SPPS resins impact the PNA-syntheses' improvement Pipkorn, Rüdiger; Rawer, Stephan; Wiessler, Manfred ...
International journal of medical sciences,
01/2013, Letnik:
10, Številka:
3
Journal Article
Odprti dostop
The personalized medicine, also documented as "individualized medicine", is an effective and therapeutic approach. It is designed to treat the disease of the individual patient whose precise ...differential gene expression profile is well known. The trend in the biomedical and biophysical research shows important consequences for the pharmaceutical drug and diagnostics research. It requires a high variability in the design and safety of target-specific pharmacologically active molecules and diagnostic components for imaging of metabolic processes. A key technology which may fulfill the highest demands during synthesis of these individual drugs and diagnostics is the solid phase synthesis which is congenial to automated manufacturing. Additionally the choice of tools like resins and reagents is pivotal to synthesize drugs and diagnostics in high quality and yields. Here we demonstrate the solid phase synthesis effects dependent on the choice of resin and of the deprotection agent.
The availability of sophisticated hunting and sports weapons such as modern crossbows increases the incidence of uncommon types of accidental, suicidal, and homocidal head injuries. This report ...describes the case of a 47-year-old man with a nonfatal head injury due to a crossbow broadhead hunting arrow penetrating the left frontal lobe. The injury was accidentally self-inflicted by the intoxicated patient. A review of the literature has shown that self-inflicted head injuries caused by arrows are a very rare or, at least, a seldom reported entity. The mechanisms and pathophysiology of penetrating head injuries caused by different kinds of projectiles are discussed in order to clarify the management of these cases. PUBLICATION ABSTRACT
Thermodynamic properties as well as low-energy magnon excitations of \(S=1\) honeycomb-layered Na\(_3\)Ni\(_2\)SbO\(_6\) have been investigated by high-resolution dilatometry, static magnetisation, ...and high-frequency electron spin resonance studies in magnetic fields up to 16 T. At \(T_{\rm N}\) = 16.5 K, there is a tricritical point separating two distinct antiferromagnetic phases AF1 and AF2 from the paramagnetic regime. In addition, our data imply short-range antiferromagnetic correlations at least up to \(\sim 5\cdot T_{\rm N}\). Well below \(T_{\rm N}\), the magnetic field \(B_{\rm C1}\approx\) 9.5 T is needed to stabilize AF2 against AF1. The thermal expansion and magnetostriction anomalies at \(T_{\rm N}\) and \(B_{\rm C1}\) imply significant magnetoelastic coupling, both of which associated with a sign change of \(\partial L/\partial B\). The transition at \(B_{\rm C1}\) is associated with softening of the antiferromagnetic resonance modes observed in the electron spin resonance spectra. The anisotropy gap \(\Delta = 360\) GHz implies considerable uniaxial anisotropy. We conclude the crucial role of axial anisotropy favoring the AF1 spin structure over the AF2 one. While the magnetostriction data disprove a simple spin-flop scenario at \(B_{\rm C1}\), the nature of a second transition at \(B_{\rm C2}\approx\) 13 T remains unclear. Both the sign of the magnetostriction and Gr\"uneisen analysis suggest the short-range correlations at high temperatures to be of AF2-type.
The essays brought together in this volume share a common objective: To bring a unifying methodological approach to the analysis of financial problems in developing, open economies. While the primary ...focus is on contemporary Latin America, the methods employed and the lessons learned are of wider applicability. The papers address the financial integration issue from three different perspectives. In some cases, a country study is the vehicle for an econometric investigation of a particular external linkage. In other cases, an individual country's experience suggests an economic model in which the stylized facts may be analyzed and developed. A third direction is unabashedly theoretical and formulates more general principles which are broadly applicable rather than country-specific.
Perceptual issues in optical-see-through displays Huckauf, Anke; Urbina, Mario H.; Grubert, Jens ...
Proceedings of the 7th Symposium on Applied Perception in Graphics and Visualization,
07/2010
Conference Proceeding
Optical see-through devices enable observers to see additional information embedded in real environments. There is already some evidence of increasing visual load in respective systems. We ...investigated visual performance when users performed visual search tasks or dual tasks only on the optical see-through device, only on a computer screen, or switching between both. In spite of having controlled for basic differences between both devices, switching between the presentation devices produced costs in visual performance. The assumption that these decreases in performance are partly due to differences localizing the presented objects was confirmed by convergence data.
The potential of Augmented Reality (AR) to support industrial processes has been demonstrated in several studies. While there have been first investigations on user related issues in the ...long-duration use of mobile AR systems, to date the impact of theses systems on physiological and psychological aspects is not explored extensively. We conducted an extended study in which 19 participants worked 4 hours continuously in an order picking process with and without AR support. Results of the study comparing strain and work efficiency are presented and open issues are discussed.
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