We report the discovery of a microlensing planet-MOA-2016-BLG-227Lb-with a large planet/host mass ratio of q 9 × 10−3. This event was located near the K2 Campaign 9 field that was observed by a large ...number of telescopes. As a result, the event was in the microlensing survey area of a number of these telescopes, and this enabled good coverage of the planetary light-curve signal. High angular resolution adaptive optics images from the Keck telescope reveal excess flux at the position of the source above the flux of the source star, as indicated by the light-curve model. This excess flux could be due to the lens star, but it could also be due to a companion to the source or lens star, or even an unrelated star. We consider all these possibilities in a Bayesian analysis in the context of a standard Galactic model. Our analysis indicates that it is unlikely that a large fraction of the excess flux comes from the lens, unless solar-type stars are much more likely to host planets of this mass ratio than lower mass stars. We recommend that a method similar to the one developed in this paper be used for other events with high angular resolution follow-up observations when the follow-up observations are insufficient to measure the lens-source relative proper motion.
ABSTRACT We report the discovery of a microlensing planet OGLE-2012-BLG-0950Lb with a planet/host mass ratio of . A long term distortion detected in both MOA and OGLE light curve can be explained by ...the microlens parallax due to the Earth's orbital motion around the Sun. Although the finite source effect is not detected, we obtain the lens flux by the high resolution Keck AO observation. Combining the microlens parallax and the lens flux reveal the nature of the lens: a planet with mass of is orbiting around an M-dwarf with mass of with a planet-host projected separation of au located at kpc from us. This is the first mass measurement from only microlens parallax and the lens flux without the finite source effect. In the coming space observation-era with Spitzer, K2, Euclid, and WFIRST, we expect many such events for which we will not be able to measure any finite source effect. This work demonstrates an ability of mass measurements in such events.
We present the analysis of four candidate short-duration binary microlensing events from the 2006-2007 MOA Project short-event analysis. Three of these events are determined to be microlensing ...events, while the fourth is most likely caused by stellar variability. One of these events, MOA-bin-1, is due to a planet, and it is the first example of a planetary event in which the stellar host is only detected through binary microlensing effects. This is one of the most massive and widest separation planets found by microlensing. The scarcity of such wide-separation planets also has implications for interpretation of the isolated planetary mass objects found by this analysis. In particular, if the entire isolated planet sample found by Sumi et al. consists of planets bound in wide orbits around stars, we find that it is likely that the median orbital semimajor axis is <30 AU.
Although tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of chronic myeloid leukemia (CML), the ability of TKIs to eradicate CML remains uncertain and patients must ...continue TKI therapy for indefinite periods. In this study, we performed whole-exome sequencing to identify somatic mutations in 24 patients with newly diagnosed chronic phase CML who were registered in the JALSG CML212 study. We identified 191 somatic mutations other than the BCR-ABL1 fusion gene (median 8, range 1-17). Age, hemoglobin concentration and white blood cell counts were correlated with the number of mutations. Patients with mutations ⩾6 showed higher rate of achieving major molecular response than those<6 (P=0.0381). Mutations in epigenetic regulator, ASXL1, TET2, TET3, KDM1A and MSH6 were found in 25% of patients. TET2 or TET3, AKT1 and RUNX1 were mutated in one patient each. ASXL1 was mutated within exon 12 in three cases. Mutated genes were significantly enriched with cell signaling and cell division pathways. Furthermore, DNA copy number analysis showed that 2 of 24 patients had uniparental disomy of chromosome 1p or 3q, which disappeared major molecular response was achieved. These mutations may play significant roles in CML pathogenesis in addition to the strong driver mutation BCR-ABL1.
The contamination of hazardous metal(loid) is one of the serious environmental and human health risks. This study isolated a total of 40 cadmium (Cd)- and arsenic (As)-resistant bacterial isolates ...from coastal sediments by pour plate technique using tryptic soy agar supplemented with Cd or As (50 mg l⁻¹) for use as metal(loid) bioremediation agents. Out of 40, 4 isolates, RCd3, RCd6, RAs7, and RAs10, showed a relatively higher growth rate in Cd- or As-supplemented culture media which were selected for further study. The selected isolates showed a high minimum inhibitory concentration (60–400 mg l⁻¹for Cd and 400–2200 mg l⁻¹for As), which demonstrated their remarkable Cd and As resistance capabilities. The metal(loid) removal efficiencies (0.032–0.268 μg Cd h⁻¹ mg⁻¹and 0.0003–0.0172 μg As h⁻¹ mg⁻¹wet weight cell) of selected isolates indicated their greater magnitude in absorbing Cd compared to As from water. Phylogenetic analysis of the 16S rDNA sequences revealed that isolates RCd3, RCd6, RAs7, and RAs10 were closely related to Acinetobacter brisouii, Pseudomonas abietaniphila, Exiguobacterium aestuarii, and Planococcus rifietoensis, respectively. Because of high Cd and As resistance and removal efficiency, the selected isolates can survive in a high metal(loid)-contaminated environment and could be a potential tool for bioremediation of high metal(loid)-contaminated effluents to protect the aquatic environment.
We report the detection of an extrasolar planet of mass ratio image in microlensing event MOA-2007-BLG-192. The best-fit microlensing model shows both the microlensing parallax and finite source ...effects, and these can be combined to obtain the lens masses of image for the primary and image for the planet. However, the observational coverage of the planetary deviation is sparse and incomplete, and the radius of the source was estimated without the benefit of a source star color measurement. As a result, the 2 capital sigma limits on the mass ratio and finite source measurements are weak. Nevertheless, the microlensing parallax signal clearly favors a substellar mass planetary host, and the measurement of finite source effects in the light curve supports this conclusion. Adaptive optics images taken with the Very Large Telescope (VLT) NACO instrument are consistent with a lens star that is either a brown dwarf or a star at the bottom of the main sequence. Follow-up VLT and/or Hubble Space Telescope (HST) observations will either confirm that the primary is a brown dwarf or detect the low-mass lens star and enable a precise determination of its mass. In either case, the lens star, MOA-2007-BLG-192L, is the lowest mass primary known to have a companion with a planetary mass ratio, and the planet, MOA-2007-BLG-192Lb, is probably the lowest mass exoplanet found to date, aside from the lowest mass pulsar planet.
The purpose of the present study was to isolate and identify the metal-resistant lactic acid bacteria from sediments of coastal aquaculture habitats for removal of cadmium and lead from ambience. ...Collected sediment samples were used to isolate the cadmium- and lead-resistant bacterial colonies by spread plate technique using agar media (De Man, Rogosa and Sharpe) supplemented with cadmium or lead at 50 mg/l. Isolates were identified by bacterial colony polymerase chain reaction and sequencing of 16S ribosomal deoxyribonucleic acid. Metal removing probiotic was determined by characterizing the lactic acid yield in culture media, viability in fish intestine, metal-resistant and metal-removal efficiencies. 16S ribosomal deoxyribonucleic acid sequencing data of five (Cd10, Cd11, Pb9, Pb12 and Pb18) and other all isolates clearly showed 99 % similarities to
Enterococcus faecium
and
Bacillus cereus,
respectively. The Pb12 exhibited higher lactic acid yield (180 mmol) than that of the remaining
E. faecium
strains and excellent viability without pathogenicity; therefore, further study was carried out using Pb12 strain. The selected Pb12 strain showed elevated metal resistant (minimum inhibitory concentrations 120 and 800 mg/l for cadmium and lead, respectively) and removal efficiencies Cadmium 0.0377 mg/h/g and lead 0.0460 mg/h/g of cells (wet weight). From the viability and metal removal points of view, it can be concluded that isolated metal-resistant
E. faecium
Pb12 strains might be used as potential probiotic strains for removing heavy metals from fish intestinal milieu to control the progressive bioaccumulation of heavy metals in the fish.
Bilateral teleoperation has been needed in many areas, such as space activities, work on an atomic power plant, minimally invasive surgery, etc. In bilateral teleoperation, transfer of keen tactile ...sense, which is as if the operator directly touches the environment, is required. Sensing of wide-frequency-bandwidth force information is required in achieving the transferring of a keen tactile sensation. A bilateral controller based on acceleration control with disturbance observers is available to achieve transfer of a keen tactile sensation. In this bilateral controller, the frequency bandwidth of sensed force is determined by the cutoff frequency of a low-pass filter used in the disturbance observer. The cutoff frequency is in inverse proportion to a sampling period. Therefore, shortening of the sampling period improves performance of bilateral teleoperation. In this paper, a bilateral-teleoperation system using a field-programmable gate array (FPGA) is introduced. The FPGA is an large scale integration where a user can design its internal logic. When the motion controller is implemented on an FPGA, it operates faster than that implemented in a personal computer with a real-time operating system. The sampling period is shortened from 100 to 10 mus by using an FPGA. The implemented controller is evaluated by experiments.
Angelica keiskei Koidzumi (Ashitaba) is a large perennial herb that is native to the Pacific coast of Japan, and it has recently become popular as herbal medicine, dietary supplement and health food ...in Asian countries. The structures of various constituents isolated from Ashitaba
such as chalcones, flavanones and coumarins have been precisely characterized, and many of them have bioactivities. A recent study clarified that Angelica keiskei exerts actions that lead to the prevention of thrombosis. Here, we introduce the possibility that ingesting Ashitaba could
help to prevent thrombotic diseases.
We report on the discovery and analysis of the short-timescale binary-lens microlensing event, MOA-2015-BLG-337. The lens system could be a planetary system with a very low-mass host, around the ...brown dwarf (BD)/planetary-mass boundary, or a BD binary. We found two competing models that explain the observed light curves with companion/host mass ratios of q ∼ 0.01 and ∼0.17, respectively. A significant finite source effect in the best-fit planetary model (q ∼ 0.01) reveals a small angular Einstein radius of θE 0.03 mas, which favors a low-mass lens. We obtain the posterior probability distribution of the lens properties from a Bayesian analysis. The results for the planetary models strongly depend on a power-law index in planetary-mass regime, pl, in the assumed mass function. In summary, there are two solutions of the lens system: (1) a BD/planetary-mass boundary object orbited by a super-Neptune (the planetary model with pl = 0.49) and (2) a BD binary (the binary model). If the planetary models are correct, this system can be one of a new class of planetary system, having a low host mass and also a planetary-mass ratio (q < 0.03) between the companion and its host. The discovery of the event is important for the study of planetary formation in very low-mass objects. In addition, it is important to consider all viable solutions in these kinds of ambiguous events in order for the future comprehensive statistical analyses of planetary/binary microlensing events.
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