A 79-y-old man developed erythema and superficial sloughing of the turbinate following accidental intranasal administration of 89.2% phenol solution. Previous documented reports of phenol exposure ...include exposures via dermal and oral routes, but no reports of nasal phenol administration were found.
Rediscovering Sierra Leone Morris, Lynn
E (Norwalk, Conn.),
03/2012, Letnik:
23, Številka:
2
Magazine Article
Ten years on from its brutal civil war, the small West African country has started rebuilding its tourism industry. Protecting Africa with Ecotourism Sierra Leone desperately needs to make money from ...its natural resources whether these are iron ore, diamonds, timber or spectacular scenery and wildlife.
On one island, Nair, which has been reduced in size by half over the last 10 years, ornithologists working in the park are trying to protect the bird population by building nesting platforms a few ...feet high where the birds' eggs will be protected from the rising tide. In particular, rising sea levels will increase the risk of floods, and stronger tropical storms may further increase the flood risk.
U.S. Attorney Bradley Schlozman said that after Saundra McFadden-Weaver failed to get financing for the renovations, she approached Kind in September 2005 to purchase a home in Lee's Summit. Under ...the deal, the $400,000 mortgage would have paid for the home and provided McFadden-Weaver with about $35,000 for the renovations. Kind would have lived in the Lee's Summit home. The commission, inactive this decade until McFadden-Weaver requested its review, has met regularly since October, taking testimony from the councilwoman and others, including the escrow closer who said McFadden-Weaver received clear explanation of the documents she was signing and appeared to understand what she was signing. "Of course, she is entitled to the presumption of innocence and will have every opportunity to defend herself against these allegations," Kay Barnes said. "At the same time, the citizens of the 3rd Council District are also entitled to full and competent representation. It is important that Councilwoman McFadden-Weaver recognize that obligation."
She has been under federal investigation since The Kansas City Star reported in August that she bought a $400,000 Lee's Summit home in 2005. Saundra McFadden-Weaver signed mortgage documents ...attesting that she would live in the home, which would have violated a city charter requirement that she live inside Kansas City's 3rd Council District, the area she represents. In September, McFadden-Weaver asked the city's ethics commission, which had been inactive since the 1990s, to investigate her involvement in the Lee's Summit deal. The Municipal Officials Ethics Commission has met regularly since October, taking testimony from others involved, including the escrow closer who said that McFadden- Weaver received clear explanation of the documents she was signing and appeared to understand what she was signing. Others involved, including the mortgage broker, testified that McFadden-Weaver originally sought a loan to renovate a home on Benton Boulevard owned by her church. When that fell through, she agreed to sign for the Lee's Summit home and allow Kind to live in the home. In return, money from the real estate deal was used to pay a $5,000 loan with Douglass Bank, they testified.
To evaluate changes in myocardial energetics and systemic and cardiac sympathetic activity associated with improved left ventricular function after MDL 17043, a new inotropic vasodilator agent, ...systemic and coronary hemodynamics and myocardial catecholamine balance were determined in 17 patients with severe heart failure. After the administration of MDL 17043, cardiac index increased by 67% and pulmonary capillary wedge pressure decreased (25 ± 5 to 14 ± 7 mm Hg, p < 0.01), indicating improved left ventricular function. Coronary sinus blood flow (75 ± 29 to 111 ± 51 ml/min, p < 0.01) and myocardial oxygen consumption (9.9 ± 3.3 to 11.8 ± 5.4 ml/min, p < 0.05) increased despite decreased myocardial oxygen extraction (11.7 ± 2 to 10.1 ± 3.3 vol %, p < 0.05) and a higher coronary sinus oxygen content. Although transmyocardial lactate extraction remained unchanged, increased myocardial oxygen consumption has potential deleterious effects on myocardial metabolic function. Arterial norepinephrine concentrations and transmyocardial norepinephrine release also remained unchanged.
These findings suggest that MDL 17043 improves left ventricular pump function, but produces no detectable change in systemic and cardiac sympathetic activity. Improved left ventricular function is associated with increased myocardial oxygen consumption despite primary coronary vasodilation.
This study examined the relational-interdependent self-construal (RISC; Cross, Bacon, & Morris, 2000) and relations to work-related variables such as job satisfaction and organizational citizenship ...behavior. It was hypothesized that the RISC scale (Cross et al., 2000) would predict the altruism facet of organizational citizenship behavior, and moderate the relationships between interactional justice and coworker satisfaction when predicting other important attitudes such as job satisfaction and organizational commitment. Employees from three different organizations completed surveys either with on paper or over the Internet at a secure website. The results largely failed to support hypotheses involving the RISC, although relations among work-related variables were largely consistent with previous theory and research. The results did indicate some unexpected findings, such as a positive relation between RISC scale scores and age, and between RISC scale scores and work withdrawal. RISC scale scores also moderated several relations between work attitudes and organizational withdrawal.
Studies were undertaken to characterize DNA sequence determinants responsible for regulation of expression of an outer membrane iron-siderophore protein (FepA) in Escherichia coli. Site-directed ...mutations were generated in the two tandemly arranged fepA promoters and the overlapping fes promoter and their effects at the transcriptional level analyzed using reporter gene expression and primer extension. Results have revealed a previously unidentified regulatory region between the −10 and −35 elements of the minor promoter, which enhance transcription of the major promoter while simultaneously repressing transcription from the minor promoter. Experiments using wild type and mutant carboxy-terminal domains of the α subunit of RNA polymerase have shown that binding of this subunit to this region may play a minor role in transcriptional regulation of the two promoters. Conformational DNA analysis suggests that this region is bent, therefore, preventing stable binding of RNA polymerase to the minor promoter. The overlapping, divergently oriented fes promoter, was also found to negatively regulate activity of the major fepA promoter by competition for RNA polymerase. The results demonstrate unique and complex regulation of the promoters. The data presented define a regulatory role for the fes promoter and provide prey evidence that a five-base pair substitution mutation in the suboptimal spacer region of the minor promoter of fepA induces a DNA conformational change which enhances its activity. Kinetic studies of fepA expression have also been performed and shown that physiochemically distinct iron chelators may cause differential expression patterns of the mRNA due to the unique effects the chelators have on modification of the internal regulatory iron pool of the cell.
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