Power Quality Moreno-Muñoz, Antonio
2007, 2007-04-25
eBook
With the generalized use of personal computers, microelectronic-based instrumentation and other susceptible devices, the subject of power quality and its relationship to the vulnerability of ...high-tech facilities is becoming an increasing concern, not only to the utility companies but also to the end-customer. In the 21st century, instrumentation and control operations require high quality and ultra-reliable power in quantities and time frames never experienced before. Power Quality: Mitigation Technologies in a Distributed Environment presents a solid theoretical foundation of the modern mitigation technologies employed in the power quality arena, and provides an overview of the most recent challenges in this field. Readers will learn about: how to deal with the multifaceted characteristics of power quality studies, how circuit and process design can be affected by the most common power disturbances, the implications that electromagnetic compatibility has on the equipment and installation design, how power electronic devices can improve the power quality of the distribution supply, and, the advances in IT that can support a better power quality. Power Quality: Mitigation Technologies in a Distributed Environment introduces the advanced concepts associated with power quality to engineers and students. It will make an excellent reference for facility electrical power engineers and maintenance technicians.
Using a proprietary data set, we analyze the impact of the implementation of a "buy-online, pick-up-in-store" (BOPS) project. The implementation of this project is associated with a reduction in ...online sales and an increase in store sales and traffic. These results can be explained by two simultaneous phenomena: (1) additional store sales from customers who use the BOPS functionality and buy additional products in the stores (cross-selling effect) and (2) the shift of some customers from the online to the brick-and-mortar channel and the conversion of noncustomers into store customers (channel-shift effect). We explain these channel-shift patterns as an increase in "research online, purchase offline" behavior enabled by BOPS implementation, and we validate this explanation with evidence from the change of cart abandonment and conversion rates of the brick-and-mortar and online channels. We interpret these results in light of recent operations management literature that analyzes the impact of sharing inventory availability information. Our analysis illustrates the limitations of drawing conclusions about complex interventions using single-channel data.
This paper was accepted by Alok Gupta, special issue on business analytics
.
The Impact of Studying Brain Plasticity Mateos-Aparicio, Pedro; Rodríguez-Moreno, Antonio
Frontiers in cellular neuroscience,
02/2019, Letnik:
13
Journal Article
Recenzirano
Odprti dostop
Importantly, both Tanzi and Lugaro were declared supporters of Cajal's ideas (DeFelipe, 2006; Berlucchi and Buchtel, 2009). ...while it may remain unclear who first coined the term plasticity, the ...work of Cajal undoubtedly stimulated and influenced the first theories about synapses, synaptic transmission, and synaptic plasticity. ...more detailed studies will be required to define the recently demonstrated role of glial cells in synaptic plasticity (e.g., Perea and Araque, 2007; Navarrete et al., 2012; Allen and Lyons, 2018), determining the exact role of glial cells in plasticity at different ages. ...the time windows for plasticity exist during development shape the connections in the brain and its activity (Hensch, 2004; Rodríguez-Moreno et al., 2013; Pérez-Rodríguez et al., 2018). ...investigating how synaptic plasticity occurs and how it is modified during specific developmental time windows will provide key information as to how the brain develops. ...better understanding how synaptic modifications take place during learning and memory, and/or development, may help shape, and improve the efficacy of current protocols at early stages of academic learning.
Broad-spectrum antimicrobial activity of quaternary ammonium surfactants (QAS) makes them attractive and cheap topical prophylactic options for sexually transmitted infections and perinatal ...vertically transmitted urogenital infections. Although attributed to their high affinity for biological membranes, the mechanisms behind QAS microbicidal activity are not fully understood. We evaluated how QAS structure affects antimicrobial activity and whether this can be exploited for use in prophylaxis of bacterial infections.
Acute toxicity of QAS to in vitro models of human epithelial cells and bacteria were compared to identify selective and potent bactericidal agents. Bacterial cell viability, membrane integrity, cell cycle and metabolism were evaluated to establish the mechanisms involved in selective toxicity of QAS.
QAS toxicity normalized relative to surfactant critical micelle concentration showed n-dodecylpyridinium bromide (C12PB) to be the most effective, with a therapeutic index of ∼10 for an MDR strain of Escherichia coli and >20 for Neisseria gonorrhoeae after 1 h of exposure. Three modes of QAS antibacterial action were identified: impairment of bacterial energetics and cell division at low concentrations; membrane permeabilization and electron transport inhibition at intermediate doses; and disruption of bacterial membranes and cell lysis at concentrations close to the critical micelle concentration. In contrast, toxicity to mammalian cells occurs at higher concentrations and, as we previously reported, results primarily from mitochondrial dysfunction and apoptotic cell death.
Our data show that short chain (C12) n-alkyl pyridinium bromides have a sufficiently large therapeutic window to be good microbicide candidates.
Omnichannel environments where customers shop online and offline at the same retailer are ubiquitous, and are deployed by online-first and traditional retailers alike. We focus on the relatively ...understudied domain of online-first retailers and the engagement of a key omnichannel tactic; specifically, introduction of showrooms (physical locations where customers can view and try products) in combination with online fulfillment that uses centralized inventory management. We ask whether, and if so, how, showrooms benefit the two most basic retail objectives: demand generation and operational efficiency. Using quasi-experimental data on showroom openings by
WarbyParker.com
, the leading and iconic online-first eyewear retailer, we find that showrooms: (1) increase demand overall
and
in the online channel as well; (2) generate
operational spillovers
to the
other
channels by attracting customers who, on average, have a higher cost-to-serve; (3) improve overall operational efficiency by increasing conversion in a sampling channel and by decreasing returns; and (4) amplify these demand and operational benefits in dealing with customers who have the most acute need for the firm’s products. Moreover, the effects we document strengthen with time as showrooms contribute not only to brand awareness but also to what we term
channel awareness
as well. We conclude by elaborating the underlying customer dynamics driving our findings and by offering implications for how online-first retailers might deploy omnichannel tactics.
This paper was accepted by Vishal Gaur, operations management.
We study the effects of the introduction of cross-channel functionalities on the overall sales dispersion of retailers and the implications of these effects for inventory management. To do that, we ...analyze data from a leading U.S. retailer who introduced a “ship-to-store” (STS) functionality that allows customers to ship products to their local store free of charge when those products are not available in their local store. Based on the fact that stores prioritize carrying products for which local demand is high, we test the hypothesis that introducing the STS functionality increased the retailer’s overall sales dispersion. We find that, on average, the contribution of the 90% lowest-selling products to total sales increased by 0.75 percentage points, increasing sales dispersion. Calibrating conventional inventory-ordering models, we show that to respond optimally to the observed increase in dispersion, the retailer would need to increase its cycle and safety inventories by approximately 2.7%. Our paper points out the effect of an increasingly important retail phenomenon (channel integration) on a key factor for inventory management (sales dispersion).
This paper was accepted by Vishal Gaur, operations management
.
Kainate receptors: from synaptic activity to disease Negrete‐Díaz, José Vicente; Falcón‐Moya, Rafael; Rodríguez‐Moreno, Antonio
The FEBS journal,
September 2022, 2022-09-00, 20220901, Letnik:
289, Številka:
17
Journal Article
Recenzirano
Odprti dostop
Kainate receptors (KARs) are glutamate receptors that participate in the postsynaptic transmission of information and in the control of neuronal excitability, as well as presynaptically modulating ...the release of the neurotransmitters GABA and glutamate. These modulatory effects, general follow a biphasic pattern, with low KA concentrations provoking an increase in GABA and glutamate release, and higher concentrations mediating a decrease in the release of these neurotransmitters. In addition, KARs are involved in different forms of long‐ and short‐term plasticity. Importantly, altered activity of these receptors has been implicated in different central nervous system diseases and disturbances. Here, we describe the pre‐ and postsynaptic actions of KARs, and the possible role of these receptors in disease, a field that has seen significant progress in recent years.
Kainate receptors (KARs) located in the axons of interneurons contacting CA1 pyramidal cells (PC) mediate a decrease in GABA release altering the excitation/inhibition balance. KARs located at CA1 pyramidal neurons increase excitability of these cells by decreasing the after hyperpolarization currents altering the excitation/inhibition balance in the same direction. This unbalance mediated by the activation of pre‐ and postsynaptic KARs is one proposed mechanism for epilepsy in the hippocampus.
Accessible summary
What is known on the subject?
Empathy is one of the main attributes for establishing the nurse–patient therapeutic relationship. Davis (1983) identified four components on an ...empathic response: perspective taking, fantasy, empathetic concern and personal distress.
It is essential to deepen our knowledge on the influence of the dimensions of empathy for the construction and development of the therapeutic alliance during the different phases of the therapeutic relationship.
What the paper adds to existing knowledge?
A significant association exists between the dimensions of empathy and the construction and development of the therapeutic alliance during the different phases of the therapeutic relationship between nurses and patients in mental health units.
This study shows that the nurses' perspective on the patient's situation improves the bond, and therefore, this skill is especially useful in the first phase or orientation phase of the therapeutic relationship. However, for the second phase or working phase of the therapeutic relationship, a greater empathic concern among nurses, together with less personal distress, improves collaborative goal setting with patients.
What are the implications for practice?
It is important for mental health nurses to be aware of the importance of personal self‐awareness and the emotional management of empathy for the construction and development of therapeutic relationships of quality with patients.
Knowledge of the relationship between each of the dimensions of empathy in the different stages of the therapeutic relationship is useful for the design of educational programmes, by including training on empathic strategies.
Introduction
Empathy and its dimensions (perspective taking, empathic concern, personal distress and fantasy) are essential for establishing the nurse–patient therapeutic relationship. It is important to know how this influences the construction and development of the therapeutic alliance during the different phases of the therapeutic relationship.
Aim
To examine whether the dimensions of empathy influence the nurse–patient therapeutic relationship within mental health units.
Method
A cross‐sectional design was used to collect data to measure the therapeutic alliance and the different dimensions of empathy via an online form completed by nurses working at 18 mental health units. Linear regressions were used in the analysis.
Results
A total of 198 participants completed the questionnaires. Nurses established a greater therapeutic alliance with patients when they were able to adopt their patient's perspective and experience concern.
Discussion
Nurses’ perspective taking is an influential factor impacting the nurse–patient bond in the orientation phase, whereas experiencing greater concern and decreased emotional distress were associated with improved therapeutic alliance in the working phase.
Implications for practice
These findings may help gain awareness among nurses of the importance of empathy in the nurse–patient relationships, as well as inform educational programmes, by including training in empathic strategies and emotional management.
Currently, people use online social media such as Twitter or Facebook to share their emotions and thoughts. Detecting and analyzing the emotions expressed in social media content benefits many ...applications in commerce, public health, social welfare, etc. Most previous work on sentiment and emotion analysis has only focused on single-label classification and ignored the co-existence of multiple emotion labels in one instance. This paper describes the development of a novel deep learning-based system that addresses the multiple emotion classification problem in Twitter. We propose a novel method to transform it to a binary classification problem and exploit a deep learning approach to solve the transformed problem. Our system outperforms the state-of-the-art systems, achieving an accuracy score of 0.59 on the challenging SemEval2018 Task 1:E-cmulti-label emotion classification problem.
Doxorubicin (DOX) is an anticancer anthracycline that presents a dose‐dependent and cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been advanced to explain ...DOX cardiac side effects, which culminate in the development of life‐threatening cardiomyopathy. One of the most studied mechanisms involves the activation of DOX molecule into a more reactive semiquinone by mitochondrial Complex I, resulting in increased oxidative stress. The present review describes and critically discusses what is known about some of the potential mechanisms of DOX‐induced cardiotoxicity including mitochondrial oxidative damage and loss of cardiomyocytes. We also discuss alterations of mitochondrial metabolism and the unique characteristics of DOX delayed toxicity, which can also interfere on how the cardiac muscle handles a “second‐hit stress.” We also present pharmaceutical and nonpharmaceutical approaches that may decrease DOX cardiac alterations in animal models and humans and discuss the limitations of each strategy.
PDF
