Lektura poezji Bolesława Leśmiana pozwala wskazać zasadniczą cechę w postaci wielowymiarowego uwrażliwienia na brak. W liryce autora Sadu rozstajnego wyróżniam te zabiegi, które wydobywają już na ...poziomie językowym poczucie niepełni, nieobecności, nieistnienia. Apofatyczność języka przekłada się na problem niebytu jako braku znaczącego. Zajmuję się brakiem nie tyle jako kategorią zaprzeczenia istnienia, ile raczej jako samodzielnym, ukonstytuowanym, afektywnym rodzajem przeżycia. Zastanawiam się, co dzieje się z „ja” mówiącym, które konfrontuje się z innym w sytuacji przeżywania bólu wynikającego z braku. Najbardziej istotne okazuje się empatyczne współodczuwanie „ja” z innym. W momencie odkrycia cudzego bólu następuje stan afektywny, który nie podlega już ani uświadomieniu, ani opisaniu. Zderzenie na osi „ja” – inny – brak przynosi i stwarza afekt. Empatycznie nakierowane „ja” liryczne zderza się z innym, który przeżywa brak. Odczucia nnego zostają przez osobę mówiącą w tekście – do pewnego przynajmniej stopnia – rozpoznane, a nawet nazwane. Dopiero w tym, co rozgrywa się później, upatruję stanu afektywnego. Empatyczne zderzenie i współodczuwanie wybija „ja” z samego siebie, rozbija czasami tekst – doprowadza bowiem do przeżycia, które plasuje się poniżej uświadomionego, tym bardziej wyrażonego i wreszcie niewyrażalnego. Jest przeżyciem nie-do-nazwania.
Posg Hermesa (The Statue of Hermes), a poem by Kazimierz Przerwa-Tetmajer, features a myriad of references to the act of sculpting, the statue itself, the myth of Hermes, the myth of Pygmalion, ...images of fertility, female libido, and, last but not least, the possibility that the reader, the poet, and the girl in the text are ticked by Hermes. The symbols incorporated in the poem illuminate each other and, as a result, the myth is reenacted in the very act of reading the sonnet. At the same time, it is not possible to put forward a single interpretation of the text. The myth can only be actualized if all the interpretations or the poem are simultaneously combined.
The paper focuses on Young Polands portrait of the human being and attempts to throw the human out of nature and the world. It reveals and analyses how poets hesitate between admiration of human ...power (Leopold Staff, Adam) and being weary of human omnipresence. The article shows how poets (Kazimierz Tetmajer, Ta trawa, Muszla) seek a pristine primeval time and space without human beings before the Anthropocene. The paper reveals poetic situations in which the subjects differ from humans. The conclusion emphasizes a connection between the utopia without a man with the moment of subject formation as well as symbolistic ways of expression.
The article explores multi-dimensional sensitivity to the void as a major feature of Bolesław Leśmian’s poetry. The author distinguishes those stylistic devices which extract, on the level of ...language, the the feeling of non-fullness, absence, or nonexistence in Leśmian’s poems. Apophatic language translates itself into the issue of nonexistence seen as meaningful lack. The article focuses not so much on the category of the negation of existence as on independent, fixed, affective type of experience. The author inquires what happens with the poetic voice confronted with the Other in a situation experiencing pain resulting from lack. Empathetic co-feeling of “I” with the other turns out to be the most important state. The moment someone else’s pain is discovered, feelings change into the affective state which cannot be either realized or described. The I-Other-void confrontation brings about an affect. The empathetic “I” meets the Other who experiences various kinds of absence. The Other’s feelings become recognized and even, to some extent, defined by the person who speaks in the text but the affect happens afterwards. The emphatic confrontation and co-feeling destruct the coherent voice and the text itself for it causes that kind of unspeakable experience that cannot be realized, expressed or represented. This is an experience not-to-be-named.
Multiple myeloma (MM) remains an incurable malignancy of plasma cells despite constantly evolving therapeutic approaches including various types of immunotherapy. Increased arginase activity has been ...associated with potent suppression of T-cell immune responses in different types of cancer. Here, we investigated the role of arginase 1 (ARG1) in Vκ*MYC model of MM in mice. ARG1 expression in myeloid cells correlated with tumor progression and was accompanied by a systemic drop in ʟ-arginine levels. In MM-bearing mice antigen-induced proliferation of adoptively transferred T-cells was strongly suppressed and T-cell proliferation was restored by pharmacological arginase inhibition. Progression of Vκ*MYC tumors was significantly delayed in mice with myeloid-specific ARG1 deletion. Arginase inhibition effectively inhibited tumor progression although it failed to augment anti-myeloma effects of bortezomib. However, arginase inhibitor completely prevented development of bortezomib-induced cardiotoxicity in mice. Altogether, these findings indicate that arginase inhibitors could be further tested as a complementary strategy in multiple myeloma to mitigate adverse cardiac events without compromising antitumor efficacy of proteasome inhibitors.
Vibration therapy interventions are an attractive alternative for people with contraindications to physical activity or manifesting kinesiophobia; they constitute an equivalent to physical activity.
...A group of female volunteers with hypercholesterolemia (LDL over 3 mmol/l) aged over 65 years were randomized into 2 subgroups: the study group (taking part in interventions on mattresses generating oscillatory-cycloid vibrations) and the control group (receiving interventions on placebo mattresses). All the subjects underwent two 30-minute interventions 5 times a week for the period of 21 days, in the prone position. Before the intervention and after completing the series of sessions, body composition and waist and hip circumferences were assessed. Venous blood for biochemical studies was collected before the intervention, one day after its completion, and one week after completing the series of vibration sessions. On the basis of the lipid profile results, atherogenicity indices were calculated.
After 21 days, a statistically significant decrease in the level of total cholesterol and LDL cholesterol was observed in subjects who received oscillatory-cycloid vibration therapy. No statistically significant changes were noted in the concentrations of HDL cholesterol or triglycerides. The 21-day therapeutic intervention also resulted in lowering the AIP in the study group, as well as a decrease of hip circumference.
Oscillatory-cycloid vibration applied regularly for a longer time can beneficially impact on lowering the level of total cholesterol and LDL cholesterol in people with hypercholesterolemia, although it does not influence body composition in women aged 65 years or more.
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