A QSAR study on novel Pyrimidine derivatives as specific COX-2 inhibitory agents was performed with 69 (59 training + 10 test) compounds. Molecular modeling studies were performed using chemoffice ...6.0 supplied by cambridgesoft. The sketched structures were subjected to energy minimization and the lowest energy structure was used to calculate the physiochemical properties. The regression analysis was carried out using a computer program called SYSTAT 10.2. The best models were selected from the various statistically significant equations. The study revealed that the hydrogen bond donar groups at position-4 enhances the activity, electron with-drawing groups at position-2 reduces the activity, electron donating groups at position-6 enhances the activity. The analysis resulted in QSAR equation, which suggests that,
n
= 59,
r
= 0.957,
r
2
= 0.915, adjusted squared multiple
R
= 0.901, Standard error of estimate(s) = 0.294 & validated
r
2
(
q
2
) = 0.642. This study can help in rational drug design and synthesis of new selective cyclooxygenase-2 inhibitor with predetermined affinity.
We report the first complete genome sequence of a classical swine fever (CSF) virus of subgenotype 2.2. The virus (CSFV/IND/UK/LAL-290) was isolated from the Uttarakhand state of India from a ...backyard pig suspected of having CSF. This genome sequence will give useful insight for future molecular epidemiological studies and the development of an effective vaccine in India.
On investigations, his hemoglobin was 7 g%, total lymphocyte count (TLC) was 4200/mm 3 , erythrocyte sedimentation rate (ESR) was 40 mm/1 st hour and peripheral blood smear was suggestive of ...hemolytic anemia. ... early diagnosis is important in such cases to prevent or reduce morbidity.
PDF
