We report the amplification of an all-normal dispersion supercontinuum pulse in a Thulium / Holmium co-doped all-fiber chirped pulse amplification system. With a -20 dB bandwidth of more than 300 nm ...in the range 1800-2100 nm the system delivers high quality 66 fs pulses with more than 70 kW peak power directly from the output fiber. The coherent seeding of the entire emission bandwidth of the doped fiber and the stability of the supercontinuum generation dynamics in the silicate glass all-normal dispersion photonic crystal fiber result in excellent noise characteristics of the amplified ultrashort pulses.
We demonstrate that time-domain ptychography, a recently introduced ultrafast pulse reconstruction modality, has properties ideally suited for the temporal characterization of complex light pulses ...with large time-bandwidth products as it achieves temporal resolution on the scale of a single optical cycle using long probe pulses, low sampling rates, and an extremely fast and robust algorithm. In comparison to existing techniques, ptychography minimizes the data to be recorded and processed, and drastically reduces the computational time of the reconstruction. Experimentally we measure the temporal waveform of an octave-spanning, 3.5~ps long supercontinuum pulse generated in photonic crystal fiber, resolving features as short as 5.7~fs with sub-fs resolution and 30~dB dynamic range using 100~fs probe pulses and similarly large delay steps.
The sodium dicarboxylate cotransporter located at the basolateral side supplies renal proximal tubule cells with Krebs cycle intermediates and maintains the driving force for the exchange of organic ...anions like PAH against alpha-ketoglutarate through the organic anion transporter-1. Recently, we cloned sodium dicarboxylate cotransporter-3 from winter flounder kidney (fNaDC-3). To understand the regulation of fNaDC-3, we preincubated fNaDC-3-expressing oocytes with PMA, a PKC activator. PMA dose and time dependently inhibited fNaDC-3-mediated succinate uptake. Simultaneous preincubation of fNaDC-3-expressing oocytes with 50 nM PMA and either staurosporine or RO 31-8220 for 30 min attenuated PKC-mediated inhibition of succinate uptake. Site-directed mutagenesis of the five putative PKC sites (S7, T167, S174, T188, and S396) resulted in no change in PKC-mediated inhibition of the transporter. In electrophysiological studies performed at -60 mV, the K0.5 for succinate was not significantly affected (56 +/- 13 vs. 42 +/- 19 micro M), but deltaImax was reduced from -139 +/- 49 to -20 +/- 8 nA by PMA (50 nM, 30 min). Immunofluorescence analysis of fNaDC-3-expressing oocytes revealed that PMA leads to an endocytosis of fNaDC-3 protein. In conclusion, fNaDC-3 expressed in oocytes is downregulated by PMA through endocytosis. PKC consensus sites appear not to be important for this process. PUBLICATION ABSTRACT
Pushing the limit of instrument capabilities Shulyak, Denis V.; Weiss, Werner W.; Mathys, Gautier ...
Proceedings of the International Astronomical Union,
11/2009, Letnik:
5, Številka:
H15
Journal Article
Recenzirano
Odprti dostop
Chemically Peculiar (CP) stars have been the subject of systematic research for more than 50 years. With the discovery of pulsation of some of the cool CP stars, and the availability of advanced ...spectropolarimetric instrumentation and high signal-to-noise, high resolution spectroscopy, a new era of CP star research emerged about 20 years ago. Together with the success in ground-based observations, new space projects are developed that will greatly benefit future investigations of these unique objects. In this contribution we will give an overview of some interesting results obtained recently from ground-based observations and discuss the future outstanding Gaia space mission and its impact on CP star research.
Controversy and disagreement abound within the world of international food assistance. Significant and enduring differences are evident in many U.S. and EU policies, programs, and institutions, ...including the appropriate uses of food assistance, the impacts of practices such as food aid tying and monetization, the most effective and efficient institutional architecture for administering emergency food assistance and longer-term food-security programs, and even the definition of food assistance itself.
We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we ...obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.
The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the ...surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.
Neutrinos in the cosmic ray flux with energies near 1 EeV and above are detectable with the Surface Detector array of the Pierre Auger Observatory. We report here on searches through Auger data from ...1 January 2004 until 20 June 2013. No neutrino candidates were found, yielding a limit to the diffuse flux of ultra-high energy neutrinos that challenges the Waxman-Bahcall bound predictions. Neutrino identification is attempted using the broad time-structure of the signals expected in the SD stations, and is efficiently done for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for "Earth-skimming" neutrino interactions in the case of tau neutrinos. In this paper the searches for downward-going neutrinos in the zenith angle bins \(60^\circ-75^\circ\) and \(75^\circ-90^\circ\) as well as for upward-going neutrinos, are combined to give a single limit. The \(90\%\) C.L. single-flavor limit to the diffuse flux of ultra-high energy neutrinos with an \(E^{-2}\) spectrum in the energy range \(1.0 \times 10^{17}\) eV - \(2.5 \times 10^{19}\) eV is \(E_\nu^2 dN_\nu/dE_\nu < 6.4 \times 10^{-9}~ {\rm GeV~ cm^{-2}~ s^{-1}~ sr^{-1}}\).
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