Summary
Background
Up‐to‐date information regarding the recurrence rate of Helicobacter pylori (H. pylori) after eradication therapy is not available.
Aim
To evaluate the global recurrence rate ...following H. pylori eradication therapy and confirm its association with socioeconomic and sanitary conditions.
Methods
A systematic search of PubMed, EMBASE and the Cochrane library was performed to identify potentially relevant publications using the following keywords: “Helicobacter pylori” or “H. pylori” or “Hp” and “recurrence” or “recrudescence” or “reinfection” or “recurrent” or “recurred” or “re‐infect*” or “relapse*.”
Results
A total of 132 studies (53 934 patient‐years) were analysed. Each study was weighted according to the duration of patient‐years. The global annual recurrence, reinfection and recrudescence rate of H. pylori were 4.3% (95% CI, 4‐5), 3.1% (95% CI, 2‐5) and 2.2% (95% CI, 1‐3), respectively. The H. pylori recurrence rate was inversely related to the human development index (HDI) (ie, 3.1% 95% CI, 2‐4, 6.2% 95% CI, 4‐8 and 10.9% 95% CI, 6‐18 in countries with a very high, high and medium or low HDI) (P <.01) and directly related to H. pylori prevalence (10.9% 95% CI, 7‐16, 3.7% 95% CI, 3‐5, 3.4% 95% CI, 2‐5 and 1.6% 95% CI, 0.5‐3 in countries with a very high, high, medium or low local H. pylori prevalence) (P <.01). Global recurrence rates remained relatively stable between 1990s, 2000s and 2010s but varied across different regions (P <.05).
Conclusions
H. pylori recurrence remains a problem closely associated with socioeconomic and sanitary conditions. Methods to reduce recurrence in developing countries are needed.
Linked ContentThis article is linked to Willington and Gearry, and Roblin et al papers. To view these papers visit https://doi.org/10.1111/apt.14370 and https://doi.org/10.1111/apt.14385.
Shape memory alloy (SMA) is a novel functional material and has found increasing applications in many areas. Recently, research efforts have been extended to using SMA for control of civil ...structures. This paper presents a review of applications of the SMA materials for passive, active and semi-active controls of civil structures. First, an overview of the characteristics of SMA is presented. The shape memory effect (SME) and pseudoelasticity, two major properties of SMA associated with the thermal-induced or stress-induced reversible hysteretic phase transformation between austenite and martensite, are reviewed. These unique properties enable SMA to be used as actuators, passive energy dissipators and dampers for civil structure control. This paper then reviews current research using SMA-based devices for passive, semi-active or active control of civil structures. The operation mechanism, design and experimental results of these SMA-based devices are also presented in the paper.
Summary
Background
Inherited epidermodysplasia verruciformis (EV) is a rare skin disorder characterized by susceptibility to specific types of human papilloma virus (HPV) and is strongly associated ...with skin carcinomas. Inactivating mutations in EVER1/EVER2 account for most cases of EV. However, more phenotypes related to but distinct from EV have been reported with an immunodeficiency state but without EVER1/EVER2 mutation, and the genetic basis for these atypical EV cases is poorly understood.
Objectives
To identify the causative gene responsible for three siblings affected by atypical EV but without EVER1/EVER2 mutation.
Methods
Whole‐exome sequencing followed by Sanger sequencing was performed to identify the gene responsible for the patients with atypical EV enrolled in our study.
Results
A homozygous splicing mutation was detected in LCK (c.188‐2A>G). This mutation resulted in an exon 3 deletion T lymphocyte‐specific protein tyrosine kinase isoform, which further led to frameshift mutation and subsequent mRNA decay.
Conclusions
We demonstrate a novel mutation in LCK in a family affected by atypical EV with T‐cell defects, HPV infection and virus‐induced malignancy, providing new clues in the understanding of host defences against HPV and better genetic counselling of patients with the EV phenotype.
What's already known about this topic?
Epidermodysplasia verruciformis (EV) is an unusual genodermatosis characterized by an increased susceptibility to β‐human papillomavirus and is associated with a high risk of skin carcinoma.
Inactivating mutations in EVER1/EVER2 account for most cases of EV.
What does this study add?
Our study suggests an association between a novel splicing mutation in LCK and EV susceptibility.
What is the translational message?
Patients with EV should be tested for T lymphocyte‐specific protein tyrosine kinase deficiency and T‐cell function, which will help guide treatment.
Linked Comment: Uitto and Vahidnezhad. Br J Dermatol 2016; 175:1138–1139.
Background and purpose
Restless legs syndrome (RLS) is an underestimated movement disorder in patients with end‐stage renal disease (ESRD). Several clinical and laboratory factors were inconsistently ...reported to associate with RLS. We aim to perform a large‐scale multicenter study to investigate the possible associated risk factors of RLS in patients with ESRD in Taiwan, a country with the highest incidence of uremia in the world.
Methods
From October 2009 to October 2011, we constitutively recruited 1130 patients with ESRD from 17 hemodialysis centers. Demographic, laboratory data, presence and severity of RLS were collected. Odds ratios (ORs) were estimated by logistic regression models.
Results
We found the prevalence of RLS to be 25.3% in patients with ESRD. Having type 2 diabetes OR = 3.61 (2.27–5.77), P < 0.01, low serum transferrin saturation OR = 1.42 (1.01–2.03), P < 0.05 and duration of dialysis OR = 1.09 (1.03–1.14), P < 0.01 were associated with RLS. In contrast, high serum hemoglobin level was inversely associated with RLS OR = 0.61 (0.40–0.89), P < 0.05. RLS has a significant impact on sleep quality in dialysis patients. Among patients with RLS, history of type 2 diabetes OR = 4.04 (1.65–10.79), P < 0.05, low serum hemoglobin level OR = 5.41 (2.43–13.12), P < 0.01 and duration of dialysis OR = 1.01 (1.01–1.02), P < 0.01 were associated with increased severity of RLS.
Conclusions
Our findings demonstrated that RLS is common in Taiwanese dialysis patients. Clinicians should have a high suspicion for the presence of RLS symptoms in patients with ESRD, especially those with type 2 diabetes, anemia, low serum iron status and long duration of dialysis.
Abstract
In crystalline materials, electron-phonon coupling (EPC) is a ubiquitous many-body interaction that drives conventional Bardeen-Cooper-Schrieffer superconductivity. Recently, in a new kagome ...metal CsV
3
Sb
5
, superconductivity that possibly intertwines with time-reversal and spatial symmetry-breaking orders is observed. Density functional theory calculations predicted weak EPC strength, λ, supporting an unconventional pairing mechanism in CsV
3
Sb
5
. However, experimental determination of λ is still missing, hindering a microscopic understanding of the intertwined ground state of CsV
3
Sb
5
. Here, using 7-eV laser-based angle-resolved photoemission spectroscopy and Eliashberg function analysis, we determine an intermediate λ=0.45–0.6 at
T
= 6 K for both Sb 5
p
and V 3
d
electronic bands, which can support a conventional superconducting transition temperature on the same magnitude of experimental value in CsV
3
Sb
5
. Remarkably, the EPC on the V 3
d
-band enhances to λ~0.75 as the superconducting transition temperature elevated to 4.4 K in Cs(V
0.93
Nb
0.07
)
3
Sb
5
. Our results provide an important clue to understand the pairing mechanism in the kagome superconductor CsV
3
Sb
5
.
Summary
A growing elderly population is expected worldwide, and the burden of hip fractures on health care system will continue to increase. By 2035, there will be a 2.7-fold increase in the number ...of hip fractures in Taiwan. The study provides quantitative basis for the future distribution of medical resources.
Introduction
Hip fractures have long been recognized as a major public health concern. The study aimed to determine time trends in the incidence of hip fractures and to forecast the number of hip fractures expected in Taiwan up to 2035.
Methods
A nationwide survey was conducted using data from the Taiwan National Health Insurance Research Database from 2004 to 2011. A total of 141,397 hip fractures were identified, with a mean of 17,675 fractures/year. Annual incidences of hip fractures were calculated and tested for trends. Projections of the incidence rates of hip fractures and bed days associated with hip fractures were calculated using Poisson regression on the historical incidence rates in combination with population projections from 2012 to 2035.
Results
The incidence rates of hip fracture during 2004–2011 were 317 and 211 per 100,000 person-years among women and men, respectively. Over this 8-year period, the age-standardized incidence of hip fracture decreased by 13.4 % among women and 12.2 % among men. Despite the decline in the age-standardized incidence, the absolute number of hip fractures increased owing to the aging population. The number of hip fractures is expected to increase from 18,338 in 2010 to 50,421 in 2035—a 2.7-fold increase. The number of bed days for 2010 and 2035 was estimated at 161,248 and 501,995, respectively, representing a 3.1-fold increase.
Conclusions
The socioeconomic impact of hip fractures will be high in the near future. This study provides a quantitative basis for future policy decisions to serve this need.
Abstract
The intertwining between spin, charge, and lattice degrees of freedom can give rise to unusual macroscopic quantum states, including high-temperature superconductivity and quantum anomalous ...Hall effects. Recently, a charge density wave (CDW) has been observed in the kagome antiferromagnet FeGe, indicative of possible intertwining physics. An outstanding question is that whether magnetic correlation is fundamental for the spontaneous spatial symmetry breaking orders. Here, utilizing elastic and high-resolution inelastic x-ray scattering, we observe a c-axis superlattice vector that coexists with the 2
$$\times$$
×
2
$$\times$$
×
1 CDW vectors in the kagome plane. Most interestingly, between the magnetic and CDW transition temperatures, the phonon dynamical structure factor shows a giant phonon-energy hardening and a substantial phonon linewidth broadening near the c-axis wavevectors, both signaling the spin-phonon coupling. By first principles and model calculations, we show that both the static spin polarization and dynamic spin excitations intertwine with the phonon to drive the spatial symmetry breaking in FeGe.
A review is presented for vibration suppression of civil structures. Special emphasis is laid upon smart structures with piezoelectric control actuation. The last decade has seen spiraling efforts ...going on around the world into development of the smart structures field. The success of these smart structures is orchestrated by the materials, such as piezoceramics, shape memory alloys, controllable fluids such as magneto-rheological fluids and electro-rheological fluids, fiber-optic sensors and various other materials.
Piezoceramics have been known as low-cost, lightweight, and easy-to-implement materials for active control of structural vibration. Piezoceramics are available in various forms such as rigid patch, flexible patch, stack, Macro-Fiber Composite (MFC) actuator, and piezoceramic friction dampers. Piezoelectric patch actuators can be surface bonded to high strain areas of the structure with minimal modification of the original structure or they can be embedded into such as composites structures. On the other hand, stack type actuators can be incorporated into the structures, which require high control forces and micron level displacements, with slight modifications.
This paper first presents basics about piezoceramic materials, various actuation methods and types of piezoceramic actuators. Then this paper reviews research into the application of piezoceramic actuators in various civil structures such as beams, trusses, steel frames and cable-stayed bridges.
Abstract Lagrangian perspectives on the small-scale structure of anisotropic Alfvénic turbulence are adopted. We are interested in relating the statistical properties of the Eulerian field increments ...evaluated along the fluid particle trajectories, in the direction perpendicular to the guiding magnetic field and along the magnetic field lines. We establish the basis for a unified multifractal phenomenology of Eulerian and Lagrangian Alfvénic turbulence. The critical balance condition is generalized to structure functions of an order different than 2. A Lagrangian perspective is not only useful for investigating the small-scale structure of Alfvénic turbulence, it is also tailored to the modeling of large-scale turbulent transport. Therefore, we develop Lagrangian stochastic models for the dispersion of fluid particles and magnetic field lines in the solar wind. The transport models are based on the integrated Ornstein–Uhlenbeck process that is not Markov, yielding smooth stochastic fluid particle trajectories and magnetic field lines. Brownian diffusion is recovered by tending the integral scale parameter to zero while keeping the diffusivity finite.
Abstract
In this work, we extend Leighton’s diffusion model describing the turbulent mixing of magnetic footpoints on the solar wind source surface. The present Lagrangian stochastic model is based ...on the spherical Ornstein–Uhlenbeck process with drift that is controlled by the rotation frequency Ω of the Sun, the Lagrangian integral timescale
τ
L
, and the root-mean-square footpoint velocity
V
rms
. The Lagrangian velocity and the positions of magnetic footpoints on the solar wind source surface are obtained from the solutions of a set of stochastic differential equations, which are solved numerically. The spherical diffusion model of Leighton is recovered in the singular Markov limit when the Lagrangian integral timescale tends to zero while keeping the footpoint diffusivity finite. In contrast to the magnetic field lines driven by standard Brownian processes on the solar wind source surface, the interplanetary magnetic field lines are smooth differentiable functions with finite path lengths in our model. The path lengths of the boundary-driven interplanetary magnetic field lines and their probability distributions at 1 au are computed numerically, and their dependency with respect to the controlling parameters is investigated. The path-length distributions are shown to develop a significant skewness as the width of the distributions increases.
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