Historical demography is generally concerned with the changing economic, social and normative contexts of human behaviour and health outcomes. To most historical demographers, the 'genetic' component ...of behaviour and health is either unknown or assumed to be constant. However, several studies point at the shift over time in the relative importance of environment and genes: in periods and social groups with strong normative or economic constraints on behaviour, the 'genetic potential' is often not realized. Therefore, to some extent, the waning of environmental constraints on heritability plays a role in changes in demographic outcomes over time. Determining the relative importance of heritability versus shared environment in historical populations for which only genealogies are available poses a challenge. Kin may live in different periods, and in different cultural and social settings. This explorative paper analyses the association between heights of conscripted relatives, as well as their life span. I estimate how the associations are affected by respectively genetic relatedness, shared historical period and shared social and geographical environment. Furthermore, I make a distinction between kin related via the mother versus kin related via the father. All kinds of kin are involved in the analysis: (half, full and twin) brothers, fathers, grandfathers, uncles and cousins. The data consist of about 3,000 men culled from Texel island genealogies, which also include descendants of families who had left the island. Life span has a weak, but still discernible, genetic element. The heritability of height is much stronger, especially at age 19/20. The correlations of mother’s kin with her son's heights are stronger than those of her husband's kin. The analysis does not yield a consistent effect of a protective environment on kin correlations in either height or life span.
Large historical databases, although intended to last for a long time, can become obsolete for a variety of reasons. In this essay these reasons are explored and used for a 'health check' of the ...Historical Sample of the Netherlands (HSN). The HSN leaders are examined for their visionary qualities and their sense of ownership, and the database for its complementarity, versatility and consistency. The essay concludes that, despite challenges ahead, HSN is sound of mind and body.
•5 patients with pelvic lymph node metastases received SBRT using a 1.5 T MR-linac.•Session time was <60 min for all 25 treatment fractions.•All quality assurance tests were passed (dose calculations ...& film measurements).
Online adaptive radiotherapy using the 1.5 Tesla MR-linac is feasible for SBRT (5 × 7 Gy) of pelvic lymph node oligometastases. The workflow allows full online planning based on daily anatomy. Session duration is less than 60 min. Quality assurance tests, including independent 3D dose calculations and film measurements were passed.
Identifying genes encoding bacteriocins and ribosomally synthesized and posttranslationally modified peptides (RiPPs) can be a challenging task. Especially those peptides that do not have strong ...homology to previously identified peptides can easily be overlooked. Extensive use of BAGEL2 and user feedback has led us to develop BAGEL3. BAGEL3 features genome mining of prokaryotes, which is largely independent of open reading frame (ORF) predictions and has been extended to cover more (novel) classes of posttranslationally modified peptides. BAGEL3 uses an identification approach that combines direct mining for the gene and indirect mining via context genes. Especially for heavily modified peptides like lanthipeptides, sactipeptides, glycocins and others, this genetic context harbors valuable information that is used for mining purposes. The bacteriocin and context protein databases have been updated and it is now easy for users to submit novel bacteriocins or RiPPs. The output has been simplified to allow user-friendly analysis of the results, in particular for large (meta-genomic) datasets. The genetic context of identified candidate genes is fully annotated. As input, BAGEL3 uses FASTA DNA sequences or folders containing multiple FASTA formatted files. BAGEL3 is freely accessible at http://bagel.molgenrug.nl.
In this paper, we argue why, in our view, the so-called dynamic classification method should be favored when determining the contribution of small businesses towards job creation. First, it is the ...only method that consistently attributes job creation or loss to the size class in which it actually occurs. In addition, dynamic classification has two other advantages: (1) it is not vulnerable to the so-called regression to the mean bias, and (2) only a small number of aggregated data are required for its application. Using the dynamic classification, we analyze job creation within the different size classes for the 27 Member States of the European Union. Our main findings are as follows. For the EU as a whole, smaller firms contribute on a larger scale towards job creation than do larger firms. Net job creation rates decrease with each firm size class. This pattern occurs in most industries, however, not in all; the manufacturing industry and trade industry show different patterns. At the level of individual countries, the net job creation rate also tends to decrease with each firm size class. However, this relationship is not perfect.
Stress Physiology of Lactic Acid Bacteria Papadimitriou, Konstantinos; Alegría, Ángel; Bron, Peter A ...
Microbiology and molecular biology reviews,
09/2016, Letnik:
80, Številka:
3
Journal Article
Recenzirano
Odprti dostop
Lactic acid bacteria (LAB) are important starter, commensal, or pathogenic microorganisms. The stress physiology of LAB has been studied in depth for over 2 decades, fueled mostly by the ...technological implications of LAB robustness in the food industry. Survival of probiotic LAB in the host and the potential relatedness of LAB virulence to their stress resilience have intensified interest in the field. Thus, a wealth of information concerning stress responses exists today for strains as diverse as starter (e.g., Lactococcus lactis), probiotic (e.g., several Lactobacillus spp.), and pathogenic (e.g., Enterococcus and Streptococcus spp.) LAB. Here we present the state of the art for LAB stress behavior. We describe the multitude of stresses that LAB are confronted with, and we present the experimental context used to study the stress responses of LAB, focusing on adaptation, habituation, and cross-protection as well as on self-induced multistress resistance in stationary phase, biofilms, and dormancy. We also consider stress responses at the population and single-cell levels. Subsequently, we concentrate on the stress defense mechanisms that have been reported to date, grouping them according to their direct participation in preserving cell energy, defending macromolecules, and protecting the cell envelope. Stress-induced responses of probiotic LAB and commensal/pathogenic LAB are highlighted separately due to the complexity of the peculiar multistress conditions to which these bacteria are subjected in their hosts. Induction of prophages under environmental stresses is then discussed. Finally, we present systems-based strategies to characterize the "stressome" of LAB and to engineer new food-related and probiotic LAB with improved stress tolerance.
This study examines determinants of professional human resource management (HRM) practices within a sample of approximately 700 small to medium-sized firms. Predictions from the agency theory and the ...resource-based view of organizations lead to alternate hypotheses regarding the direct and indirect negative effects of family ownership and management on the usage of professional HRM practices. Results support predictions for both direct and indirect effects. These indirect effects occur through intermediary variables that reflect organizational complexity, such as firm size, (the presence of a) formal business plan, and HRM specialization. The findings lend partial support to both theories.
Organic amendments (OAs) can improve the hydro‐physical properties of a soil and thereby potentially enhance the resilience of agricultural systems to droughts and floods. An OA's contribution to ...this resilience, however, depends on the timeliness of its impacts, as soil improvements should be achieved when droughts are most frequent or flood risks are greatest. Yet little is known regarding the temporal variability of OA impacts or the influence of OA quantity and quality thereupon. In this research, therefore, we investigated at two agricultural sites the temporal variability of improvements in soil bulk density, aggregate stability, infiltration capacity and water retention after the application of compost, farmyard manure, bokashi, a selection of organic residues from landscape maintenance, and a combination of these residues with manure. Results showed that, depending on management practices and soil type, OAs decrease bulk density by up to 9.8%, increase infiltration capacity by up to 108.1%, aggregate stability by up to 60.0%, and water retention by up to 77.8% relative to unamended controls within 3 years of repeated application. However, the magnitude of these improvements varies up to 96% between seasons, depending on the soil property and OA treatment. On average, for all treatments, impacts relative to the control varied between different seasons by 5% for bulk density, 47.1% for infiltration capacity, 22.6% for aggregate stability, and 26.3% for water retention. When offsetting OA nutrient differences with mineral fertilizers, this variability showed a stronger correlation to differences in OA application quantity than quality (i.e., chemical composition). Results suggest that disregarding temporal variability in OA impacts can result in an inaccurate valuation of OAs as either effective or ineffective in improving soil resilience, given that impacts may, instead of their frequently presumed persistency, actually be highly transient or lagged. Our findings highlight the importance of considering the potential intra‐annual variability of OA impacts on soil hydro‐physical properties when designing OA application strategies to ameliorate the effects of specific seasonal climatic challenges.
Core Ideas
Hydro‐physical properties improved within 3 years of repeated organic amendment (OA) application.
Improvements were more closely related to OA application rates than to OA composition.
The impact of OAs on hydro‐physical properties showed significant temporal variability.
Temporal variability in OA impacts was influenced by soil type and land management practices.
No single OA quantity or qualitative property could consistently explain the observed temporal variability.
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