Apocalyptic biblical literature has played a significant role in motivating and mobilising Christians. As part of this genre, the Apocalypse of John has played this mobilising role within the church ...throughout its history. Jerusalem is often incorporated into this genre to conjure up different emotions and images to impact many different people. For example, the Jew annually recites the words to fellow Jews at every Passover meal: ‘Next year in Jerusalem’. Most Christians know the hymn ‘The holy city’, originally penned by Frederic Weatherly in 1892. It lifts many a spirit as it conjures up the idea of a beautiful, perfect, heavenly city of God. However, there is more to this apocalyptic vision, which will be explored in this article. The city upholds the hope of decent godly living today. Whilst Jerusalem is a city with an extremely chequered history, it remains to be the launching pad of a dream that believers can embrace in order to impact society for the better. The vision in Revelation 21–22 is the launch of the ‘idea’ of God’s intention for society today, and the ‘implementation impetus’ is the primary role of the church. In the greater scheme of things, the world community is the target group for a better society for everyone. Aanneming van ’n visioen van die Nuwe Jerusalem (Op 21:1–22:5) ten einde ’n invloed op lewe en die samelewing uit te oefen. Apokaliptiese Bybelliteratuur het ’n beduidende rol in die motivering en aansporing van Christengemeenskappe gespeel. Die Openbaring van Johannes het hierdie motiveringsrol deurgaans in die geskiedenis van die kerkas deel van dié genre vertolk. Jerusalem is dikwels hierby ingesluit om ’n verskeidenheid van emosies en beelde op te roep ten einde ’n impak op ’n verskeidenheid mense te maak. Die Jood, byvoorbeeld, haal jaarliks die volgende woorde teenoor mede-Jode tydens die Paasmaaltyd aan: ‘Volgende jaar in Jerusalem’. Die meeste Christene ken die gesang ‘The holy city’ wat oorspronklik deur Frederic Weatherly in 1892 geskryf is. Dit hef menige gelowiges se gemoedere op omdat dit die beeld van ’n pragtige, perfekte stad van God oproep. Daar is egter meer aan hierdie openbaringsuitsig wat in hierdie artikel verder ondersoek word. Die hemelstad bekragtig die hoop vir ’n godvrugtige lewe vandag. Alhoewel Jerusalem ’n stad met ’n uiters veelbewoë geskiedenis is, is dit tog die beginpunt vir hierdie droom van gelowiges om die samelewing te verbeter. Die visioen in Openbaring 21–22 is die bekendstelling van die ‘idee’ van God se bedoeling vir ons hedendaagse samelewing en die ‘vervullende beweegkrag’ is die primêre rol van die kerk. Holisties beskou, is die wêreldgemeenskap die teikengroep vir ’n beter samelewing vir almal.
The recent introduction of immune checkpoint inhibitor therapy with anti- PD-1 agents has shown encouraging responses in gastrointestinal oncology. However, it is also known to possibly result in ...uncontrolled T cell autoreactivity, leading to a broad range of immune related adverse events. We present a patient who developed sequential immune-related hematologic and hepatic complications following pembrolizumab therapy for metastatic colon cancer. In particular, we describe in detail the histopathologic and immunohistochemical findings in the liver and bone marrow, adding to the spectrum of morphological changes which may be observed in association with PD-1 inhibitor therapy. The report also highlights the occurrence of these adverse reactions even after discontinuation of immunotherapy, eventually resulting in the death of the patient.
In this study the latest version of the MiKlip decadal hindcast system is analyzed, and the effect of an increased horizontal and vertical resolution on the prediction skill of the extratropical ...winter circulation is assessed. Four different metrics – the storm track, blocking, cyclone and windstorm frequencies – are analyzed in the North Atlantic and European region. The model bias and the deterministic decadal hindcast skill are evaluated in ensembles of five members in a lower-resolution version (LR, atm: T63L47, ocean: 1.5∘ L40) and a higher-resolution version (HR, atm: T127L95, ocean: 0.4∘ L40) of the MiKlip system based on the Max Planck Institute Earth System model (MPI-ESM). The skill is assessed for the lead winters 2–5 in terms of the anomaly correlation of the quantities' winter averages using initializations between 1978 and 2012. The deterministic predictions are considered skillful if the anomaly correlation is positive and statistically significant. While the LR version shows common shortcomings of lower-resolution climate models, e.g., a storm track that is too zonal and southward displaced as well as a negative bias of blocking frequencies over the eastern North Atlantic and Europe, the HR version counteracts these biases. Cyclones, i.e., their frequencies and characteristics like strength and lifetime, are particularly better represented in HR. As a result, a chain of significantly improved decadal prediction skill between all four metrics is found with the increase in the spatial resolution. While the skill of the storm track is significantly improved primarily over the main source region of synoptic activity – the North Atlantic Current – the other extratropical quantities experience a significant improvement primarily downstream thereof, i.e., in regions where the synoptic systems typically intensify. Thus, the skill of the cyclone frequencies is significantly improved over the central North Atlantic and northern Europe, the skill of the blocking frequencies is significantly improved over the Mediterranean, Scandinavia and eastern Europe, and the skill of the windstorms is significantly improved over Newfoundland and central Europe. Not only is the skill improved with the increase in resolution, but the HR system itself also exhibits significant skill over large areas of the North Atlantic and European sector for all four circulation metrics. These results are particularly promising regarding the high socioeconomic impact of European winter windstorms and blocking situations.
Recent emergence of SARS-CoV-1 variants demonstrates the potential of this virus for targeted evolution, despite its overall genomic stability. Here we show the dynamics and the mechanisms behind the ...rapid adaptation of SARS-CoV-2 to growth in Vero E6 cells. The selective advantage for growth in Vero E6 cells is due to increased cleavage efficiency by cathepsins at the mutated S1/S2 site. S1/S2 site also constitutes a heparan sulfate (HS) binding motif that influenced virus growth in Vero E6 cells, but HS antagonist did not inhibit virus adaptation in these cells. The entry of Vero E6-adapted virus into human cells is defective because the mutated spike variants are poorly processed by furin or TMPRSS2. Minor subpopulation that lack the furin cleavage motif in the spike protein rapidly become dominant upon passaging through Vero E6 cells, but wild type sequences are maintained at low percentage in the virus swarm and mediate a rapid reverse adaptation if the virus is passaged again on TMPRSS2
human cells. Our data show that the spike protein of SARS-CoV-2 can rapidly adapt itself to available proteases and argue for deep sequence surveillance to identify the emergence of novel variants.
Recently emerging SARS-CoV-2 variants B.1.1.7 (alpha variant), B.1.617.2 (delta variant), and B.1.1.529 (omicron variant) harbor spike mutations and have been linked to increased virus pathogenesis. The emergence of these novel variants highlights coronavirus adaptation and evolution potential, despite the stable consensus genotype of clinical isolates. We show that subdominant variants maintained in the virus population enable the virus to rapidly adapt to selection pressure. Although these adaptations lead to genotype change, the change is not absolute and genomes with original genotype are maintained in the virus swarm. Thus, our results imply that the relative stability of SARS-CoV-2 in numerous independent clinical isolates belies its potential for rapid adaptation to new conditions.
Proceeding from the α‐B‐SbW9O33 fragment 1, various novel large heteropolyanions (Na2Sb8W36O132(H2O)422– (2), Sb2W22O74(OH)212− (3) and Sb2W20M2O70(H2O)6(14−2n)− (4); Mn+ = Fe3+, Co2+, Mn2+, Ni2+) ...have been obtained in crystalline form by systematic synthesis. Their unexpected structures have been studied by X‐ray diffraction: 2, 3 and 4 contain β‐SbW9 units connected to each other by Sb3+ ions, WO2/WO2OH groups, and WO2/Mn+ (H2O)3 groups, respectively. Structural details and especially the systematic synthesis strategy for the formation of these interesting polytungstates are discussed in order to explain the unusual behaviour of 1 in aqueous solution under different reaction conditions.
A vision or reality in the near future? The systematic synthesis of large heteropolymetalate clusters, long considered a near‐impossible task, has been achieved for Sb via intermediates likeβ‐β‐SbW9O339− (right). Furthermore, it is possible to fix transition‐metal atoms in the framework of these anions.
The influence of the Atlantic and Indo‐Pacific oceans on Atlantic‐European climate is investigated by analyzing ensemble integrations with the atmospheric general circulation model ECHAM4 forced by ...anomalous sea surface temperature and sea ice conditions restricted to the Atlantic (AOGA) and Indo‐Pacific (I+POGA) oceans. The forcing from both the Indo‐Pacific and Atlantic oceans are important for the generation of the sea level pressure (SLP) variability in the Atlantic region in the boreal winter season. Over the North Atlantic the SLP response in the I+POGA experiment projects on the North Atlantic Oscillation, while it projects on the East Atlantic Pattern in the AOGA experiment. In both experiments (I+POGA and AOGA) a quadrupole‐type 500 hPa height anomaly pattern is simulated which emerges from the tropical Pacific and Atlantic oceans, respectively. In boreal summer the influence of the Atlantic Ocean dominates the SLP response in the Atlantic region. The tropical North Atlantic is a key region in forcing the SLP response over the Caribbean Sea in this season.
Apocalyptic biblical literature has played a significant role in motivating and mobilising Christians. As part of this genre, the Apocalypse of John has played this mobilising role within the church ...throughout its history. Jerusalem is often incorporated into this genre to conjure up different emotions and images to impact many different people. For example, the Jew annually recites the words to fellow Jews at every Passover meal: 'Next year in Jerusalem'. Most Christians know the hymn 'The holy city', originally penned by Frederic Weatherly in 1892. It lifts many a spirit as it conjures up the idea of a beautiful, perfect, heavenly city of God. However, there is more to this apocalyptic vision, which will be explored in this article. The city upholds the hope of decent godly living today. Whilst Jerusalem is a city with an extremely chequered history, it remains to be the launching pad of a dream that believers can embrace in order to impact society for the better. The vision in Revelation 21-22 is the launch of the 'idea' of God's intention for society today, and the 'implementation impetus' is the primary role of the church. In the greater scheme of things, the world community is the target group for a better society for everyone.
Apocalyptic biblical literature has played a significant role in motivating and mobilising Christians. As part of this genre, the Apocalypse of John has played this mobilising role within the church ...throughout its history. Jerusalem is often incorporated into this genre to conjure up different emotions and images to impact many different people. For example, the Jew annually recites the words to fellow Jews at every Passover meal: ‘Next year in Jerusalem’. Most Christians know the hymn ‘The holy city’, originally penned by Frederic Weatherly in 1892. It lifts many a spirit as it conjures up the idea of a beautiful, perfect, heavenly city of God. However, there is more to this apocalyptic vision, which will be explored in this article. The city upholds the hope of decent godly living today. Whilst Jerusalem is a city with an extremely chequered history, it remains to be the launching pad of a dream that believers can embrace in order to impact society for the better. The vision in Revelation 21–22 is the launch of the ‘idea’ of God’s intention for society today, and the ‘implementation impetus’ is the primary role of the church. In the greater scheme of things, the world community is the target group for a better society for everyone.Aanneming van ’n visioen van die Nuwe Jerusalem (Op 21:1–22:5) ten einde ’n invloed op lewe en die samelewing uit te oefen. Apokaliptiese Bybelliteratuur het ’n beduidende rol in die motivering en aansporing van Christengemeenskappe gespeel. Die Openbaring van Johannes het hierdie motiveringsrol deurgaans in die geskiedenis van die kerkas deel van dié genre vertolk. Jerusalem is dikwels hierby ingesluit om ’n verskeidenheid van emosies en beelde op te roep ten einde ’n impak op ’n verskeidenheid mense te maak. Die Jood, byvoorbeeld, haal jaarliks die volgende woorde teenoor mede-Jode tydens die Paasmaaltyd aan: ‘Volgende jaar in Jerusalem’. Die meeste Christene ken die gesang ‘The holy city’ wat oorspronklik deur Frederic Weatherly in 1892 geskryf is. Dit hef menige gelowiges se gemoedere op omdat dit die beeld van ’n pragtige, perfekte stad van God oproep. Daar is egter meer aan hierdie openbaringsuitsig wat in hierdie artikel verder ondersoek word. Die hemelstad bekragtig die hoop vir ’n godvrugtige lewe vandag. Alhoewel Jerusalem ’n stad met ’n uiters veelbewoë geskiedenis is, is dit tog die beginpunt vir hierdie droom van gelowiges om die samelewing te verbeter. Die visioen in Openbaring 21–22 is die bekendstelling van die ‘idee’ van God se bedoeling vir ons hedendaagse samelewing en die ‘vervullende beweegkrag’ is die primêre rol van die kerk. Holisties beskou, is die wêreldgemeenskap die teikengroep vir ’n beter samelewing vir almal.
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