U radu se raspravlja o kipu Svetog Ivana Nepomuka iz vrta dvorca Slivnica – remek djelu barokne umjetnosti. Navedeni kip do sada nije bio izlagan, analiziran ili vrednovan. Ovaj rad objašnjava ...njegovu ikonografiju i fokusira se na njegove značajne karakteristike. Na temelju kritičke stilističke analize kip se pripisuje Josipu Straubu, kasnom baroknom kiparu koji je radio u Štajerskoj u periodu između 1743. i 1756. Od ključne je važnosti osigurati očuvanje kipa, budući da je trenutno izložen na milost i nemilost surovim vremenskim prilikama koje uzrokuju njegovo propadanje, pa čak i uništenje.
Gastrointestinal tract is an important connector between food intake and body weight, it senses basic tastes in a similar manner as the tongue. The aim of the study was to find out how gut hormone ...glucagon-like peptide-1 (GLP-1) influences taste preference. Fourteen healthy participants (six male and eight female) were included in this double-blind, placebo-controlled crossover study. After overnight fast and salty fluid (oral sodium load), participants were randomized to receive placebo (500 mL of 0.9% saline) or GLP-1 infusion (1.5 pmol/kg/min) over a 3-hour period. At the end of infusion, participants chose food preferences from illustrations of food types representing 5 tastes. After 7 days, the protocol was repeated, this time those that had received placebo first got GLP-1 infusion, and those having received GLP-1 first got placebo. Change of taste preference after GLP-1 infusion but not after placebo was reported as response, and non-response was reported in case of taste persistence. A statistically significant difference in response type was found between genders, with women being more likely to change their taste preference after GLP-1 than men. The change of taste upon GLP-1 infusion observed in women might be ascribed to estrogen weight-lowering effects accomplished by receptor-mediated delivery.
Introduction. Periodontal disease is a chronic inflammatory disease caused by
pathologic microorganisms/periopathogens from oral biofilm. Standard
periodontal therapy consists of scaling and root ...planing (SRP). Probiotics
can be used as an adjunctive to standard periodontal therapy, since it is
known that probiotics can modify pathogenic potential of biofilm by
suppressing the colonization of periopathogens. The aim of this study was to
assess the clinical effect of Bifidobacterium and Lactobacillus probiotic
lozenges, probiotic mouthwash, as an adjuvant to SRP in the treatment of
initial to moderate chronic periodontitis. Material and methods. Thirty
patients with initial to moderate chronic periodontitis were recruited and
monitored clinically at baseline (before SRP) and 60 days following SRP. All
patients were randomly assigned to experimental group: SRP + probiotic (n =
15) and control group: SRP only (n = 15). The probiotic mouthwash was used
twice a day for 60 days. Clinical parameters: the probing pocket depth
(PPD), clinical attachment level (CAL) and bleeding on probing (BOP) were
measured at baseline and 60th day following SRP. Data were statistically
analyzed using the one-way Anova test and SPSS 19 software (IMB Company, New
York, U.S.). The Friedman and Mann Whitney tests were used as a post hoc
test for intergroup analysis. Statistical significance was set at p < 0.05.
Results. After 60 days of treatment, the clinical parameters PPD, CAL and
BOP were significantly lower in both groups compared to the baseline. In the
experimental group, the clinical parameters PPD, CAL and BOP were
significantly reduced after 60 days of treatment compared to the initial
measurements (p < 0.05). In the control group, statistically significant
decrease after 60 days of treatment was recorded only for BOP parameter,
while there was no statistically significant decrease of PPD and CAL values
(p > 0.05). Conclusion. The results of the present study demonstrated
clinical benefits of adjunctive use of probiotics to SRP in terms of pocket
depth reduction in initial to moderate periodontal disease.
Este Foro de Debate reflexiona sobre el proceso constituyente en marcha en Chile. A partir de la crisis social de 2019, una multiplicidad de demandas sociales se toma el espacio público por fuera de ...los canales institucionales percibidos como poco legítimos. Los artículos indagan acerca de las desigualdades de género y su impacto sobre algunas de estas demandas sociales. Las organizaciones feministas y la paridad de género vienen a oxigenar el sistema político, generando una sinergia importante de participación y representación. Asimismo, se evalúan los legados represivos en relación con el pueblo mapuche y los conflictos con el estado chileno. Se establece el relato criminalizador a la hora de abordar una cuestión eminentemente política. La Convención Constitucional paritaria y con representación de pueblos indígenas obliga a enfrentar estos legados de exclusión y represión para pensar el Chile del mañana.
Introduction: Urgent demand for high-esthetic material, which at the same time has the possibility of absorption of mastication stress, has led to the technological development of hybrid nanoceramics ...used in CAD / CAM technology. Aim: The aim of the study was to evaluate the effects of different surface modification of hybrid nanoceramic crowns on the quality of the cement retention and the influence of the mastication stress after one year of function. Material and methods: 50 hybrid nanoceramic CAD/CAM crowns (CERASMART, GC) are cemented on titanium implant abutments with self-adhesive resin cement (G-CEM, LinkAce). The samples were divided into five main groups according to surface treatment (n=10): I (sandblasted with 50 microns Al2O3), II (treated with CERAMIC PRIMER II, GC), III (treated with 5% hydrofluoric acid), IV (treated with combination of 5% hydrofluoric acid and CERAMIC PRIMER II), V (control, non-treated group). The samples were storaged during 24 hours at 37°C, thermocycled and loaded under 10 000 mechanical cycles loads (simulation of 12 months of function). Retention forces measured in Universal testing machine. The data were represented as mean ± standard deviation, and for statistical analysis ANOVA test was used. Results: The highest initial retention force was demonstrated in the group IV (6.99±1.18), followed by group I (6.22±1.29), group III (5,97±1,25), group II (5,86±1,17) and control group samples (4.92±1.19). A statistically significant decline in retention force was recorded in all tested groups, with the lowest decrease observed in samples treated with a combination of 5% hydrofluoric acid and CERAMIC PRIMER II (6.08 ± 1.03). Conclusion: Mechanical and chemical surface modification can strongly influence the retentions between resin cement and hybrid nanoceramics. The results from this study are suggesting that the most efficient clinical outcome is the combination of 5% hidrofluoric acid and CERAMIC PRIMER II.
Pemphigus vulgaris is a relatively rare, chronic, autoimmune vesiculobullous disorder characterized by formation of intraepithelial vesiculae and/or bullae in the skin and mucous membrane. Systemic ...steroids are considered to be the standard first-line therapy for pemphigus vulgaris. However, for patients unresponsive to standard therapy, the new treatment modalities are being sought. Low-level laser therapy has been accepted as an alternative or adjunctive treatment modality for many conditions in medicine and dentistry. Therefore, this study was aimed at presenting the effects of low-level laser therapy in the treatment of pemphigus vulgaris and to emphasize the crucial role of dentists in early recognition and diagnosis of pemphigus vulgaris.
The articles published until May 2013 were obtained from the Medline/PubMed online database, using following search terms and key words: "laser therapy" and "pemphigus vulgaris", "low-level laser irradiation" and "pemphigus vulgaris", "lasers" and "pemphigus vulgaris" and "pemphigus vulgaris".
Low-level laser therapy could result in immediate and significant analgesia and improved wound healing within the observation period and follow-up. Furthermore, a decrease in patients' discomfort as well as the absence of recurrence of the pemphigus vulgaris lesions has been claimed.
Even though available literature suggests that low-level laser therapy can be efficiently used in treatment of oral pemphigus vulgaris, either independently or as a part of combined therapy approach, these results should be interpreted with caution since there are no solid evidence-based proofs to provide the guidelines for the treatment of pemphigus vulgaris with low-level laser therapy. Therefore, further long-term randomized controlled clinical studies are necessary in order to give any solid recommendations on the use of low-level laser therapy in the treatment of pemphigus vulgaris.
Introduction: Cements in the oral cavity are subjected to many factors affecting cement retention, the major ones being masticatory loads and thermal stress. The gold standard in cementing ...restorations in the contemporary implant prosthodontics are resin cements while their predisposition to the effects of oral cavity environment presents a major factor for the efficiency of dental implant treatment. Material and method: In the study, we used 40 test models made up of a combination of original components of the Nobel Biocare system (implant replica NobRplN and titanium suprastructure Easy abatement NP 0.75) and the restoration cast in CoCrMo alloy. The specimens were divided in 4 test groups with 10 specimens each. The specimens in each group were cemented with resin composite cement with or without using the metal primer. Group I – Multilink Implant, IvoclarVivadent, Liechtenstein, Group II – Multilink Implant, IvoclarVivadent, Liechtenstein + Monobond Plus, Group III G-CEM LinkAce®, Group IV - G-CEM LinkAce® + GC Metalprimer II. The specimens were stored in 100% relative humidity for 24 hours whereupon each group underwent 5 rounds of testing. The specimens were subjected to thermal and mechanical load cycling tests whose number reflected the period of simulation of the function in the oral cavity (unloaded specimens, 7 days of function, 3 months, 6 months and 12 months). The retention force was measured by the Universal testing machine. Results: The highest retention values of the resin composite cement were recorded during the initial tests, which then declined in the subsequent rounds of testing. The biggest fall was measured in the first week after the cementation, while the cross-comparison of the later rounds of testing did not show any statistically significant differences. The values of the retention force of resin composite cements 12 months after the cementation dropped by one third of the initial values. All recorded values were higher in the specimens with primer coating. Conclusion: Masticatory forces and temperature changes in the oral cavity reduced the retention values of resin cement, but its values after 12 months of function were still high and provided stability and retention of the restoration in function. The usage of metal primer had a significant effect on retention force values at all levels of testing.
Introduction. Pemphigus vulgaris is a relatively rare, chronic, autoimmune vesiculobullous disorder characterized by formation of intraepithelial vesiculae and/or bullae in the skin and mucous ...membrane. Systemic steroids are considered to be the standard first-line therapy for pemphigus vulgaris. However, for patients unresponsive to standard therapy, the new treatment modalities are being sought. Low-level laser therapy has been accepted as an alternative or adjunctive treatment modality for many conditions in medicine and dentistry. Therefore, this study was aimed at presenting the effects of low-level laser therapy in the treatment of pemphigus vulgaris and to emphasize the crucial role of dentists in early recognition and diagnosis of pemphigus vulgaris. Material and Methods. The articles published until May 2013 were obtained from the Medline/PubMed online database, using following search terms and key words: "laser therapy" and "pemphigus vulgaris", "low-level laser irradiation" and "pemphigus vulgaris", "lasers" and "pemphigus vulgaris" and "pemphigus vulgaris". Results. Low-level laser therapy could result in immediate and significant analgesia and improved wound healing within the observation period and follow-up. Furthermore, a decrease in patients' discomfort as well as the absence of recurrence of the pemphigus vulgaris lesions has been claimed. Conclusion. Even though available literature suggests that low-level laser therapy can be efficiently used in treatment of oral pemphigus vulgaris, either independently or as a part of combined therapy approach, these results should be interpreted with caution since there are no solid evidence-based proofs to provide the guidelines for the treatment of pemphigus vulgaris with low-level laser therapy. Therefore, further long-term randomized controlled clinical studies are necessary in order to give any solid recommendations on the use of low-level laser therapy in the treatment of pemphigus vulgaris. Key words: Pemphigus; Laser Therapy; Dentistry; Laser Therapy, Low-Level; Skin Diseases, Vesiculobullous; Treatment Outcome Uvod. Pemfigus vulgaris relativno je retko, hronicno, autoimuno, vezikulo-bulozno oboljenje, koje karakterise stvaranje intraepitelnih vezikula (mehurica) i/ili bula (mehura) na kozi i sluzokozi. Danas se terapijom izbora u lecenju pacijenata obolelih od pemfigusa smatraju sistemski kortikosteroidi. Medutim, za pacijente koji ne reaguju na standardnu terapiju, neprestano se traga za novim terapijskim resenjima. Laseroterapija je prihvacena kao alternativni ili dodatni vid terapije za mnoga oboljenja iz oblasti savremene medicine i stomatologije. Cilj ove studije je da predstavi efekte laseroterapije u lecenju oralnih lezija izazvanih pemfigusom vulgaris, te da podseti na vaznost uloge stomatologa u ranom prepoznavanju i pravilnom dijagnostikovanju ovog obolenja. Materijali i metode. U razmatranje su uzete studije objavljene do maja 2013. godine, dostupne na Medline/PubMed onlajn bazi podataka. Baza podataka je pretrazivana ukucavanjem kljucnih reci i termina: laser therapy i pemphigus vulgaris, lowlevel laser irradiation i pemphigus vulgaris, lasers i pemphigus vulgaris i pemphigus vulgaris. Rezultati. Laseroterapija izaziva trenutnu i statisticki znacajnu analgeziju, te ubrzano zarastanje rana u datom vremenskom okviru (i tokom posmatranja, kao i tokom pracenja). Takode, uoceno je i smanjenje tegoba kod pacijenata, kao i prestanak ponovnog pojavljivanja novih oralnih lezija nakon laseroterapije. Zakljucak. Iako dostupna literatura predlaze upotrebu laseroterapije kao efikasne metode za lecenje oralnih lezija, bilo kao samostalan vid terapije, ili kombinovan sa drugim terapijskim postupcima, ovi rezultati se moraju vrlo oprezno interpretirati, buduci da nema cvrstih dokaza koji bi dali smernice za laseroterapiju oralnog pemfigusa vulgaris. Zato su neophodne dodatne klinicke studije kako bi se dala optimalna preporuka o lecenju laseroterapijom oralnih lezija izazvanih pemfigusom vulgaris. Kljucne reci: Pemfigus; Laseroterapija; Stomatologija; Laserska terapija niskog nivoa; Vezikulobulozna oboljanja koze; Ishod lecenja
Probavni sustav povezuje unos hrane i tjelesnu masu razlikujući osnovne okuse sličnim mehanizmima kao i jezik. Cilj ove studije bio je istražiti kako glukagonu sličan peptid-1 (GLP-1) utječe na ...sklonost određenom okusu. Četrnaestoro zdravih ispitanika (šest muškaraca i osam žena) uključeno je u randomiziranu, placebom kontroliranu ukriženu studiju. Ispitanicima koji su bili natašte dana je slana tekućina (oralno opterećenje solju), nakon čega su randomizirani za placebo (500 mL 0.9% fiziološke otopine) ili infuziju GLP-1 (1.5 pmol/kg/min) tijekom 3 sata. Na kraju infuzije ispitanicama su predočene slike hrane koje predstavljaju 5 osnovnih okusa pa su birali okus kojem su najviše skloni. Nakon 7 dana postupak se ponovio; onima kojima je prvi puta dan placebo primijenjen je GLP-1, a onima koji su prvi put dobili GLP-1 primijenjen je placebo. Promjena sklonosti određenom okusu nakon infuzije GLP-1, no ne i nakon placeba, smatrala se pozitivnim odgovorom, a negativan je bila nepromijenjena sklonost okusu. Analizirajući ispitanike prema spolu nađeno je da žene imaju veću vjerojatnost promjene sklonosti okusa nakon GLP-1 nego muškarci, što je bilo statistički značajno. Navedeno opažanje promjeni okusa nakon infuzije GLP-1 u ispitanica može se objasniti učinkom estrogena na gubitak tjelesne mase koji se objašnjava receptorski posredovnim prijenosom.
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