Therapeutic options are limited in cases of autosomal recessive congenital ichthyosis with inadequate response to topical agents. Acitretin is the current standard of care in these patients, but its ...use is limited by cumulative toxicity when prolonged therapy is needed in children. There is evidence to suggest that high doses of vitamin D can normalize keratinization and suppress inflammatory cytokines. Here, we report a patient with lamellar ichthyosis with a novel mutation in the Nipa-like Domain-Containing 4 (NIPAL4) gene. High dose short-term vitamin D therapy was administered with a dramatic and sustained clinical response.
The clinician's quest for time-saving and technique-insensitive technology has led to the development of simplified self-etch adhesives that are predominantly water or solvent based. Several studies ...have shown that conventional air-drying procedures are incapable of eliminating all the residual water in the adhesive and that it may even cause collapse of the underlying collagen matrix. We hypothesized that heat from a light source may be effective in removing water from these adhesives. The aim of this study was, therefore, to evaluate the effectiveness of heat vs conventional air drying in eliminating water droplets from self-etch adhesive. A self-etch adhesive was applied to bur-cut dentin surfaces, which were then allotted to one of two treatment procedures for eliminating residual water from the adhesive: conventional air drying or the experimental heat application. Specimens were then prepared and analyzed using SEM. Specimens in the experimental group showed no evidence of water treeing within the adhesive layer. Thus, it was concluded that heat radiation was an effective method to remove residual water from simplified adhesives.
Milia: A dermoscopic pitfall Behera, Biswanath; Mathews, Irene; Vinupriya, Sakkaravarthi ...
Journal of the American Academy of Dermatology,
August 2017, 2017-08-00, 20170801, Letnik:
77, Številka:
2
Journal Article
Lichen planus pigmentosus: A short review Mathews, Irene; Thappa, DevinderMohan; Singh, Nidhi ...
Pigment international (Online),
2016, Letnik:
3, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Lichen planus pigmentosus (LPP) is a condition characterized by persistent and asymptomatic slaty-gray pigmentation, predominantly in the face. Classically, the pattern is "actinic" with symmetric ...and diffuse pigmentation in sun-exposed areas, commonly in dark-skinned individuals. It can also rarely present as macular pigmentation of the flexures in the lighter-skinned. LPP is a disease of the middle-aged, with onset in the third to fourth decades of life and few studies show as slightly greater incidence in females. The photo-distributed or actinic pattern, which is more common, is a disease of tropics and Type IV-Type V skin types. Reports are mainly from India, the Middle East, and South America. The inversus type is relatively rare, predominantly occurring in Caucasians. LPP is thought to be a type hypersensitivity IV reaction to unknown antigen with lichenoid inflammation, leading to melanin incontinence and superficial dermal pigmentation. The natural course of the disease is not clear with some cases showing spontaneous resolution, and some cases with persistence of pigmentation for years. In addition, LPP may have marked overlap clinically and histologically with conditions such as pigmented contact dermatitis, differentiation of which may not be possible in routine practice. Because of these issues, as well as the relative rarity of the condition, there is not much evidence on the efficacy of the various treatment options. Currently, none of the available treatment options show consistent responses or a clear superiority to other modalities, the evidence on efficacy being restricted to a few case series.
PDF
