Uvod: Kakovost študijskih programov je povezana s strokovno in znanstveno usposobljenostjo visokošolskih učiteljev. Namen raziskave je bil pregledati publicistično aktivnost visokošolskih učiteljev ...izbranih strokovnih predmetov v visokošolskih institucijah za zdravstveno nego v Sloveniji.Metoda: Retrospektivno so bili pregledani javno dostopni podatki o publiciranju 76 visokošolskih učiteljev, nosilcev dvanajstih strokovnih predmetov v sedmih visokošolskih institucijah na področju zdravstvene nege, za obdobje 2010–2015. Podatki so prikazani z opisno statistiko.Rezultati: V prikazanem obdobju je bilo evidentiranih 4.337 enot publiciranja, na enega visokošolskega učitelja povprečno 57,32 (s = 59,05). Od tega je bilo največ mentorstev diplom (n = 2928, 67,30 %), najmanj izvirnih znanstvenih člankov (n = 268, 6,21 %), še manj preglednih znanstvenih člankov (n = 46, 1,10 %). Obstajajo razlike v publiciranju na splošno med fakultetami (χ2(2) = 14,272, p = 0,027), pri mentorstvih (χ2(2) = 16,767, p = 0,010), preglednih znanstvenih člankih (χ2(2) = 28,442, p < 0,001) uredništvih (χ2(2) = 17,870, p = 0,007).Diskusija in zaključek: Nosilci strokovnih predmetov zdravstvene nege kažejo različne aktivnosti na področju publiciranja bibliografskih enot. Visokošolske institucije naj spodbujajo visokošolske učitelje k publiciranju ter s tem pospešujejo njihov strokovni in znanstveni razvoj. Publiciranje znanstvenih bibliografskih enot bi bilo smiselno dodati tudi merilom za habilitacijo v naziv predavatelja.
Uvod: Kakovost študijskih programov je povezana s strokovno in znanstveno usposobljenostjo visokošolskih učiteljev. Namen raziskave je bil pregledati publicistično aktivnost visokošolskih učiteljev ...izbranih strokovnih predmetov v visokošolskih institucijah za zdravstveno nego v Sloveniji. Metoda: Retrospektivno so bili pregledani javno dostopni podatki o publiciranju 76 visokošolskih učiteljev, nosilcev dvanajstih strokovnih predmetov v sedmih visokošolskih institucijah na področju zdravstvene nege, za obdobje 2010-2015. Podatki so prikazani z opisno statistiko. Rezultati: V prikazanem obdobju je bilo evidentiranih 4.337 enot publiciranja, na enega visokošolskega učitelja povprečno 57,32 (s = 59,05). Od tega je bilo največ mentorstev diplom (n = 2928, 67,30 %), najmanj izvirnih znanstvenih člankov (n = 268, 6,21 %), še manj preglednih znanstvenih člankov (n = 46, 1,10 %). Obstajajo razlike v publiciranju na splošno med fakultetami (x2(2) = 14,272, p = 0,027), pri mentorstvih (x2(2) = 16,767, p = 0,010), preglednih znanstvenih člankih (x2(2) = 28,442, p < 0,001) uredništvih (x2(2) = 17,870, p = 0,007). Diskusija in zaključek: Nosilci strokovnih predmetov zdravstvene nege kažejo različne aktivnosti na področju publiciranja bibliografskih enot. Visokošolske institucije naj spodbujajo visokošolske učitelje k publiciranju ter s tem pospešujejo njihov strokovni in znanstveni razvoj. Publiciranje znanstvenih bibliografskih enot bi bilo smiselno dodati tudi merilom za habilitacijo v naziv predavatelja.
This is a brief communication stressing some critical points associated with cystic nodal metastasis (CNM) in human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) and its ...implication on treatment protocols and outcomes.
Lacrimal gland prolapse (LGP) is a term used to describe a benign, anterior displacement of the lacrimal gland. If this condition is not properly addressed during upper blepharoplasty, the aesthetic ...and functional results are less than optimal. This study aimed to report the surgical outcomes of upper blepharoplasty combined with dacryoadenopexy in patients with LGP.
We reported an unusual case of severe LGP in a young patient. In addition, we performed a systematic review of the English literature on surgical cases of LGP published between 1973 and 2023. Eligible articles were analyzed for individual patient data (IPD) and aggregate patient data (APD). The primary predictor variable was the surgical technique used for lacrimal gland repositioning/suspension. The primary outcome variable was relapse rate.
The bibliographic search retrieved 488 surgical cases of LGP: 12 in IPD, and 476 in APD datasets. The relapse rates in the IPD and APD cohorts were 8.3% (1/12) and 1.2% (6/476), respectively. Within the APD dataset, no significant difference in the relapse rates between dacryoadenopexy via suture suspension and Whitnall's ligament suspension (5/409 and 1/20, respectively; P > 0.05) was observed. Light cauterization of the lacrimal gland capsule and surrounding soft tissues was performed in mild LGP cases (< 4 mm prolapse), with a relapse rate of 0% (0/47).
Upper blepharoplasty combined with dacryoadenopexy proved to be a safe surgical procedure with very satisfactory aesthetic outcome and minimal relapse rate.
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Antiepileptic/teratogen valproate (VPA) is a histone deacetylase inhibitor/epigenetic drug proposed for the antitumor therapy where it is generally crucial to target poorly or undifferentiated cells ...to prevent a recurrence. Transplanted rodent gastrulating embryos‐proper (primitive streak and three germ layers) are the source of teratoma/teratocarcinoma tumors. Human primitive‐streak remnants develop sacrococcygeal teratomas that may recur even when benign (well differentiated). To screen for unknown VPA impact on teratoma‐type tumors, we used original 2‐week embryo‐derived teratoma in vitro biological system completed by a spent media metabolome analysis. Gastrulating 9.5‐day‐old rat embryos‐proper were cultivated in Eagle's minimal essential medium (MEM) with 50% rat serum (controls) or with the addition of 2 mmVPA. Spent media metabolomes were analyzed by FTIR. Compared to controls, VPA acetylated histones; significantly diminished overall teratoma growth, impaired survival, increased the apoptotic index, and decreased proliferation index and incidence of differentiated tissues (e.g., neural tissue). Control teratomas continued to grow and differentiate for 14 days in isotransplants in vivo, but in vitro VPA‐treated teratomas resorbed. Principal component analysis of FTIR results showed that spent media metabolomes formed well‐separated clusters reflecting the treatment and day of cultivation. In metabolomes of VPA‐treated teratomas, we found elevation of previously described histone acetylation biomarkers amide I α‐helix and A(CH3)/A(CH2)) with apoptotic biomarkers within the amide I region for β‐sheets, and unordered and CH2 vibrations of lipids. VPA may be proposed for therapy of the undifferentiated component of teratoma tumors and this biological system completed by metabolome analysis, for a faster dual screening of antitumor/embryotoxic agents.
Valproate (VPA; antiepileptic/teratogen/histone deacetylase inhibitor) negatively affected embryo‐derived teratoma development in vitro and abolished its potential to recover in vivo. FTIR spectroscopy results separated all VPA‐treated and control metabolomes, while FTIR biomarkers reflected processes of apoptosis and histone acetylation assessed in teratomas by immunohistochemistry and western blotting. We propose this in vitro biological system, completed by analysis of spent media metabolomes, as a screening system for embryotoxic and antitumor agents.
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