The implanting of a hip endoprosthesis changes the mechanical loading in a hip. The changing in loading causes bone remodeling. The loss of loading leads to bone atrophy, whereas an increase in ...loading leads to hypertrophy of the bones. We investigated the relationship between the clinical result and change in periprosthetic bone mineral density. The Harris hip score was used to measure the clinical outcome. The dual photon densitometry method was used to measure periprosthetic bone mineral density. The obtained results showed that a loss in bone mass around the hip endoprosthesis does not affect the clinical outcome of the operation. Bone hypertrophy has a positive effect on the clinical outcome. The patient's age, sex and body weight in the investigated population did not have an negative impact on functional status. The time passing from the operation to measuring had a negative impact on the functional status.
The aim of this study was to determine the number of D-type personality patients in the group with a history of myocardial infarction (MI) and the influence of comprehensive in-hospital cardiac ...rehabilitation (iCR) on their psychological status (PS). The study included 316 consecutive patients aged 18 to 65 with MI in the last six months admitted into the programme of iCR. Surgical revascularized patients, clinically unstable patients and patients with sever chronic diseases and disorders were excluded. At the beginning and in the end of iCR diagnostic exam, hematological/biochemical blood analysis, ergometric testing was conducted. At the beginning and four weeks after the finish of the iCR estimation of PS was conducted. Distress scale 14 (DS14) questioner was used for that purpose. In the period of three weeks, patients were included in the programme of comprehensive iCR. Out of 316 patients in the study group 83.2% were male, while 16.8% were female. Average age of the patient was 51.3 +/- 7.2. When being admitted to iCR 42.7% patients had characteristics of D-type personality. Those patients had substantially lower level of body mass and body mass index. In the same time there were no differences among groups in risk factors, values of clinical, laboratory and diagnostic parameters. During iCR study group had more complications in comparison to the control group. At the end of iCR substantial rise of functional capacity of patients, improvement of lipid profile and lowering of glycaemia was recorded. Also at the end of iCR antiarrhythmics and psychopharmaceutical medicaments were more often prescribed to the patients in the study group. Four weeks after the iCR share of D-type personality patients was 41% and 71% of study group patients kept their D-type structure.
The implanting of a hip endoprosthesis changes the mechanical loading in a hip. The changing in loading causes bone remodeling. The loss of loading leads to bone atrophy, whereas an increase in ...loading leads to hypertrophy of the bones.We investigated the relationship between the clinical result and change in periprosthetic bone mineral density. The Harris hip score was used to measure the clinical outcome. The dual photon densitometry method was used to measure periprosthetic bone mineral density. The obtained results showed that a loss in bone mass around the hip endoprosthesis does not affect the clinical outcome of the operation. Bone hypertrophy has a positive effect on the clinical outcome. The patient’s age, sex and body weight in the investigated population did not have an negative impact on functional status. The time passing from the operation to measuring had a negative impact on the functional status.
Spazam kao pozitivni simptom oštećenja gornjih motoneurona uslijed teške traumatske ozljede mozga, ukoliko se ne počne liječiti rano nakon oštećenja neurona, može biti uzrok kontraktura. U ovoj je ...prospektivnoj studiji istraživano djelovanje fizioterapije i botulinum toksina A u liječenju kontraktura koljena u pacijenata kod kojih sama fizioterapija nije dovela do smanjenja kontraktura i tonusa mišića. U studiju je bilo uključeno 26 pacijenata koji su imali kontrakturu u jednom ili oba koljena (ukupno 30 koljena), a kod kojih se tonus mišića i kontraktura koljena nisu umanjili nakon tromjesečne fizioterapije. Nakon aplikacije botulinum toksina A i nastavka fizioterapije, kod pacijenata je došlo do značajnoga poboljšanja pokretljivosti u koljenu, kao i do smanjenja spazma u mišićima u koje je bio apliciran botulinum toksin A. Primjenom botulinum toksina A i fizioterapijom mogu se značajno umanjiti kontrakture koljena koje su bile otporne na fizioterapiju, čime je izbjegnuto operativno liječenje i poboljšana aktivnost i participacija bolesnika u aktivnostima svakodnevnoga života.
The aim of this study was to determine the number of D-type personality patients in the group with a history of myocardial
infarction (MI) and the influence of comprehensive in-hospital cardiac ...rehabilitation (iCR) on their psychological
status (PS). The study included 316 consecutive patients aged 18 to 65 with MI in the last six months admitted into
the programme of iCR. Surgical revascularized patients, clinically unstable patients and patients with sever chronic diseases
and disorders were excluded. At the beginning and in the end of iCR diagnostic exam, hematological/biochemical
blood analysis, ergometric testing was conducted. At the beginning and four weeks after the finish of the iCR estimation
of PS was conducted. Distress scale 14 (DS14) questioner was used for that purpose. In the period of three weeks, patients
were included in the programme of comprehensive iCR. Out of 316 patients in the study group 83.2% were male, while
16.8% were female. Average age of the patient was 51.3±7.2. When being admitted to iCR 42.7% patients had characteristics
of D-type personality. Those patients had substantially lower level of body mass and body mas index. In the same
time there were no differences among groups in risk factors, values of clinical, laboratory and diagnostic parameters.
During iCR study group had more complications in comparison to the control group. At the end of iCR substantial rise of
functional capacity of patients, improvement of lipid profile and lowering of glycaemia was recorded. Also at the end of
iCR antiarrhythmics and psychopharmaceutical medicaments were more often prescribed to the patients in the study
group. Four weeks after the iCR share of D – type personality patients was 41% and 71% of study group patients kept
their D-type structure.
Osteoarthritis (OA) is a degenerative joint disease accompanied by pain and loss of function. Adipose tissue harbors mesenchymal stem/stromal cells (MSC), or medicinal signaling cells as suggested by ...Caplan (Caplan, 2017), used in autologous transplantation in many clinical settings. The aim of the study was to characterize a stromal vascular fraction from microfragmented lipoaspirate (SVF-MLA) applied for cartilage treatment in OA and compare it to that of autologous lipoaspirate (SVF-LA). Samples were first stained using a DuraClone SC prototype tube for the surface detection of CD31, CD34, CD45, CD73, CD90, CD105, CD146 and LIVE/DEAD Yellow Fixable Stain for dead cell detection, followed by DRAQ7 cell nuclear dye staining, and analyzed by flow cytometry. In SVF-LA and SVF-MLA samples, the following population phenotypes were identified within the CD45
fraction: CD31
CD34
CD73
CD90
CD105
CD146
endothelial progenitors (EP), CD31
CD34
CD73
CD90
CD105
CD146
mature endothelial cells, CD31
CD34
CD73
CD90
CD105
CD146
pericytes, CD31-CD34
CD73
CD90
CD105-CD146
transitional pericytes, and CD31
CD34
CD73
CD90
CD105
CD146
supra-adventitial-adipose stromal cells (SA-ASC). The immunophenotyping profile of SVF-MLA was dominated by a reduction of leukocytes and SA-ASC, and an increase in EP, evidencing a marked enrichment of this cell population in the course of adipose tissue microfragmentation. The role of EP in pericyte-primed MSC-mediated tissue healing, as well as the observed hormonal implication, is yet to be investigated.
Osteoarthritis (OA) is a widely prevalent disease worldwide, and with an increasingly ageing society, it has become a challenge for the field of regenerative medicine. OA is a disease process ...involving multiple joint tissues, including those not visible on radiography, and is a complex disease process with multiple phenotypes that require evaluation by a multimodality imaging assessment. The purpose of this study was to evaluate the effect of micro-fragmented fat tissue intra-articular injection 24 months after application in two ways: Indirectly using functional magnetic resonance imaging (MRI) assessment analyzing the glycosaminoglycans (GAG) content in cartilage by means of delayed gadolinium (Gd)-enhanced magnetic resonance imaging of cartilage (dGEMRIC), as well as clinical outcome on observed level of GAG using standard orthopedic physical examination including VAS assessment. In our previous study assessing comprehensive results after 12 months, the dGEMRIC results have drawn attention. The present study explores the long-term effect of intra-articular injection of autologous microfragmented adipose tissue to host chondrocytes and cartilage proteoglycans in patients with knee OA. A prospective, non-randomized, interventional, single-center, open-label clinical trial was conducted from January 2016 to April 2018. A total of 17 patients were enrolled in the study, and 32 knees were assessed in a 12-month follow-up, but only 10 patients of them with 18 knees are included in a 24-month follow-up. The rest of the seven patients dropped out of the study 12 months after follow-up: three patients underwent knee arthroplasty, and the remaining four did not fulfil the basic criteria of 24 months involvement in the study. Surgical intervention (lipoaspiration), followed by tissue processing and intra-articular injection of the final microfragmented adipose tissue product into the affected knee(s), was performed in all patients. Patients were assessed for a visual analog scale (VAS), dGEMRIC at the baseline, three, six, 12 and 24 months after the treatment. A magnetic resonance sequence in dGEMRIC due to infiltration of the anionic, negatively-charged contrast gadopentetate dimeglumine (Gd-DTPA2) into the cartilage indicated that the contents of cartilage glycosaminoglycans significantly increased in specific areas of the treated knee joint. Our results suggest that this method of single intra-articular injection of autologous microfragmented adipose tissue improves GAG content on a significant scale, with over half of the measurements suggesting relevant improvement 24 months after intra-articular injection opposed to the expected GAG decrease over the natural course of the disease.
Artropatija ohronotika Matoković, Damir; Plečko, Mihovil; Crnogaća, Krešimir ...
Rad Hrvatske akademije znanosti i umjetnosti (1991). Medicinske znanosti,
12/2020, Letnik:
., Številka:
544 = 52-53
Journal Article
Odprti dostop
Alkaptonurija (AKU) je rijetka autosomno recesivna metabolička bolest uzrokovana poremećajem metabolizma fenilalanina i tirozina, što rezultira nakupljanjem i taloženjem homogentizinske kiseline ...(HGA) u tijelu. Ovo taloženje uzrokuje progresivne funkcionalne poremećaje u različitim organskim sustavima, pri čemu je najčešće zahvaćen lokomotorni sustav. Specifična trijada simptoma javlja se u bolesnika koji pate od AKU: 1. pri rođenju je vidljiva promjena boje urina kada je urin izložen zraku, 2. pojava tamnih pigmentacija u vezivnom tkivu s vremenom postaje vidljiva, 3. postepeno se razvijaju komplikacije koje zahvaćaju lokomotorni, urogenitalni i kardiovaskularni sustav.
Artropatija ohronotica javlja se u bolesnika koji pate od AKU zbog taloženja HGA u zglobnom tkivu (hrskavica, tetive, ligamenti, meniskusi itd.). Akumulacija se može vidjeti kao mala žarišta plavo-crnih pigmentacija. HGA se taloži u kolagenskim vlaknima, uzrokujući zadebljanje tetiva i ligamenata.
Zbog toga su ona manje otporna na mehaničke sile, što rezultira čestim puknućima uzrokovanim minimalnom traumom. Također, taloženje ubrzava degeneraciju hrskavice, što dovodi do češće potrebe za operativnim liječenjem. Koljena su najčešće zahvaćena, dok se promjene također mogu vidjeti na kralježnici i drugim velikim zglobovima.
Kako ne postoji specifično liječenje, ublažavanje simptoma jedina je opcija liječenja. Cilj mu je povećati individualnu funkcionalnost i kvalitetu života. Kao opcija za završnu fazu liječenja, ugradnja umjetnih zglobova pokazala se sigurnom i učinkovitom. U budućnosti se očekuje razvoj enzimske ili genske terapije za uspješno ciljano liječenje AKU.
Arthropathia ochronotica Matoković, Damir; Plečko, Mihovil; Crnogaća, Krešimir ...
Rad Hrvatske akademije znanosti i umjetnosti (1991). Medicinske znanosti,
2020, Letnik:
544, Številka:
52-53
Journal Article
PDF
