Platelet transfusion practice varies widely since many aspects of platelet concentrate (PC) use have not been definitively determined. The objectives of this retrospective study were to present ...platelet transfusion practice and evaluate PC and patient characteristics, as well as their association with transfusion reaction (TR) rate.
Platelet transfusions over a 5-year period were analysed regarding PC characteristics (the ABO and RhD compatibility, product type, and storage duration), patient characteristics (most responsible diagnosis, age, and gender), and TR type.
A total of 46,351 PCs were transfused: 76.4% whole blood-derived (WBD) and 23.6% single donor apheresis (SDA). Three thousand seven hundred seventy-six patients received platelet transfusions: 24.7% paediatric and 75.3% adult patients, 79.6% outpatients and 20.4% inpatients. As much as 63.1% of all transfused PCs were fresh (stored for≤3 days), 98.0% ABO-identical, and 87.3% of all PCs given to RhD− patients were RhD−. PCs were mainly transfused to haemato-oncology (76.8%) and cardiovascular surgery patients (6.5%). Overall, 84 (0.18%) TRs were reported, with allergic TRs (ATRs) being the most common. Although PC ABO compatibility and storage duration, as well as patient age and gender, showed differences in TR rate, only the use of PCs in platelet additive solution (PAS) showed a statistically significant reduction of TRs (P<0.001).
Transfusion practice at the University Hospital Centre Zagreb resulted in almost all patients receiving ABO and RhD identical PCs, and most of them were fresh PCs. The most important factor affecting the incidence of TRs was platelet storage solution. The use of PAS effectively reduced the rate of TRs, particularly allergic TRs.
La pratique de la transfusion de plaquette varie considérablement car de nombreux aspects du concentré de plaquettes (utilisation de CP) n’ont pas été définitivement déterminés. Les objectifs de cette étude rétrospective étaient de présenter la pratique de transfusion de plaquettes et d’évaluer les caractéristiques des CP et des patients, ainsi que leur association avec le taux de TR.
Les transfusions de plaquettes sur une période de 5 ans ont été analysées en fonction des caractéristiques du CP (compatibilité ABO et RhD, type de produit et durée de stockage), des caractéristiques du patient (diagnostic principal, âge et sexe) et du type de TR.
Au total, 46 351 CP ont été transfusés : 76,4 % (35 424) dérivés du sang total (DWB) et 23,6 % (10 927) aphérèse (SDA). Trois mille sept cent soixante-seize patients ont reçu des transfusions de plaquettes : 24,7 % de patients pédiatriques et 75,3 % de patients adultes, 79,6 % de patients ambulatoires et 20,4 % de patients hospitalisés. Même 63,1 % de tous les CP transfusés étaient frais (stockés pendant≤3jours), 98,0 % ABO-identiques, et 87,3 % de tous les CP ont été administrés à des patients RhD− étaient des RhD−. Les CP ont été principalement transfusés à des patients en hémato-oncologie (76,8 %) et en chirurgie cardiovasculaire (6,5 %). Dans l’ensemble, 84 RT (0,18 %) ont été signalées, les TR allergiques étant les plus fréquents. Bien que la compatibilité ABO des CP et la durée de stockage, ainsi que l’âge et le sexe des patients, aient montré des différences de taux de TR, seule l’utilisation de CP dans une solution additive plaquettaire (PAS) a montré une réduction statistiquement significative des TR (p<0,001).
Dans le cadre de la pratique transfusionnelle du Centre hospitalier universitaire de Zagreb, presque tous les patients ont reçu des PC identiques aux normes ABO et RhD, et la plupart d’entre elles étaient des PC fraîches. Le facteur le plus important affectant l’incidence des TR était la solution de stockage des plaquettes. L’utilisation du PAS a effectivement réduit le taux de TR, en particulier les TR allergiques.
Several studies have raised concerns that transfusion of O red blood cells (RBCs) to ABO and D non-identical recipients can intensify group O inventory shortages. The aim of this study was to ...retrospectively analyse particular clinical indications and polices responsible for O RBCs use by ABO and D non-identical recipients, as well as to assess the impact of this practice on the overall utilisation of O RBCs.
Data of all transfused RBCs from 2014 to 2018 were extracted from the comprehensive database of transfusion service. Extracted variables included date of transfusion, ABO and D group of the transfused RBCs and recipients, recipient's demographic, and specific characteristics regarding transfusion requirements.
Over a 5-year period, 124,220 RBCs were transfused: 38,962 (31.4%) group O D+ and 9109 (7.3%) group O D−. ABO and D non-identical recipient received 4842 (10.1%) of all administered O RBCs: 2880 (7.4%) of all transfused O D+ and 1962 (21.5%) of all transfused O D− RBCs. The common indications for this practice were: ABO and D mismatched hematopoietic stem cell transplantation (HSCT) (52.5%), infants under the age of 4 months (18.6%), shortage of ABO identical RBCs (9.0%), phenotype-matched RBCs (8,1%), and urgent transfusion (7.2%).
A significant proportion of O RBCs was transfused to ABO and D non-identical recipients, mainly due to transfusion of ABO and D mismatched HSCT recipients. However, the proportion of all transfused RBCs O D+ and especially O D− remained relatively low.
Plusieurs études ont soulevé des inquiétudes quant au fait que la transfusion de globules rouges O (globules rouges) à des receveurs ABO et D non identiques peut intensifier les pénuries d’inventaire du groupe O. Le but de cette étude était d’analyser rétrospectivement les indications cliniques particulières et les politiques responsables de l’utilisation des globules rouges O par des receveurs non identiques ABO et D, ainsi que d’évaluer l’impact de cette pratique sur l’utilisation globale des globules rouges.
Les données de tous les globules rouges transfusés de 2014 à 2018 ont été extraites de la base de données complète des services de transfusion. Les variables extraites comprenaient la date de transfusion, le groupe ABO et D des globules rouges transfusés et des receveurs, la démographie du receveur et des caractéristiques spécifiques concernant les besoins transfusionnels.
Sur une période de 5 ans, 124 220 globules rouges ont été transfusés : 38 962 (31.4 %) groupe O D+ et 9109 (7.3 %) groupe O D−. Les receveurs ABO et D non identiques ont reçu 4842 (10.1 %) de tous les globules rouges O administrés : 2880 (7.4 %) de tous les O D+transfusés et 1962 (21.5 %) de tous les globules O D− transfusés. Les indications courantes de cette pratique étaient : la transplantation de cellules souches hématopoïétiques (GCSH) (52.5 %) sans correspondance ABO et D, les nourrissons de moins de 4 mois (18.6 %), la pénurie de globules rouges ABO identiques (9.0 %), les globules rouges phénotypiques (8.1 %) et les transfusions urgentes (7.2 %).
Une proportion significative d’érythrocytes O a été transfusée à des receveurs ABO et D non identiques, principalement en raison de la transfusion de receveurs de GCSH ABO et D non appariés. Cependant, la proportion de tous les O D+ et sortout les O D− globules rouges transfusés est restée relativement faible.
This issue provides a comprehensive overview of state-of-the-art implantable biomimetic microelectronics systems, the diverse range of applications they serve, and the technologies enabling such ...systems. The 13 papers in this issue are summarized here.
Deep brain stimulation (DBS) is widely used as a safe and effective medical treatment for certain neurological disorders. It continues to evolve with improving techniques in functional neurosurgery ...and biomedical device engineering. This paper provides an overview of the enabling science and technology that have allowed DBS to successfully treat certain neurological disorders. It also points toward some of the engineering advances that will enable DBS to yield a more predictable outcome for current indications and to be systematically developed as a treatment for new indications.
Keywords O RBCs; ABO non-identical; Inventory; Transfusion Objectives Several studies have raised concerns that transfusion of O red blood cells (RBCs) to ABO and D non-identical recipients can ...intensify group O inventory shortages. The aim of this study was to retrospectively analyse particular clinical indications and polices responsible for O RBCs use by ABO and D non-identical recipients, as well as to assess the impact of this practice on the overall utilisation of O RBCs. Material and methods Data of all transfused RBCs from 2014 to 2018 were extracted from the comprehensive database of transfusion service. Extracted variables included date of transfusion, ABO and D group of the transfused RBCs and recipients, recipient's demographic, and specific characteristics regarding transfusion requirements. Results Over a 5-year period, 124,220 RBCs were transfused: 38,962 (31.4%) group O D+ and 9109 (7.3%) group O D-. ABO and D non-identical recipient received 4842 (10.1%) of all administered O RBCs: 2880 (7.4%) of all transfused O D+ and 1962 (21.5%) of all transfused O D- RBCs. The common indications for this practice were: ABO and D mismatched hematopoietic stem cell transplantation (HSCT) (52.5%), infants under the age of 4 months (18.6%), shortage of ABO identical RBCs (9.0%), phenotype-matched RBCs (8,1%), and urgent transfusion (7.2%). Conclusions A significant proportion of O RBCs was transfused to ABO and D non-identical recipients, mainly due to transfusion of ABO and D mismatched HSCT recipients. However, the proportion of all transfused RBCs O D+ and especially O D- remained relatively low. Author Affiliation: (a) Clinical Department of Transfusion Medicine and Transplantation biology, University Hospital Centre of Zagreb, Kispaticeva 12, 10 000 Zagreb, Croatia (b) General Hospital of Gospic, Gospic, Croatia (c) University of Applied Health Sciences of Zagreb, Zagreb, Croatia (d) School of Medicine, University of Zagreb, Zagreb, Croatia (e) Department of Health Studies, University of Split, Split, Croatia * Corresponding author. Byline: M. Liker milica.liker@kbc-zagreb.hr (a), I.K. Lukac (b), I.L. Burnac (a), I. Bojanic (a,c,d), M. Raos (a,c), B.G. Cepulic (a,c,d,e)
Although numerous studies have investigated supraglottal strategies for signalling voicing in fricatives, there is still no agreement about the precise characteristics of tongue-to-palate contact ...timing during voiced as opposed to voiceless fricatives. In this study we use electropalatography (EPG) to investigate articulatory and coarticulatory characteristics of tongue-to-palate contact timing during /s/ and /z/ in English. Five typically speaking participants, speakers of Southern British English, produced 500 trochaic words containing the intervocalic alveolar fricatives /s/ or /z/. The time between the start of the frication and the maximum contact at the place of articulation was expressed as a percentage of each fricative's total duration (time to target, TT).This measure was used to analyse articulatory and coarticulatory timing during /s/ and /z/. Data for absolute timing were also presented. The results showed that the time between the start of the frication and the maximum contact point was longer for /s/ than for /z/. This difference was consistent across speakers but was not significant for all of them. The results of the coarticulatory effects showed that the influence of vowel context on TT values for /s/ and /z/ did not differ significantly, but there was a tendency for /z/ to be more resistant to coarticulation effects than /s/.
Comparison of alaryngeal voice and speech Globlek, D.; Stajner-Katusic, S.; Musura, M. ...
Logopedics, phoniatrics, vocology,
2004, Letnik:
29, Številka:
2
Journal Article
Recenzirano
The aim of the research was to compare voice and speech in three groups of alaryngeal speakers: 1) patients using esophageal speech, 2) patients with electro-acoustical speech aids and 3) patients ...with voice prostheses. Acoustic analysis and pronunciation tests were used for the analysis. Acoustic analysis included fundamental frequency, maximum phonation time, jitter, shimmer and intensity. Pronunciation parameters were: phonetic block duration, number of syllables in a phonetic block, rate of speech, maximum number of syllables in a phonetic block and rate of articulation in a maximal phonetic block. Our results demonstrated the advantages of tracheoesophageal puncture with implantation of a voice prosthesis over the other two techniques of alaryngeal speech. Voice and pronunciation with voice prostheses were closer to normal in many parameters: fundamental frequency, maximum phonation time, jitter, shimmer, duration of a phonetic block, number of syllables in a phonetic block, rate of speech and rate of articulation in maximal phonetic block.
Although medical history and physical examination should lead to diagnosis of chronic subdural hematomas, 40% of these patients are likely to be misdiagnosed because many of these symptoms occur in ...other disease processes, such as transient ischemic attacks, stroke, dementia, and tumors. Computed tomography remains one of the most useful tools in the evaluation of these patients because of its rapidity, cost, availability, and pathologic sensitivity.
Patients with cochlear implants have the ability to exercise auditory control over their own speech production and over the speech of others, which is important for the development of speech control. ...In the present investigation three groups of 10 subjects were compared. The groups comprised: (1) cochlear implant users, (2) profoundly deaf using traditional hearing aids, and (3) hearing controls. The subjects in three groups were matched in age. While repeating after a model the subjects were recorded and the following linguistic voice variables were analysed: (1) vowel formant space, (2) voice vs. voiceless difference, (3) closure duration and VOT, (4) word accent production, (5) sentence stress production, (6) voice quality, (7) pronunciation quality. Acoustic analysis and perceptual assessment by phoneticians showed that in great majority of variables, subjects with cochlear implants performed better than the profoundly deaf subjects with traditional hearing-aids.
The Fundamental Gravity Network (FGN) is foundation for all national gravity measurements. This network consists of 42 points: 6 absolute gravity points (0. Order Gravity Network) and 36 relative ...gravity points (I. Order Gravity Network). Further densification of FGN will be carried out by the lower order networks (II. Order Gravity Network). Fundamental gravity points should be homogeneously spaced over the whole state. In some large countries the distance between gravity points can be more than few hundred kilometres. Levelling connection of the absolute and first order gravity points at the national levelling network benchmarks was not performed. Also, the position of gravity points in respect to existing geodetic network stayed unknown. Quality positional and height definition of gravity points is necessary for calculating different corrections, which are needed for processing gravimetric measurements. By implementation of the FGN Finalization Project, along with already finalized projects, the modern gravity foundation for the Republic of Croatia will be established
