Heavy quarks, i.e. charm and beauty, are sensitive probes of the medium produced in high-energy heavy-ion collisions. They are produced in the early stage of the collision, mainly in hard partonic ...scattering processes, and are expected to experience the whole collision evolution interacting with the medium constituents via both elastic and inelastic processes. The nuclear modification factor (RAA) is one of the main experimental observables that allow us to investigate the interaction strength of heavy quarks with the medium. The ALICE collaboration measured the production of open heavy-flavour hadrons via their semi-leptonic decays to electrons at mid-rapidity and to muons at forward rapidity in elementary proton-proton (pp) collisions as well as p–Pb, Pb–Pb and in Xe–Xe collisions.
ALICE is the experiment specifically designed to study the Quark-Gluon Plasma (QGP) in heavy-ion collisions at the CERN LHC. The ALICE detector will be upgraded during the Long Shutdown 2, planned ...for 2019-2020, in order to cope with the maximum interaction rate of 50 kHz of Pb-Pb collisions foreseen for Runs 3 and 4. The ambitious programme of high-precision measurements, expected for muon physics after 2020, requires an upgrade of the front-end and readout electronics of the existing Muon Spectrometer. This concerns the Cathode Pad Chambers (CPC) used for tracking and the Resistive Plate Chambers (RPC) used for triggering and for muon identification. The Muon Forward Tracker (MFT), an internal tracker added in front of the front absorber of the existing Muon Spectrometer, is also part of the ALICE detector upgrade programme. It is based on an assembly of circular planes made of Monolithic Active Pixel Sensors (MAPS), covering the pseudorapidity range 2.5 <η < 3.6. The MFT will improve present measurements and enable new ones. A selection of results from physics performance studies will be presented, together with an overview of the technical aspects of the upgrade project.
ϕ
meson measurements provide insight into strangeness production, which is one of the key observables for the hot medium formed in high-energy heavy-ion collisions. ALICE measured
ϕ
production ...through its decay in muon pairs in Pb–Pb collisions at
s
NN
=
2.76
TeV in the intermediate transverse momentum range
2
<
p
T
<
5
GeV/c and in the rapidity interval
2.5
<
y
<
4
. The
ϕ
yield was measured as a function of the transverse momentum and collision centrality. The nuclear modification factor was obtained as a function of the average number of participating nucleons. Results were compared with the ones obtained via the kaon decay channel in the same
p
T
range at midrapidity. The values of the nuclear modification factor in the two rapidity regions are in agreement within uncertainties.
Provide guidelines presented as an algorithm for practical evaluation and first line therapy of urinary incontinence in elderly.
Guidelines using formalized consensus guidelines method. These ...guidelines have been validated by a group of 40 experts quoting proposals, subsequently reviewed by an independent group of multidisciplinary experts (urologist, general practitioner, neurologist, gynecologist, geriatrist, specialist in physical medicine and rehabilitation).
By means of 3 rounds of interrogation of the expert panel, GRAPPPA algorithm was constructed. This algorithm take in account both evaluation and first line therapeutic options in the different type of incontinences observed in this population (urge, stress and mixed incontinence). Initial evaluation consists to track down urinary retention (and subsequently fecal stool impaction, use of anticholinergic or morphinic drugs), urinary tract infection and cognitive impairment. Haematuria, bladder-pelvic pain, history of radiotherapy or recent pelvic surgery, lead to refer the patient to a specialized unit. First line therapy is in all the cases pelvic floor training, use of local oestrogenotherapy and dietetic measures. In urge incontinence, anticholinergic drugs may be used.
Implementation of this algorithm may promote best practice in management of urinary incontinence in elderly.
Four series of new pyrazoles, namely, 5 4-carboxypyrazolo-3-tert-butylcarboxamide and 6 4-carboxypyrazolo-3-cyclopropylcarboxamide derivatives and 10 pyrazolo3,4-d1,3thiazine-4-one and 9 ...pyrazolo3,4-d1,3thiazine-4-thione derivatives, were synthesized and screened as potential inhibitors of photosynthetic electron transport. The structures were confirmed by 1H NMR, elemental, and IR analyses. Their biological activity was evaluated in vitro as the ability to interfere with the light-driven reduction of ferricyanide by isolated spinach chloroplasts. Only a few compounds exhibited excellent inhibitory properties in the micromolar range, comparable to those of commercial herbicides sharing the same target, such as diuron, lenacil, and hexazinone. Nevertheless, most of the remaining molecules exerted a remarkable inhibition in the millimolar range. Combined with previous results on 6 pyrazolo1,5-a1,3,5triazine-2,4-dione and 4 pyrazolo1,5-c1,3,5thiadiazine-2-one derivatives, these data allowed a comprehensive analysis of structure−activity relationship. Molecular modeling studies were undertaken to rationalize the structural determinants of activity in terms of shape, size, and molecular fields. Results suggested that the inhibitory potential of these compounds is associated mainly with their electrostatic properties. Keywords: Herbicides; photosynthetic electron transport inhibitors; pyrazole derivatives; structure−activity relationship
Measurements of open heavy flavour production in p–A collisions allow the investigation of Cold Nuclear Matter effects. In addition, they are an important tool for a complementary investigation of ...the long-range correlations found in small systems in the light flavour sector. In this work, production measurements of D mesons at mid-rapidity in p–Pb collisions at sNN=5.02TeV are reported. Production yields are also reported for the heavy-flavour hadron decay electrons at central rapidity at sNN=5.02 and 8.16 TeV. The elliptic flow (v2) of heavy-flavour hadron decay electrons in high-multiplicity p-Pb collisions at sNN=5.02TeV is found to be positive with a significance larger than 5σ.
We present recent results on strange and non-strange D-meson production measured with ALICE in Pb–Pb collisions at the LHC. In addition, the measurements of the Λc+-baryon production and of the ...Λc+/D0 ratio in pp, p–Pb, and, for the first time ever, Pb–Pb collisions are reported.
Two-particle number and transverse momentum correlations are powerful tools for studying the medium produced in heavy-ion collisions. Correlations in the angular separation of pairs of hadrons can ...provide information on the medium transport characteristics. In particular, the transverse momentum correlations are sensitive to momentum currents, and provide information about the system life time, the shear viscosity over entropy density ratio (η/s) and the system relaxation time (τπ). Furthermore, the interaction of the jets produced in the initial stages of a collision can be studied using number correlations, by observing the medium-induced modification of the near-side jet peak. Measurements of both sets of correlations from Pb–Pb collisions are reported as a function of centrality. Theoretical interpretations and results from Monte Carlo generators are then confronted with the experimental data.
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