Background
Thoracic pial arteriovenous fistulas (pAVFs) are rare vascular malformations that usually consist of a single dilated pial artery connecting directly to an enlarged draining vein. Multiple ...shunting point thoracic pAVFs are even rarer entities causing progressive myelopathy.
Method
We present our surgical technique to identify and exclude multiple shunting point thoracic pAVF with appropriate pre-operative planning. This surgical technique is illustrated by an intraoperative video.
Conclusion
Double injection pre-operative angiography represents a helpful tool to plan the surgery. Intraoperative exposure with pedicle removal and the use of micro-Doppler improve the identification and the exclusion of a multiple shunting thoracic pAVF.
Discovery of a radio galaxy at z = 5.72 Saxena, A; Marinello, M; Overzier, R A ...
Monthly notices of the Royal Astronomical Society,
10/2018, Letnik:
480, Številka:
2
Journal Article
Aims. We wish to investigate the physical properties of a sample of Lyα emitting galaxies in the VANDELS survey, with particular focus on the role of kinematics and neutral hydrogen column density in ...the escape and spatial distribution of Lyα photons. Methods. From all the Lyα emitting galaxies in the VANDELS Data Release 2 at 3.5 ≲ z ≲ 4.5, we selected a sample of 52 galaxies that also have a precise systemic redshift determination from at least one nebular emission line (HeII or CIII). For these galaxies, we derived different physical properties (stellar mass, age, dust extinction, and star formation rate) from spectral energy distribution (SED) fitting of the exquisite multiwavelength photometry available in the VANDELS fields, using the dedicated spectral modeling tool BEAGLE and the UV β slope from the observed photometry. We characterized the Lyα emission in terms of kinematics, equivalent width (EW), full width at half-maximum, and spatial extension and then estimated the velocity of the neutral outflowing gas. The ultra-deep VANDELS spectra (up to 80 h on-source integration) enable this for individual galaxies without the need to rely on stacks. We then investigated the correlations between the Lyα properties and the other measured properties to study how they affect the shape and intensity of Lyα emission. Results. We reproduce some of the well-known correlations between Lyα EW and stellar mass, dust extinction, and UV β slope, in the sense that the emission line appears brighter in galaxies with lower mass that are less dusty and bluer. We do not find any correlation with the SED-derived star formation rate, while we find that galaxies with brighter Lyα tend to be more compact in both UV and in Lyα. Our data reveal an interesting correlation between the Lyα velocity offset and the shift of the interstellar absorption lines with respect to the systemic redshift, observed for the first time at high redshifts: galaxies with higher interstellar medium (ISM) outflow velocities show smaller Lyα velocity shifts. We interpret this relation in the context of the shell-model scenario, where the velocity of the ISM and the HI column density contribute together in determining the Lyα kinematics. In support to our interpretation, we observe that galaxies with high HI column densities have much more extended Lyα spatial profiles; this is a sign of increased scattering. However, we do not find any evidence that the HI column density is related to any other physical properties of the galaxies, although this might be due in part to the limited range of parameters that our sample spans.
•FNA cytology can obtain a precise insight of the salivary gland lumps.•The MSRSGC is a 6-tiered classification which estimates the risk of malignancy (ROM).•The revised MSRSGC supplements FNA ...cytology with some crucial clinical consideration.
Fine-needle aspiration cytology (FNAC) is a basic step in the diagnosis of salivary gland tumors that have a wide variety of histological types. The recent Milan system for reporting salivary gland cytopathology (MSRSGC) can correlate the risk of malignancy with precise cytological features. A revised version was recently proposed to improve the surgical relevance and facilitate uniform management.
A multicenter study retrospectively used the original and revised MSRSGC criteria to classify a series of patients who received surgery after FNAC.
We enrolled 503 patients from three tertiary centers. The risk of malignancy for the MSRSGC resulted 19.5% in cat. I, 14.3% in cat. II, 17.6% in cat. III, 3.6% in cat. IVa, 24.6% in cat. IVb, 66.7% in cat. V, and 96.8% in cat. VI. The results from the revised MSRSGC were consistent with the original values.
The MSRSGC is a promising classification system. In our opinion, the revised version of the MSRSGC supplements FNAC with some crucial clinical information and can better identify the appropriate treatment in each category.
We evaluated the effects of supplemental calcium ammonium nitrate (CAN) fed to dairy cows on dry matter (DM) intake, nutrient digestibility, milk quality, microbial protein synthesis, and ruminal ...fermentation. Six multiparous Holstein cows at 106 ± 14.8 d in milk, with 551 ± 21.8 kg of body weight were used in a replicated 3 × 3 Latin square design. Experimental period lasted 21 d, with 14 d for an adaptation phase and 7 d for sampling and data collection. Cows were randomly assigned to receive the following treatments: URE, 12 g of urea/kg of DM as a control group; CAN15, 15 g of CAN/kg of DM; and CAN30, 30 g of CAN/kg of DM. Supplemental CAN reduced DM intake (URE 19.0 vs. CAN15 18.9 vs. CAN30 16.5 kg/d). No treatment effects were observed for apparent digestibility of DM, organic matter, crude protein, ether extract, and neutral detergent fiber; however, CAN supplementation linearly increased nonfiber carbohydrate digestibility. Milk yield was not affected by treatments (average = 23.1 kg/d), whereas energy-corrected milk (ECM) and 3.5% fat-corrected milk (FCM) decreased as the levels of CAN increased. Nitrate residue in milk increased linearly (URE 0.30 vs. CAN15 0.33 vs. CAN30 0.38 mg/L); however, treatments did not affect nitrite concentration (average: 0.042 mg/L). Milk fat concentration was decreased (URE 3.39 vs. CAN15 3.35 vs. CAN30 2.94%), and the proportion of saturated fatty acids was suppressed by CAN supplementation. No treatment effects were observed on the reducing power and thiobarbituric acid reactive substances of milk, whereas conjugated dienes increased linearly (URE 47.6 vs. CAN15 52.7 vs. CAN30 63.4 mmol/g of fat) with CAN supplementation. Treatments had no effect on microbial protein synthesis; however, molar proportion of ruminal acetate and acetate-to-propionate ratio increased with CAN supplementation. Based on the results observed, supplementing CAN at 30 g/kg of DM should not be recommended as an optimal dose because it lowered DM intake along with ECM and 3.5% FCM, although no major changes were observed on milk quality and ruminal fermentation.
Abstract
We present the results of a new study of dust attenuation at redshifts 3 < z < 4 based on a sample of 236 star-forming galaxies from the VANDELS spectroscopic survey. Motivated by results ...from the First Billion Years (FiBY) simulation project, we argue that the intrinsic spectral energy distributions (SEDs) of star-forming galaxies at these redshifts have a self-similar shape across the mass range 8.2 ≤ log (M⋆/M⊙) ≤ 10.6 probed by our sample. Using FiBY data, we construct a set of intrinsic SED templates which incorporate both detailed star formation and chemical abundance histories, and a variety of stellar population synthesis (SPS) model assumptions. With this set of intrinsic SEDs, we present a novel approach for directly recovering the shape and normalization of the dust attenuation curve. We find, across all of the intrinsic templates considered, that the average attenuation curve for star-forming galaxies at z ≃ 3.5 is similar in shape to the commonly adopted Calzetti starburst law, with an average total-to-selective attenuation ratio of RV = 4.18 ± 0.29. In contrast, we find that an average attenuation curve as steep as the SMC extinction law is strongly disfavoured. We show that the optical attenuation (AV) versus stellar mass (M⋆) relation predicted using our method is consistent with recent ALMA observations of galaxies at 2 < z < 3 in the Hubble Ultra Deep Field (HUDF), as well as empirical AV − M⋆ relations predicted by a Calzetti-like law. In fact, our results, combined with other literature data, suggest that the AV–M⋆ relation does not evolve over the redshift range 0 < z < 5, at least for galaxies with log(M⋆/M⊙) ≳ 9.5. Finally, we present tentative evidence which suggests that the attenuation curve may become steeper at lower masses log(M⋆/M⊙) ≲ 9.0.
Context.
The star formation rate density (SFRD) evolution presents an area of great interest in the studies of galaxy evolution and reionization. The current constraints of SFRD at
z
> 5 are based ...on the rest-frame UV luminosity functions with the data from photometric surveys. The VIMOS UltraDeep Survey (VUDS) was designed to observe galaxies at redshifts up to ∼6 and opened a window for measuring SFRD at
z
> 5 from a spectroscopic sample with a well-controlled selection function.
Aims.
We establish a robust statistical description of the star-forming galaxy population at the end of cosmic HI reionization (5.0 ≤
z
≤ 6.6) from a large sample of 49 galaxies with spectroscopically confirmed redshifts. We determine the rest-frame UV and Ly
α
luminosity functions and use them to calculate SFRD at the median redshift of our sample
z
= 5.6.
Methods.
We selected a sample of galaxies at 5.0 ≤
z
spec
≤ 6.6 from the VUDS. We cleaned our sample from low redshift interlopers using ancillary photometric data. We identified galaxies with Ly
α
either in absorption or in emission, at variance with most spectroscopic samples in the literature where Ly
α
emitters (LAE) dominate. We determined luminosity functions using the 1/
V
max
method.
Results.
The galaxies in this redshift range exhibit a large range in their properties. A fraction of our sample shows strong Ly
α
emission, while another fraction shows Ly
α
in absorption. UV-continuum slopes vary with luminosity, with a large dispersion. We find that star-forming galaxies at these redshifts are distributed along the main sequence in the stellar mass vs. SFR plane, described with a slope
α
= 0.85 ± 0.05. We report a flat evolution of the specific SFR compared to lower redshift measurements. We find that the UV luminosity function is best reproduced by a double power law, while a fit with a Schechter function is only marginally inferior. The Ly
α
luminosity function is best fitted with a Schechter function. We derive a logSFRD
UV
(
M
⊙
yr
−1
Mpc
−3
) = −1.45
+0.06
−0.08
and logSFRD
Ly
α
(
M
⊙
yr
−1
Mpc
−3
) = −1.40
+0.07
−0.08
. The SFRD derived from the Ly
α
luminosity function is in excellent agreement with the UV-derived SFRD after correcting for IGM absorption.
Conclusions.
Our new SFRD measurements at a mean redshift of
z
= 5.6 are ∼0.2 dex above the mean SFRD reported in Madau & Dickinson (2014, ARA&A, 52, 415), but in excellent agreement with results from Bouwens et al. (2015a, ApJ, 803, 34). These measurements confirm the steep decline of the SFRD at
z
> 2. The bright end of the Ly
α
luminosity function has a high number density, indicating a significant star formation activity concentrated in the brightest LAE at these redshifts. LAE with equivalent width EW > 25 Å contribute to about 75% of the total UV-derived SFRD. While our analysis favors low dust content in 5.0 <
z
< 6.6, uncertainties on the dust extinction correction and associated degeneracy in spectral fitting will remain an issue, when estimating the total SFRD until future surveys extending spectroscopy to the NIR rest-frame spectral domain, such as with JWST.
Cancer cell lines are widely used as in vitro models of tumorigenesis, facilitating fundamental discoveries in cancer biology and translational medicine. Currently, there are few options for ...glioblastoma (GBM) treatment and limited in vitro models with accurate genomic and transcriptomic characterization. Here, a detailed characterization of a new GBM cell line, namely AHOL1, was conducted in order to fully characterize its molecular composition based on its karyotype, copy number alteration (CNA), and transcriptome profiling, followed by the validation of key elements associated with GBM tumorigenesis. Large numbers of CNAs and differentially expressed genes (DEGs) were identified. CNAs were distributed throughout the genome, including gains at Xq11.1-q28, Xp22.33-p11.1, Xq21.1-q21.33, 4p15.1-p14, 8q23.2-q23.3 and losses at Yq11.21-q12, Yp11.31-p11.2, and 15q11.1-q11.2 positions. Nine druggable genes were identified, including HCRTR2, ETV1, PTPRD, PRKX, STS, RPS6KA6, ZFY, USP9Y, and KDM5D. By integrating DEGs and CNAs, we identified 57 overlapping genes enriched in fourteen pathways. Altered expression of several cancer-related candidates found in the DEGs-CNA dataset was confirmed by RT-qPCR. Taken together, this first comprehensive genomic and transcriptomic landscape of AHOL1 provides unique resources for further studies and identifies several druggable targets that may be useful for therapeutics and biologic and molecular investigation of GBM.
Ullmann coupling of halogenated aromatics is widely used in on-surface synthesis of two-dimensional (2D) polymers and graphene nanoribbons. It stands out among other reactions for regioselectively ...connecting aromatic monomers into 1D and 2D π-conjugated polymers, whose final structure and properties are determined by the initial building blocks. Thanks to their exceptional electronic properties, thiophene-containing monomers are frequently used for the synthesis of various conjugated materials. On the other hand, their use in on-surface polymerization is hampered by the possibility of ring opening when adsorbed on metal surfaces. In the present work, we mapped the temperature regime for these two competing reactions by investigating the adsorption of a thiophene-based prochiral molecule using scanning tunneling microscopy, X-ray photoelectron spectroscopy and density functional theory calculations. We followed the formation of organometallic (OM) networks, their evolution into covalent structures and the competition between C-C coupling and thiophene ring opening. The effect of surface reactivity was explored by comparing the adsorption on three (111) coinage metal substrates, namely Au, Ag and Cu. While outlining strategies to minimize the ring opening reaction, we found that the surface temperature during deposition is of paramount importance for the preparation of 2D OM networks, greatly enhancing the overall ordering of the product by depositing on hot Ag surface. Notably, the same protocol permits the creation of OM structures on the air-stable Au surface, thereby allowing the synthesis and application of 2D OM networks outside the ultra-high vacuum environment.
Temperature mapping of the different molecular phases of tribromoterthienobenzene on (111) coinage metals.
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