To assess the therapeutic effect of Xuebijing injection on adult patients with acute respiratory distress syndrome (ARDS).
A multicenter prospective randomized control study was conducted at 10 ...intensive care units in Jiangsu province. A total of 172 early ARDS patients were randomly divided into Xuebijing treatment and control groups. All patients received routine therapy of ARDS while additional Xuebijing injection 100 ml was administered in the treatment group intravenously for 7 days. Lung injury score, acute physiology and chronic health evaluation II (APACHE II) score, multiple organ dysfunction score (MODS) and PaO2/FiO2 of the patients was recorded before and after treatment. Mortality at 28 days and the duration of mechanical ventilation were compared between two groups.
Ninety-one patients were assigned to receive Xuebijing injection and 81 patients as control; Mortality at Days 28 and 90, the duration of mechanical ventilation and ventilation free days showed no difference between two groups (P > 0
The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinetic resolution under acidic conditions, providing a facile access to ...chiral
trans
cycloalkanol derivatives with excellent enantioselectivities.
The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinetic resolution under acidic conditions, providing a facile access to chiral
trans
cycloalkanols.
This paper proposes a hybrid evaluation approach combining fuzzy comprehensive assessment method and AHP that measures the safety performance of construction site. The weight of each index was ...calculated through AHP model which use in fuzzy comprehensive assessment, and then the safety level of construction sites was determined by multi-layer fuzzy comprehensive assessment technique. In order to find out the main causes of safety level of construction site’ changes, the grey correlation analysis was used to quantify the influence degree of each factor of safety level of construction site. The effectiveness of our methodology was verified with an empirical study by using the data of 3 construction sites we investigated. The results show that this approach can be an effective tool to predict the safety performance of construction projects sites, which is useful to provide a scientific basis for the management and decisions of accident prevention.
In this paper, we propose a simple and tunable robust compensator for an Adaptive Optics system, based on the Robust Model Matching strategies. In order to evaluate the performance of the system, we ...made some laboratory experiments with the atmospheric simulation instruments. Experimental result shows that by using the designed controller, the performance of the system has improved significantly comparing with some conventional works.
This paper presents a method to support real-time data communication over switched Ethernet. The work without modifications in the Ethernet hardware and coexists with TCP/IP suites. Experiment ...results shows that compared with conventional real-time network protocol, the proposed work has better real-time performances and meets the requirements for industrial control network real-time applications.
To explore schistosomiasis endemic factors in large mountainous areas where schistosomiasis transmission has been controlled.
Qingjiang Village, Lushan County, Sichuan Province, a alpine "Pingba" ...type of large mountain area, Wuxing Village, a alpine hilly type of large mountainous area, and Huoju Village, a alpine canyon type of large mountainous area were selected as study areas, and the agricultural structure, health facilities, and human behavior were investi-gated. The Oncomelania snail status was surveyed by using the system sampling method combined with the environmental sampling method. The schistosome infections of population were investigated with the serum immunology method and stool hatching method, and the schistosome infections of cattle and dogs were investigated with the plastic cup top tube hatching method.
There was a traditional agricultural structure in these villages, and the coverage rates of harmless toilets were 23.20%, 41.17%, and 41.64% in Qingjiang Village, Wuxing Village, and Huoju
Non-small cell lung carcinoma is a leading cause of cancer-related death. Amplification of the two oncogenes MET and SOX2 is frequently encountered in non-small-cell lung carcinoma. This study aimed ...to use real-time quantitative PCR to assess the correlation of MET and SOX2 amplification with clinicopathological factors. This study was conducted using 115 tissue samples including 57 squamous cell carcinomas (SCCs), 50 adenocarcinomas (ADCs) and 8 adenosquamous carcinomas (ADSCs). A total of 67 patients (58.3%) had a history of smoking. Our results showed that the frequency of MET amplification in SCCs was significantly higher compared to ADCs (χ2=8.0, P=0.005). SOX2 showed a markedly preferential amplification in SCCs compared to ADCs in the smoking group cases (P=0.014). Lymph node invasion correlated with MET amplification in SCCs marginally more significantly compared to ADCs (P=0.02). The amplified MET occurred more frequently in SCCs compared to ADCs correlated to tumor dimension at a small scale (<5 cm) (P=0.01). No significant difference in SOX2 amplification was found with regards to lymph node metastasis or tumor dimension. SOX2 and MET amplifications were not associated with gender or age. However, MET amplification in SCCs among patients younger than 64 years of age was higher compared to ADCs and ADSCs (P=0.03). Among ADSCs, MET was not amplified among patients who had never been smokers or were younger than 64 years of age. Neither MET nor SOX2 were amplified in tumors with dimensions <5 cm and without lymph node invasion. Findings of this study showed that MET and SOX2 amplifications are more common in the SCCs of smokers. Moreover, MET amplification is intrinsic in SCCs particularly among smokers, with regards to tumor growth, lymph node invasion and negative correlation to SOX2 amplification. The incidence of discrepancy in the amplifications of MET and SOX2 in SCCs and ADCs suggests that the MET and SOX2 genes play different roles in SCC and ADC tumorigenesis, respectively, particularly among smokers.
In recent years, with the center of the city to promote ecological construction, polluting enterprises have gradually transferred to the county, and serious environmental pollution and environmental ...conflicts are brought to the county. And because of county governments are in the end of the status of the urban power pyramid system, the regional environmental collaborative development mechanism remains to be further improve, the county government performance evaluation is still mainly in terms of GDP, the tenure system led to the prevalence of short-term behavior, supervision of production safety and technological transformation not in place, as well as lack of environmental accountability and effective environmental compensation mechanism and so on, the county environmental crisis happened frequently, governance falls into trouble. Therefore, in the context of the environmental crisis, effective county governance embodies fair regional collaborative development mechanism, further innovate performance evaluation and reform the existing cadres of the tenure system, strengthen supervision of production safety and technological innovation, improve environmental accountability and environmental compensation system, etc.
One of the most successful approaches for balancing the high stability and activity of water oxidation in alkaline solutions is to use amorphous and crystalline heterostructures. However, due to the ...lack of direct evidence at the molecular level, the nano/micro processes of amorphous and crystalline heterostructure electrocatalysts, including self-reconstruction and reaction pathways, remain unknown. Herein, the Leidenfrost effect assisted electrospray approach combined with phase separation was used for the first time to create amorphous NiO
x
/crystalline α-Fe
2
O
3
(a-NiO
x
/α-Fe
2
O
3
) nanowire arrays. The results of
in situ
Raman spectroscopy demonstrate that with the increase of the potential at the a-NiO
x
/α-Fe
2
O
3
interface, a significant accumulation of OH can be observed. Combining with XAS spectra and DFT calculations, we believe that more OH adsorption on the Ni centers can facilitate Ni
2+
deprotonation to achieve the high-valence oxidation of Ni
4+
according to HSAB theory (Fe
3+
serves as a strong Lewis acid). This result promotes the electrocatalysts to follow the lattice oxygen activation mechanism. This work, for the first time, offers direct spectroscopic evidence for deepening the fundamental understanding of the Lewis acid effect of Fe
3+
, and reveals the synergistic effect on water oxidation
via
the unique amorphous and crystalline heterostructures.
The amorphous NiO
x
/crystalline α-Fe
2
O
3
heterojunctions were constructed and exhibited outstanding OER activities. Through the collaboration of multiple characterization techniques, the Lewis acid effect of Fe
3+
was revealed at molecular level.
To investigate the mutations of the mismatch repair genes hMLH1 and hMSH2 in hereditary nonpolyposis colorectal cancer (HNPCC).
The DNA samples of 76 probands of HNPCC families underwent PCR ...amplification and sequencing on 35 exons in hMLH1 and hMSH2 genes.
(1) The overall mutation rate of the hMLH1 and hMSH2 genes was 33% (25/76). (2) 22 mutations were found, 16 in the hMLH1 gene and 6 in the hMSH2 gene. (3) The spectrum of mutation type included frame shift, nonsense, splice site, and missense mutations. Missense mutation was the most common mutation type.
The hMLH1 and hMSH2 mutations in Chinese HNPCC families show a wide spectrum. It seems that hMLH1 gene is involved more frequently than hMSH2 gene. A certain number of HNPCC families can be benefited from the genetic screening for mutation of the mismatch repair genes.
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