Region-level demand forecasting is an essential task in ridehailing services. Accurate ride-hailing demand forecasting can guide vehicle dispatching, improve vehicle utilization, reduce the ...wait-time, and mitigate traffic congestion. This task is challenging due to the complicated spatiotemporal dependencies among regions. Existing approaches mainly focus on modeling the Euclidean correlations among spatially adjacent regions while we observe that non-Euclidean pair-wise correlations among possibly distant regions are also critical for accurate forecasting. In this paper, we propose the spatiotemporal multi-graph convolution network (ST-MGCN), a novel deep learning model for ride-hailing demand forecasting. We first encode the non-Euclidean pair-wise correlations among regions into multiple graphs and then explicitly model these correlations using multi-graph convolution. To utilize the global contextual information in modeling the temporal correlation, we further propose contextual gated recurrent neural network which augments recurrent neural network with a contextual-aware gating mechanism to re-weights different historical observations. We evaluate the proposed model on two real-world large scale ride-hailing demand datasets and observe consistent improvement of more than 10% over stateof-the-art baselines.
Abstract The bright star λ Ser hosts a hot Neptune with a minimum mass of 13.6 M ⊕ and a 15.5 day orbit. It also appears to be a solar analog, with a mean rotation period of 25.8 days and surface ...differential rotation very similar to the Sun. We aim to characterize the fundamental properties of this system and constrain the evolutionary pathway that led to its present configuration. We detect solar-like oscillations in time series photometry from the Transiting Exoplanet Survey Satellite, and we derive precise asteroseismic properties from detailed modeling. We obtain new spectropolarimetric data, and we use them to reconstruct the large-scale magnetic field morphology. We reanalyze the complete time series of chromospheric activity measurements from the Mount Wilson Observatory, and we present new X-ray and ultraviolet observations from the Chandra and Hubble space telescopes. Finally, we use the updated observational constraints to assess the rotational history of the star and estimate the wind braking torque. We conclude that the remaining uncertainty on the stellar age currently prevents an unambiguous interpretation of the properties of λ Ser, and that the rate of angular momentum loss appears to be higher than for other stars with a similar Rossby number. Future asteroseismic observations may help to improve the precision of the stellar age.
Oral supplemented nutraceuticals derived from food sources are surmised to improve the human health through interaction with the gastrointestinal bacteria. However, the lack of fundamental quality ...control and authoritative consensus (e.g., formulation, route of administration, dose, and dosage regimen) of these non-medical yet bioactive compounds are one of the main practical issues resulting in inconsistent individual responsiveness and confounded clinical outcomes of consuming nutraceuticals. Herein, we studied the dose effects of widely used food supplement, microalgae
(
), on the colonic microbiota and physiological responses in healthy male
mice. Based on the analysis of 16s rDNA sequencing, compared to the saline-treated group, oral administration of
once daily for 24 consecutive days altered the diversity, structure, and composition of colonic microbial community at the genus level. More importantly, the abundance of microbial taxa was markedly differentiated at the low (1.5 g/kg) and high (3.0 g/kg) dose of
, among which the relative abundance of
, and
were modulated at various degrees. Evaluation of serum biomarkers in mice at the end of
intervention showed reduced the oxidative stress and the blood lipid levels and increased the level of appetite controlling hormone leptin in a dose-response manner, which exhibited the significant correlation with differentially abundant microbiota taxa in the cecum. These findings provide direct evidences of dose-related modulation of gut microbiota and physiological states by
, engendering its future mechanistic investigation of
as potential sources of prebiotics for beneficial health effects
the interaction with gut microbiota.
The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor that affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell survival, and ...counteracting inflammation. Its role in renal injury, in particular, unilateral ureteral obstruction (UUO) or ischemia-reperfusion injury (IRI)-induced renal injury remains unclear. In our study, WT and Trem2−/− mice were employed to evaluate the role of TREM2 in renal macrophage infiltration and tissue injury after UUO. Bone marrow-derived macrophages (BMDM) from both mouse genotypes were cultured and polarized for in vitro experiments. Next, the effects of TREM2 on renal injury and macrophage polarization in IRI mice were also explored. We found that TREM2 expression was upregulated in the obstructed kidneys. TREM2 deficiency exacerbated renal inflammation and fibrosis 3 and 7 days after UUO, in association with reduced macrophage infiltration. Trem2−/− BMDM exhibited increased apoptosis and poorer survival compared with WT BMDM. Meanwhile, TREM2 deficiency augmented M1 and M2 polarization after UUO. Consistent with the in vivo observations, TREM2 deficiency led to increased polarization of BMDM towards the M1 proinflammatory phenotype. Mechanistically, TREM2 deficiency promoted M1 and M2 polarization via the JAK-STAT pathway in the presence of TGF-β1, thereby affecting cell survival by regulating mTOR signaling. Furthermore, cyclocreatine supplementation alleviated cell death caused by TREM2 deficiency. Additionally, we found that TREM2 deficiency promoted renal injury, fibrosis, and macrophage polarization in IRI mice. The current data suggest that TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway. These findings have implications for the role of TREM2 in the regulation of renal injury that justify further evaluation.
Urban trees are usually planted on a periodic layout in the spatial configuration. We regard urban trees as large-scale natural phononic crystals. The entire forest is reduced to a reasonable ...“tree-soil” unit cell based on the phononic crystal theory and finite element method by COMSOL software is used to obtain the dispersion curves. The Rayleigh wave band gaps of phononic trees are distinguished by the sound cone method. The influences of soil elastic modulus and tree height on band gaps are investigated. A three-dimensional simulation model and experiment test are applied to validate the effect of phononic trees on vibration control. The numerical frequency reduction zones coincide exactly with the theoretical band gaps. Increasing soil stiffness results in a higher-frequency and wider band gap. An increasing tree height is beneficial to obtain low-frequency band gaps. A periodically arranged plantation that Rayleigh wave band gaps at frequency ≤60 Hz could be designed. This study opens up a new theoretical basis for the quantitative analyses of urban trees to the ground vibration mitigation at a certain frequency range.
Growing evidence has shown the oncogenic function of matrix metallopeptidase 7 (MMP7) in various tumors. However, no systemic pan-cancer analysis on the association between MMP7 and different cancers ...based on big clinical data is available. TIMER2, GEPIA2, UALCAN, cBioPortal, String, Metascape, and other web databases were searched in the present study. Generally,
MMP7
expression is significantly upregulated in most The Cancer Genome Atlas (TCGA) cancer types compared to the paired normal controls, yet is downregulated in tumor tissues of invasive breast carcinoma (BRCA), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), and skin cutaneous melanoma (SKCM). MMP7 protein expression is notably higher in the primary tumor tissues of colon cancer, lung adenocarcinoma (LUAD), and uterine corpus endometrial carcinoma (UCEC) than in normal tissues and is significantly lower in the primary tumor tissues of breast cancer, clear cell renal carcinoma, and ovarian cancer. Furthermore,
MMP7
expression is strongly associated with pathological stages, clinical outcomes, tumor mutational burden (TMB), and microsatellite instability (TSI). Gene amplification was detected in most TCGA cancer types. In addition, the missense mutation is the primary type of MMP7 genetic alteration in tumors. Significant positive correlations between
MMP7
expression and cancer-associated fibroblasts (CAFs) have been demonstrated in most TCGA cancers.
MMP7
expression was also found to be positively correlated with infiltration of dendritic cells and macrophages in some specific tumor types. Functional enrichment analysis by the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and gene ontology (GO) methods revealed that RNA processing and DNA damage checkpoints might reveal the pathogenetic mechanisms of MMP7. This pan-cancer analysis provides a clear panorama for the tumorigenic roles of MMP7 across different cancer types. Moreover, MMP7 could be a potential drug therapeutic target in such cancers.
Highlights
Hierarchically structured Nb
2
O
5
microflowers consiste of porous and ultrathin nanosheets.
Nb
2
O
5
microflowers exhibit enhanced capacity and rate performance boosting Na ion storage.
...Planar NIMSCs with charge and kinetics matching show superior areal capacitance and lifespan.
Planar Na ion micro-supercapacitors (NIMSCs) that offer both high energy density and power density are deemed to a promising class of miniaturized power sources for wearable and portable microelectronics. Nevertheless, the development of NIMSCs are hugely impeded by the low capacity and sluggish Na ion kinetics in the negative electrode. Herein, we demonstrate a novel carbon-coated Nb
2
O
5
microflower with a hierarchical structure composed of vertically intercrossed and porous nanosheets, boosting Na ion storage performance. The unique structural merits, including uniform carbon coating, ultrathin nanosheets and abundant pores, endow the Nb
2
O
5
microflower with highly reversible Na ion storage capacity of 245 mAh g
−1
at 0.25 C and excellent rate capability. Benefiting from high capacity and fast charging of Nb
2
O
5
microflower, the planar NIMSCs consisted of Nb
2
O
5
negative electrode and activated carbon positive electrode deliver high areal energy density of 60.7 μWh cm
−2
, considerable voltage window of 3.5 V and extraordinary cyclability. Therefore, this work exploits a structural design strategy towards electrode materials for application in NIMSCs, holding great promise for flexible microelectronics.
Hydrothermal activity played an important part in the formation of the Ordovician dolostone reservoirs in Tadong area (eastern Tarim Basin). By applying the technologies of thin rock section ...microscopic identification, cathodoluminescence analysis, carbon and oxygen isotope analysis, trace element, rare earth element analysis, among others, the mineralogical characteristics and geochemical characteristics of the hydrothermal process are studied. It can have seen that the Ordovician hydrothermal process has represented by dolomite in various forms in the aspect of petrology and mineralogy. It is mainly composed of medium-megacryst crystalline dirty dolomite and powder-megacryst crystalline cleaner dolomite. The geochemical characteristics are the hydrothermal origin, medium-megacryst crystalline dirty dolomite with lower δ18O value, high Mn-Fe content, and positive Eu anomaly. The powder-megacryst crystalline has cleaner dolomite, with higher δ18O value, the Mn content low, and the negative Eu anomaly. Provide a reference for the Ordovician carbonate in Tadong area oil and gas exploration in the study.
The development of clinically accessible biomarkers is critical for the early diagnosis of gastric cancer (GC) in patients. High-throughput proteomics techniques could not only effectively generate a ...serum peptide profile but also provide a new approach to identify potentially diagnostic and prognostic biomarkers for cancer patients.
In this study, we aim to identify potentially discriminating serum biomarkers for GC. In the discovery cohort, we screened potential biomarkers using magnetic-bead-based purification and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in 64 samples from 32 GC patients that were taken both pre- and post-operatively and 30 healthy volunteers that served as controls. In the validation cohort, the expression patterns and diagnostic values of serum FGA, AHSG and APOA-I were further confirmed by ELISA in 42 paired GC patients (pre- and post-operative samples from 16 patients with pathologic stage I/II and 26 with stage III/IV), 30 colorectal cancer patients, 30 hepatocellular carcinoma patients, and 28 healthy volunteers.
ClinProTools software was used and annotated 107 peptides, 12 of which were differentially expressed among three groups (
< 0.0001, fold > 1.5). These 12 peptide peaks were further identified as FGA, AHSG, APOA-I, HBB, TXNRD1, GSPT2 and CAKP5. ELISA data suggested that the serum levels of FGA, AHSG and APOA-I in GC patients were significantly different compared with healthy controls and had favorable diagnostic values for GC patients. Moreover, we found that the serum levels of these three proteins were associated with TNM stages and could reflect tumor burden.
Our findings suggested that FGA, AHSG and APOA-I might be potential serum biomarkers for GC diagnosis.
Discovering efficient and promising non-noble catalysts toward the alkaline hydrogen evolution reaction (HER) is vital for a clean energy system. Here, we design an efficient alkaline HER ...electrocatalyst, coating of WN nanowire core with a Ni(OH)2 shell supported on a carbon fiber paper (WN-Ni(OH)2). In a 1 M KOH solution, the hierarchical electrocatalyst affords a current density of 20 mA cm–2 at an overpotential of 170 mV and 100 mA cm–2 at 245 mV. The enhanced performance of WN-Ni(OH)2 in the HER is attributed to the synergy between WN and Ni(OH)2: during water dissociation, hydroxyl groups are preferentially adsorbed on WN and hydrogen on Ni(OH)2; meanwhile, Ni(OH)2 could promote hydroxyl group desorption from WN. Thus, the full-surface Volmer reaction kinetics could be enhanced. As a consequence, the WN-Ni(OH)2 has a reduced activation energy of the HER and enhanced intrinsic activity performance. Meanwhile, the hybrid can reach a current density of 100 mA cm–2 at an overpotential of 339 mV for the oxygen evolution reaction (OER), and an overpotential of 510 mV for the full water-splitting reaction. This interfacial cooperation offers a promising bifunctional electrocatalyst, as well as a hopeful strategy for fabricating efficient nitride-based electrocatalysts in alkaline media.
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