ‛narrow passage’, ‛opening, gate in a fence’.
Background Our aim was to determine whether child attachment to parents, parent attachment style, and morning cortisol levels were related to diabetes outcomes measured by average glycated hemoglobin ...(HbA1c), HbA1c variability over 4 years and time in range (TIR) in children with type 1 diabetes (T1D). Research design and methods 101 children with T1D and one of their parents were assessed at baseline for child attachment (Child Attachment Interview; CAI) and parent attachment (Relationship Structures Questionnaire; ECR-RS). Serum samples were collected for cortisol measurements before the interviews. HbA1c levels were measured during a 4-year follow-up period at regular 3-monthly visits, and data for TIR were exported from blood glucose measuring devices. Multivariate linear regression models were constructed to identify independent predictors of glycemic outcomes. Results More girls than boys exhibited secure attachment to their mothers. The results of the regression models showed that securely attached girls (CAI) had higher average HbA1c than did insecurely attached girls (B = -0.64, p = 0.03). In boys, the more insecure the parent's attachment style, the worse the child's glycemic outcome: the higher the average Hb1Ac (B = 0.51, p = 0.005), the higher the HbA1c variability (B = 0.017, p = 0.011), and the lower the TIR (B = -8.543, p = 0.002). Conclusions Attachment in close relationships is associated with glycemic outcomes in children with T1D, and we observed significant differences between sexes. A sex- and attachment-specific approach is recommended when treating children with less favorable glycemic outcomes. Special attention and tailored support should be offered to securely attached girls in transferring responsibility for diabetes care and at least to male children of insecurely attached parents to prevent suboptimal glycemic control. Further studies in larger samples and more daily cortisol measurements may help us better understand the links between stress response, attachment and T1D. Keywords: Attachment, Childhood and adolescence, Diabetes control, Time in range, Cortisol
Aims. This study assesses the impact of using an AP-system at home on fear of hypoglycaemia. In addition, satisfaction and acceptance of the new technology are evaluated. Methods. In a multicentre, ...multinational study of 75 patients using the MD-Logic AP during four consecutive nights in home setting 59 of them (aged 10–54 years, 54% male, HbA1c 7.89 ± 0.69% 62.72 ± 7.51 mmol/mol, diabetes duration 11.6 ± 8.4 yrs) answered standardized questionnaires (HFS, adapted TAM, and AP satisfaction) before and after using the AP. Results. After experiencing the AP in home setting worries of hypoglycaemia were significantly reduced (before 1.04 ± 0.53 versus after 0.90 ± 0.63; P=0.017). Perceived ease of use as a measure of acceptance with the AP significantly increased after personal experience (before 4.64 ± 0.94 versus after 5.06 ± 1.09; P=0.002). The overall satisfaction mean score after using the AP was 3.02 ± 0.54 (range 0–4), demonstrating a high level of satisfaction with this technology. Conclusions. The four-night home-based experience of using MD Logic AP was associated with reduced worries of hypoglycaemia, high level of satisfaction, and increased perceived ease of use of the new technology in children, adolescents, and adults.
Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is a rare, X-linked recessive multisystem lysosomal storage disease due to iduronate-2-sulfatase enzyme deficiency. We presented three ...unrelated Slovenian patients with the severe form of MPS II that received three different management approaches: natural course of the disease without received specific treatment, enzyme replacement therapy (ERT), and hematopoietic stem cell transplantation (HSCT). The decision on the management depended on disease severity, degree of cognitive impairment, and parent's informed decision. The current benefits of MPS II treatments are limited. The lifelong costly intravenous ERT brings significant benefits but the patients with severe phenotypes and neurological involvement progress to cognitive decline and disability regardless of ERT, as demonstrated in published reviews and our case series. The patient after HSCT was the only one of the three cases reported to show a slowly progressing cognitive development. The type of information from the case series is insufficient for generalized conclusions, but with advanced myeloablative conditioning, HSCT may be a preferred treatment option in early diagnosed MPS II patients with the severe form of the disease and low disease burden at the time of presentation.
Tyrosinemia type 1 (HT1) is an inborn error of tyrosine catabolism that leads to severe liver, kidney, and neurological dysfunction. Newborn screening (NBS) can enable a timely diagnosis and early ...initiation of treatment.
We presented the follow up of the only two Slovenian patients diagnosed with HT1. Metabolic control was monitored by measuring tyrosine, phenylalanine and succinylacetone from dried blood spots (DBSs). Retrograde screening of HT1 was performed from DBSs taken at birth using tandem mass spectrometry.
First patient was diagnosed at the age of 6 months in the asymptomatic phase due to an abnormal liver echogenicity, the other presented at 2.5 months with an acute liver failure and needed a liver transplantation. The first was a compound heterozygote for a novel FAH intronic variant c.607-21A>G and c.192G>T whereas the second was homozygous for c.192G>T. At the non-transplanted patient, 66% of tyrosine and 79% of phenylalanine measurements were in strict reference ranges of 200–400 μmol/L and >30 μmol/L, respectively, which resulted in a favorable cognitive outcome at 3.6 years. On retrograde screening, both patients had elevated SA levels; on the other hand, tyrosine was elevated only at one.
We showed that non-coding regions should be analyzed when clinical and biochemical markers are characteristic of HT1. DBSs represent a convenient sample type for frequent amino acid monitoring. Retrograde diagnosis of HT1 was possible after more than three years of birth with SA as a primary marker, complemented by tyrosine.
•Non-coding region variants of FAH gene can result in a symptomatic HT1.•Retrograde screening for HT1 is technically possible even three years after birth.•DBS are convenient for monitoring HT1 patients and are family-friendly.•Regular monitoring in HT1 patients can result in a favorable cognitive outcome.
The author treats the processes that lead to the establishment of a prehistorical dialect area, in other words, a connection between two or more proto-related languages in a known or unknown ...geographical territory. The dialectology of linguistic families must, as every inductive inquiry, frequently allow a certain degree of vagueness if it is to come to any conclusions. However, the discrepancy between a good and bad interpretation of linguistic material can be significant. This is demonstrated by the analysis of examples that linguists have adduced in support of a prehistorical ancient Balkan-Baltic-Slavic dialect areal. By examining the argumentation theory, the author reveals typical fallacies and questionable methods in the process of reaching conclusions. These are: 1) the attempt to interpret material from a poorly attested language (the linguistic laws are unknown, etymologies unverifiable); 2) comparison of roots (because of the small number of elements and the typically simple structures, there is high probability that the similarity is coincidental); 3) circular reasoning, in which the author explains a fact with an unproven premise; examples where the author is led to a decision among variant readings by a preferred outcome; 4) drawing equivalencies among various types of proper nouns and appellatives without consideration of the methodological problems surrounding them; 5) ignorance of facts concerning a linguistic phenomenon that exists outside of the areal under consideration, as well as failure to consider the full weight of the evidence; 6) uncritical appropriation of findings from other disciplines and the transfer of these findings to comparative linguistics; 7) the explanation of poorly attested material with further poorly attested material; 8) explanation failing to follow logically from the material. With the aid of some of the procedures adduced we can prove the existence of dialect areals that are known never to have existed in reality. Regardless of the fact that the dialectology of linguistic families has existed from the beginnings of comparative linguistic as its constitutive part, it is clear that the methodology of this field of inquiry has yet to be thought through completely. Many hasty and unacceptable conclusions can be avoided by keeping in mind the questionable procedures and fallacies in the discovery of dialect areals adduced in this article.
Dolžnost vsake družbe je, da opolnomoči vse svoje članice_e in poskrbi, da so vse informacije javnega značaja dostopne za najrazličnejše skupine uporabnic_ov. Posebnega pomena so med drugim ...izobraževalne vsebine, med katere sodijo tudi jezikovni priročniki. V pričujočem príspevku se osredotočamo na implementacijo podatkov iz Slovarja slovenskega znakovnega jezika, ki je nastal v okviru Zveze društev gluhih in naglušnih, v 3. izdajo Slovarja slovenskega knjižnega jezika, ki nastaja na Inštitutu za slovenski jezik Frana Ramovša ZRC SAZU od leta 2016, in obratno. Sodobni razlagalni slovarji so v prvi vrsti spletni slovarji, pri čemer pa spletni medij omogoča številne možnosti povezljivosti podatkov med različnimi jezikovnimi viri. Namen prispevka je prikazati obstoječe stanje tovrstne implementacije in nadaljnje načrte.
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