Building on a survey of media institutions in eighteen West European and North American democracies, Hallin and Mancini identify the principal dimensions of variation in media systems and the ...political variables which have shaped their evolution. They go on to identify three major models of media system development (the Polarized Pluralist, Democratic Corporatist and Liberal models) to explain why the media have played a different role in politics in each of these systems, and to explore the forces of change that are currently transforming them. It provides a key theoretical statement about the relation between media and political systems, a key statement about the methodology of comparative analysis in political communication and a clear overview of the variety of media institutions that have developed in the West, understood within their political and historical context.
Comparing Media Systems Beyond the Western World offers a broad exploration of the conceptual foundations for comparative analysis of media and politics globally. It takes as its point of departure ...the widely used framework of Hallin and Mancini's Comparing Media Systems, exploring how the concepts and methods of their analysis do and do not prove useful when applied beyond the original focus of their 'most similar systems' design and the West European and North American cases it encompassed. It is intended both to use a wider range of cases to interrogate and clarify the conceptual framework of Comparing Media Systems and to propose new models, concepts and approaches that will be useful for dealing with non-Western media systems and with processes of political transition. Comparing Media Systems Beyond the Western World covers, among other cases, Brazil, China, Israel, Lebanon, Lithuania, Poland, Russia, Saudi Arabia, South Africa and Thailand.
Background
Facial gunshot wounds present a complex challenge to both medical professionals and victims with significant physical, psychological, and economic implications for those who suffer these ...types of injuries. Reconstructive surgery offers satisfactory aesthetic and functional outcomes, improving a patient’s quality of life. In these cases, the surgical procedure may encompass additional phases beyond those initially identified based on the type of wound and the extent of tissue destruction. As a result, each case necessitates thorough evaluation to determine an appropriate strategy. Nonetheless, it is worth noting that the outcomes achieved in terms of both aesthetics and functionality in this domain have the potential to be excellent.
Case presentation
A 66-year-old man attempted suicide with a shotgun, causing severe facial injuries and fractures. He had a history of depression and was taken to the emergency department promptly. CT scans revealed brain and facial bone injuries, and he underwent surgery to control bleeding and tracheostomy. Postoperative recovery was successful. The patient’s condition stabilized, and he was discharged after 10 days. Follow-up visits showed gradual healing. Despite an offer for further facial reconstruction, he declined, satisfied with the achieved results.
Conclusions
The present case report is intended to support the argument that effective facial reconstruction should be considered in the medico-legal assessment. It could be beneficial to introduce a new classification system and personalized evaluation methods with careful consideration given to treatment costs (which can be very high) and expected results. Since reconstructive surgery modifies damage and impacts the long-term costs of permanent impairments, its inclusion in the decision-making process would promote improved personalized care.
Key points
- Complexity and implications of facial gunshot wounds: Facial gunshot injuries are complex, posing challenges for both medical professionals and victims. The injuries have significant physical, psychological, and economic consequences, necessitating thorough and comprehensive attention due to potential long-term effects on the patient’s life.
- Reconstructive surgery for improved quality of life: Reconstructive surgery yields satisfactory aesthetic and functional outcomes, enhancing patients’ quality of life. By addressing physical damage, it restores appearance and function, positively impacting overall well-being.
- Thorough evaluation and personalized approach: Facial gunshot wound cases can involve unforeseen complexities beyond initial assessments. Comprehensive evaluation is crucial for devising personalized surgical strategies that consider each patient’s unique circumstances.
- Advocating for medico-legal consideration and personalized care: The case report underscores the importance of integrating effective facial reconstruction in medico-legal assessments. A new classification system and personalized evaluation methods can improve care, accounting for treatment costs, expected outcomes, and long-term implications. Tailored care enhances patients’ well-being and decision-making processes.
The probability distribution of the annual maximum peak flows on the River Tiber at the town of Rome (Ripetta) can be evaluated using the information available since the XV century. In this paper the ...probability distribution of two series of annual peak flows maxima observed at the Ripetta gauge is analysed: the systematic series, including all the data observed since the beginning of the systematic stage record in 1782, and the censored series of the exceptional floods that inundated the town of Rome, starting from the XV century. In order to find a criterion for choosing the “optimum” distribution law for the high return period quantiles, an index that takes into account both the accuracy and the uncertainty of the quantiles estimation is proposed.
Fighting diseases and controlling the signs of ageing are the major goals of biomedicine. Sirtuins, enzymes with mainly deacetylating activity, could be pivotal targets of novel preventive and ...therapeutic strategies to reach such aims. Scientific proofs are accumulating in experimental models, but, to a minor extent, also in humans, that the ancient practice of calorie restriction could prove an effective way to prevent several degenerative diseases and to postpone the detrimental signs of ageing. In the present review, we summarize the evidence about the central role of sirtuins in mediating the beneficial effects of calorie restriction in skeletal and cardiac muscle since these tissues are greatly damaged by diseases and advancing years. Moreover, we entertain the possibility that the identification of sirtuin activators that mimic calorie restriction could provide the benefits without the inconvenience of this dietary style.
Įžanga Mancini, Paolo
Sociologija. Mintis ir veiksmas,
04/2015, Letnik:
23
Journal Article
Recenzirano
Odprti dostop
Introduction to a special issue of “Sociologija. Mintis ir veiksmas” that contains a number of original papers presented at the international conference “European Public Spheres, Civil Society and ...Civic Mass Media“, organized by Vytautas Magnus University, Kaunas in April 2007.
Įžanga, skirta žurnalo numeriui, kuriame pateikiami straipsniai skaityti tarptautinėje konferencijoje Vytauto Didžiojo universitete.
Evidence of epigenetic tags in cardiac fibrosis Grimaldi, Vincenzo, BiolD; De Pascale, Maria Rosaria, MD; Zullo, Alberto, BiolD, PhD ...
Journal of cardiology,
02/2017, Letnik:
69, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Abstract In cardiac fibrosis, following an injury or a stress, non-functional fibrotic tissue substitutes normal myocardium, thus leading to progressive heart failure. Activated fibroblasts are ...principal determinants of cardiac fibrosis by producing excessive fibrotic extracellular matrix and causing hypertrophy of cardiomyocytes. Epigenetic changes, such as DNA methylation, histone modifications, and miRNAs have been involved in these mechanisms. Therefore, there is a strong interest in reverting such epigenetic transformations in order to arrest myocardial fibrotic degeneration. Demethylating agents, such as 5-aza-2′-deoxycytidine, 5-azacytidine, some selective histone deacetylase inhibitors, including mocetinostat, trichostatin A, and MPT0E014, have a direct action on important inducers of cardiac fibrosis. Also dietary compounds, such as resveratrol, can suppress the differentiation of fibroblasts to myofibroblasts. Although in vivo and in vitro studies suggest specific epigenetic therapies to treat cardiac fibrosis, the related clinical trials are still lacking. A better understanding of the epigenetic effects of dietary compounds ( e.g. curcumin and green tea catechins) on the onset and progression of cardiac fibrosis, will allow the identification of protective dietary patterns and/or the generation of novel potential epidrugs.
Epigenetics is involved in the altered expression of gene networks that underlie insulin resistance and insufficiency. Major genes controlling β-cell differentiation and function, such as PAX4, PDX1, ...and GLP1 receptor, are epigenetically controlled. Epigenetics can cause insulin resistance through immunomediated pro-inflammatory actions related to several factors, such as NF-kB, osteopontin, and Toll-like receptors. Hereafter, we provide a critical and comprehensive summary on this topic with a particular emphasis on translational and clinical aspects. We discuss the effect of epigenetics on β-cell regeneration for cell replacement therapy, the emerging bioinformatics approaches for analyzing the epigenetic contribution to type 2 diabetes mellitus (T2DM), the epigenetic core of the transgenerational inheritance hypothesis in T2DM, and the epigenetic clinical trials on T2DM. Therefore, prevention or reversion of the epigenetic changes occurring during T2DM development may reduce the individual and societal burden of the disease.
This paper discusses the possible consequences of mass media fragmentation over the structure and the functioning of democracy. Media fragmentation and audience segmentation are not new but they ...greatly increased in the very last years because of the long ongoing tendency towards commercialization and mostly because of the development of new media and the internet in particular. This has determined what is usually defined “the crisis of traditional journalism” that has become the very frequent topic of most of the seminar on journalism today. The last part of the paper looks at the possible consequences of these changes over the structure of democracy beyond the well rooted techno-optimism: increasing social and political polarization, new forms of political socialization, more complex process of social and political negotiation, new forms of public scrutiny.
The
gene encodes the p57
protein which has been identified as the third member of the CIP/Kip family, also including p27
and p21
. In analogy with these proteins, p57
is able to bind tightly and ...inhibit cyclin/cyclin-dependent kinase complexes and, in turn, modulate cell division cycle progression. For a long time, the main function of p57
has been associated only to correct embryogenesis, since
-ablated mice are not vital. Accordingly, it has been demonstrated that
alterations cause three human hereditary syndromes, characterized by altered growth rate. Subsequently, the p57
role in several cell phenotypes has been clearly assessed as well as its down-regulation in human cancers.
lies in a genetic locus, 11p15.5, characterized by a remarkable regional imprinting that results in the transcription of only the maternal allele. The control of
transcription is also linked to additional mechanisms, including DNA methylation and specific histone methylation/acetylation. Finally, long non-coding RNAs and miRNAs appear to play important roles in controlling p57
levels. This review mostly represents an appraisal of the available data regarding the control of
gene expression. In addition, the structure and function of p57
protein are briefly described and correlated to human physiology and diseases.
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