In this sweeping intellectual and cultural history of the minjung ("common people's") movement in South Korea, Namhee Lee shows how the movement arose in the 1970s and 1980s in response to the ...repressive authoritarian regime and grew out of a widespread sense that the nation's "failed history" left Korean identity profoundly incomplete.
The Making of Minjungcaptures the movement in its many dimensions, presenting its intellectual trajectory as a discourse and its impact as a political movement, as well as raising questions about how intellectuals represented the minjung. Lee's portrait is based on a wide range of sources: underground pamphlets, diaries, court documents, contemporary newspaper reports, and interviews with participants. Thousands of students and intellectuals left universities during this period and became factory workers, forging an intellectual-labor alliance perhaps unique in world history. At the same time, minjung cultural activists reinvigorated traditional folk theater, created a new "minjung literature," and influenced religious practices and academic disciplines.
In its transformative scope, the minjung phenomenon is comparable to better-known contemporaneous movements in South Africa, Latin America, and Eastern Europe. Understanding the minjung movement is essential to understanding South Korea's recent resistance to U.S. influence. Along with its well-known economic transformation, South Korea has also had a profound social and political transformation. The minjung movement drove this transformation, and this book tells its story comprehensively and critically.
Although a combination of immune checkpoint inhibitors (ICIs) is recommended as the first line treatment option for metastatic renal cell carcinoma (mRCC), several immune-related adverse events ...(irAEs) occur, especially hepatitis. We explored the therapeutic benefits and safety profile of combining oncolytic vaccinia virus, JX-594, with a programmed cell death protein-1 (PD-1) inhibitor.
We used early-stage and advanced-stage orthotopic murine mRCC models developed by our group. PD-1 inhibitor monotherapy or a PD-1 inhibitor combined with either JX-594 or a cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitor were systemically injected through the peritoneum. An immunofluorescence analysis was performed to analyze the tumor immune microenvironment (TIME). irAEs were assessed in terms of hepatitis.
In the early-stage mRCC model mice, the combination of JX-594 and a PD-1 inhibitor significantly decreased the primary tumor size and number of lung nodules, compared with the ICI combination, but the JX-594 and PD-1 inhibitor combination and ICI combination did not differ significantly in the advanced-stage mRCC model mice. The JX-594 and PD-1 inhibitor combination induced tumor-suppressing TIME changes in both the early- and advanced-stage mRCC models. Furthermore, mice treated with the ICI combination had significantly greater hepatic injuries than those treated with the JX-594 and PD-1 inhibitor combination which was evaluated in early-stage mRCC model.
The JX-594 and PD-1 inhibitor combination effectively reduced primary tumors and the metastatic burden, similar to ICI combination therapy, through dynamic remodeling of the TIME. Furthermore, hepatitis was significantly decreased in the JX-594 and PD-1 inhibitor combination group, suggesting the potential benefit of that combination for reducing ICI-induced toxicity.
BackgroundOncolytic virus immunotherapy has revolutionized cancer immunotherapy by efficiently inducing both oncolysis and systemic immune activation. Locoregional administration has been used for ...oncolytic virus therapy, but its applications to deep-seated cancers have been limited. Although systemic delivery of the oncolytic virus would maximize viral immunotherapy’s potential, this remains a hurdle due to the rapid removal of the administered virus by the complement and innate immune system. Infected cells produce some vaccinia viruses as extracellular enveloped virions, which evade complement attack and achieve longer survival by expressing host complement regulatory proteins (CRPs) on the host-derived envelope. Here, we generated SJ-600 series oncolytic vaccinia viruses that can mimic complement-resistant extracellular enveloped virions by incorporating human CRP CD55 on the intracellular mature virion (IMV) membrane.MethodsThe N-terminus of the human CD55 protein was fused to the transmembrane domains of the six type I membrane proteins of the IMV; the resulting recombinant viruses were named SJ-600 series viruses. The SJ-600 series viruses also expressed human granulocyte-macrophage colony-stimulating factor (GM-CSF) to activate dendritic cells. The viral thymidine kinase (J2R) gene was replaced by genes encoding the CD55 fusion proteins and GM-CSF.ResultsSJ-600 series viruses expressing human CD55 on the IMV membrane showed resistance to serum virus neutralization. SJ-607 virus, which showed the highest CD55 expression and the highest resistance to serum complement-mediated lysis, exhibited superior anticancer activity in three human cancer xenograft models, compared with the control Pexa-Vec (JX-594) virus, after single-dose intravenous administration. The SJ-607 virus administration elicited neutralizing antibody formation in two immunocompetent mouse strains like the control JX-594 virus. Remarkably, we found that the SJ-607 virus evades neutralization by vaccinia virus-specific antibodies.ConclusionOur new oncolytic vaccinia virus platform, which expresses human CD55 protein on its membrane, prolonged viral survival by protecting against complement-mediated lysis and by evading neutralization by vaccinia virus-specific antibodies; this may provide a continuous antitumor efficacy until a complete remission has been achieved. Such a platform may expand the target cancer profile to include deep-seated cancers and widespread metastatic cancers.
As the metaverse has been introduced into the education sector, higher education institutions have further promoted metaverse platforms for implementing problem-based learning (PBL) to enhance ...students' competencies. This research explored hospitality students’ experiences of a PBL curriculum using grounded theory to understand the educational effect of PBL in the metaverse. The findings indicated that while participants were fascinated by the fact that the metaverse platform had novel features and functions with the creation of virtual space, they faced difficulties in using it due to linguistic and technical limitations in class. However, the participants actively participated in collaboration with the group members as their willingness to adhere to the lessons grew. Therefore, the core category was derived as “enhancing learning effectiveness through active participation in changing educational environments.” Based on the research results, this study provides theoretical and practical foundations to create innovative and effective PBL educational environments in the field of hospitality education.
•This study expands the educational application of the metaverse.•Immersive and realistic learning opportunities in virtual spaces should be created.•Personal qualities and skills should be developed through cooperative activities.•Students' learning effectiveness should be enhanced in preparing future professionals.
This is the first book in English to offer an extensive introduction to the Tongmunsŏn (Selections of Refined Literature of Korea)-the largest and most important Korean literary collection created ...prior to the twentieth century-as well as translations of essays from key chapters. The Tongmunsŏn was compiled in 1478 by Sŏ Kŏjŏng (1420-1488) and other Chosŏn literati at the command of King Sŏngjong (r. 1469-1494). It was modeled after the celebrated Chinese anthology Wen Xuan and contains poetry and prose in an extensive array of styles and genres.
The Translators' Introduction begins by describing the general structure of the Tongmunsŏn and contextualizes literary output in Korea within the great sweep of East Asian literature from the eighth to the fifteenth centuries. The entire Tongmunsŏn as well as all of the essays selected for translation were written in hanmun (as opposed to Korean vernacular), which points to a close literary connection between the continent and the peninsula. The Introduction goes on to discuss the genres contained in the Tongmunsŏn and examines style as revealed through prosody.
The translation of two of these genres (treatises and discourses) in four books of the Tongmunsŏn showcases prose-writing and the intellectual concerns of the age. Through their discussions of morality, nature, and the fantastic, we see Daoist, Buddhist, and Confucian themes at work in essays by some of Korea's most distinguished writers, among them Yi Kyubo, Yi Saek, Yi Chehyŏn, and Chŏng Tojŏn. The translations also include annotations and extensive cross-references to classical allusions in the Chinese canon, making the present volume an essential addition to any East Asian literature collection.
Immune checkpoint inhibitors and tyrosine kinase inhibitors are the first-line treatment for metastatic renal cell carcinoma (mRCC), but their benefits are limited to specific patient subsets. Here, ...we aimed to evaluate the therapeutic efficacy of JX-594 (pexastimogene devacirepvec, Pexa-vec) monotherapy by systemic injection in comparison with sunitinib monotherapy in metastatic orthotopic RCC murine models. Two highly metastatic orthotopic RCC models were developed to compare the treatment efficacy in the International Metastatic RCC Database Consortium favorable-risk and intermediate- or poor-risk groups. JX-594 was systemically injected through the peritoneum, whereas sunitinib was orally administered. Post-treatment, tumor microenvironment (TME) remodeling was determined using immunofluorescence analysis. Systemic JX-594 monotherapy injection demonstrated therapeutic benefit in both early- and advanced-stage mRCC models. Sunitinib monotherapy significantly reduced the primary tumor burden and number of lung metastases in the early-stage, but not in the advanced-stage mRCC model. Systemic JX-594 delivery remodeled the primary TME and lung metastatic sites by increasing tumor-infiltrating CD4/8+ T cells and dendritic cells. Systemic JX-594 monotherapy demonstrated significantly better therapeutic outcomes compared with sunitinib monotherapy in both early- and advanced-stage mRCCs by converting cold tumors into hot tumors. Sunitinib monotherapy effectively suppressed primary tumor growth and lung metastasis in early-stage mRCC.
This paper explores tourists' perceptions of English as a lingua franca (ELF) to understand the ELF phenomenon in tourist destinations by analyzing in-depth interviews with 15 Korean tourists from a ...phenomenological approach. The findings show that participants had awareness of the growing role of ELF in tourism and perceived English use in destinations as an opportunity for selfdevelopment and the index of social development while the dominance of English was recognized as unequal linguistic power relations such as linguistic imperialism. This study provides implications for tourist destination management and marketing on language-related issues to satisfy and attract more tourists.
Spontaneous regression of tumors is an extremely rare event in hepatocellular carcinoma (HCC) with only a few reports available. With the accumulation of clinical information and tumor ...immunogenetics, several mechanisms for the cystic changes of HCC have been suggested, including arterial thrombosis, inflammation, and rapid tumor growth. This paper reports an uncommon case of the partial regression of HCC, which was initially misdiagnosed as a mucinous cystic neoplasm of the liver due to the unusual radiologic findings. A 78-year-old female with the hepatitis B virus and liver cirrhosis presented with an approximately 5 cm-sized cystic mass of the liver. From the radiologic evidence of a papillary-like projection from the cyst wall toward the inner side, the initial impression was a mucinous cystic neoplasm of the liver. The patient underwent a surgical resection and finally, cystic degeneration of HCC, in which approximately 80% necrosis was noted. This case suggests that if a cystic neoplasm of liver appears in a patient with a high risk of HCC on a hepatobiliary imaging study, it is prudent to consider the cystic degeneration of HCC in a differential diagnosis.
PDF
