Phenylpropanoid metabolism is one of the most important metabolisms in plants, yielding more than 8,000 metabolites contributing to plant development and plant–environment interplay. Phenylpropanoid ...metabolism materialized during the evolution of early freshwater algae that were initiating terrestrialization and land plants have evolved multiple branches of this pathway, which give rise to metabolites including lignin, flavonoids, lignans, phenylpropanoid esters, hydroxycinnamic acid amides, and sporopollenin. Recent studies have revealed that many factors participate in the regulation of phenylpropanoid metabolism, and modulate phenylpropanoid homeostasis when plants undergo successive developmental processes and are subjected to stressful environments. In this review, we summarize recent progress on elucidating the contribution of phenylpropanoid metabolism to the coordination of plant development and plant–environment interaction, and metabolic flux redirection among diverse metabolic routes. In addition, our review focuses on the regulation of phenylpropanoid metabolism at the transcriptional, post‐transcriptional, post‐translational, and epigenetic levels, and in response to phytohormones and biotic and abiotic stresses.
Plant development and plant‐environment interactions are modulated by phenylpropanoid metabolism, which is regulated by transcriptional, post‐transcriptional, post‐translational, and epigenetic mechanisms, and responds to phytohormones and biotic and abiotic stresses.
Aim
Up‐to‐date epidemiological studies on the global burden of severe periodontitis is scarce. This study aimed to present the latest estimates for prevalence of severe periodontitis from 1990 to ...2019, by region, age, and level of socio‐demographic development.
Materials and Methods
Estimates from the Global Burden of Disease study 2019 were used to investigate burden and trends of prevalence of severe periodontitis and its association with socio‐demographic development at global, regional, and national level. Decomposition analysis was performed to explore the contribution of demographic and epidemiological factors to the evolving burden of severe periodontitis.
Results
In 2019, there were 1.1 billion (95% uncertainty interval: 0.8–1.4 billion) prevalent cases of severe periodontitis globally. From 1990 to 2019, age‐standardized prevalence rate of severe periodontitis increased by 8.44% (6.62%–10.59%) worldwide. Prevalence of severe periodontitis is higher among less developed countries/regions. Global population growth accounted for 67.9% of the increase in the number of prevalent cases of severe periodontitis from 1990 to 2019.
Conclusions
The global burden of severe periodontitis has been substantial and increasing over the past three decades. Upstream policy changes are urgently needed to address the global public health challenge of severe periodontitis.
Grain number and size are interactive agronomic traits that determine grain yield. However, the molecular mechanisms responsible for coordinating the trade-off between these traits remain elusive. ...Here, we characterized the rice (Oryza sativa) grain size and number1 (gsn1) mutant, which has larger grains but sparser panicles than the wild type due to disordered localized cell differentiation and proliferation. GSN1 encodes the mitogen-activated protein kinase phosphatase OsMKP1, a dual-specificity phosphatase of unknown function. Reduced expression of GSN1 resulted in larger and fewer grains, whereas increased expression resulted in more grains but reduced grain size. GSN1 directly interacts with and inactivates the mitogen-activated protein kinase OsMPK6 via dephosphorylation. Consistent with this finding, the suppression of mitogen-activated protein kinase genes OsMPK6, OsMKK4, and OsMKKK10 separately resulted in denser panicles and smaller grains, which rescued the mutant gsn1 phenotypes. Therefore, OsMKKK10-OsMKK4-OsMPK6 participates in panicle morphogenesis and acts on a common pathway in rice. We confirmed that GSN1 is a negative regulator of the OsMKKK10-OsMKK4-OsMPK6 cascade that determines panicle architecture. The GSN1-MAPK module coordinates the trade-off between grain number and grain size by integrating localized cell differentiation and proliferation. These findings provide important insights into the developmental plasticity of the panicle and a potential means to improve crop yields.
SUMMARY
Grain size is one of the essential components determining rice yield and is a target for both domestication and artificial breeding. Gibberellins (GAs) are diterpenoid phytohormones that ...influence diverse aspects of plant growth and development. Several quantitative trait loci (QTLs) have been identified that control grain size through phytohormone regulation. However, little is known about the role of GAs in the control of grain size. Here we report the cloning and characterization of a QTL, GW6 (GRAIN WIDTH 6), which encodes a GA‐regulated GAST family protein and positively regulates grain width and weight. GW6 is highly expressed in the young panicle and increases grain width by promoting cell expansion in the spikelet hull. Knockout of GW6 exhibits reduced grain size and weight, whereas overexpression of GW6 results in increased grain size and weight. GW6 is induced by GA and its knockout downregulates the expression of GA biosynthesis genes and decreases GA content in the young panicle. We found that a natural variation in the cis element CAAT‐box in the promoter of GW6 is associated with its expression level and grain width and weight. Furthermore, introduction of GW6 to Oryza indica variety HJX74 can lead to a 10.44% increase in rice grain yield, indicating that GW6 has great potential to improve grain yield in rice.
Significance Statement
GW6 participates in the regulation of gibberellin biosynthesis in the rice panicle, by which it can positively regulate grain size and weight by promoting cell expansion in the spikelet hull and accelerating the grain filling rate, leading to a significant increase in grain yield. Therefore, GW6 has great potential to improve grain yield in rice breeding.
Grain size is an important component trait of grain yield, which is frequently threatened by abiotic stress. However, little is known about how grain yield and abiotic stress tolerance are regulated. ...Here, we characterize GSA1, a quantitative trait locus (QTL) regulating grain size and abiotic stress tolerance associated with metabolic flux redirection. GSA1 encodes a UDP-glucosyltransferase, which exhibits glucosyltransferase activity toward flavonoids and monolignols. GSA1 regulates grain size by modulating cell proliferation and expansion, which are regulated by flavonoid-mediated auxin levels and related gene expression. GSA1 is required for the redirection of metabolic flux from lignin biosynthesis to flavonoid biosynthesis under abiotic stress and the accumulation of flavonoid glycosides, which protect rice against abiotic stress. GSA1 overexpression results in larger grains and enhanced abiotic stress tolerance. Our findings provide insights into the regulation of grain size and abiotic stress tolerance associated with metabolic flux redirection and a potential means to improve crops.
In wireless sensor networks nodes can be static or mobile, depending on the application requirements. Dealing with mobility can pose some formidable challenges in protocol design, particularly, at ...the link layer. These difficulties require mobility adaptation algorithms to localize mobile nodes and predict the quality of link that can be established with them. This paper surveys the current state-of-art in handling mobility. It first describes existing mobility models and patterns; and analyzes the challenges caused by mobility at the link layer. It then provides a comparative study of several mobility-aware MAC protocols.
Microplastic pollution has become emerging environmental concern around world. The wastewater treatment plants (WWTPs) are attributed to a major pathway for microplastics (MPs) to enter into aquatic ...environment. To understand the fate and control strategies of MPs in WWTPs, we investigated MPs at a full-scale WWTP, Eastern China, with two parallel wastewater treatment systems, i.e. oxidation ditch (OD) and membrane bioreactor (MBR) for case study. The influent MPs consisted of polyethylene terephthalate (PET, 47%), polystyrene (PS, 20%), polyethylene (PE, 18%) and polypropylene (PP, 15%). MP morphotypes dominated in fragments (65%) and fibers (21%), which mainly were PET, with limited films (12%) and foams (2%). Typical plastic microbeads were not observed. The dominant size of MPs was >500 μm (40%) and 62.5–125 μm (29%). MP concentrations increased across the treatment systems depends on facility of treatment process. Influent MPs were removed by 99.5% in MBR system versus 97% in OD system on the basis of plastic mass while 82.1% versus 53.6% on MP number. The removed MPs accumulated in sludge phase. MBR system has much higher MP removal efficiency than OD system, likely due to membrane filtration. The results suggest that the source control of MPs by eliminating MP fibers from laundry facilities, banning use of plastic microbeads, Styrofoam products and plastic bags and properly selecting WWTP treatment unit could significantly reduce the mass and number of MPs from WWTPs.
Display omitted
•Microplastics (MP) numbers increased cross oxidation ditch and MBR systems.•MPs belonging to PET, PS, PE and PP dominated in morphotypes of fragments and fibers.•MPs removed from water phase by >97% and accumulated in sludge phase.•MBR was superior in MP removal due to micromembrane filtration.•Strategies for MP source reduction and enhancement of WWTP management are proposed.
In plant cells, calcium (Ca
) serves as a versatile intracellular messenger, participating in several fundamental and important biological processes. Recent studies have shown that the actin ...cytoskeleton is not only an upstream regulator of Ca
signaling, but also a downstream regulator. Ca
has been shown to regulates actin dynamics and rearrangements via different mechanisms in plants, and on this basis, the upstream signaling encoded within the Ca
transient can be decoded. Moreover, actin dynamics have also been proposed to act as an upstream of Ca
, adjust Ca
oscillations, and establish cytosolic Ca
(Ca
) gradients in plant cells. In the current review, we focus on the advances in uncovering the relationship between the actin cytoskeleton and calcium in plant cells and summarize our current understanding of this relationship.
Globalization policies are encouraging manufacturing companies to produce environment-friendly products that offer a sustainable competitive advantage. Currently, product recovery and zero-waste ...supply chains have caught the attention of manufacturers and professionals. Reverse logistics (RL) is considered as the most significant part of supply chain management in developed countries; unfortunately, its implementation in developing countries is in the initial stages due to certain barriers. This study aims to identify and verify the barriers to implementation of reverse logistics using a two-stage methodology: the Delphi Method and Structural Equation Modeling. A comprehensive literature review was considered to identify a primary set of barriers. Using the Delphi Method, a team of experts screened out barriers after performing three iterations. A survey-based questionnaire was then sent out to supply chain and logistics employees in the manufacturing industry and relevant government authorities. Five hundred and forty-seven useful responses were analyzed in the Statistical Package for the Social Science (SPSS) & AMOS 21 softwares using Structural Equation Modeling to verify barriers, and ranked according to their severity. The most critical barriers with respect to each category are: high cost of reverse logistics adoption (finance and economics), lack of skilled professionals (knowledge and experience), lack of government supportive policies (law and regulation), poor organizational culture (management), lack of human resources (infrastructure and technology), lack of environmental law awareness (environment), lack of community pressure (market) and company policies (reverse logistics in policy). Overall, the top five barriers found in this study include lack of initial capital, lack of skilled professional in RL, companies’ policies against RL, lack of new technologies and information systems, and lack of community pressure. Knowledge about barriers to reverse logistics allows manufacturing companies to prepare a priority list of actions for better implementation of the reverse logistics system.
The surging global demand for renewable energy has fueled the expansion of offshore wind energy, leveraging superior wind profiles and technological advancements in offshore wind turbine technology. ...Despite this growth, the operational experience of floating offshore wind turbines still needs to be improved as an emerging technology. Addressing this knowledge gap, our study compiles a comprehensive database of failure events associated with these turbines. Employing a rigorous analytical approach through the Fuzzy Failure Mode and Effect Analysis (FMEA) methodology, we conduct an in‐depth failure analysis of floating offshore wind turbines. This investigation allows us to identify the most critical failure modes and pinpoint components vulnerable to failures. The paper delves into the root causes of these significant failure modes, proposing preventive and corrective measures based on our findings. Our recommendations serve as a strategic guide for stakeholders, offering insights to enhance offshore wind turbines’ design, operation, and maintenance practices and the broader wind farm infrastructure. Despite this, further clarification on the application and highlights of the fuzzy FMEA model is warranted in the , a point we address in the revised conclusion to enhance our study's overall clarity and completeness.
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