Previous studies have suggested submarine landslides as sources of the tsunami that damaged coastal areas of Palu Bay after the 2018 Sulawesi earthquake. Indeed, tsunami run-up heights as high as ...10 m determined by field surveys cannot be explained by the earthquake source alone although the earthquake is definitely the primary cause of the tsunami. The quantitatively re-examined results using the earthquake fault models reported so far showed that none of them could fully explain the observed tsunami data: tsunami waveforms inferred from video footage and the field survey run-up tsunami height distribution. Here, we present probable tsunami source models including submarine landslides that are consistent with the observed tsunami data. We simulated tsunamis generated by submarine landslides using a simplified depth-averaged two-dimensional model. The estimated submarine landslide model consisted of two sources in the northern and southern parts of the bay, and it explained the observed tsunami data well. Their volumes were 0.02 and 0.07 km
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. The radius of the major axis and the maximum thickness of the initial paraboloid masses and the maximum horizontal velocity of the masses were 0.8 km, 40 m and 21 m/s in the northern bay, and 2.0 km, 15 m and 19 m/s in the southern bay, respectively. The landslide source in the northern bay needed to start to move about 70 s after the earthquake to match the calculated and observed arrival times.
Aim: In patients with end-stage kidney disease (ESKD), it is unclear whether an imbalance between myocardial oxygen supply and demand leads to myocardial injury (MI). This study clarifies the ...association between the balance of the rate pressure product (RPP), consisting of the systolic blood pressure multiplied by the pulse rate (PR), a marker for myocardial oxygen demand, and hemoglobin (Hb), a marker for oxygen supply, with MI. Methods: A total of 283 consecutive unselected patients for hemodialysis were enrolled in this retrospective, cross-sectional study, and were divided into four groups according to Hb levels (high or low) and RPP. Potential imbalances between myocardial oxygen supply and demand were defined as patients with simultaneous high RPP and low Hb levels. The odds ratio (OR) for MI, defined as cardiac troponin T (cTnT) of ≥ 0.15 ng/mL was investigated using logistic regression analysis between the four patient groups.Results: The mean age was 68.7 years, 71.3% were men, and 52.6% had diabetes. The mean Hb level was 9.0 g/dL, and 20.5% of patients were latently diagnosed with MI. The median RPP and cTnT level was 12,144 and 0.083 ng/mL, respectively. When exposed to simultaneous high RPP with low Hb, OR significantly increased compared with that of the well-balanced group (RPP ＜12,500 and Hb ≥ 9.0 g/dL; OR 3.63, p＜0.05). Similar results were obtained in multivariate analysis after adjusting for confounding variables. These associations were enhanced or weakened when the Hb cut-off level became lower (Hb=8 g/dL) or higher (Hb=10 g/dL). Conclusions: As the myocardial oxygen supply and demand balance in patients with ESKD is potentially associated with MI, appropriate management for blood pressure, PR, and anemia may prevent MI.
In patients undergoing hemodialysis, the impact of atrial fibrillation (AF) through cardiac thromboembolism on the development of ischemic stroke may be influenced by the severity of atherosclerosis ...present. However, there are no large-scale reports confirming whether the severity of atherosclerosis influences the relationship between AF and stroke development in patients requiring hemodialysis. We aimed to investigate the effects of atherosclerotic disease on the relationship between AF and new-onset ischemic stroke. This nationwide longitudinal study based on dialysis facilities across Japan used data collected from the Japanese Renal Data Registry at the end of 2019 and 2020. The exposure was AF at the end of 2019, identified using a resting 12-lead electrocardiography. The primary outcome was the incidence of cerebral infarction (CI) after 1 year. To examine whether the number of atherosclerotic diseases modified the association between AF and the outcome, we estimated the odds ratios (ORs) using a logistic regression model and then assessed the presence of global interaction using Wald test. Following the study criteria, data from 151,350 patients (mean age, 69 years; men, 65.2%; diabetic patients, 48.7%) were included in the final analysis. A total of 9841 patients had AF (prevalence, 6.5%). Between 2019 and 2020, 4967 patients (3.2%) developed ischemic stroke. The adjusted OR of AF for new-onset CI was 1.5, which showed a decreasing trend with an increasing number of atherosclerotic diseases; the interaction was not significant (P = 0.34). While age, diabetes mellitus, smoking, systolic blood pressure, and serum C-reactive protein concentration were positively associated with CI, intradialytic weight gain, body mass index, and serum albumin level were negatively associated. While we demonstrated the association between AF and new-onset CI among Japanese patients on hemodialysis, we failed to demonstrate the evidence that the association was attenuated with an increasing numbers of atherosclerotic complications.
Cardiovascular medicine, especially for ischemic heart disease, has evolved and advanced over the past two decades, leading to substantially improved outcomes for patients, even those with chronic ...kidney disease. However, the prognosis for patients with end-stage kidney disease (ESKD) has not improved so greatly. Recent studies have reported that myocardial fibrosis in chronic kidney disease patients is characterized by patchy and interstitial patterns. Areas of fibrosis have been located in the perivascular space, and severe fibrotic lesions appear to spread into myocardial fiber bundles in the form of pericellular fibrosis. These findings are fully consistent with known characteristics of reactive fibrosis. In hemodialysis patients, a greater extent of myocardial fibrosis is closely associated with a poorer prognosis. In this review, we focus on non-ischemic cardiomyopathy, especially reactive myocardial fibrosis, in ESKD patients.
To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic ...Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic Consortium (ADGC). In Stage 1, we evaluated data for 5,877,918 genotyped and imputed SNPs in Japanese cases (n = 1,008) and controls (n = 1,016). Genome-wide significance was observed with 12 SNPs in the APOE region. Seven SNPs from other distinct regions with p-values <2×10(-5) were genotyped in a second Japanese sample (885 cases, 985 controls), and evidence of association was confirmed for one SORL1 SNP (rs3781834, P = 7.33×10(-7) in the combined sample). Subsequent analysis combining results for several SORL1 SNPs in the Japanese, Korean (339 cases, 1,129 controls) and Caucasians (11,840 AD cases, 10,931 controls) revealed genome wide significance with rs11218343 (P = 1.77×10(-9)) and rs3781834 (P = 1.04×10(-8)). SNPs in previously established AD loci in Caucasians showed strong evidence of association in Japanese including rs3851179 near PICALM (P = 1.71×10(-5)) and rs744373 near BIN1 (P = 1.39×10(-4)). The associated allele for each of these SNPs was the same as in Caucasians. These data demonstrate for the first time genome-wide significance of LOAD with SORL1 and confirm the role of other known loci for LOAD in Japanese. Our study highlights the importance of examining associations in multiple ethnic populations.
Disrupted-In-Schizophrenia-1 (DISC1) is a promising susceptibility gene for major mental illness, but the mechanism of the clinical association is unknown. We searched for DISC1 transcripts in adult ...and fetal human brain and tested whether their expression is altered in patients with schizophrenia and is associated with genetic variation in DISC1. Many alternatively spliced transcripts were identified, including groups lacking exon 3 (Δ3), exons 7 and 8 (Δ7Δ8), an exon 3 insertion variant (extra short variant-1, Esv1), and intergenic splicing between TSNAX and DISC1. Isoforms Δ7Δ8, Esv1, and Δ3, which encode truncated DISC1 proteins, were expressed more abundantly during fetal development than during postnatal ages, and their expression was higher in the hippocampus of patients with schizophrenia. Schizophrenia risk-associated polymorphisms non-synonymous SNPs rs821616 (Cys704Ser) and rs6675281 (Leu607Phe), and rs821597 were associated with the expression of Δ3 and Δ7Δ8. Moreover, the same allele at rs6675281, which predicted higher expression of these transcripts in the hippocampus, was associated with higher expression of DISC1Δ7Δ8 in lymphoblasts in an independent sample. Our results implicate a molecular mechanism of genetic risk associated with DISC1 involving specific alterations in gene processing.
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6.9 earthquake off Fukushima Prefecture, Japan, of 22 November 2016 was followed by a tsunami that struck the Japanese coast from Hokkaido in northern Japan to Wakayama Prefecture in western ...Japan. We compared the performance of a seismologically deduced single-fault model, a seismologically deduced finite fault slip model (FFM), an optimized single-fault model based on tsunami data, the FFM with horizontal shift, and the tsunami waveform inversion models of the previous studies considered for this earthquake regarding reproduction of tsunami waves by tsunami computations. It is important to discuss how these models work well because it is sometimes desirable to obtain an earthquake source model to estimate tsunami waves with a simple process obtained with limited data from the viewpoint of tsunami prediction. The seismologically deduced FFM has an advantage in terms of the information of slip regions of fault plane and was superior to the seismologically deduced single-fault model, especially in predicting amplitudes of tsunami waves. This means that when only with seismic data, the FFM could narrow the range of forecast of tsunami amplitude. In the comparison of models optimized with tsunami data, the single-fault model showed the almost equivalent performance of the tsunami waveform inversion models of previous studies regarding the waveform coincidence with observations and the horizontal location at the negative peak of the initial sea surface displacement. In case the main generation region of the tsunami is concentrated in one place, the tsunamis can be expressed by a single-fault model by conducting the detailed grid search. We also confirmed that the centroid location of centroid moment tensor (CMT) solution and the absolute location of the FFM were not necessarily suitable to express tsunamis, while the moment magnitude, the focal mechanism, the centroid depth of CMT solution, and the relative slip distribution of the FFM were effective to represent tsunamis. Since this event occurred at the shallow depth, the speed of tsunami wave is particularly slow. Therefore, it would be advisable to pay attention to the horizontal uncertainty to apply seismologically obtained solution to tsunami forecast, especially when a tsunami occurs in shallow water.
Rare non-synonymous variants of TREM2 have recently been shown to be associated with Alzheimer's disease (AD) in Caucasians. We here conducted a replication study using a well-characterized Japanese ...sample set, comprising 2,190 late-onset AD (LOAD) cases and 2,498 controls. We genotyped 10 non-synonymous variants (Q33X, Y38C, R47H, T66M, N68K, D87N, T96K, R98W, H157Y, and L211P) of TREM2 reported by Guerreiro et al. (2013) by means of the TaqMan and dideoxy sequencing methods. Only three variants, R47H, H157Y, and L211P, were polymorphic (range of minor allele frequency MAF, 0.0002-0.0059); however, no significant association with LOAD was observed in these variants. Considering low MAF of variants examined and our study sample size, further genetic analysis with a larger sample set is needed to firmly evaluate whether or not TREM2 is associated with LOAD in Japanese.
Around the Ogasawara Islands, only a few seismic stations in the area can be used to determine the hypocenters of regional earthquakes; thus, hypocenter location precision tends to be low. To more ...precisely determine hypocenter locations, we deployed a temporary seismic observation network of pop-up ocean bottom seismometers around the Ogasawara Islands from July to October 2015. We identified a double seismic zone in the 70–200 km depth range associated with the subducting Pacific slab. The slab-normal distance between the two planes of the double seismic zone is about 30–35 km, similar to such distances observed along the Japan and Mariana trenches. Furthermore, we found unusual seismicity in the mantle wedge at 20–50 km depth beneath the Ogasawara trough that might be related to structure formed at the onset of the oceanic slab subduction. The hypocenters determined from the ocean bottom seismometer observation were horizontally separated by a few tens of kilometers from hypocenters published by the
Seismological Bulletin of Japan
. USGS locations (Preliminary Determination of Epicenters) seem to be offset westward about 30 km compared with the locations determined in this study.
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