Objective
To investigate the relief of low back pain after hip arthroplasty in patients with hip joint and spinal degenerative diseases, and to discuss the effects of unilateral and bilateral hip ...surgery on the relief of low back pain.
Methods
In this retrospective study, we followed 153 patients (69 males and 84 females, age: 43–88 years) who had undergone total hip arthroplasty (THA) via a posterolateral approach and also suffered from lumbar degenerative diseases in the period of 2009 to 2019. The inclusion criteria were: (i) patients who had been diagnosed with severe hip degenerative disease and also been diagnosed with lumbar degenerative disease; (ii) patients who had undergone THA surgery; and (iii) patients who were retrospectively recruited. The exclusion criteria were: (i) patients who had undergone lumbar fusion or internal fixation surgery; or (ii) patients who had vascular claudication, history of major trauma, diabetic polyneuropathy, lumbar and pelvic infections, tumor diseases; (iii) or patients who had undergone THA because of femoral neck fracture or ankylosing spondylitis. The improvement of hip joint function and the relief of low back pain (LBP) were studied, and the effect of unilateral and bilateral THA on the relief of LBP were discussed. Hip pain and function were evaluated by the Harris Hip Score (HHS), LBP was evaluated by Visual Analog Scale (VAS), and lumbar function was evaluated by the Japanese Orthopaedic Association (JOA) scoring system.
Results
The average follow‐up time was 44.3 months (24–108 months). All patients recovered smoothly without complications. The LBP VAS of 153 patients decreased from 4.13 ± 1.37 preoperatively to 1.90 ± 1.44 postoperatively. The average HHS increased from 45.33 ± 13.23 preoperatively to 86.44 ± 7.59 postoperatively at the latest follow‐up. According to Japanese Orthopaedic Association scoring system, the proportion of patients with good response to treatment in these 153 patients reached 93.46%. LBP VAS decreased from 4.18 ± 1.38 preoperatively to 1.95 ± 1.49 postoperatively in unilateral group and from 3.94 ± 1.32 preoperatively to 1.73 ± 1.23 postoperatively in bilateral group, respectively. There were only nine patients with persistent or aggravated LBP after operation. Among them, six patients underwent subsequent lumbar surgery (five patients had pain relieved after reoperation and one patient had not) and the other three patients chose conservative treatment for pain.
Conclusion
THA can relieve LBP while relieving hip pain and restoring hip function in patients with both hip and lumbar degenerative disease, thus possibly avoiding further spinal surgery.
After THA, LBP in some patients will be effectively relieved, thus avoiding further spinal surgery. Therefore, the results of this study highlight the need to treat hip osteoarthritis first when patients have both hip disease (hip osteoarthritis, osteonecrosis of the femoral head, or both) and lumbar degenerative disease.
As Gansu accelerates the building of green eco-industrial system, improving the quality and efficiency of cultural tourism industry has become an important driving force for the transformation of ...economic quality. To effectively optimize economic structure with tourism resources, a measurement index system of cultural tourism and urban economic development is established, based on which the coordination development model on cultural tourism and urban economy of Gansu is established. The paper can provide theoretical basis for evaluating, tracking and comparing the coordination level between cultural tourism and urban economy of Gansu. It can provide city managers with decision-making basis on developing cultural tourism, protecting cultural heritage and enhancing the comprehensive urban development level.
With Hexi Corridor as the study case, this study established an evaluation index system for the development of the industrial parks and industrial clusters, and used the coupling coordination model ...and exploratory spatial data analysis method (ESDA) to explore the evolution and spatial correlation of the coupling coordination between the industrial park and industrial clusters in Hexi Corridor from 2005 to 2017. It is found that from 2005 to 2017, the industrial parks and industrial clusters has shown closer correlations; despite the high level of coordination, the degree of coupling remains low; the Hexi Corridor has not yet developed a growth engine for the coordinated development of the industrial parks and the clusters, and there is no county-level industrial entities that have strong stimulating power. Given the requirements of the current industrial agglomeration model for regional innovation capabilities, this study proposes suggestions for coordinated development of industrial parks and industrial clusters in Hexi Corridor.
In this talk, I present the recent measurement of the Collins fragmentation function based on a set of 62 pb-1 e+e- annihilation data at √s = 3.65 GeV collected with the BESIII detector at the BEPCII ...storage rings. In this work, the azimuthal asymmetries of two charged pions in the inclusive process e+e- → ππX are explored. These asymmetries can be attributed to the Collins fragmentation function, which describes the behavior of a hadron produced from a transversely polarized quark. The corresponding four-momentum transfer of the virtual photon, Q2, is close to the energy scale of the existing semi-inclusive DIS experimental data. We observe a nonzero asymmetry, which increases with increasing pion momentum and also indicates a larger spin-dependent Collins effect than at higher energy scale. The dependence of the asymmetry on the transverse momentum of hadrons to the reference axis is also investigated. The measured asymmetries are important inputs for the global analysis of extracting the quark transversity distribution inside the nucleon, and are valuable to explore the energy evolution of the spin-dependent fragmentation function.
Temporal lobe epilepsy (TLE) is a common kind of refractory epilepsy. More than 30% TLE patients were multi-drug resistant. Some patients may even develop into status epilepticus (SE) because of ...failing to control seizures. Thus, one of the avid goals for anti-epileptic drug development is to discover novel potential compounds to treat TLE or even SE. Crocin, an effective component of
, has been applied in several epileptogenic models to test its anti-epileptic effect. However, it is still controversial and its effect on TLE remains unclear. Therefore, we investigated the effects of crocin on epileptogenesis, generalized seizures (GS) in hippocampal rapid electrical kindling model as well as SE and spotaneous recurrent seizure (SRS) in pilocarpine-induced TLE model in ICR mice in this study. The results showed that seizure stages and cumulative afterdischarge duration were significantly depressed by crocin (20 and 50 mg/kg) during hippocampal rapid kindling acquisition. And crocin (100 mg/kg) significantly reduced the incidence of GS and average seizure stages in fully kindled animals. In pilocarpine-induced TLE model, the latency of SE was significantly prolonged and the mortality of SE was significantly decreased by crocin (100 mg/kg), which can also significantly suppress the number of SRS. The underlying mechanism of crocin may be involved in the protection of neurons, the decrease of tumor necrosis factor-α in the hippocampus and the increase of brain derived neurotrophic factor in the cortex. In conclusion, crocin may be a potential and promising anti-epileptic compound for treatment of TLE.
Critically ill patients in intensive care units (ICUs) are at high risk of venous thromboembolism (VTE). This study aimed to explore the prophylaxis effect under a guideline-based thromboprophylaxis ...protocol among critically ill patients in a respiratory ICU.
For this single-center prospective cohort study, we followed the thromboprophylaxis protocol, which was drawn up based on relevant guidelines and Chinese experts' advice. Clinical data were entered into an electronic case report form and analyzed. Multivariate logistic regression was conducted to explore independent risk factors of VTE event under this protocol.
From August 1, 2014, to December 31, 2020, 884 patients underwent thromboprophylaxis according to this protocol; 10.5% of them received mechanical prophylaxis, 43.8% received pharmacological prophylaxis, and 45.7% received pharmacological combined with mechanical prophylaxis. The proportion of VTE events was 14.3% for patients who received the thromboprophylaxis protocol, of which 0.1% had pulmonary thromboembolism (PTE), 2.0% had proximal deep vein thrombosis (DVT), and 12.1% had isolated distal DVT. There was no significant difference between different thromboprophylaxis measures. Cirrhosis (OR 5.789, 95% CI 1.402, 23.894, P = 0.015), acute asthma exacerbation (OR 39.999, 95% CI 4.704, 340.083, P = 0.001), and extracorporeal membrane oxygenation treatment (OR 22.237, 95%CI 4.824, 102.502, P < 0.001) were independent risk factors for proximal DVT under thromboprophylaxis.
The thromboprophylaxis protocol based on guidelines applied in the ICU was practicable and could help decrease the proportion of PTE and proximal DVT events. The risk factors of VTE events happening under the thromboprophylaxis protocol require more attention.
ClinicalTrials.gov: NCT02213978.
Random variate generation has been widely used in various engineering applications and model frameworks. The introduction of the proposal distribution makes this kind of methods can deal with more ...general sampling problems with complex probability density representation. However, the design of proposal distribution is usually difficult, especially when the target distribution is so complex that it contains asymmetric, multimodal and skewed, or even unsmooth, heavy tailed and illegal density, the sampling performance and efficiency will be greatly affected. In this paper, a novel parameter optimization method with efficient self-tuning strategy is proposed in order to automatically construct the optimal proposal distribution for any complex target density, which treats the design of proposal distribution as a parameter search process and search the optimal solution in an infeasible region by evaluating the loss of solution. The significant advantage of the proposed method is that the search based on infeasible region can converge to a good solution with only a few iterations, making our method far superior to other existing methods in efficiency, which is very suitable for the complex target distribution model with time-consuming density calculation process. Experimental results show the advantages of the proposed method in terms of search strategy, optimal solution performance, search efficiency and robustness.
Abstract
A comprehensive review of weak decays of charmed hadrons (D0/ +, $D^+_s$ and $\Lambda ^+_c$) based on analyses of the threshold data from e+e− annihilation in the BESIII experiment is ...presented. Current experimental challenges and successes in understanding decays of the charmed hadrons are discussed. Precise calibrations of quantum chromodynamics and tests of the standard model are provided by measurements of purely leptonic and semi-leptonic decays of charmed hadrons, and lepton universality is probed in purely leptonic decays of charmed mesons to three generations of leptons. Quantum correlations in threshold data samples provide access to strong phases in the neutral D meson decays and probe the decay dynamics of the charmed Λc baryon. Charm physics studies with near-threshold production of charmed particle pairs are unique to BESIII, and provide many important opportunities and challenges.
The BESIII experiment aims to unveil the fundamental physics inside the charmed hadrons, which consists of one charm quark and light quark(s). With unique advantage of threshold production and quantum coherence, BESIII has been very successful in examining the standard model and searching for new physics in particle physics.
Electrochemical interfaces determine the performance of electrochemical devices, including energy-related systems. An in-depth understanding of the heterogeneous interfaces requires in situ ...techniques with high sensitivity and high temporal and spatial resolution. We develop here an electrochemical reflective absorption microscope (EC-RAM) by using the absorption signals of reacting species with a reasonably good spatial resolution and high sensitivity. We systematically study the response of absorbance (A) and its derivative, i.e. dA/dt, at different positions of the electrode surface and at electrodes with different sizes (50 μm, 500 μm, and 2 mm) both experimentally and theoretically. We find that the derivative cyclic voltabsorptometry (DCVA) frequently used to obtain the local current response in conventional electrochemical optical microscopy techniques is only applicable to reactions of surface species or solution species under linear diffusion control. For processes when the radial diffusion cannot be ignored, as in the case of a microelectrode or the edge of a large electrode, the DCVA curves show distinct diffusion behaviors for the electroactive species in different regions of the electrode, which cannot be directly related to the CV curves. When the radial diffusion dominates the reaction, CVA curves follow the same shape as the CV curves. The developed EC-RAM technique can be applied to extract in situ the local response of an electrochemical system during the dynamic reaction processes.
Skewness (
S
) and kurtosis (
K
) of temperature in the surface layer over a grassland are investigated under unstable thermal stratifications.We find that both skewness and kurtosis generally obey ...Monin–Obukhov similarity theory and tend to be constant values (1.5 and 5.3, respectively) when the stability parameter
z
/
L
< −2. Quantitative formulas of the similarity functions are proposed. The temperature probability density function (PDF) is close to Gaussian in near neutral stratification and non-Gaussian in unstable stratification. The influence of coherent motions on the PDF behavior is analyzed using the quadrant analysis technique. It shows that PDF behaviors are controlled by ejections and sweeps. The results also indicate that the PDF type of the ejections always follows a Gaussian distribution, while the PDF of the sweeps changes with stability.
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