Provider: - Institution: Gredos. Repositorio Documental de la Universidad de Salamanca - Data provided by Europeana Collections- ES Within the scope of European policies and to combat educational ...disadvantages for migrant children, numerous actions have been taken to improve the position of migrant children in education. In secondary education the emphasis lies on diversification of the offered teaching methods and extra guidance of the pupils. Some schools in Europe have set up measures to increase the continuity of the educational support in terms of migrant pupil inclusion and orientation. Despite these measures, dropout rates are still high among migrant youth and compared to their native peers a disproportionately large number attend the lowest levels of secondary school after completing primary school. The disappointing results of regular guidance are partly the reason for the development of more innovative forms of guidance. The project aims to promote strategies and methods that help students with a migrant background at risk of ESL to maintain their motivation through the development, testing and validation of an Intercultural Mentoring Programme based on the empowered peer education methodology.The Intercultural mentor profile will be adapted to different European contexts, developed in collaboration with at least 100 school staff members (headmaster and secondary school teachers from 5 different European countries) and tested with at least 50 students with a migrant background trained as Intercultural Mentors. The impact of the project will be sustained thanks to its outcomes: (i) Didactic Kit: conceived as self-teaching materials will contain the training framework to directly implement the model of intervention in secondary schools system; (ii) Guideline Handbook: support the future implementation of training courses – by other education organizations and secondary school, (iii) Project website: it will include not only the results and materials of the project (handbooks, e-learning platform, reports, etc.) but will also include updated information on young migrants.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
La voie du mévalonate (MVA) est impliquée dans la régulation de la proliférationcellulaire. Nous avons étudié l'effet de divers composés agissant au niveau de différentes réactions enzymatiques de la ...voie du MVA, sur la proliférationde cellules musculaireslisses (CML) aortiques de Rat. Dans la gamme des concentrationscomprises entre 0,1 μM et 10 μM, nous avons observé une inhibition dose-dépendante de la proliférationdes CML par des composés inhibiteurs compétitifs de la 3-hydroxy-3-méthylglutaryl coenzyme A réductase, avec un maximum d'environ 90 %. Cet effet fut réversé par le MVA à 100 μM, all-trans farnésol (F-OH) à 10 μM et all-trans géranylgéraniol (GG-OH) à 5 μM — précurseurs de groupes prényls des protéines — mais non par le 2-cis géranylgéraniol — précurseurde dolichols — le squalène et l'ubiquinone. Le même effet inhibiteur de la proliférationcellulaire fut induit par un inhibiteur de la MVA PP décarboxylase, le 6-fluoromévalonate, aux concentrations de 1 à 50 μM. Dans ce cas, une restaurationpartielle de la proliférationcellulaire a pu être obtenue par le all-trans F-OH et le all-trans GG-OH, mais non par le MVA. Utilisant la squalestatine 1, puissant inhibiteur de la squalène synthase, nous avons observé une inhibition totale de la synthèse du cholestérol ainsi qu'une légère diminution (21 %) de la proliférationdes CML à la concentrationla plus forte seulement de la gamme étudiée, de 1 à 25 μM. En revanche, le NB-598 (1-10 μM), puissant inhibiteur de la squalèneépoxidase, a provoqué une inhibition totale de la synthèse de cholestérol sans aucune modification sur la prolifération des CML. Enfin, la benzodiazépine peptidomimétique BZA-5B (10-100 μM), inhibiteur spécifique de la protéine-farnésyltransférase (PFTase), a induit une diminution de la prolifération des CML, atteignant jusqu'à 62 % après 9 jours de traitement. Cet effet est dose-dépendant et augmente en fonction du temps de traitement. II est inhibé par le MVA et le all-trans GG-OH mais non par le all-trans F-OH. Le BZA-7B, composé similaire au BZA-5B ne possédant pas d'activité inhibitrice de la PFTase, fut sans effet sur la proliférationdes CML. L'ensemble de ces résultats souligne le rôle de la voie du MVA dans la prolifération cellulaire et suggère que les métabolites spécifiques isoprénoïdes sont impliqués dans le contrôle de ces processus prolifératifs, probablement par l'intermédiaire de protéines farnésylées et géranylgéranylées.
The role of mevalonic acid (MVA) and its products (isoprenoids) in cell proliferation prompted us to investigate the effect of drugs affecting diverse enzymatic steps of the MVA pathway on rat aorta smooth muscle cell (SMC) proliferation. Competitive inhibitors of HMGCoA reductase (statins) decreased SMC proliferation in a dose-dependent manner. The inhibitory effect induced by simvastatin 3.5 μM (70 % ± 3.8 decrease) was prevented by addition of 100 μM MVA, (100 % ± 2.3), 10 μM farnesol (F-OH) (85 % ± 1.2) and 5 μM of all-trans geranylgeraniol (GG-OH) (precursor of prenylated proteins) (81 % ± 1.1), but not by 2-cis GG-OH (precursor of dolichols), squalene and ubiquinone. The same inhibitory effect was obtained with 6-fluoromevalonate (1-50 μM), an inhibitor of MVA-PP decarboxylase. Squalestatin 1 (1-25 μM) and NB-598 (1-10 μM), potent squalene synthase and epoxidase inhibitors, respectively, caused a complete inhibition of cholesterol synthesis without affecting SMC proliferation. Finally, BZA-5B (10-50 μM) a specific inhibitor of protein farnesyl tranferase (PFTase), inhibited SMC proliferation in a dose- (10-50 μM) and time-dependent manner, reaching 52 % ± 6.3 inhibition after 9 days, in the presence of 50 μM BZA-5B, without affecting cholesterol synthesis. This effect was partially prevented by mevalonate (76 % ± 3.2) and GG-OH (87 % ± 7.3) but not by FOH. On the other hand, SMC proliferationwas not affected by the closely related compound BZA-7B (93 % ± 4), wich does not inhibit PFTase. Taken together, these findings support the involvement of specific isoprenoid metabolites,probably through farnesylatedand geranylgeranylated proteins in cell proliferation.
Santa Maria del Carmine Paoletti? (Fotograf) (Aufnahme); Lorenzo da Bologna (Architekt) (Herstellung); Biagio Bigoio (Architekt) (Herstellung)
1968 (Zugangsdatum) (Aufnahme)
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