Modeling a Nb3Sn cryounit in GPT at UITF Pokharel, S; Hofler, A S; Krafft, G A
Journal of physics. Conference series,
01/2023, Letnik:
2420, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Nb3Sn is a prospective material for future superconducting radio frequency (SRF) accelerator cavities. Compared to conventional niobium, the material can achieve higher quality factors, higher ...temperature operation, and potentially higher accelerating gradients (Eacc ≈ 96 MV/m). In this work, we performed modeling of the Upgraded Injector Test Facility (UITF) at Jefferson Lab utilizing newly constructed Nb3Sn cavities. We studied the effects of the buncher cavity and varied the gun voltage from 200-500 keV. We have calibrated and optimized the SRF cavity gradients and phases for the Nb3Sn five-cell cavities’ energy gains with the framework of the General Particle Tracer (GPT). Our calculations show the beam goes cleanly through the unit. There is full energy gain out of the second SRF cavity but not from the first SRF cavity due to non-relativistic phase shifts.
Abstract
The material point method (MPM) has garnered significant attention in recent years owing to its advantages in solving soil–water-structure interaction problems involving large deformations ...in geotechnical engineering. The MPM combines the benefits of point-based and mesh-based approaches (finite element method) with both Eulerian computational mesh and continuum descriptions of materials. The successful integration of MPM in simulated landslides, internal erosion, and excavation has been frequently reported. However, solving the soil–geosynthetic interaction problem with the MPM has not been explored, although such problems often entail large deformations. The goal of this study is to collate studies on the simulation of geosynthetics and their interactions with soil using MPM. This paper first discusses the basics of MPM and the formation of thin membrane materials using MPM. It also includes limited applications of MPM in simulating soil–geosynthetic interactions. The applications demonstrate that the MPM is particularly effective in resolving large deformation problems associated with geosynthetics, including problems of landfill settlement, reinforced-slope stability, and geocontainer dropping.
Essentials
The role of von Willebrand factor (VWF) domains in regulating platelet adhesion was studied in vivo.
Multimeric VWF with spacers at the N‐ and C‐terminus of VWF‐A1 were systematically ...tested.
N‐terminal modified VWF avidly bound platelet GpIbα, causing VWD Type2B like phenotype in mice.
Novel anti‐D'D3 mAbs suggest that changes at the D'D3‐A1 interface may be biologically relevant.
Summary
Background
Previous ex vivo studies using truncated VWF (von Willebrand factor) suggest that domain‐level molecular architecture may control platelet‐GpIbα binding function.
Objective
We determined if this is the case with multimeric VWF in vivo.
Methods
Full‐length human VWF (‘hV’) was modified with a 22‐amino acid mucinous stretch at either the N‐terminus of VWF‐A1 to create ‘hNV’ or C‐terminus to yield ‘hCV’. This extends the physical distance between VWF‐A1 and the adjacent domains by ~6 nm. Similar mucin inserts were also introduced into a human‐murine chimera (‘hmA1V’) where murine‐A1 replaced human‐A1 in hV. This yielded ‘hmA1NV’ and ‘hmA1CV’, with N‐ and C‐terminal inserts. The constructs were tested ex vivo and in vivo.
Results
Mucin insertion at the N‐terminus, but not C‐terminus, in both types of constructs resulted in >50‐fold increase in binding to immobilized GpIbα. N‐terminal insertion also resulted in greater shear‐induced platelet activation, more thrombus formation on collagen, enhanced platelet accumulation and slower platelet translocation on immobilized VWF in microfluidics assays. Hydrodynamic injection‐based expression of hmA1NV, but not hmA1V or hmA1CV, in VWF−/− mice caused profound thrombocytopenia, reduced plasma VWF concentrations, lower multimer distribution, and incessant tail bleeding that is reminiscent of von Willebrand disease type 2B. Platelet plugs were noted in the portal veins and hepatic arteries. An anti‐D'D3 mAb DD3.3 that displays enhanced binding to VWF containing the N‐terminal mucin insert also exhibited increased binding to wild‐type VWF under shear and upon ristocetin addition.
Conclusion
Conformation changes at the VWF D'D3‐A1 interface may be a key regulator of thrombosis in vivo. Structural features at the A1‐A2 interface are likely of less significance.
B-flavor tagging at Belle II Akopov, N.; Banerjee, Sw; Bauer, M. ...
European physical journal. C, Particles and fields,
04/2022, Letnik:
82, Številka:
4
Journal Article
Recenzirano
Odprti dostop
We report on new flavor tagging algorithms developed to determine the quark-flavor content of bottom (
) mesons at Belle II. The algorithms provide essential inputs for measurements of quark-flavor ...mixing and charge-parity violation. We validate and evaluate the performance of the algorithms using hadronic
decays with flavor-specific final states reconstructed in a data set corresponding to an integrated luminosity of 62.8 fb
-
1
, collected at the
resonance with the Belle II detector at the SuperKEKB collider. We measure the total effective tagging efficiency to be
ε
eff
=
(
30.0
±
1.2
(
stat
)
±
0.4
(
syst
)
)
%
for a category-based algorithm and
ε
eff
=
(
28.8
±
1.2
(
stat
)
±
0.4
(
syst
)
)
%
for a deep-learning-based algorithm.
Abstract The construction industry began emphasizing the three major pillars of sustainable development after the 1987 Brundtland Report. Sustainable design methodologies focus on life-cycle costs ...and the associated impacts of construction, operation, and maintenance. Maintaining road infrastructure accounts for a significant portion of the development budget owing to recurring costs, construction, and material extraction, while also resulting in other difficulties for the society. Poor road quality induce increased cost of living and degraded quality of life. Owing to front-end costs, road owners are typically motivated to pursue designs focused on the project’s initial cost. This is primarily attributable to a lack of understanding of sustainable development parameters. Life cycle cost attempts to quantify the environmental costs of sustainable construction. However, societal factors have been generally ignored. Currently, road section design is open to the designers’ choice of conventional unreinforced sections or a wide variety of planar and three-dimensional geosynthetic reinforcements. This study defined quantitative and scaled qualitative measures for designing road infrastructure using a sustainable approach. The methodology was explained using a full-scale real-life road project.
A
bstract
We present a measurement of the ratio
R
μ
=
B
τ
−
→
μ
−
ν
¯
μ
ν
τ
/
B
τ
−
→
e
−
ν
¯
e
ν
τ
of branching fractions
B
of the
τ
lepton decaying to muons or electrons using data collected with ...the Belle II detector at the SuperKEKB
e
+
e
−
collider. The sample has an integrated luminosity of 362 ± 2 fb
−
1
at a centre-of-mass energy of 10.58 GeV. Using an optimised event selection, a binned maximum likelihood fit is performed using the momentum spectra of the electron and muon candidates. The result,
R
μ
= 0.9675 ± 0.0007 ± 0.0036, where the first uncertainty is statistical and the second is systematic, is the most precise to date. It provides a stringent test of the light-lepton universality, translating to a ratio of the couplings of the muon and electron to the
W
boson in
τ
decays of 0.9974 ± 0.0019, in agreement with the standard model expectation of unity.
Objective
We determined mean main portal vein diameter in healthy patients evaluated with CT, compared this value to the “upper limit of normal” reported previously, and evaluated effects of age, ...sex, height, and BMI on portal vein diameter.
Materials and methods
Our cohort of healthy patients underwent abdominal CT as potential renal donors. We excluded patients with evidence of liver or severe cardiac disease. We recorded patients’ age, sex, height, weight, and BMI. Patients’ main portal vein diameters were measured by fellowship-trained abdominal imagers on non-contrast and post-contrast images in axial and coronal projections at a defined location. A general linear mixed model was used for analysis.
Results
191 patients with 679 main portal vein measurements were included in the analysis. Mean main portal vein diameter was 15.5 ± 1.9 mm; this value was significantly different from the upper limit of normal of 13 mm commonly referenced in the literature (95% CI: 2.22–2.69 mm
higher
,
p
< 0.0001). Portal vein diameter does not vary significantly when measured on axial vs. coronal images. On average, post-contrast main portal veins were 0.56 mm larger compared to non-contrast, (95% CI: 0.40–0.71 mm,
p
< 0.0071). Patient height and BMI are positively correlated with MPV diameter.
Conclusions
Normal mean portal vein diameter measured on CT was significantly larger (mean 15.5 mm) than the accepted upper limit of 13 mm. Contrast-enhanced main portal veins are significantly larger (0.56 mm) than unenhanced. Sex, height, and BMI significantly affect main portal vein diameter.
BACKGROUND AND PURPOSE:Ultrasound is a standard technique to detect lymph node metastasis in papillary thyroid cancer. Cystic changes and microcalcifications are the most specific features of ...metastasis, but with low sensitivity. This prospective study compared the diagnostic accuracy of a predictive model for sonographic evaluation of lymph nodes relative to the radiologist's standard assessment in detecting papillary thyroid cancer metastasis in patients after thyroidectomy.MATERIALS AND METHODS:Cervical lymph node sonographic images were reported by a radiologist (R method) per standard practice. The same images were independently evaluated by another radiologist using a sonographic predictive model (M method). A test was considered positive for metastasis if the R or M method suggested lymph node biopsy. The result of lymph node biopsy or surgical pathology was used as the reference standard. We estimated relative true-positive fraction and relative false-positive fraction using log-linear models for correlated binary data for the M method compared with the R method.RESULTS:A total of 237 lymph nodes in 103 patients were evaluated. Our analysis of relative true-positive fraction and relative false-positive fraction included 54 nodes with pathologic results in which at least 1 method (R or M) was positive. The M method had a higher relative true-positive fraction of 1.46 (95% CI, 1.12–1.91; P = .006) and a lower relative false-positive fraction of 0.58 (95% CI, 0.36–0.92; P = .02) compared with the R method.CONCLUSIONS:The sonographic predictive model outperformed the standard assessment to detect lymph node metastasis in patients with papillary thyroid cancer and may reduce unnecessary biopsies.
Acute Primary Tuberculous Ulcer of Glans Penis Pandey, D; Agrawal, S; Pokharel, S
Kathmandu University medical journal,
2019 Oct.-Dec., 20191001, Letnik:
17, Številka:
68
Journal Article
Recenzirano
Acute primary tuberculous ulcer of glans penis is a rare entity even in the endemic region. We present a 55 year old male with multiple undermined ulcers for short duration of 4 weeks with raised ...erythrocyte sedimentation rate, negative Mantoux test and histopathology revealed a diagnosis of tuberculous ulcer which responded well to antitubercular therapy.
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