The outbreak of the coronavirus disease-19 (COVID-19) has caused enormous stress among the public in China. Intellectual input from various aspects is needed to fight against COVID-19, including ...understanding of the public's emotion and behaviour and their antecedents from the psychological perspectives. Drawing upon the cognitive appraisal theory, this study examined three cognitive appraisals (i.e., perceived severity, perceived controllability, and knowledge of COVID-19) and their associations with a wide range of emotional and behavioural outcomes among the Chinese public.
Participants were 4607 citizens (age range: 17-90 years, Mage = 23.71 years) from 31 provinces in China and they took part in a cross-sectional survey online.
The results showed that the public's emotional and behavioural reactions were slightly affected by the outbreak of COVID-19. Moreover, the public had limited participation in the events regarding COVID-19 but actively engaged in precautionary behaviour. In addition, results of structural equation model with latent variables revealed that the three appraisals were differentially related to the outcome variables (i.e., negative emotion, positive emotion, sleep problems, aggression, substance use, mobile phone use, social participation, and precautionary behaviour).
The findings highlight the utility of cognitive appraisal, as a core process of coping stress, in explaining the public's emotion and behaviour in the encounter of public health concern. Practically, the findings facilitate the government and practitioners to design and deliver targeted intervention programs to the public.
Reported is a highly enantioselective copper‐catalyzed Markovnikov protoboration of unactivated terminal alkenes. A variety of simple and abundant feedstock α‐olefins bearing a diverse array of ...functional groups and heterocyclic substituents can be used as substrates, and the reaction proceeds under mild reaction conditions at ambient temperature to provide expedient access to enantioenriched alkylboronic esters in good regioselectivity and with excellent enantiocontrol. Critical to the success of the protocol was the development and application of a novel, sterically hindered N‐heterocyclic carbene, (R,R,R,R)‐ANIPE, as the ligand for copper.
By design: A highly enantioselective copper‐catalyzed Markovnikov protoboration of α‐olefins is described. This mild and general process effectively converts simple and abundant feedstock α‐olefins into a diverse array of chiral alkylboronic esters with excellent enantiocontrol. Key to the success of the protocol was the use of a newly developed, sterically hindered N‐heterocyclic carbene, (R,R,R,R)‐ANIPE, as the ligand.
Editorial: Machine Learning and Intelligent Communications Huang, Xin-Lin; Ma, Xiaomin; Hu, Fei
Journal on special topics in mobile networks and applications/Mobile networks and applications,
02/2018, Letnik:
23, Številka:
1
Journal Article
A general, efficient, highly enantio‐ and chemoselective N‐heterocyclic carbene (NHC)/Ni‐catalyzed addition of readily available and stable arylboronic esters to ketones is reported. This protocol ...provides unexpectedly fast access (usually 10 min) to various chiral tertiary alcohols with exceptionally broad substrate scope and excellent functional group tolerance (76 examples, up to 98 % ee). This process is orthogonal to other known Ni‐mediated Suzuki–Miyaura couplings, as it tolerates aryl chlorides, fluorides, ethers, esters, amides, nitriles, and alkyl chlorides. The reaction is applied to late‐stage modifications of various densely functionalized medicinally relevant molecules. Preliminary mechanistic studies suggest that a rare enantioselective η2‐coordinating activation of ketone carbonyls is involved. This cross‐coupling‐like mechanism is expected to enable other challenging transformations of ketones.
A method for general asymmetric addition of arylborons to simple ketones is reported, which is enabled by nickel/N‐heterocyclic carbene catalysis. Chiral tertiary alcohols are furnished with high efficiency and excellent levels of enantio‐ and chemocontrol, and the method offers a broad substrate scope.
Epstein-Barr virus (EBV)-associated epithelial cancers, including nasopharyngeal carcinoma (NPC) and approximately 10% of gastric cancers, termed EBVaGC, represent 80% of all EBV-related ...malignancies. However, the exact role of EBV in epithelial cancers remains elusive. Here, we report that EBV functions in vasculogenic mimicry (VM). Epithelial cancer cells infected with EBV develop tumor vascular networks that correlate with tumor growth, which is different from endothelial-derived angiogenic vessels and is VEGF-independent. Mechanistically, activation of the PI3K/AKT/mTOR/HIF-1α signaling cascade, which is partly mediated by LMP2A, is responsible for EBV-induced VM formation. Both xenografts and clinical samples of NPC and EBVaGC exhibit VM histologically, which are correlated with AKT and HIF-1α activation. Furthermore, although anti-VEGF monotherapy shows limited effects, potent synergistic antitumor activities are achieved by combination therapy with VEGF and HIF-1α-targeted agents. Our findings suggest that EBV creates plasticity in epithelial cells to express endothelial phenotype and provides a novel EBV-targeted antitumor strategy.
The common cytokine receptor γ chain, γc, is a component of the receptors for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γc results in X-linked severe ...combined immunodeficiency in humans, and γc family cytokines collectively regulate development, proliferation, survival, and differentiation of immune cells. Here, we review the basic biology of these cytokines, highlighting mechanisms of signaling and gene regulation that have provided insights for immunodeficiency, autoimmunity, allergic diseases, and cancer. Moreover, we discuss how studies of this family stimulated the development of JAK3 inhibitors and present an overview of current strategies targeting these pathways in the clinic, including novel antibodies, antagonists, and partial agonists. The diverse roles of these cytokines on a range of immune cells have important therapeutic implications.
The γc family of cytokines control development, growth, survival, and differentiation of immune cells. Leonard, O’Shea, and Lin review the diverse functions of this cytokine family and the clinical interventions that leverage the growing understanding of their complex biology for the treatment of disease.
Market planning for regional economic development is a crucial task connected to stability and systematicness and influences the unique outcomes of regional economic growth. As a result, market ...planning for regional economic development must be given more weight. There are several issues with regional economies currently developing in many parts of our country. Lack of focus on market planning for regional economic growth results in several flaws in market planning, making it challenging to support sustainable development. The accurate analysis of diverse massive economic datasets has significant research value. The aim of this study is to provide an overview of market planning and regional economic and industrial development, analyze the effects of market planning on regional economic and industrial development, identify issues with market planning and regional economic and industrial development, and suggest solutions. This article employs big data analysis technology to forecast corporate market value and develop regional economic markets. The system is employed to conduct experimental big data analysis within a specific field for an extended period. According to test analysis results, the system’s data analysis accuracy can reach up to 95.8%, which has a promising future for use.
Wenzhou City, one of the key areas in China for private economic development, has been actively pushing for the deep integration of the private sector and vocational education in recent years, ...seizing the chance presented by the "Ministry and Province Coconstructing" National Highland of Vocational Education Innovation pilot project. This study attempts to investigate the creative growth path by using the integration of the private business and vocational education in Wenzhou City as the research object and the "four-chaindriven" model as the theoretical foundation. This study determines the research status, issues, and influencing factors of the industry and education integration mode by methodically arranging the academic history and dynamics of related research both domestically and internationally. It also incorporates the chain theory into the relevant research on the evolution of the integration of industry and education, which offers the theoretical foundation for this investigation. Research on the current state of Wenzhou's integration of the private sector and vocational education, research on influencing factors, and research on the "four-chain-driven" model are all included in the study. In order to provide references for governmental decision-making, this study aims to thoroughly analyse the current state of affairs, issues, and potential mechanisms of the integration of the private economy and vocational education in Wenzhou from multiple dimensions through empirical investigation, statistical analysis, and case studies. In the end, this research seeks to create an innovative "four-chain-driven" model of industry-education integration and development that is in line with Wenzhou's real circumstances. It also offers theoretical direction and doable avenues for Wenzhou to achieve superior industry-education integration development.
Combat helmets provide protection against ballistic threats and blunt impact forces, and wearing them has greatly reduced head injuries and saved lives of many soldiers. With the new challenges from ...improvised explosive devices and urban combat operations in modern asymmetric military conflicts, future combat helmets are required to be highly protective, lightweight, comfortable to wear, and compatible with communication and other systems. The aim of this paper is to provide a comprehensive review of existing combat helmets based on aramid and UHMWPE fibers by addressing the critical issues including materials, ballistic impact mechanisms, design, manufacturing, performance, and head injury protection. Various ballistic fabrics and composites used for combat helmets are discussed. The ballistic impact mechanisms and mechanical responses of helmet composites are examined in view of experimental methods, analytical models, and numerical simulations. The strategies for helmet designs, including head coverage and curvature of helmet shell, manufacturing processes, and liner foam pads, are outlined. The performance of combat helmets as evaluated by ballistic testing and finite element simulations is summarized. Finally, the ballistic and blast impact induced head injuries are elaborated, and the possibility of behind armor blunt trauma predicted by available injury criteria is discussed. The state-of-the-art knowledge of combat helmets reviewed in this paper provides the foundation for the development of next-generation combat helmets, which are expected to protect against ballistic, blunt, and blast impacts to minimize traumatic brain injuries, while enabling wearing comfort and effective communications.
Huashi Baidu formula (HSBDF) was developed to treat the patients with severe COVID-19 in China. The purpose of this study was to explore its active compounds and demonstrate its mechanisms against ...severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through network pharmacology and molecular docking.
All the components of HSBDF were retrieved from the pharmacology database of TCM system. The genes corresponding to the targets were retrieved using UniProt and GeneCards database. The herb-compound-target network was constructed by Cytoscape. The target protein-protein interaction network was built using STRING database. The core targets of HSBDF were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The main active compounds of HSBDF were docked with SARS-CoV-2 and angiotensin converting enzyme II (ACE2).
Compound-target network mainly contained 178 compounds and 272 corresponding targets. Key targets contained MAPK3, MAPK8, TP53, CASP3, IL6, TNF, MAPK1, CCL2, PTGS2, etc. There were 522 GO items in GO enrichment analysis (p < .05) and 168 signaling pathways (p < .05) in KEGG, mainly including TNF signaling pathway, PI3K-Akt signaling pathway, NOD-like receptor signaling pathway, MAPK signaling pathway, and HIF-1 signaling pathway. The results of molecular docking showed that baicalein and quercetin were the top two compounds of HSBDF, which had high affinity with ACE2.
Baicalein and quercetin in HSBDF may regulate multiple signaling pathways through ACE2, which might play a therapeutic role on COVID-19.
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