Mr. Kingdon and at least two other former Bankers Trust employees have received so-called target letters from federal prosecutors, indicating they are likely to soon be indicted by a federal grand ...jury reviewing the evidence, according to individuals with knowledge of the probe. Mr. Kingdon's attorney, Stanley Arkin, says his client never believed his division was doing anything wrong. While the bank promptly notified the government of the problem in 1996, the impetus to resolve the case came from Deutsche Bank AG. The German bank, which agreed last fall to buy Bankers Trust for $10.1 billion, sought to resolve the case so the extent of potential liability would be known before the purchase was completed, according to individuals involved in the plea negotiations. The government, too, indicated it wasn't inclined to sign off on the merger until the criminal case was resolved, these people say. Resolving the lingering fallout from the derivatives scandal was one of the first big priorities of Mr. (Charles S.) Sanford's successor, Frank N. Newman, a former deputy secretary at the U.S. Treasury Department, who became chief executive officer in January 1996 and chairman several months later. But within weeks of taking the helm, Mr. Newman discovered that fraudulent activities were occurring elsewhere, in the transactions-processing business.
The diet is emerging as the dominant source of arsenic exposure for most of the U.S. population. Despite this, limited regulatory efforts have been aimed at mitigating exposure, and the role of diet ...in arsenic exposure and disease processes remains understudied. In this brief, we discuss the evidence linking dietary arsenic intake to human disease and discuss challenges associated with exposure characterization and efforts to quantify risks. In light of these challenges, and in recognition of the potential longer-term process of establishing regulation, we introduce a framework for shorter-term interventions that employs a field-to-plate food supply chain model to identify monitoring, intervention, and communication opportunities as part of a multisector, multiagency, science-informed, public health systems approach to mitigation of dietary arsenic exposure. Such an approach is dependent on coordination across commodity producers, the food industry, nongovernmental organizations, health professionals, researchers, and the regulatory community. https://doi.org/10.1289/EHP3997.
Epstein-Barr virus (EBV) persistently infects more than 90% of the human population and is etiologically linked to several B cell malignancies, including Burkitt lymphoma (BL), Hodgkin lymphoma (HL), ...and diffuse large B cell lymphoma (DLBCL). Despite its growth transforming properties, most immune-competent individuals control EBV infection throughout their lives. EBV encodes various oncogenes, and of the 6 latency-associated EBV-encoded nuclear antigens, only EBNA3B is completely dispensable for B cell transformation in vitro. Here, we report that infection with EBV lacking EBNA3B leads to aggressive, immune-evading monomorphic DLBCL-like tumors in NOD/SCID/γc-/- mice with reconstituted human immune system components. Infection with EBNA3B-knockout EBV (EBNA3BKO) induced expansion of EBV-specific T cells that failed to infiltrate the tumors. EBNA3BKO-infected B cells expanded more rapidly and secreted less T cell-chemoattractant CXCL10, reducing T cell recruitment in vitro and T cell-mediated killing in vivo. B cell lines from 2 EBV-positive human lymphomas encoding truncated EBNA3B exhibited gene expression profiles and phenotypic characteristics similar to those of tumor-derived lines from the humanized mice, including reduced CXCL10 secretion. Screening EBV-positive DLBCL, HL, and BL human samples identified additional EBNA3B mutations. Thus, EBNA3B is a virus-encoded tumor suppressor whose inactivation promotes immune evasion and virus-driven lymphomagenesis.
This study describes the development, evaluation and application of a computer vision and deep learning system capable of capturing sprinting and skeleton push start step characteristics and mass ...centre velocities (sled and athlete). Movement data were captured concurrently by a marker-based motion capture system and a custom markerless system. High levels of agreement were found between systems, particularly for spatial based variables (step length error 0.001 ± 0.012 m) while errors for temporal variables (ground contact time and flight time) were on average within ± 1.5 frames of the criterion measures. Comparisons of sprinting and pushing revealed decreased mass centre velocities as a result of pushing the sled but step characteristics were comparable to sprinting when aligned as a function of step velocity. There were large asymmetries between the inside and outside leg during pushing (e.g. 0.22 m mean step length asymmetry) which were not present during sprinting (0.01 m step length asymmetry). The observed asymmetries suggested that force production capabilities during ground contact were compromised for the outside leg. The computer vision based methods tested in this research provide a viable alternative to marker-based motion capture systems. Furthermore, they can be deployed into challenging, real world environments to non-invasively capture data where traditional approaches are infeasible.
Because the bioavailability of oral furosemide is erratic and often incomplete, we tested the hypothesis that patients with heart failure who were treated with torsemide, a predictably absorbed ...diuretic, would have more favorable clinical outcomes than would those treated with furosemide.
We conducted an open-label trial of 234 patients with chronic heart failure (mean ± SD age, 64 ± 11 years) from an urban public health care system. Patients received oral torsemide (n = 113) or furosemide (n = 121) for 1 year. The primary endpoint was readmission to the hospital for heart failure. Secondary endpoints included readmission for all cardiovascular causes and for all causes, numbers of hospital days, and health-related quality of life.
Compared with furosemide-treated patients, torsemide-treated patients were less likely to need readmission for heart failure (39 32% vs. 19 17%, P <0.01) or for all cardiovascular causes (71 59% vs. 50 44%, P = 0.03). There was no difference in the rate of admissions for all causes (92 76% vs. 80 71%, P = 0.36). Patients treated with torsemide had significantly fewer hospital days for heart failure (106 vs. 296 days, P = 0.02). Improvements in dyspnea and fatigue scores from baseline were greater among patients treated with torsemide, but the differences were statistically significant only for fatigue scores at months 2, 8, and 12.
Compared with furosemide-treated patients, torsemide-treated patients were less likely to be readmitted for heart failure and for all cardiovascular causes, and were less fatigued. If our results are confirmed by blinded trials, torsemide may be the preferred loop diuretic for patients with chronic heart failure.
On its surface, the proposal was crafted to appease some of the commission's concerns regarding the deal, particularly about GE Capital Aviation Services. The commission has argued that the ...aircraft-finance unit, a large purchaser of airplanes, unfairly pressures manufacturers to buy GE products.
Cervicofacial infections carry significant morbidity. Patients present on a broad spectrum of severity, with some requiring outpatient management and others admission to higher level care. ...Recognition of risk factors is helpful in decision making regarding the need for admission to higher level care. Prospective data were captured on 1002 patients in 25 centres across 17 regions of the United Kingdom (UK) by the Maxillofacial Trainee Research Collaborative (MTReC). Patients admitted to critical care were compared with those who received ward-level care. Multivariate and receiver operating characteristic curve analyses were used to identify predictors for critical care admission. Our results show that the best predictor for critical care admission is the presence of three or more features of airway compromise (AUC 0.779), followed by C-reactive protein (CRP) >100 mg/L (OR 2.70; 95% CI 1.59 to 4.58; p < 0.005), submandibular space involvement (OR 3.82; 95% CI 1.870 to 7.81; p = 0.003), white cell count (WCC) >12 × 109/ dl (1.05; 95% CI 1.01 to 1.10; p = 0.03), and positive systemic inflammatory response syndrome criteria (OR 2.78; CI 1.35 to 5.80; p = 0.006). Admission to critical care is multifactorial, however, the presence of three or more features of airway compromise is the best predictor. Awareness of this alongside other key clinical findings in cervicofacial infections may allow for the early recognition of patients who may require escalation to critical care.
Lower respiratory infections (LRIs) are the leading cause of death in children under the age of 5, despite the existence of vaccines against many of their aetiologies. Furthermore, more than half of ...these deaths occur in Africa. Geospatial models can provide highly detailed estimates of trends subnationally, at the level where implementation of health policies has the greatest impact. We used Bayesian geostatistical modelling to estimate LRI incidence, prevalence and mortality in children under 5 subnationally in Africa for 2000-2017, using surveys covering 1.46 million children and 9,215,000 cases of LRI. Our model reveals large within-country variation in both health burden and its change over time. While reductions in childhood morbidity and mortality due to LRI were estimated for almost every country, we expose a cluster of residual high risk across seven countries, which averages 5.5 LRI deaths per 1,000 children per year. The preventable nature of the vast majority of LRI deaths mandates focused health system efforts in specific locations with the highest burden.
PDF
