This paper provides details about modeling tools being developed under the Defense Advanced Research Projects Agency's (DARPA) knowledge-based sensor signal processing and expert reasoning (KASSPER) ...program to efficiently predict the performance of GMTS sensors operating in real-world environments. Specifically this paper addresses model to compute losses due to targets corrupting the training data (W.L. Melvin and J.R. Guerci, May 2001) (J.S. Bergin et al., April 2002) for airborne radars that employ space-time adaptive processing (STAP) (J. Ward, December 1994). The modeling tools can be used to predict losses in a computationally efficient manner and therefore allow analysis of GMTI performance for realistic simulation scenarios that span very long time periods.
We have developed techniques to read DVD-RAM discs with DVD-ROM drives. The key techniques are the reduction of feedthrough in the focusing error signal, the reduction of the push-pull signal offset, ...and the half tracking jump function.
We describe the molecular components, subunit assembly, and cell surface expression of mu-chain complexes in mu+kappa- pre-B
cell lines as revealed by two-dimensional gel electrophoresis. The ...mu-chain complexes of these cell lines contain several
previously unreported components, p42(6.4), p39(6.7), p18(8.6), and p14(7.0), in addition to lambda 5, VpreB1, VpreB3 (formerly
named 8HS20), MB-1(Ig-alpha), and B29(Ig-beta). These new components are not detected in mu+kappa+ immature B cell lines.
The mu-chain associates with lambda 5, VpreB3, and p56(5.0) at an early phase of assembly, preceding the association of other
molecules. mu-Associated VpreB3 decreased during assembly as the association of VpreB1 became dominant, suggesting that the
change in the ratio of these two VL-like surrogate light chains is involved in the mechanism of assembly. Lambda 5, VpreB1,
p56(5.0), p32(5.0), p36(5.5), and p14(7.0) were shown to be expressed on the cell surface in association with mu-chain. The
association of the other molecules with mu-chain is most likely restricted to the intracellular compartment. An interaction
between VpreB1 and VpreB3 was also suggested. These findings might be important for understanding the function of mu-chain
complexes in pre-B cells. A possible signaling mechanism of mu/surrogate light chain complexes is discussed.
We detected a high level of CD4+CD8+ double marker cells in the peripheral blood of a male patient with pulmonary tuberculosis (TB), ranging from 10% to 12%. Three color staining was useful for the ...further examination of surface markers of these abnormal lymphocytes. Three color staining of his CD4+CD8+ cells demonstrated that his CD4+CD8+ cells expressed CD2, CD3 and TCR alpha beta. Stimulation of his PBMC with OKT3 (or rIL-2) for 4 days resulted in the increase of up to about 50% (20%) of CD4+CD8+ cells. His PBMC had a normal proliferative response to mitogen. Although we could not evaluate the significance of the presence of an expanded CD4+CD8+ cells, it was not correlate with the disease of TB or the activity of the disease at least.
To determine the effects of the space environment on gene instability from the point of view of human health for long-term stays in space, we have studied the formation of DNA strand breaks and the ...induction of gene expression in mammalian cells. We previously measured DNA damage in human cultured cells and the accumulation of a tumor suppressor gene product, p53, in muscle and skin of rats after space flight, and the relative importance of microgravity and space radiation in causing these effects remains to be clarified. Our results suggest that the p53 pathway may play a role in safeguarding genomic stability against the stressful space environment. We review here the present knowledge on cellular stress signaling and present our space experimental data. The importance of the stress response to the space environment is also discussed.
The features on computed tomographic (CT) scans of nonalcoholic fatty liver were investigated in 24 patients with nonalcoholic fatty liver related to overweight. CT examinations were performed before ...and after 3 months of a low-calorie diet. The reversibility of fatty infiltration during diet therapy could be monitored by changes in appearance on repeated CT scans. Hepatic steatosis improved, as assessed from increases in attenuation values on CT scans after 3 months of the diet, and the improvement was accompanied by a decrease in the elevated serum glutamic-pyruvic transaminase activity. Hepatic fatty infiltration in these patients was not always uniform, and attenuation values in the right lobe of the liver were significantly lower than those in the left lobe. After the 3-month diet therapy, the mean liver volume was significantly reduced, while the spleen volume was unchanged. Two sequential CT examinations, performed before and after diet therapy, may be useful for evaluating obese patients with elevated serum transaminase activity.
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