A
bstract
We perform a statistical combination of the ATLAS and CMS results for the search of a heavy resonance decaying to a pair of vector bosons with the
s
=
8
TeV datasets collected at the LHC. ...We take into account six searches in hadronic and semileptonic final states carried out by the two collaborations. We consider only public information provided by ATLAS and CMS in the HEPDATA database and in papers published in refereed journals. We interpret the combined results within the context of a few benchmark new physics models, such as models predicting the existence of a W′ or a bulk Randall-Sundrum spin-2 resonance, for which we present exclusion limits, significances,
p
-values and best-fit cross sections. A heavy diboson resonance with a production cross section of ∼4-5 fb and mass between 1.9 and 2.0 TeV is the exotic scenario most consistent with the experimental results. Models in which a heavy resonance decays preferentially to a WW final state are disfavoured.
The aim of the current project was to characterize the luteal vascularity and the plasma concentrations of progesterone (P4), prolactin (PRL) and 13,14-dihydro-15-keto-PGF2α (PGFM) in mares with ...luteal disturbances during early and mid-diestrus. In Experiment 1, twenty-one mares were treated with 2 mL of 0.9% NaCl, or 1 mg Dinoprost, or 10 mg Dinoprost on day two after ovulation (Control-D2, 1/10PGF-D2 and PGF-D2 groups, respectively; n = 7 mares/group). In Experiment 2, similar treatments were performed eight days post-ovulation using a different cohort of 21 mares (Control-D8, 1/10PGF-D8 and PGF-D8 groups, respectively; n = 7 mares/group). Blood samples were collected hourly and power-Doppler examinations of the corpus luteum (CL) were performed every 6 h from H0 (moment immediately before treatment) to H48. Data collection was also done once a day from D0 (day of ovulation) to D20. In Experiment 1, the PGF-D2 and 1/10PGF-D2 groups had lower increase of plasma concentration of P4 until H48 and reduced maximum P4 concentrations on D8-D11 than mares from the Control-D2 group. However, no differences among groups were detected for luteal vascularity during early and mid-diestrus. In Experiment 2, complete and partial luteolysis were detected in mares from the PGF-D8 and 1/10PGF-D8 groups, respectively. Luteal vascularity and plasma P4 concentrations differed among Control-D8, PGF-D8 and 1/10PGF-D8 groups on H48. Partially regressed CLs (1/10PGF-D8 group) generated more Doppler signals than completed regressed CLs (PGF-D8 group) between D10 and D13. In both experiments, a transient increase in PRL activity was observed in parallel to the PGFM pulse in mares receiving 1 or 10 mg Dinoprost. The use of prostaglandin on D2 at conventional or 1/10 of the dose impaired the luteal development in mares. Moreover, the low dose of prostaglandin lead to partial regression of mature CLs. The blood supply was reduced in partially regressed CLs, but not in CLs undergoing impaired luteogenesis.
•A single prostaglandin treatment on day two after ovulation reduced the maximum production of P4 during diestrus.•Impaired luteogenesis did not affect the vascularity of mid-cycle CLs.•The vascularity was reduced in CLs undergoing partial luteolysis during mid-diestrus.•Partially regressed CLs did not rebound to normality.•The use of Doppler ultrasonography was efficient to detect partially regressed CLs.
With the successful control of rabies transmitted by dogs in Brazil, wild animals have played a relevant epidemiological role in the transmission of rabies virus (RABV). Bats, non-human primates and ...wild canines are the main wild animals that transmit RABV in the country. It is worth highlighting the possibility of synanthropic action of these species, when they become adapted to urban areas, causing infections in domestic animals and eventually in humans. This work aimed to evaluate the circulation of RABV in the Pedra Branca Forest, an Atlantic Forest area, located in the state of Rio de Janeiro, Southeast Brazil. Saliva and blood samples were obtained from 60 individuals of eight species of bats, captured with mist nets, and 13 individuals of callitrichid primates, captured with tomahawk traps. Saliva samples were subjected to Reverse Transcription Polymerase Chain Reaction (RT-PCR), targeting the RABV N gene, with all samples being negative. Blood samples of all animals were submitted to the Rapid Fluorescent Focus Inhibition Test (RFFIT) to detect neutralizing antibodies (Ab) for RABV. Six bat samples (8%) were seropositive for RABV with antibody titers greater than or equal to 0.1 IU/mL. The detection of Ab but not viral RNA indicates exposure rather than current RABV transmission in the analyzed populations. The results presented here reinforce the importance of serological studies in wildlife to access RABV circulation in a region.With the successful control of rabies transmitted by dogs in Brazil, wild animals have played a relevant epidemiological role in the transmission of rabies virus (RABV). Bats, non-human primates and wild canines are the main wild animals that transmit RABV in the country. It is worth highlighting the possibility of synanthropic action of these species, when they become adapted to urban areas, causing infections in domestic animals and eventually in humans. This work aimed to evaluate the circulation of RABV in the Pedra Branca Forest, an Atlantic Forest area, located in the state of Rio de Janeiro, Southeast Brazil. Saliva and blood samples were obtained from 60 individuals of eight species of bats, captured with mist nets, and 13 individuals of callitrichid primates, captured with tomahawk traps. Saliva samples were subjected to Reverse Transcription Polymerase Chain Reaction (RT-PCR), targeting the RABV N gene, with all samples being negative. Blood samples of all animals were submitted to the Rapid Fluorescent Focus Inhibition Test (RFFIT) to detect neutralizing antibodies (Ab) for RABV. Six bat samples (8%) were seropositive for RABV with antibody titers greater than or equal to 0.1 IU/mL. The detection of Ab but not viral RNA indicates exposure rather than current RABV transmission in the analyzed populations. The results presented here reinforce the importance of serological studies in wildlife to access RABV circulation in a region.
Purpose
Bariatric surgery (BS) promotes carotid intima-media thickness (C-IMT) regression as early as 6 months post-surgery. To verify whether C-IMT regression occurs even earlier, we aimed at the ...effect of Roux-en-Y gastric bypass (RYGBP) and biliopancreatic diversion (BPD) on C-IMT 1–2 months and 12 months post-surgery.
Subjects/Methods
Prospective trial. BS was performed on 109 patients either with (RYGBP = 42; BDP = 40) or without type 2 diabetes (RYGBP = 27). Healthy volunteers served as control group. Follow-up: baseline, 1–2 months, 12 months post-surgery. Endpoints: changes (∆) in C-IMT, weight, body mass index, fat mass, waist and neck circumferences, blood pressure, HbA1c, glucose, insulin, insulin sensitivity HOMA-IR; OGIS, from meal tolerance test, lipids, C-reactive protein, leptin, adiponectin, MCP-1.
Results
All surgery subgroups had similar levels of ∆-C-IMT. C-IMT in the pooled surgery group reduced from mean (95% confidence interval) 0.81 (0.77–0.84) mm to 0.66 (0.63–0.69) mm,
p
< 0.001 −17.1 (−20.4 to −13.8)% at 1–2 months, and to 0.63 (0.59–0.66) mm,
p
< 0.001 −21.8 (−25.3 to −18.4)% at 12 months post-surgery. ∆-C-IMT 1–2 months and 12 months post-surgery correlated to baseline C-IMT, and with ∆-leptin at 1–2 months, but not at 12 months post-surgery. In linear regression analysis, ∆-leptin and baseline C-IMT were predictors of ∆-C-IMT 1–2 months post-surgery.
Conclusions
A remarkable C-IMT regression occurred as early as 1–2 months after BS in obese patients either with or without type 2 diabetes, which was associated to the early reduction in leptin, (at least partially) independent of weight loss. Whether this is a causative or correlative association needs further investigation.
Hydroxypropyl methylcellulose (HPMC) E4M chains are crosslinked with citric acid and ethylenediaminetetraacetic acid (EDTA), resulting in adsorbent sponges (SpE4M), which are impregnated with ...magnetic nanoparticles (SpE4M‐mag) for the adsorption of 17 α‐ethinyl estradiol (EE). The characterization of SpE4M and SpE4M‐mag characterization includes X‐ray microcomputer tomography (Micro‐CT), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) vibrational spectroscopy, elemental analysis, inductively coupled plasma optical emission spectrometry (ICP‐OES), and X‐ray diffraction (XRD). SpE4M and SpE4M‐mag present porosities of 72±6 % and 80±7 %, respectively, and outstanding stability in water, in the pH range 4 to 8, and in alcohols, alkanes, and acetone. The compressive moduli of SpE4M and SpE4M‐mag amount to 2.75 and 4.37 MPa, respectively. The adsorption of 17 α‐ethinyl estradiol (EE), an estrogenic pollutant, on SpE4M and SpE4M‐mag follows the pseudo‐first‐order kinetic model. The EE removal capacity by SpE4M is 78±5 %, which is twice that presented by SpE4M‐mag. The new sponges are recovered successfully either by flotation or by an external magnet, and can be recycled five times keeping 80 % of their initial removal capacity after the fifth cycle, disclosing their potential for environmental remediation.
Water remediation: The estrogenic water pollutant 17 α‐ethinyl estradiol is removed successfully by using hydroxypropyl methylcellulose sponges and their magnetic counterparts. These sponges can be recovered easily from water by flotation or magnets. They can be recycled at least five times without significant efficiency loss (see figure).
•FSH treatment alters endometrial histomorphometry in prepubertal gilts.•Changes in uterine morphology do not occur from 140 to 160 d of age in prepubertal gilts.•Ovarian preantral follicles are not ...responsive to FSH treatment in prepubertal gilts.
This study investigated the effect of age and follicle stimulating hormone (FSH) treatment on the estradiol (E2) plasma concentration, ovarian follicle development, endometrial histomorphometry, and ultrasonographic parameters of the ovaries and uterus in prepubertal gilts. Thirty-five prepubertal gilts were grouped according to age (140 or 160 d), and within each age, gilts were allotted to receive 100 mg of FSH (treated; G140 + FSH n = 10 and G160 + FSH n = 7) or saline solution (control; G140 + control n = 10 and G160 + control n = 8). The total dose of FSH was divided into 6 similar doses administered every 8 h (days 0–2). Before and after FSH treatment, blood sample was collected, and transabdominal scanning of the ovaries and uterus was performed. Twenty-four hours after the last FSH injection, the gilts were slaughtered and their ovaries and uterus were processed for histological and histomorphometric analysis. The histomorphometric parameters of the uterus differed (P < 0.05) between prepubertal gilts at 160 d and 140 d of age. Moreover, changes (P < 0.05) in uterine and ovarian ultrasound images occurred between 140 and 160 d of age. Age and FSH treatment did not affect (P > 0.05) E2 plasma concentrations. Follicle stimulating hormone treatment did not affect (P > 0.05) the early stage of folliculogenesis in the prepubertal gilts; however, the number of early atretic follicles decreased (P < 0.05) after the FSH treatment. Follicle stimulating hormone administration increased (P < 0.05) the number of medium follicles and decreased (P < 0.05) the number of small follicles in 140 and 160 d old gilts. In the endometrium, luminal/glandular epithelium height and glandular diameter increased (P < 0.05) after FSH treatment. Thus, injections of 100 mg of FSH stimulate the endometrium epithelium and induce follicular growth to a medium follicle size without affecting the preantral stages in prepubertal gilts; also, the uterine macroscopic morphometry does not change from 140 to 160 d of age.
The BINGO project Fornazier, Karin S. F.; Abdalla, Filipe B.; Remazeilles, Mathieu ...
Astronomy and astrophysics (Berlin),
08/2022, Letnik:
664
Journal Article
Recenzirano
Context.
Observing the neutral hydrogen distribution across the Universe via redshifted 21 cm line intensity mapping constitutes a powerful probe for cosmology. However, the redshifted 21 cm signal ...is obscured by the foreground emission from our Galaxy and other extragalactic foregrounds. This paper addresses the capabilities of the BINGO survey to separate such signals.
Aims.
We show that the BINGO instrumental, optical, and simulations setup is suitable for component separation, and that we have the appropriate tools to understand and control foreground residuals. Specifically, this paper looks in detail at the different residuals left over by foreground components, shows that a noise-corrected spectrum is unbiased, and shows that we understand the remaining systematic residuals by analyzing nonzero contributions to the three-point function.
Methods.
We use the generalized needlet internal linear combination, which we apply to sky simulations of the BINGO experiment for each redshift bin of the survey. We use binned estimates of the bispectrum of the maps to assess foreground residuals left over after component separation in the final map.
Results.
We present our recovery of the redshifted 21 cm signal from sky simulations of the BINGO experiment, including foreground components. We test the recovery of the 21 cm signal through the angular power spectrum at different redshifts, as well as the recovery of its non-Gaussian distribution through a bispectrum analysis. We find that non-Gaussianities from the original foreground maps can be removed down to, at least, the noise limit of the BINGO survey with such techniques.
Conclusions.
Our component separation methodology allows us to subtract the foreground contamination in the BINGO channels down to levels below the cosmological signal and the noise, and to reconstruct the 21 cm power spectrum for different redshift bins without significant loss at multipoles 20 ≲
ℓ
≲ 500. Our bispectrum analysis yields strong tests of the level of the residual foreground contamination in the recovered 21 cm signal, thereby allowing us to both optimize and validate our component separation analysis.
The BINGO project Abdalla, Elcio; Ferreira, Elisa G. M.; Landim, Ricardo G. ...
Astronomy and astrophysics (Berlin),
08/2022, Letnik:
664
Journal Article
Recenzirano
Odprti dostop
Context.
Observations of the redshifted 21-cm line of neutral hydrogen (H
I
) are a new and powerful window of observation that offers us the possibility to map the spatial distribution of cosmic H
...I
and learn about cosmology. Baryon Acoustic Oscillations from Integrated Neutral Gas Observations (BINGO) is a new unique radio telescope designed to be one of the first to probe baryon acoustic oscillations (BAO) at radio frequencies.
Aims.
BINGO has two science goals: cosmology and astrophysics. Cosmology is the main science goal and the driver for BINGO’s design and strategy. The key of BINGO is to detect the low redshift BAO to put strong constraints on the dark sector models and test the ΛCDM (cold dark matter) model. Given the versatility of the BINGO telescope, a secondary goal is astrophysics, where BINGO can help discover and study fast radio bursts (FRB) and other transients, as well as study Galactic and extragalactic science. In this paper, we introduce the latest progress of the BINGO project, its science goals, describing the scientific potential of the project for each goal and the new developments obtained by the collaboration.
Methods.
BINGO is a single dish transit telescope that will measure the BAO at low-
z
by making a 3D map of the H
I
distribution through the technique of intensity mapping over a large area of the sky. In order to achieve the project’s goals, a science strategy and a specific pipeline for cleaning and analyzing the produced maps and mock maps was developed by the BINGO team, which we generally summarize here.
Results.
We introduce the BINGO project and its science goals and give a general summary of recent developments in construction, science potential, and pipeline development obtained by the BINGO Collaboration in the past few years. We show that BINGO will be able to obtain competitive constraints for the dark sector. It also has the potential to discover several FRBs in the southern hemisphere. The capacity of BINGO in obtaining information from 21-cm is also tested in the pipeline introduced here. Following these developments, the construction and observational strategies of BINGO have been defined.
Conclusions.
There is still no measurement of the BAO in radio, and studying cosmology in this new window of observations is one of the most promising advances in the field. The BINGO project is a radio telescope that has the goal to be one of the first to perform this measurement and it is currently being built in the northeast of Brazil. This paper is the first of a series of papers that describe in detail each part of the development of the BINGO project.