Physical activities can have important impacts on human health. For example, a physically active lifestyle, which is one of the most important goals for overall health promotion, can diminish the ...risk for a range of physical disorders, as well as reducing health-related expenditures. Thus, a long-term goal is to detect different physical activities, and an important initial step toward this goal is the ability to classify such activities. A recent and promising technology to discriminate among diverse physical activities is the smart textile system (STS), which is becoming increasingly accepted as a low-cost activity monitoring tool for health promotion. Accordingly, our primary aim was to assess the feasibility and accuracy of using a novel STS to classify physical activities. Eleven participants completed a lab-based experiment to evaluate the accuracy of an STS that featured a smart undershirt (SUS) and commercially available smart socks (SSs) in discriminating several basic postures (sitting, standing, and lying down), as well as diverse activities requiring participants to walk and run at different speeds. We trained three classification methods-K-nearest neighbor, linear discriminant analysis, and artificial neural network-using data from each smart garment separately and in combination. Overall classification performance (global accuracy) was ~98%, which suggests that the STS was effective for discriminating diverse physical activities. We conclude that, overall, smart garments represent a promising area of research and a potential alternative for discriminating a range of physical activities, which can have positive implications for health promotion.
The substantial kinematic degrees-of-freedom available in human movement lead to inherent variations in a repetitive movement, or motor variability (MV). Growing evidence suggests that characterizing ...MV permits a better understanding of potential injury mechanisms. Several diverse methods, though, have been used to quantify MV, but limited evidence exists regarding the merits of these methods in the occupational context. In this work, we explored different classes of methods for characterizing MV during symmetric and asymmetric box lifting tasks. Kinematic MV of both the whole-body center-of-mass (COM) and the box were quantified, using metrics derived from a linear method (Standard Deviation), a non-linear method (Sample Entropy; an index of movement regularity), and a novel application of an equifinality method (Goal Equivalent Manifold; an index related to the set of effective motor solutions). Our results suggest that individuals manipulate regularity and the set of effective motor solutions to overcome unwanted motor noises related to the COM. These results, together with earlier evidence, imply that individuals may prioritize stability over variability with increasing task difficulty. Task performance also appeared to deteriorate with decreasing variability and regularity of the COM. We conclude that diverse metrics of MV may be complimentary to reveal differences in MV.
We present and discuss the results of the Herschel Gould Belt survey (HGBS) observations in an ~11 deg2 area of the Aquila molecular cloud complex at d ~ 260 pc, imaged with the SPIRE and PACS ...photometric cameras in parallel mode from 70 μm to 500 μm. Using the multi-scale, multi-wavelength source extraction algorithm getsources, we identify a complete sample of starless dense cores and embedded (Class 0-I) protostars in this region, and analyze their global properties and spatial distributions. We find a total of 651 starless cores, ~60% ± 10% of which are gravitationally bound prestellar cores, and they will likely form stars inthe future. We also detect 58 protostellar cores. The core mass function (CMF) derived for the large population of prestellar cores is very similar in shape to the stellar initial mass function (IMF), confirming earlier findings on a much stronger statistical basis and supporting the view that there is a close physical link between the stellar IMF and the prestellar CMF. The global shift in mass scale observed between the CMF and the IMF is consistent with a typical star formation efficiency of ~40% at the level of an individual core. By comparing the numbers of starless cores in various density bins to the number of young stellar objects (YSOs), we estimate that the lifetime of prestellar cores is ~1 Myr, which is typically ~4 times longer than the core free-fall time, and that it decreases with average core density. We find a strong correlation between the spatial distribution of prestellar cores and the densest filaments observed in the Aquila complex. About 90% of the Herschel-identified prestellar cores are located above a background column density corresponding to AV ~ 7, and ~75% of them lie within filamentary structures with supercritical masses per unit length ≳16 M⊙/pc. These findings support a picture wherein the cores making up the peak of the CMF (and probably responsible for the base of the IMF) result primarily from the gravitational fragmentation of marginally supercritical filaments. Given that filaments appear to dominate the mass budget of dense gas at AV> 7, our findings also suggest that the physics of prestellar core formation within filaments is responsible for a characteristic “efficiency” \hbox{${\it SFR}/M_{\rm dense} \sim 5^{+2}_{-2} \times 10^{-8}\, {\rm yr}^{-1}$}SFR/Mdense~5-2+2×10-8 yr-1 for the star formation process in dense gas.
The purpose of this study was to investigate the effects of arm- and back-support exoskeletons on reactive balance after slip-like and trip-like perturbations on a treadmill. Twenty-eight ...participants used two arm-support exoskeletons and two back-support exoskeletons with support (i.e., assistive joint torque) activated or deactivated. In each exoskeleton condition, as well in as a control without any exoskeleton, participants were exposed to 12 treadmill perturbations during upright standing. The exoskeletons did not significantly increase the probability of a failed recovery after the perturbations compared to wearing no exoskeleton, but did elicit effects on kinematic variables that suggested balance recovery was more challenging. Moreover, reactive balance differed when wearing back-support and arm-support exoskeletons, and when wearing an activated exoskeleton compared to a deactivated exoskeleton. Together, our results suggest these exoskeletons may increase the risk of slip- and trip-induced falls. The potential mechanisms of this increased risk are discussed and include the added mass and/or motion restrictions associated with wearing these exoskeletons. Our results do not support the assistive hip/back extension moment provided by back-support exoskeletons adversely affecting fall risk.
While most stars are believed to form in stellar clusters, the formation and early evolution of young stellar clusters is still largely unknown. Improving our knowledge of the earliest phases of ...clustered star formation is crucial for understanding the origin of the stellar initial mass function and the efficiency of the star formation process, which both play a key role in the evolution of galaxies. Here, we present an analysis of the Aquila rift complex which addresses the questions of the star formation rate (SFR), star formation efficiency (SFE) and typical lifetime of the Class 0 protostellar phase in two nearby cluster-forming clumps: the Serpens South and W40 protoclusters. We carried out a 1.2 mm dust continuum mapping of the Aquila rift complex with the MAMBO bolometer array on the IRAM 30 m telescope. Using a multi-scale source extraction method, we perform a systematic source extraction in our millimeter continuum map. Based on complementary data from the Herschel Gould Belt survey and Spitzer maps, we characterize the spectral energy distributions (SEDs) of the 77 mm continuum sources detected with MAMBO and estimate their evolutionary stages. Taking advantage of the comprehensive dataset available for the Serpens South region, spanning wavelengths from 2 μm to 1.2 mm, we estimate the numbers of young stellar objects (YSOs) at different evolutionary stages and find a ratio of Class 0 to Class I protostars N(0)/N(I) = 0.19−0.27. This low ratio supports a scenario of relatively fast accretion at the beginning of the protostellar phase, and leads to a Class 0 lifetime of ~4−9 × 104 yr. We also show that both the Serpens South and W40 protoclusters are characterized by large fractions of protostars and high SFRs ~ 20−50M⊙ Myr-1 pc-2, in agreement with the idea that these two nearby clumps are active sites of clustered star formation currently undergoing bursts of star formation, and have the potential ability to form bound star clusters. While the formation of these two protoclusters is likely to have been initiated in a very different manner, the resulting protostellar populations are observed to be very similar. This suggests that after the onset of gravitational collapse, the detailed manner in which the collapse has been initiated does not affect much the ability of a clump to form stars.
Context. Fast jets are thought to be a crucial ingredient of star formation because they might extract angular momentum from the disk and thus allow mass accretion onto the star. However, it is ...unclear whether jets are ubiquitous, and likewise, their contribution to mass and angular momentum extraction during protostar formation remains an open question. Aims. Our aim is to investigate the ejection process in the low-mass Class 0 protostar L1157. This source is associated with a spectacular bipolar outflow, and the recent detection of high-velocity SiO suggests the occurrence of a jet. Methods. Observations of CO 2 −1 and SiO 5 − 4 at ~ \hbox{$0\farcs8$} 0 .̋ 8 resolution were obtained with the IRAM Plateau de Bure Interferometer (PdBI) as part of the CALYPSO large program. The jet and outflow structure were fit with a precession model. We derived the column density of CO and SiO, as well as the jet mass-loss rate and mechanical luminosity. Results. High-velocity CO and SiO emission resolve for the first time the first 200 au of the outflow-driving molecular jet. The jet is strongly asymmetric, with the blue lobe ~0.65 times slower than the red lobe. This suggests that the large-scale asymmetry of the outflow is directly linked to the jet velocity and that the asymmetry in the launching mechanism has been at work for the past 1800 yr. Velocity asymmetries are common in T Tauri stars, which suggests that the jet formation mechanism from Class 0 to Class II stages might be similar. Our model simultaneously fits the properties of the inner jet and of the clumpy 0.2 pc scale outflow by assuming that the jet precesses counter-clockwise on a cone inclined by 73° to the line of sight with an opening angle of 8° on a period of ~1640 yr. The estimated jet mass flux and mechanical luminosity are Ṁjet ~ 7.7 × 10-7M⊙ yr-1 and Ljet ~ 0.9L⊙, indicating that the jet could extract at least 25% of the gravitational energy released by the forming star.
Existing research indicates that repetitive motions are strongly correlated with the development of work-related musculoskeletal disorders (WMSDs). Resulting from the redundant degrees-of-freedom in ...the human body, there are variations in motions that occur while performing a repetitive task. These variations are termed motor variability (MV), and may be beneficial for reducing WMSD risks. To better understand the potential role of MV in preventing injury risk, we evaluated the effects of fatigue on MV using data collected during a lab-based prolonged, repetitive lifting/lowering task. We also investigated whether experienced workers used different motor control strategies than novices to adapt to fatigue. MV of the whole-body center-of-mass (COM) and box trajectory were quantified using cycle-to-cycle standard deviation, sample entropy, and goal equivalent manifold (GEM) methods. In both groups, there were significantly increased variations of the COM with fatigue, and with a more substantial increase in a direction that did not affect task performance. Fatigue deteriorated the task goal and made it more difficult for participants to maintain their performance. Experienced workers also had higher MV than novices. Based on these results, we conclude that flexible motor control strategies are employed to reduce fatigue effects during a prolonged repetitive task.
Evidence is emerging on how whole-body powered exoskeleton (EXO) use impacts users in basic occupational work scenarios, yet our understanding of how users learn to use this complex technology is ...limited. We explored how novice users adapted to using an EXO during gait. Six novices and five experienced users completed the study. Novices completed an initial training/familiarization gait session, followed by three subsequent gait sessions using the EXO, while experienced users completed one gait session with the EXO. Spatiotemporal gait measures, pelvis and lower limb joint kinematics, muscle activities, EXO torques, and human-EXO interaction forces were measured. Adaptations among novices were most pronounced in spatiotemporal gait measures, followed by joint kinematics, with smaller changes evident in muscle activity and EXO joint torques. Compared to the experienced users, novices exhibited a shorter step length and walked with significantly greater anterior pelvic tilt and less hip extension. Novices also used lower joint torques from the EXO at the hip and knee, and they had greater biceps femoris activity. Overall, our results may suggest that novices exhibited clear progress in learning, but they had not yet adopted motor strategies similar to those of experienced users after the three sessions. We suggest potential future directions to enhance motor adaptations to powered EXO in terms of both training protocols and human-EXO interfaces.
Abstract
Background
Meningiomas are the most common primary intracranial tumor in adults. Clinical care is currently guided by the World Health Organization (WHO) grade assigned to meningiomas, a ...3-tiered grading system based on histopathology features, as well as extent of surgical resection. Clinical behavior, however, often fails to conform to the WHO grade. Additional prognostic information is needed to optimize patient management.
Methods
We evaluated whether chromosomal copy-number data improved prediction of time-to-recurrence for patients with meningioma who were treated with surgery, relative to the WHO schema. The models were developed using Cox proportional hazards, random survival forest, and gradient boosting in a discovery cohort of 527 meningioma patients and validated in 2 independent cohorts of 172 meningioma patients characterized by orthogonal genomic platforms.
Results
We developed a 3-tiered grading scheme (Integrated Grades 1-3), which incorporated mitotic count and loss of chromosome 1p, 3p, 4, 6, 10, 14q, 18, 19, or CDKN2A. 32% of meningiomas reclassified to either a lower-risk or higher-risk Integrated Grade compared to their assigned WHO grade. The Integrated Grade more accurately identified meningioma patients at risk for recurrence, relative to the WHO grade, as determined by time-dependent area under the curve, average precision, and the Brier score.
Conclusion
We propose a molecularly integrated grading scheme for meningiomas that significantly improves upon the current WHO grading system in prediction of progression-free survival. This framework can be broadly adopted by clinicians with relative ease using widely available genomic technologies and presents an advance in the care of meningioma patients.
Whole-body powered exoskeletons (WB-PEXOs) can be effective in reducing the physical demands of heavy occupational work, yet almost no empirical evidence exists on the effects of WB-PEXO use. This ...study assessed the effects of WB-PEXO use on back and leg muscle activities during lab-based simulations of load handling tasks. Six participants (4M, 2F) completed two such tasks (load carriage and stationary load transfer), both with and without a WB-PEXO, and with a range of load masses in each task. WB-PEXO use reduced median levels of muscle activity in the back (∼42–53% in thoracic and ∼24–43% in lumbar regions) and legs (∼41–63% in knee flexors and extensors), and mainly when handling loads beyond low-moderate levels (10–15 kg). Overall, using the WB-PEXO also reduced inter-individual variance (smaller SD) in muscle activities. Future work should examine diverse users, focus on finding effective matches between WB-PEXO use and specific tasks, and identify applications in varied work environments.
•Use of a whole-body powered exoskeleton was examined in simulated load handling tasks.•Reduction in back muscle activities were more evident for loads beyond low-moderate levels.•Smaller inter-individual variance was found for most muscle groups when using the system.
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