New fluorinated 2-aryl-benzothiazoles, -benzoxazoles, and -chromen-4-ones have been synthesized and their activity against MCF-7 and MDA 468 breast cancer cell lines compared with the potent ...antitumor benzothiazole 5. Analogues such as 9a,b and 12a,d yielded submicromolar GI50 values in both cell lines; however, none of the new compounds approached 5 in terms of antitumor potency. For 5, binding to the aryl hydrocarbon receptor appeared to be necessary but not sufficient for growth inhibition.
Abstract
We present the first results from the Transiting Exoplanet Survey Satellite (TESS) on the rotational and pulsational variability of magnetic chemically peculiar A-type stars. We analyse TESS ...2-min cadence data from sectors 1 and 2 on a sample of 83 stars. Five new rapidly oscillating Ap (roAp) stars are announced. One of these pulsates with periods around 4.7 min, making it the shortest period roAp star known to date. Four out of the five new roAp stars are multiperiodic. Three of these and the singly periodic one show the presence of rotational mode splitting. Individual frequencies are provided in all cases. In addition, seven previously known roAp stars are analysed. Additional modes of oscillation are found in some stars, while in others we are able to distinguish the true pulsations from possible aliases present in the ground-based data. We find that the pulsation amplitude in the TESS filter is typically a factor of 6 smaller than that in the B filter, which is usually used for ground-based observations. For four roAp stars we set constraints on the inclination angle and magnetic obliquity, through the application of the oblique pulsator model. We also confirm the absence of roAp-type pulsations down to amplitude limits of 6 and 13 $\mu$mag, respectively, in two of the best characterized non-oscillating Ap (noAp) stars. We announce 27 new rotational variables along with their rotation periods, and provide different rotation periods for seven other stars. Finally, we discuss how these results challenge state-of-the-art pulsation models for roAp stars.
Researchers around the globe are working to develop environmentally friendly, completely biodegradable <">green" composites based on plant-based fibers and resins. The starches and fibers used for ...these types of products are renewable, unlike the petroleum-based products they are intended to replace. Green composite materials can be composted effectively, thereby completing the natural carbon cycle. Findings are reported from a study in which soy flour was modified by cross-linking it with glutaraldehyde. Data are presented from tests implemented to characterize the tensile and thermal characteristics of the cross-linked soy flour (CSF) polymer. Techniques used to evaluate and optimize the impacts of glycerol on the mechanical characteristics of the soy flour are detailed.
An ITER-like wall for JET Paméla, J.; Matthews, G.F.; Philipps, V. ...
Journal of nuclear materials,
06/2007, Letnik:
363-365
Journal Article, Conference Proceeding
Recenzirano
This article presents an overview of the new ITER-like wall project in JET. It aims at an optimal use of JET’s unique features: physical size, plasma parameters most closely to ITER and the ...capability to handle beryllium and tritium, allowing the study of critical questions related to operating within the limits of the ITER wall materials. A full replacement of the first wall materials is planned (beryllium in the main wall and tungsten in the divertor). This should deliver answers to urgent plasma surface interaction questions such as tritium retention and provide operational experience in steady and transient conditions with ITER wall materials under relevant geometry and relevant plasma parameters. In addition, the JET auxiliary heating power will be upgraded to ∼45MW, allowing access to ITER-relevant disruption and edge localised modes energy loss densities. This will open access to conditions of melt layer formation both on the beryllium first wall and the tungsten divertor.
This contribution aims to improve existing scalings of the L-mode power decay length λqomp, especially for plasma configurations with strike points at the ITER-relevant location-closed vertical ...divertor targets. We propose 13 new λqomp scalings based on data from the tokamaks JET, EAST, MAST, Alcator C-mod and COMPASS, and validate them against the output of the 2D turbulence code HESEL. The analysis covers 500 divertor heat flux profiles (obtained by probes or IR cameras), measured in L-mode discharges with varying 12 global plasma parameters (all well predictable). We find that the two previously published scalings (Eich 2013 J. Nucl. Mat. 438 S72) and (Scarabosio 2013 J. Nucl. Mat. 438 S426), which were based on outer target data from AUG and JET, describe the JET, C-mod and COMPASS profiles well. This holds not only at the outer horizontal and vertical targets, but surprisingly also at the inner vertical targets. In contrast, EAST, HESEL and especially MAST data are poorly described by these two scalings. We therefore derive 13 new scalings, which account for 85-92 % of the measured λqomp variability across all five tokamaks. Although each of the scalings is based on a different parameter combination, their predictions for the ITER and COMPASS-Upgrade tokamaks are very similar. Just before the L-H transition in the ITER baseline scenario, the presented scalings predict values λqomp=3.0±0.5 mm. For the COMPASS-Upgrade tokamak, all the scalings predict λqomp=2.1±0.5 mm with a single exception of the scaling based on the stored plasma energy which predicts only 1.2 mm for both tokamaks. We encourage the reader to use as many of these scalings as possible, depending on available data. In attached plasma and using significant assumptions, our results imply steady-state surface-perpendicular heat flux around 10 MW/m2 for ITER, and 20 MW/m2 for COMPASS-Upgrade.
CoverCress (low erucic acid, lower fiber pennycress) is being developed as a cover crop to be planted in the fall after corn and harvested in the spring prior to planting soybeans. Two experiments ...were conducted to evaluate 2 lines of the whole grain (CCWG-1: natural mutation and mutation breeding; CCWG-2: gene edited) and the whole grain pretreated with the potential palatability agent copper sulfate (CCWG-1-CuSO4; CCWG-2-CuSO4) as an ingredient for broilers. In Experiment 1, CCWG-1-CuSO4 was included in the diet at 0, 4, and 6% for 41 d. Feed intake, body weight gain, feed conversion, processing characteristics, organ weights, serum thyroid, macropathology and histology data were collected. In Experiment 2, broilers were fed diets containing Control, 2% CCWG-1, 4% CCWG-1, 4% CCWG-2, and 4.35% CCWG-1-CuSO4 for 42 d. Feed intake, body weight gain, feed conversion, organ weights, serum thyroid, blood chemistries, macropathology, and histology data were collected. In Experiment 1, feed intake and body weight were diminished with no effect on feed conversion for the birds consuming diets containing CCWG-1-CuSO4. In Experiment 2, feed intake and body weight were lower with no difference in feed conversion in birds fed diets containing greater than 2% CoverCress grain during d 0 to 28. During d 28 to 42 no difference in feed intake, body weight and an improvement in feed conversion was observed in birds fed all of the CoverCress grain products. In both experiments no significant negative effects were observed in processing, liver, kidney, and thyroid weights, T3, T4, blood chemistries, macropathology, and histopathology between the control and any of the CoverCress grain treatments. No difference in performance was observed in birds fed the mutant (4% CCWG-1) and gene-edited (4% CCWG-2) products. Pretreating CoverCress grain with copper sulfate did not have a significant effect on improving palatability. In conclusion, CoverCress grain can be safely fed to broilers when included at a target rate of 4% in diets and with total glucosinolate levels not to exceed 4.9 µmoles g-1.
Increased chondroitin sulfate proteoglycan (CSPG) expression in the vicinity of a spinal cord injury (SCI) is a primary participant in axonal regeneration failure. However, the presence of similar ...increases of CSPG expression in denervated synaptic targets well away from the primary lesion and the subsequent impact on regenerating axons attempting to approach deafferented neurons have not been studied. Constitutively expressed CSPGs within the extracellular matrix and perineuronal nets of the adult rat dorsal column nuclei (DCN) were characterized using real-time PCR, Western blot analysis and immunohistochemistry. We show for the first time that by 2 days and through 3 weeks following SCI, the levels of NG2, neurocan and brevican associated with reactive glia throughout the DCN were dramatically increased throughout the DCN despite being well beyond areas of trauma-induced blood brain barrier breakdown. Importantly, regenerating axons from adult sensory neurons microtransplanted 2 weeks following SCI between the injury site and the DCN were able to regenerate rapidly within white matter (as shown previously by Davies et al. Davies, S.J., Goucher, D.R., Doller, C., Silver, J., 1999. Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J. Neurosci. 19, 5810–5822) but were unable to enter the denervated DCN. Application of chondroitinase ABC or neurotrophin-3-expressing lentivirus in the DCN partially overcame this inhibition. When the treatments were combined, entrance by regenerating axons into the DCN was significantly augmented. These results demonstrate both an additional challenge and potential treatment strategy for successful functional pathway reconstruction after SCI.
The Sonic Kayak is a musical instrument used to investigate nature and developed during open hacklab events. The kayaks are rigged with underwater environmental sensors, which allow paddlers to hear ...real-time water temperature sonifications and underwater sounds, generating live music from the marine world. Sensor data is also logged every second with location, time and date, which allows for fine-scale mapping of water temperatures and underwater noise that was previously unattainable using standard research equipment. The system can be used as a citizen science data collection device, research equipment for professional scientists, or a sound art installation in its own right.
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