The Saturnian droplet Marin, A.
Journal of fluid mechanics,
02/2021, Letnik:
908
Journal Article
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Electrohydrodynamic instabilities at liquid interfaces continue to defy our intuition, from the pioneering work of Taylor (Proc. R. Soc. Lond. A, vol. 280, issue 1382, 1964, pp. 383–397) on conical ...tips of electrified droplets to a recent numerical study by Wagoner et al. (J. Fluid Mech., vol. 904, 2020, R4). The problem studied by Wagoner et al. (2020) consists of a droplet immersed in a more conducting and more dielectric liquid medium, in a strong electrical field. When the droplet is more viscous than the outer medium, the droplet develops a biconcave shape which might eventually evolve to a torus shape (or doughnut). In contrast, when the droplet is less viscous, it adopts a lenticular shape and emits a thin fluid sheet from its equator which in turn breaks up into droplets. These droplets form a ring of satellites around the original droplet, which justifies its appellation ‘Saturnian droplet’. The numerical simulations bring light to this complex phenomenon and confirm the robustness of the leaky-dielectric framework (Melcher & Taylor, Annu. Rev. Fluid Mech., vol. 1, 1969, pp. 111–146).
•Projections of multiple climate risks to critical infrastructures are assessed.•Impacts could rise up to 10 times present damages by 2100 due to global warming alone.•Damages from heatwaves, ...droughts and coastal floods show the most dramatic rise.•Economic losses could be highest for the industry, transport and energy sectors.•Southern and south-eastern European countries will likely be most affected.
Extreme climatic events are likely to become more frequent owing to global warming. This may put additional stress on critical infrastructures with typically long life spans. However, little is known about the risks of multiple climate extremes on critical infrastructures at regional to continental scales. Here we show how single- and multi-hazard damage to energy, transport, industrial, and social critical infrastructures in Europe are likely to develop until the year 2100 under the influence of climate change. We combine a set of high-resolution climate hazard projections, a detailed representation of physical assets in various sectors and their sensitivity to the hazards, and more than 1100 records of losses from climate extremes in a prognostic modelling framework. We find that damages could triple by the 2020s, multiply six-fold by mid-century, and amount to more than 10 times present damage of €3.4 billion per year by the end of the century due only to climate change. Damage from heatwaves, droughts in southern Europe, and coastal floods shows the most dramatic rise, but the risks of inland flooding, windstorms, and forest fires will also increase in Europe, with varying degrees of change across regions. Economic losses are highest for the industry, transport, and energy sectors. Future losses will not be incurred equally across Europe. Southern and south-eastern European countries will be most affected and, as a result, will probably require higher costs of adaptation. The findings of this study could aid in prioritizing regional investments to address the unequal burden of impacts and differences in adaptation capacities across Europe.
Background
Apical periodontitis (AP) frequently presents as a chronic asymptomatic disease. To arrive at a true diagnosis, in addition to the clinical examination, it is mandatory to undertake ...radiographic examinations such as periapical or panoramic radiographs, or cone‐beam computed tomography (CBCT). Thus, the worldwide burden of AP is probably underestimated or unknown. Previous systematic reviews attempted to estimate the prevalence of AP, but none have investigated which factors may influence its prevalence worldwide.
Objectives
To assess: (i) the prevalence of AP in the population worldwide, as well as the frequency of AP in all teeth, nontreated teeth and root filled teeth; (ii) which factors can modify the prevalence of AP.
Methods
A search was conducted in the PubMed‐MEDLINE, EMBASE, Cochrane‐CENTRAL, LILACS, Google scholar and OpenGrey databases, followed by hand searches, until September 2019. Cross‐sectional, case–control and cohort studies reporting the prevalence of AP in humans, using panoramic or periapical radiograph or CBCT as image methods were included. No language restriction was applied. An adaptation of the Newcastle‐Ottawa Scale was used to evaluate the quality of the studies. A meta‐analysis was performed to determine the pooled prevalence of AP at the individual level. Secondary outcomes were the frequency of AP in all teeth, nontreated teeth and rootfilled teeth. Subgroup analyses using random‐effect models were carried out to analyse the influence of explanatory covariables on the outcome.
Results
The search strategy identified 6670 articles, and 114 studies were included in the meta‐analysis, providing data from 34 668 individuals and 639 357 teeth. The prevalence of AP was 52% at the individual level (95% CI 42%–56%, I2 = 97.8%) and 5% at the tooth level (95% CI 4%–6%; I2 = 99.5%). The frequency of AP in root‐filled teeth and nontreated teeth was 39% (95% CI 36%–43%; I2 = 98.5%) and 3% (95% CI 2%–3%; I2 = 99.3%), respectively. The prevalence of AP was greater in samples from dental care services (DCS; 57%; 95% CI 52%–62%; I2 = 97.8%) and hospitals (51%; 95% CI 40%–63%; I2 = 95.9%) than in those from the general population (GP; 40%; 95% CI 33%–46%; I2 = 96.5%); it was also greater in people with a systemic condition (63%; 95% CI 56%–69%, I2 = 89.7%) compared to healthy individuals (48%; 95% CI 43%–53%; I2 = 98.3%).
Discussion
The subgroup analyses identified explanatory factors related to the variability in the prevalence of AP. However, the high clinical heterogeneity and high risk of bias across the primary studies indicate that the findings must be interpreted with caution.
Conclusions
Half of the adult population worldwide have at least one tooth with apical periodontitis. The prevalence of AP is greater in samples from the dental care services, but it is also high amongst community representative samples from the general population. The present findings should bring the attention of health policymakers, medical and dental communities to the hidden burden of endodontic disease in the population worldwide.
The immune system is the core defense against cancer development and progression. Failure of the immune system to recognize and eliminate malignant cells plays an important role in the pathogenesis ...of cancer. Tumor cells evade immune recognition, in part, due to the immunosuppressive features of the tumor microenvironment. Immunotherapy augments the host immune system to generate an antitumor effect. Immune checkpoints are pathways with inhibitory or stimulatory features that maintain self-tolerance and assist with immune response. The most well-described checkpoints are inhibitory in nature and include the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), programmed cell death receptor-1 (PD-1), and programmed cell death ligand-1 (PD-L1). Molecules that block these pathways to enhance the host immunologic activity against tumors have been developed and become standard of care in the treatment of many malignancies. Only a small percentage of patients have meaningful responses to these treatments, however. New pathways and molecules are being explored in an attempt to improve responses and application of immune checkpoint inhibition therapy. In this review, we aim to elucidate these novel immune inhibitory pathways, potential therapeutic molecules that are under development, and outline particular advantages and challenges with the use of each one of them.
Dermal exposure to metal(loid)s from contaminated soils has received less attention than oral and inhalation exposure. Still, it can be a relevant pathway for some contaminants. Comparison of ...synthetic sweats (donor solutions), the influence of sebum, and the characterization of diffusion parameters through a synthetic membrane (acting as skin surrogate) in the permeation of metal(loid)s (As, Cr, Cu, Ni, Pb, and, Zn) from polluted soils is missing. The dermal bioaccessibility tests were performed using two sweat compositions EN 1811, pH 6.5 (sweat A) and NIHS 96–10, pH 4.7 (sweat B). Diffusion parameters of soluble metal(loid)s using the Franz cell methodology were calculated using the Strat-M membrane. The influence of synthetic sebum in the permeation of metal(loid)s was also investigated. The metal(loid) bioaccessibility percentage was higher for sweat B (pH 4.7) compared to sweat A (pH 6.5), attributed to lower pH of sweat B. Among the six elements tested, only chromium and copper permeated the membrane. Permeation coefficient (K p) was higher for chromium in sweat A (0.05–0.11 cm h–1) than sweat B (0.0007–0.0037 cm h–1) likely due to a higher pH and thus more permeable Cr species. The presence of sebum increased lag times for copper permeation. Additional studies regarding speciation of metal(loid)s following extractions in synthetic sweat and comparison of synthetic membrane Strat-M and human skin in the permeation of metal(loid)s are recommended.
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•Bioreactor operated at 28 °C/20 °C with pH 5.5 to 4.5 using mixed culture.•Lower temperature and pH led to increased electron yields to acetate.•The highest H2 and CO consumption was ...at 20 °C and pH 4.5.•Methanogens were not completely suppressed under any conditions.•Different microbial genera dominated distinct experimental periods.
Syngas fermentation to acetate offers a promising solution for its valorisation, particularly when syngas contains a high N2 concentration, which otherwise impedes the utilisation of syngas biomethanation gaseous product in cogeneration or upgrading units. In this study, continuous lab-scale syngas fermentation assessing the effects of acidic pH and psychrophilic conditions (28 °C and 20 °C) on bioconversion efficiency and anaerobic consortium diversity was studied. The results showed that as temperature and pH decrease, acetate yield increases. The highest H2 and CO consumption rates were observed at 20 °C and pH 4.5, reaching 48.4 mmol/(L·d) and 31.5 mmol/(L·d), respectively, and methanogenic activity was not completely suppressed. The microbial community composition indicated an enhanced abundance of acetate-producing bacteria and hydrogenotrophic methanogens at 28 °C. The PICRUSt2 prediction of metabolic potential indicated that temperature and pH changes appear to have a more pronounced impact on acetotrophic methanogenesis genes than carbon dioxide-based methanogenesis genes.
Exposure to potentially toxic metal(loid)s (PTMs) in soil may happen via ingestion, inhalation, and dermal pathway. A more accurate risk characterization should consider PTM bioavailability. Using ...ten soil samples collected in the Montreal area (Canada) near CCA-treated utility poles, this study aims to characterize non-carcinogenic and carcinogenic human health risks associated with As, Cr, Cu, Pb, and Zn through a multi-pathway exposure approach. This innovative study incorporates, for the first time, the bioaccessible fraction of the metal(loid)s for three exposure routes and two different scenarios. For the residential and industrial scenarios, the oral and dermal pathways yielded a hazard index (HI) much higher than 1 with and without bioaccessibility considerations (range 1.7 – 349 without bioaccessibility and 0.8–134 with bioaccessibility), whereas the inhalation pathway caused a lower hazard (HI < 1). For the dermal pathway, the hazard quotient was higher when bioaccessibility of field-collected samples was considered due to inherent assumptions from the US EPA soil approach to calculate the dermal dose. For carcinogenic risk, As and Pb were the most significant contributors to risk for the oral pathway, followed by the same elements for the dermal pathway. The overall carcinogenic risk was higher than the acceptable risk ( > 10−4) with and without bioaccessibility considerations (range 1.9E-4 – 9.6E-3 without bioaccessibility and 6.8E-5 – 3.8E-3 with bioaccessibility). Bioaccessibility tests provide a more accurate assessment of exposure to PTMs compared to total concentrations in soils.
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•Non-carcinogenic risk is associated with the oral and dermal pathways.•Main carcinogenic risk is associated with the oral pathway (As and Pb).•For some scenarios, there is a higher non-carcinogenic risk associated with the dermal than the oral pathway.•For the dermal pathway, HQ is higher when bioaccessibility is considered.•Inhalation pathway contribution to risk is very low.
Immune checkpoints consist of inhibitory and stimulatory pathways that maintain self-tolerance and assist with immune response. In cancer, immune checkpoint pathways are often activated to inhibit ...the nascent anti-tumor immune response. Immune checkpoint therapies act by blocking or stimulating these pathways and enhance the body's immunological activity against tumors. Cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), programmed cell death receptor-1 (PD-1), and programmed cell death ligand-1(PD-L1) are the most widely studied and recognized inhibitory checkpoint pathways. Drugs blocking these pathways are currently utilized for a wide variety of malignancies and have demonstrated durable clinical activities in a subset of cancer patients. This approach is rapidly extending beyond CTLA-4 and PD-1/PD-L1. New inhibitory pathways are under investigation, and drugs blocking LAG-3, TIM-3, TIGIT, VISTA, or B7/H3 are being investigated. Furthermore, agonists of stimulatory checkpoint pathways such as OX40, ICOS, GITR, 4-1BB, CD40, or molecules targeting tumor microenvironment components like IDO or TLR are under investigation. In this article, we have provided a comprehensive review of immune checkpoint pathways involved in cancer immunotherapy, and discuss their mechanisms and the therapeutic interventions currently under investigation in phase I/II clinical trials. We also reviewed the limitations, toxicities, and challenges and outline the possible future research directions.
We study the large-scale clustering of galaxies in the overlap region of the Baryon Oscillation Spectroscopic Survey (BOSS) CMASS sample and the WiggleZ Dark Energy Survey. We calculate the ...auto-correlation and cross-correlation functions in the overlap region of the two data sets and detect a Baryon Acoustic Oscillation (BAO) signal in each of them. The BAO measurement from the cross-correlation function represents the first such detection between two different galaxy surveys. After applying density-field reconstruction we report distance-scale measurements
$D_V r_{\rm s}^{\rm fid} / r_{\rm s} = (1970 \pm 45, 2132 \pm 65, 2100 \pm 200)$
Mpc from CMASS, the cross-correlation and WiggleZ, respectively. The distance scales derived from the two data sets are consistent, and are also robust against switching the displacement fields used for reconstruction between the two surveys. We use correlated mock realizations to calculate the covariance between the three BAO constraints. This approach can be used to construct a correlation matrix, permitting for the first time a rigorous combination of WiggleZ and CMASS BAO measurements. Using a volume-scaling technique, our result can also be used to combine WiggleZ and future CMASS DR12 results. Finally, we show that the relative velocity effect, a possible source of systematic uncertainty for the BAO technique, is consistent with zero for our samples.
In terms of the number and diversity of living units, the prokaryotic empire is the most represented form of life on Earth, and yet it is still to a significant degree shrouded in darkness. This ...microbial "dark matter" hides a great deal of potential in terms of phylogenetically or metabolically diverse microorganisms, and thus it is important to acquire them in pure culture. However, do we know what microorganisms really need for their growth, and what the obstacles are to the cultivation of previously unidentified taxa? Here we review common and sometimes unexpected requirements of environmental microorganisms, especially soil-harbored bacteria, needed for their replication and cultivation. These requirements include resuscitation stimuli, physical and chemical factors aiding cultivation, growth factors, and co-cultivation in a laboratory and natural microbial neighborhood.
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