The determinative objective of this research is to theoretically examine MHD steady flow of the non-Newtonian Maxwell fluid due to a stretching sheet that is embedded in a porous medium with the case ...of convective boundary condition. The current detailed examination separately highlights the internal heat generation, viscous dissipation, variable conductivity and variable viscosity processes and their effects on evaluating the temperature distribution. Attention was especially concentrated on how to introduce similar solution for our problem which was achieved via our paper. Utilizing an efficient shooting method, the numerical solution for the coupled highly nonlinear ordinary differential equations describing the velocity and temperature is introduced. Accordingly, the important influence of all controlling parameters such as magnetic parameter, Maxwell parameter, Eckert number, the surface-convection parameter and viscosity parameter on the fluid flow becomes evident through diagrams. Further, to explain the present problem more comprehensively and clearly, both the local skin-friction coefficient and the local Nusselt number are discussed. Additionally, there is a noticeable good degree of internal consistency for the numerical results with early published data.
In this paper, we introduce a theoretical and numerical study for the effects of thermal buoyancy and constant heat flux on the Casson fluid flow and heat transfer over an exponentially stretching ...sheet taking into account the effects of variable thermal conductivity, heat generation/absorption and viscous dissipation. The governing partial differential equations are transformed into coupled, non-linear ordinary differential equations by using suitable transformations. Numerical solutions to these equations are obtained by using the fourth order Runge-Kutta method with the shooting technique. The effects of various physical parameters which governing the flow and heat treansfer such as the buoyancy parameter, the thermal conductivity parameter, heat generation or absorption parameter and the Prandtl number on velocity and temperature are discussed by using graphical approach. Moreover, numerical results indicate that the local skin-friction coefficient and the local Nusselt number are strongly affected by the constant heat flux.
Microbial multidrug resistance is becoming a global menace to humanity, and finding alternative approaches to combat these "superbugs" is critical. Targeting quorum sensing (QS), which is essential ...for bacterial biofilm formation and virulence factors production, represents a viable alternative strategy for combating a variety of diseases. Accordingly, the current work reports potential QS inhibitors (QSIs), which could target the transcriptional regulator protein CviR in the model QS bacterium Chromobacterium violaceum. A set of novel hybrids 4(a-k) were synthesized using the virtual screening results of structurally based hybrids of the 2-indolinone-thiazolidine scaffold on the CviR active pocket residues. The ability of these hybrids to inhibit the QS system was tested against C. violaceum, and two molecules (4h and 4i) revealed promising antivirulence activity. Biofilm formation and motility were both impaired in the treated bacterial cells. Moreover, the molecular docking of these two compounds was comparable with that of chlorolactone (CL), a native inhibitor of the C. violaceum CviR. The global chemical descriptors were calculated for compounds 4h and 4i and found to be more reactive than the native inhibitor, CL. Furthermore, the in silico ADME prediction profiles of these two lead compounds, 4h and 4i, showed good ADME profiles.
Nanoparticles have the ability to increase the impact of convective heat transfer in the boundary layer region. An investigation is made to analysis of magnetohdrodynamic nanofluid flow with heat and ...mass transfer over a vertical cone in porous media under the impact of thermal radiations and chemical reaction. In addition, thermal radiations, Hall current, and viscous and Joule dissipations and chemical reaction effects are considered. Considered three different nanoparticles types namely copper, silver, and titanium dioxide with water as base fluid. The governing equations are transformed by similarity transformations into a set of non-linear ordinary differential equations involving variable coefficients. Two numerically approaches are used to solve the transformed boundary layer system Finite Difference Method (FDM) and Chebyshev-Galerkin Method (CGM). As stated in the present analysis, it is appropriate to address a number of physical mechanisms, including velocity, temperature and concentration, as well as closed-form skin friction/mass transfer/heat transfer coefficients. Different comparisons are done with previously published data in order to validate the current study under specific special circumstances, and it is determined that there is a very high degree of agreement. The main results indicated that as the Prandtl number increases, the temperature profile decreases, but it grows for higher values of the thermophoresis parameter, Brownian motion, and Eckert number. Moreover, higher Brownian motion values lead to a less prominent concentration profile. Consequently, this speeds up the cooling process and enhances the surface’s durability and strength.
The heat and mass transfer in magnetized non-Newtonian Williamson nanofluid flow, saturated by gyrotactic microorganisms due to a stretched sheet, is debated here. The rough sheet is subjected to ...uniform heat flux, and its velocity is proportional to its distance from the slit. Nanofluid viscosity and thermal conductivity are temperature-dependent, but microbe diffusivity and Brownian motion are concentration-dependent. Through similarity transformation, the system of modeled equations is reduced to dimensionless differential equations. We employed the shooting approach in conjunction with the Runge–Kutta scheme to obtain a solution for the physical model. For various combinations of the controlling parameters, some numerical results are found. When the generated results are compared to the existing literature, the highest settlement is found. According to numerical results, the skin-friction coefficient rises as the magnetic field and thermal conductivity parameters rise, while the opposite tendency is observed for both the slip velocity and viscosity parameters.
This work aimed to present the influence of the magnetic field and Ohmic dissipation on the non-Newtonian Casson fluid on a vertical stretched sheet to numerically solve the problem. Here, the ...variable thermal conductivity is taken as a linear function of temperature. Electric fields, thermal slip, and viscous dissipation effects are taken into consideration. A collection of physical conditions on the sheet’s enclosing wall and the momentum and heat transport processes are expressed as partial differential equations (PDEs). Some of the similarity transformations are used to convert the collection of PDE into a system of ordinary differential equations. This system is numerically treated by implementing the Vieta-Lucas spectral collocation method. Some observations are made for the investigation of method convergence. The effect of some different parameters on the velocity and temperature profiles is graphically represented. Additionally, this area of study has significant practical applications in a variety of industries, including paper production, thermal power generation, nuclear reactors, cooling of metallic sheets, glass fiber, and lubrication.
The present work focuses on the attributes of flow, heat, and mass transfer together with double diffusive Cattaneo–Christov mechanism with regards to their applications. The aim of this study is to ...investigate the non-Newtonian Powell–Eyring fluid flow, taking into account the twofold impact of the heat generation mechanism and the viscous dissipation due to an extensible sheet. The chemical reaction between the fluid particles and the fluid variable properties is assumed in this study. The motive behind this study is the continuous and great interest in the utilization of non-Newtonian liquids in organic and technical disciplines. This model is administered and governed by the momentum equation, energy equation, and concentration, all of which are in the form of partial differential equations. With the help of the shooting technique, the numerical solution is obtained. Graphs show the characteristics of flow, heat, and mass transfer mechanisms for various governing parameters. Additionally, significant physical non-dimensional quantities have been presented in a tabular form. The outcomes detect that increasing the Deborah number, which is connected with the mass transfer field and the chemical reaction parameter, decreases the concentration distribution.
This research paper examines the characteristics of a two-dimensional steady flow involving an incompressible viscous Casson fluid past an elastic surface that is both permeable and convectively ...heated, with the added feature of slip velocity. In contrast to Darcy’s Law, the current model incorporates the use of Forchheimer’s Law, which accounts for the non-linear resistance that becomes significant at higher flow velocities. The accomplishments of this study hold significant relevance, both in terms of theoretical advancements in mathematical modeling of Casson fluid flow with heat mass transfer in engineering systems, as well as in the context of practical engineering cooling applications. The study takes into account the collective influences of magnetic field, suction mechanism, convective heating, heat generation, viscous dissipation, and chemical reactions. The research incorporates the consideration of fluid properties that vary with respect to temperature or concentration, and solves the governing equations by employing similarity transformations and the shooting approach. The heat transfer process is significantly affected by the presence of heat generation and viscous dissipation. Furthermore, the study illustrates and presents the impact of various physical factors on the dimensionless temperature, velocity, and concentration. From an engineering perspective, the local Nusselt number, the skin friction, and local Sherwood number are also depicted and provided in graphical and tabular formats. In the domains of energy engineering and thermal management in particular, these results have practical relevance in improving our understanding of heat transmission in similar settings. Finally, the thorough comparison analysis reveals a significant level of alignment with the outcomes of the earlier investigations, thus validating the reliability and effectiveness of our obtained results.
The cutting-edge combination of fluvoxamine (FVM) and ivermectin (IVM) has been presented as a proposed dosage form for the treatment of COVID-19 infections in early diagnosed patients. The main ...objective of this work is to develop simple, sensitive, and efficient methods for the synchronous quantification of FVM and IVM without any prior separation. Four green UV-methods were employed for the synchronous quantification, namely: Fourier functions convolution of absorption spectra, FFAS, Fourier functions convolution of derivative spectra of absorption curves, FFDS, Fourier function convolution of ratio spectra of absorption curves, FFRS and the dual-wavelength method, DWM. FFRS and DWM approaches can be able to reconcile the two components' significantly interfering spectrum presented in this commixture. Good linearity was checked in the range of 5–40, and 2.5–25 μg/mL for the FVM, and IVM, respectively. All approaches developed have been recommended in compliance with ICH principles. Furthermore, the approaches’ greenness was predestined by “National Environmental Method Index” (NEMI), “Analytical GREEnness metric (AGREE)”, the “Analytical Eco-Scale”, and the “Green Analytical Procedure Index” (GAPI). In addition, spider diagram was utilized for the assessment of the greenness index of the solvent used. Beside greenness, the sustainability of our methods was investigated using the HEXAGON tool. Continuing the constant pursuit of greenness, drug-drug interactions (DDIs) between FVM & IVM were predicted by
insilico
tools to ensure the safety of the suggested mixture as a preliminary step before invitro and in vivo studies. Because they were deemed sustainable, affordable, and successful, the suggested UV-methods may be used for routine quality control investigations of the indicated formulations FVM & IVM.
In this study, we investigated the heat and mass transport properties of a non-Newtonian Casson-Williamson nanofluid flow. We explore the effect of viscous dissipation and the velocity slip boundary ...condition on the mechanism of heat and mass transfer due to a stretching sheet which embedded in a porous medium with heat generation under the influence of both thermal radiation and a uniform magnetic field. All physicochemical characteristics of Casson-Williamson nanofluid are considered to be constant. The nanofluid concentration is investigated under chemical repercussions as a result of the movement of the nanofluid particles. This study assumes that there is no suction (solid wall). A set of nonlinear partial differential equations with boundary conditions are used to mathematically model this physical problem. The numerical solution for the differential equations with the related boundary conditions was illuminated using the Runge–Kutta approach in conjunction with the shooting technique. The numerical examination is then pictorial displayed to show the impact of various governing factors on velocity, temperature, and concentration. The non-Newtonian nanofluid has a faster velocity in the absence of a magnetic field than in the presence of it, although the temperature field has the opposite trend. Further, the skin-friction coefficient increased as the porosity parameter increased, whereas the rate of heat transfer dropped.
