Understanding the interplay of sedimentation and deformation style is essential to develop an adequate model of the evolutionary history of an extensional sedimentary basin. Due to their volume and ...temporal extent, late post-rift deposits are often in the focus of research; however, early post-rift deposits are less studied. The aim of the study is to reconstruct the tectono-sedimentary evolution of a syn-rift to early post-rift succession in the hanging wall of a low-angle detachment zone and to recognize the effects of this deformation style on turbidity current pathways and depocenters. The small Őri sub-basin of the western part of the Miocene Pannonian basin is used as a study area where the oldest early post-rift turbidites of ~15–12.8 Ma occurred. These sediments were deposited in a supradetachment setting, where inherited and actively forming structures controlled the sediment pathways and accommodation of both the distally and locally sourced marine turbidites.
Seismic data, well logs and core information were integrated to identify and analyze unconformities, structural elements, and turbidite deposits. Syn-rift, early post-rift and late post-rift system tracts were identified. The syn-rift/post-rift unconformity is a result of combined eustatic sea level drop and the change in deformation intensity. The main low-angle detachment fault, orthogonal hanging wall transfer faults and related folds together controlled the complex synformal shape of the basin, which was related to major corrugations of the footwall detachment.
Four turbidite phases were distinguished based on upward increasing sand content, areal extent, reservoir quality, and degree of confinement as the turbidity currents reached the basin margins. (1) Small fans deflected by transfer faults developed, followed by (2) an axial turbidite system that reached an anticline and was deflected by it. (3) Lateral confinement by the anticline increased significantly and thick sandstone bodies with abrupt pinch-outs formed, while the influence of smaller faults diminished. (4) The axial turbidite systems covered the basin floor and their interaction with basin margins created continuous sand bodies of confined character. The sand fairways and types of confinement of a supra-detachment basin differ from high-angle normal fault systems. The exhumed metamorphic rocks provided the sediment, and the extension-parallel antiformal and synformal corrugations acted as lateral confinement. The gentle back-tilt of the detachment hanging wall block exerted a frontal confinement for the extensive turbidite system at the distal part of the basin, but the gentle NE-ward dip over the detachment still permitted long run-out distances.
•Combination of eustasy and tectonics leads to syn-rift-early post-rift unconformity.•Corrugation fold of a detachment creates an intricate topography for sediment flows.•Deformation activity decreases during deposition of early post-rift turbidites.•Lateral, frontal confinement of turbidity currents controls reservoirs quality.•Differences between sand fairways in high- and low-angle extensional systems.
The formation and deformation history of back-arc basins play a critical role in understanding the tectonics of plate interactions. Furthermore, opening of extensional back-arc basins during the ...overall convergence between Africa and Europe is a fundamental process in the overall tectonic evolution of the Mediterranean and adjacent areas. In this frame, Miocene tectonic evolution of the western Pannonian Basin of Central Europe and its connection to inherited Cretaceous structures of the Eastern Alpine nappes are presented.
Revision of published and addition of new structural and thermochronological data, as well as seismic profiles from the western Pannonian Basin is complemented by high-resolution thermo-mechanical numerical modeling in order to propose a new physically consistent tectono-sedimentary model for the basin evolution. The onset of extension is dated as ~25–23 Ma, and higher rates are inferred between 19 and 15 Ma at the south-western part of the area (Pohorje, Kozjak Domes, Murska Sobota Ridge, and Mura-Zala Basin). Rift initiation involved the exhumation of the middle part of the Austroalpine nappe pile along low-angle detachment faults and mylonite zones. The Miocene low-angle shear zones could reactivate major Cretaceous thrust boundaries, the exhumation channel of ultra-high-pressure rocks of the Pohorje Dome, or Late Cretaceous extensional structures. Miocene extension was associated with granodiorite and dacite intrusions between 18.64 and 15 Ma. The Pohorje pluton intruded at variable depth from ~4 to 16–18 km and experienced ductile stretching, westward tilting, and asymmetric exhumation of its eastern side. Terrestrial early Miocene (Ottnangian to Karpatian, 19–17.25 Ma) syn-rift depositional environment in supradetachment basins evolved to near-shore and bathyal one by the middle Miocene (Badenian, 15.97–12.8 Ma). Deformation subsequently migrated eastwards to the western part of the Transdanubian Range (Keszthely Hills) and to newly formed grabens. In this formerly emerged terrestrial area active faulting started at 15–14.5 Ma and continued through the late Miocene almost continuously up to ~8 Ma but basically terminated in the Mura-Zala Basin by ~15 Ma (early Badenian). These observations suggest a ~200 km shift of active faulting, basin formation, and related syn-tectonic sedimentation from the SW (Pohorje and Mura-Zala Basin) toward the Pannonian Basin center. Building on the above described observational and modeling data makes the Pannonian Basin an ideal natural laboratory for understanding the coupling between deep Earth and surface processes.
•Variable extensional structures characterize the western Pannonian Basin.•Exhumation of deeper crustal rocks along detachments occurred in the Miocene.•Depocenters and faulting shifted from basin margin toward basin center.•Thermomechanical modelling predicts depocenter migration within 12 Ma.•Miocene extensional structures reactivated and were bounded to inherited weakness zones.
Recently it was proposed that the redox status of cysteines acts as a redox switch to regulate both the oligomeric status and the activity of human dUTPase. In a separate report, a human dUTPase ...point mutation, resulting in a tyrosine to cysteine substitution (Y54C) was identified as the monogenic cause of a rare syndrome associated with diabetes and bone marrow failure. These issues prompt a critical investigation about the potential regulatory role of cysteines in the enzyme. Here we show on the one hand that independently of the redox status of wild-type cysteines, human dUTPase retains its characteristic trimeric assembly and its catalytic activity. On the other hand, the Y54C mutation did not compromise the substrate binding and the catalytic properties of the enzyme at room temperature. The thermal stability of the mutant protein was found to be decreased, which resulted in the loss of 67% of its activity after 90 min incubation at the physiological temperature in contrast to the wild-type enzyme. In addition, the presence or absence of reducing agents had no effect on hDUT
activity and stability, although it was confirmed that the introduced cysteine contains a solvent accessible thiol group.
Hippocampal pyramidal cells encode memory engrams, which guide adaptive behavior. Selection of engram-forming cells is regulated by somatostatin-positive dendrite-targeting interneurons, which ...inhibit pyramidal cells that are not required for memory formation. Here, we found that γ-aminobutyric acid (GABA)-releasing neurons of the mouse nucleus incertus (NI) selectively inhibit somatostatin-positive interneurons in the hippocampus, both monosynaptically and indirectly through the inhibition of their subcortical excitatory inputs. We demonstrated that NI GABAergic neurons receive monosynaptic inputs from brain areas processing important environmental information, and their hippocampal projections are strongly activated by salient environmental inputs in vivo. Optogenetic manipulations of NI GABAergic neurons can shift hippocampal network state and bidirectionally modify the strength of contextual fear memory formation. Our results indicate that brainstem NI GABAergic cells are essential for controlling contextual memories.
The basal forebrain cholinergic system is widely assumed to control cortical functions via non-synaptic transmission of a single neurotransmitter. Yet, we find that mouse hippocampal cholinergic ...terminals invariably establish GABAergic synapses, and their cholinergic vesicles dock at those synapses only. We demonstrate that these synapses do not co-release but co-transmit GABA and acetylcholine via different vesicles, whose release is triggered by distinct calcium channels. This co-transmission evokes composite postsynaptic potentials, which are mutually cross-regulated by presynaptic autoreceptors. Although postsynaptic cholinergic receptor distribution cannot be investigated, their response latencies suggest a focal, intra- and/or peri-synaptic localisation, while GABA
receptors are detected intra-synaptically. The GABAergic component alone effectively suppresses hippocampal sharp wave-ripples and epileptiform activity. Therefore, the differentially regulated GABAergic and cholinergic co-transmission suggests a hitherto unrecognised level of control over cortical states. This novel model of hippocampal cholinergic neurotransmission may lead to alternative pharmacotherapies after cholinergic deinnervation seen in neurodegenerative disorders.
Adverse events need to be quickly evaluated and memorized, yet how these processes are coordinated is poorly understood. We discovered a large population of excitatory neurons in mouse median raphe ...region (MRR) expressing vesicular glutamate transporter 2 (vGluT2) that received inputs from several negative experience-related brain centers, projected to the main aversion centers, and activated the septohippocampal system pivotal for learning of adverse events. These neurons were selectively activated by aversive but not rewarding stimuli. Their stimulation induced place aversion, aggression, depression-related anhedonia, and suppression of reward-seeking behavior and memory acquisition-promoting hippocampal theta oscillations. By contrast, their suppression impaired both contextual and cued fear memory formation. These results suggest that MRR vGluT2 neurons are crucial for the acquisition of negative experiences and may play a central role in depression-related mood disorders.
Abstract Parvalbumin (PV)-expressing GABAergic neurons of the basal forebrain (BFPVNs) were proposed to serve as a rapid and transient arousal system, yet their exact role in awake behaviors remains ...unclear. We performed bulk calcium measurements and electrophysiology with optogenetic tagging from the horizontal limb of the diagonal band of Broca (HDB) while male mice were performing an associative learning task. BFPVNs responded with a distinctive, phasic activation to punishment, but showed slower and delayed responses to reward and outcome-predicting stimuli. Optogenetic inhibition during punishment impaired the formation of cue-outcome associations, suggesting a causal role of BFPVNs in associative learning. BFPVNs received strong inputs from the hypothalamus, the septal complex and the median raphe region, while they synapsed on diverse cell types in key limbic structures, where they broadcasted information about aversive stimuli. We propose that the arousing effect of BFPVNs is recruited by aversive stimuli to serve crucial associative learning functions.
Aortic dissection is a life threatening cardiovascular catastrophy. Its incidence estimated to 5-6 cases per 100,000 patients/year. The intimal tear happens at the ascending aorta in Type A, ...meanwhile at the aortic isthmus in Type B, but entry point may develop anywhere alongside the entire aorta. All types may affect a short aortic segment resulting in a localized false aneurysm, others separate the intimal layer at longer extension down to the visceral segment and far beyond to the femoral arteries. Dissection of orifices of side branches may lead to cerebral, upper extremity, spinal, visceral, renal and lower extremity malperfusion. These complications beyond the aortic rupture contribute significantly to high mortality of dissection. Today, first line treatment option in Type A dissection is surgery, but it can be endovascular or medical in Type B dissection. However, awareness of surgical procedures in this field remains inevitable. In this paper we summarize the surgical options for distal malperfusion affecting spinal, visceral, renal and lower extremity circulation.
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