The positron-emitting radionuclide gallium-68 has become increasingly utilised in both preclinical and clinical settings with positron emission tomography (PET). The synthesis of radiochemically pure ...gallium-68 radiopharmaceuticals relies on careful consideration of the coordination chemistry. The short half-life of 68 min necessitates rapid quantitative radiolabelling (≤10 min). Desirable radiolabelling conditions include near-neutral pH, ambient temperatures, and low chelator concentrations to achieve the desired apparent molar activity. This review presents a broad overview of the requirements of an efficient bifunctional chelator in relation to the aqueous coordination chemistry of gallium. Developments in bifunctional chelator design and application are then presented and grouped according to eight categories of bifunctional chelator: the macrocyclic chelators DOTA and TACN; the acyclic HBED, pyridinecarboxylates, siderophores, tris(hydroxypyridinones), and DTPA; and the mesocyclic diazepines.
The first-order Fermi acceleration of electrons requires an injection of electrons into a mildly relativistic energy range. However, the mechanism of injection has remained a puzzle both in theory ...and observation. We present direct evidence for a novel stochastic shock drift acceleration theory for the injection obtained with Magnetospheric Multiscale observations at the Earth's bow shock. The theoretical model can explain electron acceleration to mildly relativistic energies at high-speed astrophysical shocks, which may provide a solution to the long-standing issue of electron injection.
The role and properties of lower hybrid waves in the ion diffusion region and magnetospheric inflow region of asymmetric reconnection are investigated using the Magnetospheric Multiscale (MMS) ...mission. Two distinct groups of lower hybrid waves are observed in the ion diffusion region and magnetospheric inflow region, which have distinct properties and propagate in opposite directions along the magnetopause. One group develops near the ion edge in the magnetospheric inflow, where magnetosheath ions enter the magnetosphere through the finite gyroradius effect and are driven by the ion‐ion cross‐field instability due to the interaction between the magnetosheath ions and cold magnetospheric ions. This leads to heating of the cold magnetospheric ions. The second group develops at the sharpest density gradient, where the Hall electric field is observed and is driven by the lower hybrid drift instability. These drift waves produce cross‐field particle diffusion, enabling magnetosheath electrons to enter the magnetospheric inflow region thereby broadening the density gradient in the ion diffusion region.
Key Points
Two groups of lower hybrid waves are observed in the ion diffusion and magnetospheric inflow regions
In the magnetospheric inflow region lower hybrid waves develop when cold magnetospheric ions are present and can heat cold ions
In the diffusion region lower hybrid waves develop at the density gradient and can cause cross‐field particle diffusion
Studies of solar wind turbulence traditionally employ high-resolution magnetic field data, but high-resolution measurements of ion and electron moments have been possible only recently. We report the ...first turbulence studies of ion and electron velocity moments accumulated in pristine solar wind by the Fast Plasma Investigation (FPI) instrument on board the Magnetospheric Multiscale Mission. Use of these data is made possible by a novel implementation of a frequency domain Hampel filter, described herein. After presenting procedures for processing of the data, we discuss statistical properties of solar wind turbulence extending into the kinetic range. Magnetic field fluctuations dominate electron and ion-velocity fluctuation spectra throughout the energy-containing and inertial ranges. However, a multispacecraft analysis indicates that at scales shorter than the ion inertial length, electron velocity fluctuations become larger than ion-velocity and magnetic field fluctuations. The kurtosis of ion-velocity peaks around a few ion inertial lengths and returns to a near Gaussian value at sub-ion scales.
In 1995, the Galileo spacecraft traversed the wake of Io at ∼900 km altitude. The instruments onboard detected intense bi‐directional field‐aligned electron beams (∼140 eV–150 keV), embedded in a ...dense, cold and slow plasma wake (Nel ∼ 35,000 cm−3, Ti < 10 eV, V < 3 km/s). Similar electron beams were also detected along subsequent Galileo flybys. Using numerical simulations, we show that these electron beams are responsible for the formation of Io's dense plasma wake. We prescribe the composition of Io's atmosphere in S, O, SO and SO2, compute the atmospheric ionization by the beams with a parameterization adapted from study of auroral electrons at Earth, the plasma flow into Io's atmosphere with a Magneto‐Hydro‐Dynamic code, and the ion composition and temperature with a multi‐species physical chemistry code. Results reveal contrasting chemistries between the upstream and wake regions, leading to different ion compositions. The upstream chemistry is driven by the torus thermal electrons at 5 eV with SO2+ becoming the dominant ion because of electron‐impact ionization of the SO2 atmosphere. The wake chemistry is driven by the high‐energy electrons in the beams with S+ and SO+ becoming the dominant ions produced by dissociative‐ionization of SO2. We show that the wake ion composition is highly sensitive to the atmospheric composition. Juno, in its extended mission, will traverse Io's wake and determine its ion composition, which, compared with our numerical simulations will enable us to infer the detailed composition of the atmosphere.
Plain Language Summary
Io, the inner‐most Galilean moon of Jupiter, is the most active volcanic body of the solar system. It has a tenuous atmosphere ultimately supplied by volcanic activity. The atmosphere is mainly composed of sulfur dioxide, oxygen, sulfur and sulfur monoxide, but its detailed composition, density and spatial distribution are still surprisingly poorly known. Between 1995 and 2001, the Galileo spacecraft made five close flybys of Io. The onboard instruments detected intense high‐energy electrons moving along Jupiter's magnetic field lines embedded in a remarkably dense ion wake (∼10 times denser than the surrounding plasma). Identifying the processes that generate this dense wake remains an outstanding issue. We utilize numerical simulations to demonstrate that the production of the dense ion wake is attributed to efficient ionization of Io's atmosphere by the electron beams. Our simulations reveal that the ion composition of the wake is highly sensitive to the atmospheric composition. The Juno spacecraft, currently in orbit around Jupiter, will conduct several flybys in Io's wake in 2023 and 2024 and determine its ion composition. Similar electron beams are likely present near other moons of Jupiter. Such beams have already been detected during a single flyby of Europa by the Juno probe. The Jupiter Icy Moon Explorer spacecraft is presently en route to Ganymede and Callisto, while the future Europa Clipper mission is scheduled to be launched to Europa in 2024. These missions will have the capacity to detect the presence of electron beams and plasma wakes similar to those observed at Io. Our numerical model serves as an effective tool for inferring the atmospheric composition and density of these moons as it predicts the ion composition and density of the wake based on the energy of the electron beams.
Key Points
The Galileo spacecraft detected a dense and cold plasma wake downstream of Io and intense field‐aligned high‐energy electron beams
Using numerical simulations, we show that this dense plasma wake is produced by the electron beams ionization of Io's atmosphere
The ion composition and density in the wake strongly depend on Io's atmospheric density and its neutral composition
We report Magnetospheric Multiscale observations of electron pressure gradient electric fields near a magnetic reconnection diffusion region using a new technique for extracting 7.5 ms electron ...moments from the Fast Plasma Investigation. We find that the deviation of the perpendicular electron bulk velocity from E × B drift in the interval where the out-of-plane current density is increasing can be explained by the diamagnetic drift. In the interval where the out-of-plane current is transitioning to in-plane current, the electron momentum equation is not satisfied at 7.5 ms resolution.
We present a study of signatures of energy dissipation at kinetic scales in plasma turbulence based on observations by the Magnetospheric Multiscale mission (MMS) in the Earth's magnetosheath. Using ...several intervals, and taking advantage of the high-resolution instrumentation on board MMS, we compute and discuss several statistical measures of coherent structures and heating associated with electrons, at previously unattainable scales in space and time. We use the multi-spacecraft Partial Variance of Increments (PVI) technique to study the intermittent structure of the magnetic field. Furthermore, we examine a measure of dissipation and its behavior with respect to the PVI as well as the current density. Additionally, we analyze the evolution of the anisotropic electron temperature and non-Maxwellian features of the particle distribution function. From these diagnostics emerges strong statistical evidence that electrons are preferentially heated in subproton-scale regions of strong electric current density, and this heating is preferentially in the parallel direction relative to the local magnetic field. Accordingly, the conversion of magnetic energy into electron kinetic energy occurs more strongly in regions of stronger current density, a finding consistent with several kinetic plasma simulation studies and hinted at by prior studies using lower resolution Cluster observations.
Using observations of Earth's bow shock by the Magnetospheric Multiscale mission, we show for the first time that active magnetic reconnection is occurring at current sheets embedded within the ...quasi‐parallel shock's transition layer. We observe an electron jet and heating but no ion response, suggesting we have observed an electron‐only mode. The lack of ion response is consistent with simulations showing reconnection onset on sub‐ion time scales. We also discuss the impact of electron heating in shocks via reconnection.
Plain Language Summary
For the first time, we document an observation of magnetic reconnection occurring at Earth's bow shock. The observations have been made by NASA's Magnetospheric Multiscale mission while the bow shock is under a “quasi‐parallel” geometry, which typically results in a highly disordered structure. Models of shock waves in space plasmas do not currently account for reconnection. This therefore introduces a new avenue of research into how shocks can repartition energy when slowing the solar wind from supersonic to subsonic flow. The observations also introduce a new regime for magnetic reconnection, for which we observe only an electron response at an ion scale reconnecting structure. This work will also attract interest from the broader astrophysics community, as reconnection at shocks may influence cosmic ray generation.
Key Points
Reconnecting current sheets have been observed at a quasi‐parallel bow shock
The ion‐scale current sheet exhibits only an electron jet and heating, with no ion response
Consistent with kinetic simulations, reconnection relaxes complexity in the shock transition region