As important pollinators, bees play a critical role in maintaining the balance of the ecosystem and improving the yield and quality of crops. However, in recent years, the bee population has ...significantly declined due to various pathogens and environmental stressors including viruses, bacteria, parasites, and increased pesticide application. The above threats trigger or suppress the innate immunity of bees, their only immune defense system, which is essential to maintaining individual health and that of the colony. In addition, bees can be divided into solitary and eusocial bees based on their life traits, and eusocial bees possess special social immunities, such as grooming behavior, which cooperate with innate immunity to maintain the health of the colony. The omics approach gives us an opportunity to recognize the distinctive innate immunity of bees. In this regard, we summarize innate bee immunity from a genomic and transcriptomic perspective. The genetic characteristics of innate immunity were revealed by the multiple genomes of bees with different kinds of sociality, including honeybees, bumblebees, wasps, leaf-cutter bees, and so on. Further substantial transcriptomic data of different tissues from diverse bees directly present the activation or suppression of immune genes under the infestation of pathogens or toxicity of pesticides.
Previous research has suggested that engaging in regular physical activity (PA) can help to reduce symptoms of depression and anxiety in university students. However, there is a lack of evidence ...regarding the impact of reducing sedentary behavior (SB) and increasing light-intensity PA (LPA) on these symptoms. This study aims to address this gap by using isotemporal substitution (IS) models to explore how substituting SB with LPA or moderate-to-vigorous PA (MVPA) affects depression and anxiety symptoms among university students.
The study recruited 318 university students with a mean age of 21.13 years. Accelerometers were used to objectively measure the time spent on SB, LPA, and MVPA, while depression and anxiety symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D) and the Self-rating Anxiety Scale (SAS). IS models using multivariable linear regression were employed to estimate the associations between different behaviors and depression and anxiety symptoms when 30 min of one behavior was substituted with another.
In the single-activity model, less SB (β = 0.321, 95% CI: 0.089, 1.297) and more MVPA (β = -0.142, 95% CI: -1.496, - 0.071) were found to be significantly and negatively associated with depression scores, while less SB (β = 0.343, 95% CI: 0.057, 1.014), LPA (β = 0.132, 95% CI: 0.049, 1.023), and more MVPA (β = -0.077, 95% CI: -1.446, - 0.052) were significantly and negatively correlated with anxiety scores. The IS analysis revealed that substituting 30 min of SB with LPA (β = -0.202, 95% CI: -1.371, - 0.146) or MVPA (β = -0.308, 95% CI: -0.970, - 0.073) was associated with improvements in depressive symptoms. Substituting 30 min of SB with MVPA (β = -0.147, 95% CI: -1.863, - 0.034) was associated with reduced anxiety symptoms.
Replacing 30 min of SB with MVPA may alleviate depression and anxiety symptoms in university students. Further research is needed to explore the long-term effects of PA interventions on the mental health disorders of this population.
Although prior studies have demonstrated that children with high levels of fundamental movement skill (FMS) are more active throughout the day, little is known about children's FMS and their physical ...activity (PA) during different segments of the school day (e.g., recess, lunch break, and physical education). The present study focused on FMS and moderate-to-vigorous PA (MVPA) during school day and identifies the association between children's FMS and MVPA during different segments of the school day in China.
A total of 322 children (boys n = 163, girls n = 159; M
= 8.12, SD = 1.22 years) from four elementary schools involved in this study. Children's FMS and MVPA were measured using the Test of Gross Motor Development-2nd edition (TGMD-2) and hip-mounted accelerometers. Data such as height, weight, and socio-economic status (SES) were also obtained. Multilevel mixed regression models were used to examine the cross-sectional associations between FMS and MVPA. Models were adjusted for gender, age, standardized body mass index, and SES.
Children engaged in 32.19 min of MVPA during the whole school day. Boys were more active than girls and had higher object-control skills competency. Locomotor skills were positively associated with children's long recess (B = 1.063) and short recess time (B = 1.502) MVPA. Object-control skills were positively correlated with children's MVPA time during long recess (B = 1.244) and physical education (PE) lessons (B = 1.171).
The findings highlight the importance of developing both locomotor and object-control skills in elementary schools to lead more MVPA engagement during different segments of the school day.
•Corrosion products layer is only formed in coastal atmosphere.•In coastal atmosphere, rate controlling step is diffusion process.•In rural atmosphere, rate controlling step is charge transfer ...process.•Pitting area increases greatly in coastal site, but slightly in rural site.
Effects of native oxide and corrosion products on atmospheric corrosion of aluminium in rural and coastal sites were studied by electrochemical impedance spectroscopy (EIS), open-circuit potential (OCP) and scanning electron microscope (SEM) techniques after outdoor exposure. In the rural atmosphere, only the compact, adhesive native oxide layer exists, and the rate controlling step is diffusion process, while in the coastal atmosphere, another loose, inadhesive corrosion products layer exists, and a charge transfer process controls the corrosion process. The pitting area in the coastal atmosphere increases over time more obviously than that in the rural atmosphere.
As mobile robots are being widely used, accurate localization of the robot counts for the system. Compared with position systems with a single sensor, multi-sensor fusion systems provide better ...performance and increase the accuracy and robustness. At present, camera and IMU (Inertial Measurement Unit) fusion positioning is extensively studied and many representative Visual-Inertial Odometry (VIO) systems have been produced. Multi-State Constraint Kalman Filter (MSCKF), one of the tightly coupled filtering methods, is characterized by high accuracy and low computational load among typical VIO methods. In the general framework, IMU information is not used after predicting the state and covariance propagation. In this article, we proposed a framework which introduce IMU pre-integration result into MSCKF framework as observation information to improve the system positioning accuracy. Additionally, the system uses the Helmert variance component estimation (HVCE) method to adjust the weight between feature points and pre-integration to further improve the positioning accuracy. Similarly, this article uses the wheel odometer information of the mobile robot to perform zero speed detection, zero-speed update, and pre-integration update to enhance the positioning accuracy of the system. Finally, after experiments carried out in Gazebo simulation environment, public dataset and real scenarios, it is proved that the proposed algorithm has better accuracy results while ensuring real-time performance than existing mainstream algorithms.
Glioblastoma multiforme (GBM) is one of the most fatal malignancies due to the existence of blood-brain barrier (BBB) and the difficulty to maintain an effective drug accumulation in deep GBM ...lesions. Here we present a biomimetic nanogel system that can be precisely activated by near infrared (NIR) irradiation to achieve BBB crossing and deep tumor penetration of drugs. Synthesized by crosslinking pullulan and poly(deca-4,6-diynedioic acid) (PDDA) and loaded with temozolomide and indocyanine green (ICG), the nanogels are inert to endogenous oxidative conditions but can be selectively disintegrated by ICG-generated reactive oxygen species upon NIR irradiation. Camouflaging the nanogels with apolipoprotein E peptide-decorated erythrocyte membrane further allows prolonged blood circulation and active tumor targeting. The precisely controlled NIR irradiation on tumor lesions excites ICG and deforms the cumulated nanogels to trigger burst drug release for facilitated BBB permeation and infiltration into distal tumor cells. These NIR-activatable biomimetic nanogels suppress the tumor growth in orthotopic GBM and GBM stem cells-bearing mouse models with significantly extended survival.
Abstract We investigate a quiescent filament that erupted on 2013 August 2; the eruption was observed in EUV and H α by the Solar Dynamics Observatory and GONG. After a B9.7 flare in the nearby ...active region, the dark filament materials near its eastern footpoint start to move in the direction of eruption, and are followed by a counterclockwise rotation identified as the motion of a combination of dark and bright filament materials. Then the entire filament rises up and keeps rotating in a clockwise direction during the eruption. More interestingly, the filament exhibits an unusual two-helix structure near its western footpoint during the eruption, which indicates the existence of a highly twisted flux rope. This hypothesis is confirmed by magnetic field modeling using the flux rope insertion method. In the best-fit unstable model, the lower limits of the estimated maximum and average twist numbers of the erupting flux rope reach 7.5 π and 4 π , which suggests that kink instability plays an important role in the eruption. During these magnetically coupled sympathetic eruptions, the highly twisted filament under the western lobe of a pseudo-streamer-like structure becomes unstable and erupts due to the removal of confinement by magnetic reconnection at the overlying hyperbolic flux tube, which is initiated by the B9.7 flare in the nearby active region. The initial filament motion occurs at the more unstable eastern footpoint, where the surrounding fields are weaker and decrease with height more rapidly.
Childhood and adolescent overweight and obesity are global public health issues. Previous studies on exercise and overweight and obese children have produced inconsistent findings and lacked ...comparisons between different exercise modalities and intensities. Therefore, a network meta-analysis is necessary to provide evidence-based intervention programs. This study aims to identify the effects of different exercise modalities and intensities on changes in body composition in overweight and obese children and adolescents.
A search for randomized controlled trials was conducted on Web of Science, PubMed, Scopus, and Embase involving exercise interventions aimed at improving body composition (body fat percentage, BMI, fat mass, fat-free mass, body weight) in overweight and obese children and adolescents. A random effects network meta-analysis was performed using STATA 14.0 software within a frequentist framework. The literature quality was assessed using the Cochrane Risk of Bias Tool 2.0.
Thirty-two papers involving 1,452 participants were included. There were six types of intervention involved in the study, including moderate intensity aerobic exercise, high-intensity aerobic exercise, moderate intensity resistance exercise, high-intensity resistance exercise, moderate intensity combined exercise, and high-intensity combined exercise. The network meta-analysis results revealed that high-intensity combined exercise was the best exercise mode for improving BMI mean difference in kg/m
= -1.65, 95% CI (-3.27, -0.02) and reducing fat mass mean difference in kg = -2.87, 95% CI (-4.84, -0.91). Moderate intensity combined exercise was the best mode for weight loss mean difference in kg = -4.58, 95% CI (-5.94, -3.22) and improvement in body fat percentage mean difference in% = -2.52, 95% CI (-3.83, -1.20). High-intensity resistance exercise had the optimal effect in increasing fat-free mass mean difference in kg = 1.10, 95% CI (0.22, 1.99).
In conclusion, the study found that combined exercise, whether moderate or high intensity, was more effective than any other exercise modality in improving body fat percentage and BMI, reducing fat mass and weight. Resistance exercise was the most effective in increasing fat-free mass.
Cisplatin (DDP) is a major chemotherapeutic drug which was widely used for cervical cancer (CC) patients with advanced or recurrent although its limitation in the development of resistance. LncRNA ...nicotinamide nucleotide transhydrogenase-antisense RNA1 (NNT-AS1) has been reported to be involved in the DDP resistance. However, the role of NNT-AS1 in DDP resistance in CC remain unknown.
The mRNA expression of NNT-AS1, microRNA-186 (miR-186) and HMGB1 was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation and apoptosis abilities were measured via MTT assay or flow cytometry, respectively. Western blot was used to measure the expression level of HMGB1, Bax, Bcl-2, Cleaved-caspase 3, N-cadherin, Vimentin and E-cadherin. Cell migration and invasion abilities were analyzed using Transwell assay. The interaction among NNT-AS1, miR-186 and HMGB1 was confirmed by luciferase reporter assay and RNA pull-down assay. Murine xenograft model was established using stably transfected SiHa/DDP cells.
NNT-AS1 level was significantly elevated in CC tissues and cells, especially in DDP-resistant tumors and cell lines. Subsequently, loss-of function assays indicated that NNT-AS1 silence could attenuate DDP resistance by inhibiting proliferation, metastasis and EMT but inducing apoptosis in DDP-resistant CC cells. Besides that, knockdown of NNT-AS1 also antagonized DDP resistance in vivo. Bioinformatics predication revealed NNT-AS1 directly bound to miR-186 and HMGB1 was a target of miR-186. Additionally, NNT-AS1 could regulate HMGB1 expression via targeting miR-186. Furthermore, restoration experiments showed NNT-AS1 knockdown might improve DDP-sensitivity of CC cells via blocking HMGB1 expression by competitive interaction with miR-186.
NNT-AS1 improved chemoresistance of DDP-resistant CC cells via modulating miR-186/HMGB1 axis.
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