We report high angular resolution observations of linearly polarized dust emission toward the Class 0 young stellar object NGC1333 IRAS4A (hereafter IRAS4A) using the Karl G. Jansky Very Large Array ...at K (11.5-16.7 mm), Ka (8.1-10.3 mm), and Q bands (6.3-7.9 mm), and using the Atacama Large Millimeter Array (ALMA) at Band 6 (1.3 mm) and Band 7 (0.85-0.89 mm). On 100-1000 au scales, all of these observations consistently trace the hourglass-shaped magnetic field topology as shown in the previous studies. In the innermost 100 au region of IRAS4A1, the polarization position angles (E field) detected at 6.3-16.7 mm are consistent; however, they are nearly 90° offset from those detected at 1.3 mm and 0.85-0.89 mm. Such a 90° offset may be explained by the inner ∼100 au area being optically thick at wavelengths shorter than ∼1.5 mm, whereby the observations probe the absorption of aligned dust against the weakly or unpolarized warm dust emission from the innermost region. This can also consistently explain why the highest angular resolution ALMA images at Band 7 show that the polarization percentage increases with dust brightness temperature in the inner ∼100 au region of IRAS4A1. Following this interpretation and assuming that the dust grains are aligned with the magnetic fields, the inferred magnetic field position angle based on the 90° rotated at 6.3-7.9 mm in the central peak of IRAS4A1 is ∼−22°, which is approximately consistent with the outflow direction of ∼−9°.
The formation of filaments in molecular clouds is an important process in star formation. Hub-filament systems (HFSs) are a transition stage connecting parsec-scale filaments and protoclusters. ...Understanding the origin of HFSs is crucial to reveal how star formation proceeds from clouds to cores. Here we report James Clerk Maxwell telescope POL-2 850 m polarization and IRAM 30 m C18O (2-1) line observations toward the massive HFS G33.92+0.11. The 850 m continuum map reveals four major filaments converging to the center of G33.92+0.11 with numerous short filaments connecting to the major filaments at local intensity peaks. We estimate the local orientations of filaments, magnetic field, gravity, and velocity gradients from observations, and we examine their correlations based on their local properties. In the high-density areas, our analysis shows that the filaments tend to align with the magnetic field and local gravity. In the low-density areas, we find that the local velocity gradients tend to be perpendicular to both the magnetic field and local gravity, although the filaments still tend to align with local gravity. A global virial analysis suggests that the gravitational energy overall dominates the magnetic and kinematic energy. Combining local and global aspects, we conclude that the formation of G33.92+0.11 is predominantly driven by gravity, dragging and aligning the major filaments and magnetic field on the way to the inner dense center. Traced by local velocity gradients in the outer diffuse areas, ambient gas might be accreted onto the major filaments directly or via the short filaments.
Water-clear cell parathyroid adenoma is an uncommon cause of primary hyperparathyroidism. Herein, we report an interesting case of a 56-year-old man who presented with weight loss, bone pain, ...fatigue, and a palpable right neck mass. Laboratory tests indicated hypercalcemia, elevated parathyroid hormone (PTH) levels, and normal thyroid function. Further examinations detected osteoporosis and kidney stones. The ultrasound of neck revealed bilateral extrathyroidal tumors, which were sestamibi-avid. The patient underwent resection of the large right inferior and left inferior parathyroid tumors. Histopathology revealed a double water-clear cell parathyroid adenoma. His serum calcium and PTH levels normalized after surgery. The literature review identified 37 cases of water-clear cell parathyroid adenoma between 1985 and 2021. The median age at diagnosis was 56 years. Classic complications were common, including nephrolithiasis in nine and skeletal presentations in 10 patients. Before surgery, the median calcium and PTH levels were 12.0 mg/dL and 290 pg/mL, respectively. Overall, 89% were localized on ultrasonography, and 60% were positive on scintigraphy. Four patients had double adenomas. The median maximum diameter was 3.8 cm, and the median weight of the resected adenoma was 5.27 g. In summary, water-clear cell parathyroid adenoma has certain unique features. These include larger tumor size, relatively indolent biochemical profile, high prevalence of complications and nonspecific symptoms, an isoechoic appearance on ultrasonography, and reduced scintigraphic sensitivity.
Abstract
Understanding how material accretes onto the rotationally supported disk from the surrounding envelope of gas and dust in the youngest protostellar systems is important for describing how ...disks are formed. Magnetohydrodynamic simulations of magnetized, turbulent disk formation usually show spiral-like streams of material (accretion flows) connecting the envelope to the disk. However, accretion flows in these early stages of protostellar formation still remain poorly characterized, due to their low intensity, and possibly some extended structures are disregarded as being part of the outflow cavity. We use ALMA archival data of a young Class 0 protostar, Lupus 3-MMS, to uncover four extended accretion flow–like structures in C
18
O that follow the edges of the outflows. We make various types of position–velocity cuts to compare with the outflows and find the extended structures are not consistent with the outflow emission, but rather more consistent with a simple infall model. We then use a dendrogram algorithm to isolate five substructures in position–position–velocity space. Four out of the five substructures fit well (>95%) with our simple infall model, with specific angular momenta between 2.7–6.9 × 10
−4
km s
−1
pc and mass-infall rates of 0.5–1.1 × 10
−6
M
⊙
yr
−1
. Better characterization of the physical structure in the supposed “outflow cavities” is important to disentangle the true outflow cavities and accretion flows.
The pentose phosphate pathway (PPP) plays an important role in the biosynthesis of ribonucleotide precursor and NADPH. Cancer cells frequently increase the flux of glucose into the PPP to support the ...anabolic demands and regulate oxidative stress. Consistently, metabolomic analyses indicate an upregulation of the PPP in thyroid cancer. In the present study, we found that the combination of glucose-6-phosphate dehydrogenase (G6PD) and transketolase inhibitors (6-aminonicotinamide and oxythiamine) exerted an additive or synergistic effect on cell growth inhibition in thyroid cancer cells. Targeting PPP significantly increased cellular reactive oxygen species (ROS) and induced endoplasmic reticulum (ER) stress and apoptosis. Suppressed cell viability could be partially rescued with treatment with the ROS scavenger or apoptosis inhibitor but not ER-stress inhibitor. Taken together, dual PPP blockade leads to pharmacologic additivity or synergism and causes ROS-mediated apoptosis in thyroid cancer cells.
•Metabolomic analyses suggest an upregulation of the pentose phosphate pathway (PPP).•Dual inhibition of both branches results in pharmacologic additivity or synergism.•PPP blockade causes ROS-mediated apoptosis in thyroid cancer cells.
We present a detailed analysis of high-resolution C18O (2-1), SO (88-77), CO (3-2), and DCO+ (3-2) data obtained by the Atacama Large Millimeter/submillimeter Array toward a class 0 Keplerian ...circumbinary disk around VLA 1623A, which represents one of the most complete analyses toward a class 0 source. From the dendrogram analysis, we identified several accretion flows feeding the circumbinary disk in a highly anisotropic manner. Stream-like SO emission around the circumbinary disk reveals the complicated shocks caused by the interactions between the disk, accretion flows, and outflows. A wall-like structure is discovered south of VLA 1623B. The discovery of two outflow cavity walls at the same position traveling at different velocities suggests that the two outflows from both VLA 1623A and VLA 1623B are on top of each other in the plane of the sky. Our detailed flat and flared disk modeling shows that Cycle 2 C18O J = 2-1 data are inconsistent with the combined binary mass of 0.2 M , as suggested by early Cycle 0 studies. The combined binary mass for VLA 1623A should be modified to 0.3-0.5 M .
Abstract
We present JCMT POL-2 850
μ
m dust polarization observations and Mimir
H
-band stellar polarization observations toward the starless core L 1512. We detect the highly ordered core-scale ...magnetic field traced by the POL-2 data, of which the field orientation is consistent with the parsec-scale magnetic fields traced by Planck data, suggesting the large-scale fields thread from the low-density region to the dense core region in this cloud. The surrounding magnetic field traced by the Mimir data shows a wider variation in the field orientation, suggesting there could be a transition of magnetic field morphology at the envelope-scale. L 1512 was suggested to be presumably older than 1.4 Myr in a previous study via time-dependent chemical analysis, hinting that the magnetic field could be strong enough to slow the collapse of L 1512. In this study, we use the Davis–Chandrasekhar–Fermi method to derive a plane-of-sky magnetic field strength (
B
pos
) of 18 ± 7
μ
G and an observed mass-to-flux ratio (
λ
obs
) of 3.5 ± 2.4, suggesting that L 1512 is magnetically supercritical. However, the absence of significant infall motion and the presence of an oscillating envelope are inconsistent with the magnetically supercritical condition. Using a virial analysis, we suggest the presence of a hitherto hidden line-of-sight magnetic field strength of ∼27
μ
G with a mass-to-flux ratio (
λ
tot
) of ∼1.6, in which case both magnetic and kinetic pressures are important in supporting the L 1512 core. On the other hand, L 1512 may have just reached supercriticality and will collapse at any time.
Serological responses (Seroresponse) and durability of hepatitis A virus (HAV) vaccination are reduced among human immunodeficiency virus (HIV)‐positive patients. Incidence of and associated factors ...with early seroreversion (loss of seroresponse) among HIV‐positive patients who have achieved seroresponses after two doses of HAV vaccination remain unclear. In this multicenter study, we followed HIV‐positive adults who had mounted seroresponses after completing two doses of HAV vaccination during a recent outbreak of acute hepatitis A between 2015 and 2017, a 1:4 case‐control study was conducted to identify factors associated with seroreversion. Case patients were those with seroreversion, and controls were those with similar follow‐up durations who were able to maintain seroresponses. During the study period, 49 of the 1,256 patients (3.9%) seroreverted after a median follow‐up of 611 days. In a case‐control study, seroreversion was more likely to occur in patients with a higher weight (adjusted odds ratio aOR, 1.703; 95% confidence interval CI, 1.292‐2.323, per 10‐kg increment) and HIV viremia at the time of vaccination (aOR, 2.922; 95% CI, 1.067‐7.924), whereas positive seroresponse at 6 months of HAV vaccination and higher CD4 lymphocyte counts at vaccination were inversely associated with early seroreversion with an aOR of 0.059 (95% CI, 0.020‐0.154) and 0.837 (95% CI, 0.704‐0.979, per 100‐cell/mm3 increment), respectively, in multivariable analyses. Conclusion: During an outbreak setting, early seroreversion following two‐dose HAV vaccination occurred in 3.9% of HIV‐positive patients. Lower and delayed seroresponses to HAV vaccination, a higher weight, and HIV viremia and lower CD4 lymphocyte counts at the time of HAV vaccination were associated with early seroreversion. Regular monitoring of seroresponse and booster vaccination might be warranted, especially in HIV‐positive adults with predictors of early seroreversion.
Abstract
We present high-resolution Karl G. Jansky Very Large Array (VLA) observations of the protostar L1527 IRS at 7 mm, 1.3 cm, and 2 cm wavelengths. We detect the edge-on dust disk at all three ...wavelengths and find that it is asymmetric, with the southern side of the disk brighter than the northern side. We confirm this asymmetry through analytic modeling and also find that the disk is flared at 7 mm. We test the data against models including gap features in the intensity profile, and though we cannot rule such models out, they do not provide a statistically significant improvement in the quality of fit to the data. From these fits, we can, however, place constraints on allowed properties of any gaps that could be present in the true, underlying intensity profile. The physical nature of the asymmetry is difficult to associate with physical features owing to the edge-on nature of the disk, but it could be related to spiral arms or asymmetries seen in other imaging of more face-on disks.
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