Display omitted
Endothelial cells (EC) are able to actively control vascular permeability, coagulation, blood pressure and angiogenesis. Most recently, a role for endothelial cells in the immune ...response has been described. Therefore, the endothelium has a dual role controlling homeostasis but also being the first line for host defence and tissue damage repair thanks to its ability to mount an inflammatory response. Endothelial cells have been shown to express pattern-recognition receptors (PRR) including Toll-like receptors (TLR) that are activated in response to stimuli within the bloodstream including pathogens and damage signals. TLRs are strategic mediators of the immune response in endothelial cells but they also regulate the angiogenic process critical for tissue repair. Nevertheless, endothelial activation and angiogenesis can contribute to some pathologies. Thus, inappropriate endothelial activation, also known as endothelial dysfunction, through TLRs contributes to tissue damage during autoimmune and inflammatory diseases such as atherosclerosis, hypertension, ischemia and diabetes associated cardiovascular diseases. Also TLR induced angiogenesis is required for the growth of some tumors, atherosclerosis and rheumatoid arthritis, among others. In this review we discuss the importance of various TLRs in modulating the activation of endothelial cells and their importance in immunity to infection and vascular disease as well as their potential as therapeutic targets.
La reciente Ley Orgánica del Sistema Universitario (LOSU) ha establecido un nuevo régimen jurídico para el personal docente e investigador de las universidades públicas. Este trabajo tiene como ...objetivo desentrañar los ejes vertebradores de la reforma. Para ello se han examinado los antecedentes legislativos, jurisprudenciales y doctrinales que permiten comprender el alcance de la nueva regulación. Asimismo, se ha optado por contrastar el contenido del preámbulo con el articulado de la LOSU y se han planteado algunos problemas interpretativos. Como principales hallazgos, se sostiene que la LOSU incentiva un desarrollo de la carrera académica mediante contratos laborales, de forma paralela a la vía funcionarial, y que el anuncio de la disminución del porcentaje de contratos de carácter temporal no se corresponde con la realidad del texto aprobado. En el presente trabajo se concluye que la reforma universitaria de 2023 consagra el proceso de laboralización del personal docente e investigador y que los cambios en el ámbito de los contratos temporales y de los procesos selectivos tendrán un impacto limitado.
Recensión del libro de Juan José Rastrollo Suárez, Crisis, reacción y evolución: el teletrabajo en el sector público, Thomson Reuters Aranzadi, 2021, 183 pp.
Version control systems’ usage is a highly demanded skill in information and communication technology professionals. Thus, their usage should be encouraged by educational institutions. This work ...demonstrates that it is possible to assess if a student can pass a computer science-related subject by monitoring its interaction with a version control system. This paper proposes a methodology that compares the performance of several machine learning models so as to select the appropriate predicting model for the assessment of the students’ achievements. To fit predicting models, three subjects of the Degree in Computer Science at the University of León are considered to obtain the dataset: computer organization, computer programming, and operating systems extension. The common aspect of these subjects is their assignments, which are based on developing one or several programs with programming languages such as C or Java. To monitor the practical assignments and individual performance, a Git repository is employed allowing students to store source code, documentation, and supporting control versions. According to the presented experience, there is a huge correlation between the level of interaction for each student and the achieved grades.
Lithium bis(pyrazolyl)dialkylaluminates) complexes were prepared from equimolar amounts of Li(tBu2pz), AlR3 (R = Me, iBu) and tBu2pzH. These compounds have monomeric structure, with the presence of ...one Al-alkyl ··· Li intramolecular interaction, although they were isolated in the presence of the donor solvent THF.
Display omitted
Two lithium bis(pyrazolyl)dialkylaluminates were prepared from equimolar amounts of Li(tBu2pz), AlR3 (R = Me, iBu) and tBu2pzH. Characterization was accomplished by microanalysis and spectroscopic methods as well as SCXRD. An important feature of these aluminates in solid state, is the presence of one Al-alkyl ··· Li agostic intramolecular interaction despite having used a coordinating solvent (THF) in the synthetic route.
Water resources management is particularly challenging in water-scarce basins, where low water availability is combined with a potential water demand exceeding the supply capacity of the natural ...system. This is the case of the Segura River Basin in south-eastern Spain. This paper aims at analysing the usefulness of incorporating new hydrological data and perspectives to improve the understanding of water availability and management and help promote more integrated water planning in the Segura Basin. In this basin, agriculture amounts to approximately 1366 hm3/year and accounts for 80% of the total blue water use. The forest and agriculture use of soil water amounts to 3065 and 1962 hm3/year, respectively. The unaccounted virtual water trade is also relevant and helps in mitigating water scarcity in the basin. The basin is a net virtual water-exporting region, with an average export of 1598 hm3/year, mainly in the form of fruits and vegetables, and imports approximately 1253 hm3/year, mainly related to feed for pig farms. Virtual water imports are four times larger than the disputed water transfer rate to the Segura Basin from other river basins. Water productivity analyses by sub-sectors are useful in understanding the economic rationale of the basin activities. Two types of agriculture coexist in the basin, namely, intensive industrial agriculture and occupational farming, which maintain the territory and landscape. From a Mediterranean country perspective, the analysis recommends considering climate fluctuations and temporal variability and trends of water availability and use, moving beyond the average values considered in river basin management plans. Groundwater reserve depletion continues to occur at a rate of 231 hm3/year, as water from wells is currently cheaper than using desalinated water in farms, and it does not cause boron-related water quality problems for irrigation. If socially costly administrative measures are not taken, groundwater reserve depletion will continue.
Display omitted
•EU WFD does not address land ecosystems, rainfed agriculture nor virtual water trade.•Analysing all types and origins of water provides insight on impacts and solutions.•The temporal variability and trends analysis helps comply with environmental flows.•Virtual water imports, 1250 hm3/year in the Segura basin, mitigate water scarcity.•Integrating trade, land-use and water planning helps anticipate and solve problems
(1) Background: Adolescence is a critical stage in the development of healthy habits. In this regard, physical activity has emerged as a useful tool to improve satisfaction with life and ...health-related quality of life in adolescents. Therefore, the aim of the present study was to examine the mediating role of physical activity in the relationship between satisfaction with life and health-related quality of life in adolescent boys and girls. Also, we aimed to investigate the differences between sexes in the HRQoL, physical activity level, and satisfaction with life. (2) Methods: A total of 297 adolescents, ranging in age from 11 to 12 years (11.46 ± 1.63), participated in this cross-sectional study. The Satisfaction with life scale, Physical activity Questionnaire for Adolescents and the KIDSCREEN-10 questionnaires were employed. (3) Results: The estimated indirect effect showed that physical activity level was a mediator of the positive effect of satisfaction with life on health-related quality of life (β = 0.105, 95% CI = 0.031; 0.202). However, the index of moderated mediation showed that sex is not a significant moderator of the mediating role of physical activity in the relationship between satisfaction with life and HRQoL (β = −0.033, 95% CI = −0.023, 0.136). Furthermore, significant differences in satisfaction with life were found, with girls manifesting lower values (p-value = 0.026). (4) Conclusion: This study shows the importance of physical activity during adolescence and the association of this behavior with the health-related quality of life of adolescents.
El Gobierno de España creó el programa Préstamos Renta Universidad para financiar los estudios de posgrado. En la primera convocatoria (2007), los estudiantes sólo tenían que devolver el dinero ...prestado si ingresaban una cantidad superior a 22.000 euros anuales. Sin embargo, en sucesivas convocatorias se eliminó el umbral de devolución. A raíz de la crisis económica, numerosas personas no pueden hacer frente al pago de los préstamos. El diseño del programa Préstamos Renta Universidad es complejo: intervienen el Ministerio de Educación, el Instituto de Crédito Oficial y entidades de crédito colaboradoras. En la ejecución de este programa han existido numerosos problemas relacionados con la información administrativa. La naturaleza jurídica de los préstamos y el procedimiento de concesión también son cuestiones complejas. Finalmente, se examinan las medidas urgentes que el Gobierno ha adoptado para solucionar el problema.
PDF
