The Synthetic Aperture Radar Interferometry (InSAR) technique can quickly obtain millimeter-level surface deformation in urban areas with high coherence. However, expanding the application of time ...series InSAR in non-urban areas is an important research focus. An improved SBAS-InSAR analysis approach is applied in this study to present the surface displacement along two expressways under construction. Taking the Kejiao and Yicheng Highway in the Shenzhen Shanwei Special Cooperation Zone as examples, the deformation along the highways under construction and the surrounding ground objects is revealed. Moreover, the time series displacements and construction conditions are combined to explain the possible mechanisms behind the different displacements of various ground objects along the expressways. The results show that the climate, environment, and construction conditions of the cooperation zone had an impact on the deformation of various ground objects along the route. Compared to traditional PS-InSAR methods, the density and accuracy of coherence points are improved, which better overcomes the spatiotemporal incoherence effects in non-urban areas.
•We theoretically proposed a method to localize the antiferromagnetic skyrmions.•The stable pinning of the skyrmion for certain ranges of injected current is demonstrated.•A precise track-selecting ...of the antiferromagnetic skyrmions is proposed.
Reliable detection of antiferromagnetic (AFM) structures remains an open issue in experiments, although these structures such as skyrmions are suggested to play an important role in future spintronic applications. In this work, we theoretically proposed an alternative method to localize the AFM skyrmions along the direction of driving force through tuning magnetic anisotropy barriers by linear lattice defect design. The dependence of the depinning current on the magnitude and width of the defects and temperature is numerically investigated by solving the Landau-Lifshitz-Gilbert equation and also derived based on the Thiele’s theory. The stable pinning of the skyrmion for certain ranges of the injected current is clearly demonstrated, which suggests an effective way in localizing the skyrmion. Based on the calculated results, we propose a method of precise track-selecting of the AFM skyrmions, which are meaningful for future two- and three- dimensional AFM spintronic device design.
Dysregulation of β-catenin turnover due to mutations of its regulatory proteins including adenomatous polyposis coli (APC) and p53 is implicated in the pathogenesis of cancer. Thus, intensive effort ...is being made to search for alternative approaches to reduce abnormally activated β-catenin in cancer cells. Nur77, an orphan member of the nuclear receptor superfamily, has a role in the growth and apoptosis of cancer cells. Here, we reported that Nur77 could inhibit transcriptional activity of β-catenin by inducing β-catenin degradation via proteasomal degradation pathway that is glycogen synthase kinase 3β and Siah-1 independent. Nur77 induction of β-catenin degradation required both the N-terminal region of Nur77, which was involved in Nur77 ubiquitination, and the C-terminal region, which was responsible for β-catenin binding. Nur77/ΔDBD, a Nur77 mutant lacking its DNA-binding domain, resided in the cytoplasm, interacted with β-catenin, and induced β-catenin degradation, demonstrating that Nur77-mediated β-catenin degradation was independent of its DNA binding and transactivation, and might occur in the cytoplasm. In addition, we reported our identification of two digitalis-like compounds (DLCs), H-9 and ATE-i2-b4, which potently induced Nur77 expression and β-catenin degradation in SW620 colon cancer cells expressing mutant APC protein in vitro and in animals. DLC-induced Nur77 protein was mainly found in the cytoplasm, and inhibition of Nur77 nuclear export by the CRM1-dependent nuclear export inhibitor leptomycin B or Jun N-terminal kinase inhibitor prevented the effect of DLC on inducing β-catenin degradation. Together, our results demonstrate that β-catenin can be degraded by cytoplasmic Nur77 through their interaction and identify H-9 and ATE-i2-b4 as potent activators of the Nur77-mediated pathway for β-catenin degradation.
In this work, we study the microwave field driven domain wall (DW) motion in an antiferromagnetic nanowire, using the numerical calculations based on a classical Heisenberg spin model with the ...biaxial magnetic anisotropy. We show that a proper combination of a static magnetic field plus an oscillating field perpendicular to the nanowire axis is sufficient to drive the DW propagation along the nanowire. More importantly, the drift velocity at the resonance frequency is comparable to that induced by temperature gradients, suggesting that microwave field can be a very promising tool to control DW motions in antiferromagnetic nanostructures. The dependences of resonance frequency and drift velocity on the static and oscillating fields, the axial anisotropy, and the damping constant are discussed in details. Furthermore, the optimal orientations of the field are also numerically determined and explained. This work provides useful information for the spin dynamics in antiferromagnetic nanostructures for spintronics applications.
beta decay of proton-rich nuclei plays an important role in exploring isospin mixing. The beta decay of P-26 at the proton drip line is studied using double-sided silicon strip detectors operating in ...conjunction with high-purity germanium detectors. The T = 2 isobaric analog state (IAS) at 13 055 keV and two new high-lying states at 13 380 and 11 912 keV in Si-26 are unambiguously identified through beta-delayed two-proton emission (beta 2p). Angular correlations of two protons emitted from Si-26 excited states populated by P-26 beta decay are measured, which suggests that the two protons are emitted mainly sequentially. We report the first observation of a strongly isospin-mixed doublet that deexcites mainly via two-proton decay. The isospin mixing matrix element between the Si-26 IAS and the nearby 13 380-keV state is determined to be 130(21) keV, and this result represents the strongest mixing, highest excitation energy, and largest level spacing of a doublet ever observed in beta-decay experiments.
•We study the antiferromagnetic domain wall motion driven by the rotating field.•Two motion modes are found in the absence of Dzyaloshinskii-Moriya interaction.•The dependences of the velocity and ...the critical frequency on several internal parameters are investigated.•The roles of the Dzyaloshinskii-Moriya interaction on the wall motion are clarified.
In this work, we study the rotating magnetic field driven domain wall (DW) motion in antiferromagnetic nanowires, using the micromagnetic simulations of the classical Heisenberg spin model. We show that in low frequency region, the rotating field alone could efficiently drive the DW motion even in the absence of Dzyaloshinskii-Moriya interaction (DMI). In this case, the DW rotates synchronously with the magnetic field, and a stable precession torque is available and drives the DW motion with a steady velocity. In large frequency region, the DW only oscillates around its equilibrium position and cannot propagate. The dependences of the velocity and critical frequency differentiating the two motion modes on several parameters are investigated in details, and the direction of the DW motion can be controlled by modulating the initial phase of the field. Interestingly, a unidirectional DW motion is predicted attributing to the bulk DMI, and the nonzero velocity for high frequency is well explained. Thus, this work does provide useful information for future antiferromagnetic spintronics applications.
This study aimed to observe the dynamic changes of NUP98::NSD1 expression before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT) . Moreover, the clinical value of measurable ...residual disease (MRD) was analyzed.
Sixteen AML patients who were diagnosed with the NUP98::NSD1 fusion gene and received allo-HSCT at Peking University People's Hospital were included. The NUP98::NSD1 fusion gene and leukemia-associated immunophenotype (LAIP) were monitored before and after transplantation to evaluate their MRD status.
The median follow-up time for all patients was 526 days (139-1136 days) , with four patients (25.0%) experiencing hematological recurrence at a median of 474 days (283-607 days) after transplantation. Three patients (18.8%) died, two of whom (12.5%) died of leukemia recurrence. The median expression level of NUP98::NSD1 in newly diagnosed patients with complete data was 78.5% (18.9%-184.4%) at the time of initial diagnosis. The recurrence rate was higher in NUP98::NSD1-positive pa
Abstract
According to the standard EN 45545, fire resistant tests of floor structures in high-speed train were carried out. Two typical floor structures which were placed in the passenger train were ...tested. Integrity and insulation are main performance criteria to evaluate fire resistance of floor structures. The furnace temperature is in accordance with the requirements in the standard ISO 834. The surface temperature and deflection were recorded with time. Glass wool and aluminium corrugated sandwich structure in two structures were burned through. The experiments were terminated at 30 minutes and 31 minutes respectively for the two structures. A large amount of smoke and the sound of cracking of the exposed surface of the test piece were produced, although the unexposed surface of test pieces did not reach the failure condition.
The concept of "place" is crucial for understanding geographical environments from a human perspective. Place representation learning involves converting places into numerical low-dimensional dense ...vectors and is a fundamental procedure for artificial intelligence in geography (GeoAI). However, most studies ignore multi-level distance constraints and spatial proximity interactions that enable behavioral interactions between places. Furthermore, representing the temporal characteristics of these interactions in trajectory sequences poses a challenge for natural language processing and other field techniques. In addition, most existing methods rely on all modalities from inputs as they use joint training to integrate multiple modalities. To address these issues, we propose a Multi-Modal Contrastive Pre-training model for Place representation (MMCPP). Our model consists of three encoders that capture corresponding place attributes across different modalities, including point of interests (POIs), images, and trajectories. The trajectory encoder, named RodtFormer, takes fine-grained spatio-temporal trajectories as input and leverages self-attention with rotary temporal interval position embedding to simulate dynamic spatial and behavioral proximity interactions between places. By using a coordinated pre-training framework, MMCPP independently encodes place representations across different modalities and improves model reusability. We verify the effectiveness of our model on a taxi trajectory dataset using the location prediction task at next n seconds, including 30 seconds(s), 180(s), 300(s). Our results demonstrate that compared to existing embedding methods, our model is capable of learning higher-quality position representations during pre-training, leading to improved performance on downstream tasks.
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