•Automated processing pipeline has been developed for streak detection from CCD images.•The prototype pipeline is tuned for ground- and space-based observing scenarios.•About 90% of the long (>100 ...pixels) and bright (SNR>1) streaks can be detected.•Average processing time is 13s for a typical 2k-by-2k CCD image.
We describe a novel data-processing and analysis pipeline for optical observations of moving objects, either of natural (asteroids, meteors) or artificial origin (satellites, space debris). The monitoring of the space object populations requires reliable acquisition of observational data, to support the development and validation of population models and to build and maintain catalogues of orbital elements. The orbital catalogues are, in turn, needed for the assessment of close approaches (for asteroids, with the Earth; for satellites, with each other) and for the support of contingency situations or launches. For both types of populations, there is also increasing interest to detect fainter objects corresponding to the small end of the size distribution.
The ESA-funded StreakDet (streak detection and astrometric reduction) activity has aimed at formulating and discussing suitable approaches for the detection and astrometric reduction of object trails, or streaks, in optical observations. Our two main focuses are objects in lower altitudes and space-based observations (i.e., high angular velocities), resulting in long (potentially curved) and faint streaks in the optical images. In particular, we concentrate on single-image (as compared to consecutive frames of the same field) and low-SNR detection of objects. Particular attention has been paid to the process of extraction of all necessary information from one image (segmentation), and subsequently, to efficient reduction of the extracted data (classification).
We have developed an automated streak detection and processing pipeline and demonstrated its performance with an extensive database of semisynthetic images simulating streak observations both from ground-based and space-based observing platforms. The average processing time per image is about 13s for a typical 2k-by-2k image. For long streaks (length >100 pixels), primary targets of the pipeline, the detection sensitivity (true positives) is about 90% for both scenarios for the bright streaks (SNR>1), while in the low-SNR regime, the sensitivity is still 50% at SNR=0.5.
The Son Of X-Shooter (SOXS) is a medium resolution spectrograph R~4500 proposed for the ESO 3.6 m NTT. We present the optical design of the UV-VIS arm of SOXS which employs high efficiency ion-etched ...gratings used in first order (m=1) as the main dispersers. The spectral band is split into four channels which are directed to individual gratings, and imaged simultaneously by a single three-element catadioptric camera. The expected throughput of our design is >60% including contingency. The SOXS collaboration expects first light in early 2021. This paper is one of several papers presented in these proceedings describing the full SOXS instrument.
An overview of the optical design for the SOXS spectrograph is presented. SOXS (Son Of X-Shooter) is the new wideband, medium resolution (R>4500) spectrograph for the ESO 3.58m NTT telescope expected ...to start observations in 2021 at La Silla. The spectroscopic capabilities of SOXS are assured by two different arms. The UV-VIS (350-850 nm) arm is based on a novel concept that adopts the use of 4 ion-etched high efficiency transmission gratings. The NIR (800- 2000 nm) arm adopts the '4C' design (Collimator Correction of Camera Chromatism) successfully applied in X-Shooter. Other optical sub-systems are the imaging Acquisition Camera, the Calibration Unit and a pre-slit Common Path. We describe the optical design of the five sub-systems and report their performance in terms of spectral format, throughput and optical quality. This work is part of a series of contributions describing the SOXS design and properties as it is about to face the Final Design Review.
The VIS detector system of SOXS Cosentino, Rosario; Aliverti, Matteo; Scuderi, Salvatore ...
arXiv.org,
09/2018
Paper, Journal Article
Odprti dostop
SOXS will be a unique spectroscopic facility for the ESO NTT telescope able to cover the optical and NIR bands thanks to two different arms: the UV-VIS (350-850 nm), and the NIR (800-1800 nm). In ...this article, we describe the design of the visible camera cryostat and the architecture of the acquisition system. The UV-VIS detector system is based on a e2v CCD 44-82, a custom detector head coupled with the ESO continuous ow cryostats (CFC) cooling system and the NGC CCD controller developed by ESO. This paper outlines the status of the system and describes the design of the different parts that made up the UV-VIS arm and is accompanied by a series of contributions describing the SOXS design solutions.
SOXS (Son Of X-Shooter) is a new spectrograph for the ESO NTT telescope, currently in the final design phase. The main instrument goal is to allow the characterization of transient sources based on ...alerts. It will cover from near-infrared to visible bands with a spectral resolution of \(R \sim 4500\) using two separate, wavelength-optimized spectrographs. A visible camera, primarily intended for target acquisition and secondary guiding, will also provide a scientific "light" imaging mode. In this paper we present the current status of the design of the SOXS instrument control software, which is in charge of controlling all instrument functions and detectors, coordinating the execution of exposures, and implementing all observation, calibration and maintenance procedures. Given the extensive experience of the SOXS consortium in the development of instruments for the VLT, we decided to base the design of the Control System on the same standards, both for hardware and software control. We illustrate the control network, the instrument functions and detectors to be controlled, the overall design of SOXS Instrument Software (INS) and its main components. Then, we provide details about the control software for the most SOXS-specific features: control of the COTS-based imaging camera, the flexures compensation system and secondary guiding.
Abstract
Many hereditary cancer syndromes are associated with an increased risk of small and large intestinal adenocarcinomas. However, conditions bearing a high risk to both adenocarcinomas and ...neuroendocrine tumors are yet to be described.
We studied a family with 16 individuals in four generations affected by a wide spectrum of intestinal tumors, including hyperplastic polyps, adenomas, small intestinal neuroendocrine tumors, and colorectal and small intestinal adenocarcinomas.
To assess the genetic susceptibility and understand the novel phenotype, we utilized multiple molecular methods, including whole genome sequencing, RNA sequencing, single cell sequencing, RNA in situ hybridization and organoid culture.
We detected a heterozygous deletion at the cystic fibrosis locus (7q31.2) perfectly segregating with the intestinal tumor predisposition in the family. The deletion removes a topologically associating domain border between CFTR and WNT2, aberrantly activating WNT2 in the intestinal epithelium. These consequences suggest that the deletion predisposes to small intestinal neuroendocrine tumors and small and large intestinal adenocarcinomas, and reveals the broad tumorigenic effects of aberrant WNT activation in the human intestine.
Tumor cells use membrane type 1 matrix metalloproteinase (MT1-MMP) for invasion and metastasis. However, the signaling mechanisms that underlie MT1-MMP regulation in cancer have remained unclear. ...Using a systematic gain-of-function kinome screen for MT1-MMP activity, we have here identified kinases that significantly enhance MT1-MMP activity in tumor cells. In particular, we discovered an MT1-MMP/FGF receptor-4 (FGFR4) membrane complex that either stimulates or suppresses MT1-MMP and FGFR4 activities, depending on a tumor progression-associated polymorphism in FGFR4. The FGFR4-R388 allele, linked to poor cancer prognosis, increased collagen invasion by decreasing lysosomal MT1-MMP degradation. FGFR4-R388 induced MT1-MMP phosphorylation and endosomal stabilization, and surprisingly, the increased MT1-MMP in return enhanced FGFR4-R388 autophosphorylation. A phosphorylation-defective MT1-MMP was stabilized on the cell surface, where it induced simultaneous FGFR4-R388 internalization and dissociation of cell–cell junctions. In contrast, the alternative FGFR4-G388 variant down-regulated MT1-MMP, and the overexpression of MT1-MMP and particularly its phosphorylation-defective mutant vice versa induced FGFR4-G388 degradation. These results provide a mechanistic basis for FGFR4-R388 function in cancer invasion.
PDF
