Objectives
To determine whether metabolic phenotype is associated with the change in carotid intima-media thickness (CIMT) in patients undergoing bariatric /metabolic surgery (BMS).
Methods
We ...performed a case-control study of BMS candidates who had metabolically unhealthy obesity (MUO) or metabolically healthy obesity (MHO). We measured the change in CIMT during the 9 months following BMS. The plasma tumor necrosis factor-α, interleukin-1β, adiponectin, leptin, nitric oxide (NO), vascular endothelial growth factor A (VEGF-A), and malondialdehyde concentrations were determined, adipocyte area was measured histologically, and adipose tissue area was estimated using computed tomography.
Results
Fifty-six patients (mean age 44.5 years, mean body mass index 44.9 kg/m2, 53% women, and 53% had MUO) were studied. Nine months following BMS, the MUO phenotype was not associated with a significant reduction in CIMT, and that of the MHO group was larger. In addition, fewer participants achieved a 10% reduction in CIMT in the MUO group. A CIMT reduction was associated with lower VEGF-A and NO in the MUO group, while that in the MHO group was associated with a higher NO concentration.
Conclusion
The metabolic phenotype of patients may influence their change in CIMT following BMS, probably through circulating vasodilatory and pro-inflammatory molecules.
•Nanocrystalline Li2SiO3 powders were synthesized via microwave-assisted hydrothermal method.•Pure Li2SiO3 phase was obtained using short reaction time at low temperature.•Li2SiO3 particles exhibited ...hollow sphere morphologies and high specific surface area.•Water vapor and CO2 capture properties were evaluated by thermogravimetric analysis.•Exhibited properties suggested potential applications of Li2SiO3 as catalyst and CO2 sorbents.
A series of lithium metasilicate (Li2SiO3) powder materials has been successfully synthesized by the microwave-assisted hydrothermal route using lithium hydroxide and tetraethyl-orthosilicate-derived sol precursors. Ceramic powders were obtained under hydrothermal conditions of autogenous pressure in the presence of a nonionic surfactant. The production of pure and well-crystallized Li2SiO3 using very short reaction times at low temperatures was shown by X-ray diffraction, scanning electron microscopy, and N2 adsorption-desorption analyses. Synthesized Li2SiO3 particles were nanocrystalline and exhibited different morphologies and specific surface areas depending on the synthesis conditions. Additionally, the capability of selected Li2SiO3 samples to absorb H2O and CO2 was evaluated via thermogravimetric analyses by varying the temperature, carrier gas, and water vapor concentration. Li2SiO3 particles exhibited interesting textural and morphological characteristics that make them suitable for use as a CO2 absorbent and which suggest that they also have the potential to be used in other applications.
The wide scale and severity of consequences of tobacco use, benefits derived from cessation, low rates of intervention by healthcare professionals, and new opportunities stemming from novel ...communications technologies are the main factors motivating this project. Thus, the purpose of this study is to assess the effectiveness of an intervention that helps people cease smoking and increase their nicotine abstinence rates in the long term via a chat-bot, compared to usual practice, utilizing a chemical validation at 6 months.
Design: Randomized, controlled, multicentric, pragmatic clinical trial, with a 6-month follow-up.
Healthcare centers in the public healthcare system of the Community of Madrid (Madrid Regional Health Service).
Smokers > 18 years of age who attend a healthcare center and accept help to quit smoking in the following month. N = 460 smokers (230 per arm) who will be recruited prior to randomization. Intervention group: use of a chat-bot with evidence-based contents to help quit smoking.
Usual treatment (according to the protocol for tobacco cessation by the Madrid Regional Health Service Main variable: Continuous nicotine withdrawal with chemical validation (carbon monoxide in exhaled air). Intention-to-treat analysis. Difference between groups in continuous abstinence rates at 6 months with their corresponding 95% confidence interval. A logistic regression model will be built to adjust for confounding factors.
First expected results in January 2020.
Providing science-based evidence on the effectiveness of clinical interventions via information technologies, without the physical presence of a professional, is essential. In addition to being more efficient, the characteristics of these interventions can improve effectiveness, accessibility, and adherence to treatment. From an ethics perspective, this new type of intervention must be backed by scientific evidence to circumvent pressures from the market or particular interests, improve patient safety, and follow the standards of correct practices for clinical interventions.
ClinicalTrials.gov, reference number NCT03445507.
Objectives
The prevalence of obesity has dramatically increased in many countries and it is particularly high in patients with bipolar disorder (BD). A region in the first intron of the fat mass‐ and ...obesity‐associated (FTO) gene, encompassing markers rs9939973, rs8050136, and rs9939609, has been consistently associated with obesity and body mass index (BMI) in different populations. We sought to determine whether FTO is associated with BMI and/or obesity in patients with BD.
Methods
The sample included 129 Mexican Mestizo patients with bipolar I or bipolar II disorder. After obtaining informed consent, participants were evaluated with the Structured Clinical Interview for DSM‐IV Axis I Disorders and weight, height, and body measurements were recorded. DNA was extracted from a 5‐mL blood sample and real‐time polymerase chain reaction was performed. The results were analyzed with Haploview v4.2 and SPSS v21.
Results
Differences in mean BMI were explained by rs8050136 and rs9939609 genotypes, especially by comparing non‐carriers and carriers of two copies of the risk allele (Tukey's p ≤ 0.019), with a mean difference in BMI as high as 7.81 kg/m2. Differences in BMI were also explained by the interaction of the genotype (rs8050136 and/or rs9939609), the use of second‐generation antipsychotics, and the use of mood stabilizers (p ≤ 0.41). Obesity was also associated with these two markers when patients with and without obesity were compared.
Conclusions
In patients with BD, differences in BMI may be affected by the presence of FTO risk alleles, especially in homozygous individuals for these variants. Besides evaluating the possible metabolic effects of certain antipsychotics or mood stabilizers, it is important to evaluate the role of other factors such as FTO risk alleles.
Fluorine-doped ZnO (FZO) thin films were deposited onto glass by the spray pyrolysis process, using zinc acetate and NH
4F as precursors. The role of F/Zn atomic ratio, in the starting solution, and ...the substrate temperature were investigated and the optimum deposition conditions have been outlined. The X-ray diffraction analyses of the films show that there is incorporation of F atoms in the film. The FZO films are of polycrystalline nature with a preferential growth along (0
0
2) plane parallel to the surface of the substrate for temperatures higher than 400°C. It is observed that fluorine incorporation in the films affects the grain size, which decreases as the F/Zn atomic ratio increases, for the same substrate temperature. The films are uniform and exhibit an optical transmittance above 85% in the visible region. A critical substrate temperature (425°C) was observed at which the films show an n-type electrical dark conductivity as high as 9
(Ω
cm)
−1 when using a solution flow rate of 16
ml/min and a gas flow rate of 10
l/min.
Results After the stimulation with TLR ligands, the expression of CCR2 and CXCR4 on monocytes decreased whereas the expression of CCR4, CCR5 and CXCR3 on monocytes and CXCR3 on lymphocytes increased. ...Since peripheral blood cell cultures with TLR ligands induced the production of TNF-alpha and IL-10, we analyzed whether the observed chemokine receptor modulation was the result of the direct binding of TLR ligands or the produced pro- and anti-inflammatory mediators.
This work focuses on determining the main flavonoids with medicinal effects present in the wild ojo de gallo plant endemic to the State of Guanajuato in Mexico. For this purpose, the concentration of ...kaempferol, catechin, and rutin was determined in the wild ojo de gallo grass collected from three different sites in the state of Guanajuato (Comedero Grande, Ex – Hacienda de Márquez, and Tejamanil). The dehydration process of the plant was carried out later to determine the concentration of the metabolites of interest using the high-performance liquid chromatography (HPLC) technique. A statistical analysis was carried out to determine the relationship between the concentration of each metabolite and the various collection sites, also considering the results of the fertility analysis. The results show that the highest concentration for kaempferol was obtained in Ex – Hacienda de Márquez with a value of 24.15 ppm, while for catechin and rutin, it was in Tejamanil reporting values of 26.52 ppm and 46.98 ppm, respectively. The statistical analysis shows no significant difference between Ex -Hacienda de Márquez and Tejamanil for the three metabolites. These results indicate that the site called Comedero Grande favors the presence of kaempferol and rutin while the site called Tejamanil favors the presence of catechin; this opens the possibility of future studies that allow finding the appropriate conditions to maximize the flavonoids of interest in this plant.
The objective was to determine the effect of diet on live weight (LW) and egg weight (EW) of backyard hens (BH) during the rainy season in the Bajío region of the state of Michoacán, Mexico. ...Seventeen municipalities were sampled, where 101 BH (six hens/municipality) were captured and weighed and 101 eggs (six eggs/municipality) were harvested and weighed. The crops of the captured hens were removed Post-sacrifice, the organic content/crop (OCC) was classified and weighed by components, to later perform chemical compositional analysis. Data were analysed using generalised linear models and the differences between municipalities were obtained by the method of least squares means. The weight of the OCC (36.4 ± 22.4 g) was affected by the municipality (P<0.001), but not by the LW of the BH (P>0.05). Commercial feed (8.1 ± 6.0 g), grains: maize and sorghum (13.9 ± 13.5 g) kitchen waste (1.5 ± 2.9 g), herbaceous (0.6 ± 0.9 g) and insects (0.3 ± 0.7 g) were found in the crop. According to the commercial feed (COF) component, two feeding systems (FS) were identified: traditional FS, without COF and nontraditional FS, with COF. The diets of both FS were similar (P>0.05) in nutritional composition and do not meet the nutritional requirements of the hens. The LW (1.567 ± 0.316 kg) and EW (51.3 ± 1.0 g) of the BH cannot be completely attributed to the diet consumed during the rainy season.
PDF
