A magnetic poly (1,8-diaminonaphthalene)-nickel (PDAN-Ni@Fe3O4) composite as a multifunctional nanocatalyst was prepared in several steps including (I) synthesis of poly (1,8-diaminonaphthalene) ...(PDAN), (II) modification of PDAN with NiSO4 (PDAN-Ni) and (III) preparation of magnetic nanocatalyst by iron (I and II) salts in the existence of PDAN-Ni complex (PDAN-Ni@Fe3O4). Fourier-transform infrared spectroscopy (FTIR), elemental analysis (CHNSO), vibrating-sample magnetometer (VSM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), field emission scanning electron microscope (FESEM), ultraviolet–visible (UV–vis), and thermogravimetric analysis (TGA) were applied to characterize the prepared nanocatalyst. The PDAN-Ni@Fe3O4 was applied as an environmentally friendly nanocatalyst for the isoxazole-5(4H)-ones synthesis via a one-pot reaction between aryl/heteroaryl aldehyde, hydroxylamine hydrochloride, and β-ketoester. The nanocomposite was also used for the synthesis of some new alkylene bridging bis 4-benzylidene-3-methyl isoxazole-5(4H)-ones. The catalyst's reusability, and the antioxidant and antibacterial activities of both catalyst and products, were studied. Results showed that the nanocatalyst and isoxazole-5(4H)-ones have antioxidant activity of 75% and 92%, respectively. In addition, the antibacterial test showed that the nanocatalyst and isoxazole-5(4H)-ones have highly active versus Staphylococcus aureus and Escherichia coli bacteria. The reusability and stability of the nanocatalyst, a medium to higher product yield and conversion, a faster reaction time, and the use of green solvents were a few benefits of this study.
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•A magnetic bionanocomposite based on carboxymethyl dextrin was fabricated.•Bionanocomposite showed good antibacterial and antioxidant activities and low toxicity.•Bionanocomposite ...showed good physicochemical properties such as solubility and conductivity.•Bionanocomposite can have good potential applications in biomedical applications.
Nowadays, nanocomposites based on carbohydrate polymers owing to good physicochemical and biological properties have found promising applications in various fields especially biomedical applications. In the current study, a bioactive nanocomposite based on carboxymethyl dextrin-grafted-poly(aniline-co-meta-phenylenediamine) and iron oxide/copper oxide (CMD-g-PACPD@Fe3O4/CuO) was prepared by an in-situ copolymerization method. Several analyses such as FT-IR, NMR, EDX, BET, XRD, UV–vis, FE-SEM, TGA, VSM, and DLS were employed for the characterization of prepared materials. The NMR spectroscopy confirmed the preparation of carboxymethyl dextrin. The FTIR and EDX analysis showed that the CMD-g-PACPD@Fe3O4/CuO nanocomposite was prepared successfully. The specific surface area of about 11.30 m2/g was obtained for CMD-g-PACPD@Fe3O4/CuO nanocomposite by using BET analysis. The specific conductivity values of CMD-g-PACPD@Fe3O4/CuO were obtained in a range of 0.3 to 102 µS/cm in various solvents. The solubility test showed that the best solvent for the dispersion of the CMD-g-PACPD@Fe3O4/CuO was dimethyl sulfoxide. A superparamagnetic property of the CMD-g-PACPD@Fe3O4/CuO with saturation magnetism (MS) of 16.49 emu/g was obtained by VSM analysis. The CMD-g-PACPD@Fe3O4/CuO nanocomposite had good antioxidant (54 %) and antibacterial (against Escherichia coli and Staphylococcus aureus) activities and low toxicity at high concentrations (500 mg/mL). The current work may shed light on the potential applications of CMD-g-PACPD@Fe3O4/CuO in biomedical applications.
