With rapid development of city rail transit, a greater degree of reduced energy consumption for rail transportation has been our key issues. In this paper, adjustable ventilation platform screen door ...was combined the platform screen door and security door systems together. All advantages of the both systems have been used. In different regions different forms of air conditioning systems were used to fully exploit the seasonal advantage of systems. Then more energy was saved. According to the simulation results, the ventilation and air conditioning systems in different climatic regions can meet regulatory requirements, save more energy.
The unsupported Cu and Ag catalysts with different oxidation states were prepared, and their catalytic performances for propylene epoxidation were investigated.The metallic Cu catalyst exhibits much ...higher catalytic activity and propylene oxide(PO) selectivity than Cu2 O and Cu O catalysts.The Cu0 species are the main active sites for propylene epoxidation, but Cu2 O and Cu O species are in favor of CO2 and acrolein production.The PO selectivity of 54.2 % and propylene conversion of 2.6 % can be achieved over the metallic Cu catalyst at 160 °C in initial stage, but metallic Cu catalyst would be oxidized to Cu2 O during propylene epoxidation, resulting in a sharp decrease in the PO selectivity and propylene conversion.Nanosize Ag Cuxbimetallic catalysts were prepared.It is found that adding Ag to the metallic Cu catalysts can prevent the oxidation of Cu and make Ag Cuxbimetallic catalysts more stable under the condition of propylene epoxidation.The Ag/Cu molar ratio can remarkably affect the catalytic performance of Ag Cuxcatalyst and the selectivity to PO and acrolein.After Ag Cuxwas supported on MOx-modified a-Al2O3, its catalytic performance can be improved and has a close relationship with the acid–base property of support.
Being delivered as sprays or expressed in plant, Bacillus thuringiensis (Bt) crystalline proteins (Cry toxins) display insecticidal activities against numerous Lepidopteran, Dipteran, and Coleopteran ...larvae. Comparative study of toxicities of Bt Cry toxins between larvae and adults may afford important new insights into the interactions of the toxins with receptor proteins in host insect, and represent intriguing targets for the control of insect pests. However, the effectiveness of Bt Cry toxins in insect adults has paid less attention. In the present article, the effectiveness of Cry1Ac and Cry1Ca on lifespans and reproductive performance of Helicoverpa armigera (Huebner) and Spodoptera exigua (Huebner) adults were evaluated by in vivo experiments. Considering transgenic plants express modified, truncated versions of cry genes yielding active toxin fragment, we used activated Bt toxins at the concentration of 500, 100, and 20 mu g/ml in a 10% sucrose aquous solution. At the highest concentration, Cry1Ac and Cry1Ca shortened 48.1 and 48.9% of H. armigera female lifespan, and 43.5 and 38.5% of S. exigua female lifespan, and they reduced 37.8 and 40.3%, and 50.5 and 47.4% of H. armigera and S. exigua male lifespans respectively. Bt toxins negatively affected copulation. Exposure to 500 mu g/ml of Cry1Ac and Cry1Ca greatly reduced 50.0 and 46.8%, and 58.7 and 57.3% spermatophore acceptance by H. armigera and S. exigua females, respectively. Similarly, Cry1Ac and Cry1Ca exposure decreased 40.0 and 50.3%, and 61.3 and 60.0% of spermatophore transfer by H. armigera and S. exigua males, respectively. Moreover, exposure females rather than males to 500 mu g/ml of Cry1Ac and Cry1Ca significantly dropped 57.5 and 57.5% of the number of eggs laid by H. armigera, and 35.4 and 45.8% of the number of egg masses deposited by S. exigua. In contrast, both Cry1Ac and Cry1Ca did not negatively influence the egg hatchability. At the middle and the lowest concentrations, however, the biological effects of Cry1Ac and Cry1Ca on lifespans and reproductive performance partially or completely disappeared.
In recent years, advances in several key technologies in Internet of Things (IoT), such as radio-frequency identification, wireless sensor network, embedded intelligence and nanotechnology, and micro ...electro mechanical systems have brought enormous progresses in developing IoT-based applications. IoT integrates heterogeneous intelligent devices and supports interoperability between devices through Internet and various communication technologies, which also helps bridge the physical world and virtual world. Therefore, for IoT application developers, it is important to have a mechanism that can provide a uniform accessible interface, called middleware, which hides technical details of accessing hardware devices from application developers and helps them to concentrate their focus on the software portion of the IoT applications. To deal with this issue, we proposed, in this paper, a middleware architecture that is designed based on software engineering point of view to assist developers with an easier way to establish communication links between devices and their applications, in which devices can be plugged into a system and the user interface for accessing these devices can be downloaded, installed, and displayed on the system. To be more specific, features for manipulating a device are captured in a description file and are used as a means for matching and downloading an appropriate pluggable user interface component through the middleware. Furthermore, by using the proposed middleware, the development time used in constructing user interface can be reduced. An experimental implementation of the middleware is also established to demonstrate the feasibility of the proposed architecture.
Attribute dependency function is very important for feature selection in data mining, pattern recognition and machine learning. However, Pawlak's is inadequate for some information systems, and ...Daisuke's definition is only for categorical attribute. In this paper, we introduce a new definition based on partition for numerical attribute. The advantage of the definition is that heterogeneous features can be dealt with. At last, we apply the function to local reduction, the experimental results show that the definition is more flexible to deal with heterogeneous features as a new quantitative analysis tool for local reduction.
The role of bilirubin in inflammatory bowel disease is not only functioned as an antioxidant and anti-inflammatory factor, but also functioned in immune regulation, anti-platelet aggregation, and as ...inhibition factor of digestive protease and remodeling of microbiota. Serum bilirubin level is correlated with disease activity and severity, so is a potential serum marker of inflammatory bowel disease in terms of supporting clinical diagnosis and treatment of inflammatory bowel disease.
The crew health evaluation model based on probability neural network and the sports items intervention expert system established in the paper. The system can track and guide n the crew physical and ...psychological health status at sea in real time. The research work has important practical significance and great practical value, which may enhance the crew physical and psychological health, improve work efficiency, promote the harmony and stability of the ship small environment, maintain the normal life order and ensure safety at sea.
(E)-Methyl-4-aryl-4-oxabut-2-enoate, designated YH-8, is a novel Serflhr protein kinase B (PknB) inhibitor, which is designed for the treatment of tuberculosis. The aim of this study was to ...investigate the pharmacokinetics, bioavailability, tissue distribution and excretion characteristics of YH-8 in rats and study its plasma protein binding in vitro. The pharmacokinetic properties were examined after intravenously injected YH-8 at 10 and 20 mg/kg and oral administrated YH-8 at 50, 100 and 200 mg/kg to rats. The concentrations of YH-8 in plasma were determined with LC-MS/MS, with a liquid-liquid extraction. The tissue distribution and urinary, fecal and -biliary excretion patterns of YH-8 were investigated following a single oral dosing of 100 mg/kg. The plasma protein binding rates of YH-8 were determined using ultra-filtration method. After intra- venous and oral administration, YH-8 showed dose-independent pharmacokinetic characteristics, with T(1/2) of approximately 5.5 h and 7.1 h, respectively. The oral absolute bioavailability of YH-8 was relatively low (about 12%). YH-8 was widely distributed in various tissues and showed substantial deposition in intestine, stomach, liver, lung and kidney. The drug was mainly eliminated via fecal excretion and its binding rate with plasma protein was concentration-dependent. In conclusion, this study as first provided the full pharmacokinetic characteristics of YH-8, which would be helpful for its further development and clinical application.
AIM： To detect the expression of DPC4 in malignant and non-malignant specimens of human pancreas, and observe the inhibition of retroviral pLXSN containing DPC4 on pancreatic carcinoma cells in ...vitro. METHODS： The expression of DPC4 was determined in 40 pancreatic adenocarcinoma and 36 non-malignant pancreatic specimens by reversetranscriptase polymerase chain reaction （RT-PCR） and immunohisto-chemistry. Furthermore, we constructed retroviral vectors containing DPC4, which then infected the pancreatic carcinoma cell line BxPC-3. Cell growth in vitro after being infected was observed, and the vascular endothelial growth factor （VEGF） mRNA level in the daughter cells was determined by semi- quantitative PCR assay. RESULTS： The RT-PCR assay showed a positive rate of DPC4 mRNA in 100% （36/36） of normal specimens, compared to 40% （16/40） in adenocarcinoma specimens. The regional and intense positive cases of DPC4 expression in adenocarcinoma detected by immunohistochemistry were 10 and four, whereas it was all positive expression in normal tissues. There was a significant difference of DPC4 expression between them. The stable expression of DPC4 in the pancreatic carcinoma cells BxPC-3 could be resumed by retroviral vector pLXSN transfection, and could inhibit cell growth in vitro. Rather, DPC4 could decrease VEGF mRNA transcription levels.CONCLUSION： The deletion of DPC4 expression in pancreatic carcinoma suggests that loss of DPC4 may be involved in the development of pancreatic carcinoma. The retroviral vector pLXSN containing DPC4 can inhibit the proliferation of pancreatic carcinoma cells, and down-regulate the level of VEGF.
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