Isoniazid-hydrazone complexes (IHCs) were synthesized and thoroughly characterized by FT-IR, 1H NMR and 13C NMR spectroscopic techniques. The anti-inflammatory and antidiabetic activities were tested ...for the IHCs using protein denaturation methods and the α-amylase inhibitory method. The molecular modeling studies for IHCs were investigated and their molecular parameters were calculated using Density Functional Theory methods. The IHCs showed lower band gap and higher electrophilicity index values. Further, molecular docking studies were investigated against the α-amylase enzyme to compare the experimental results. The isoniazid hydrazone-salicylic acid complex (3c) showed five hydrogen bonding interactions with amino acid residues of the α-amylase enzyme (1HNY).
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•The synthesis of IHCs is economically cheaper and simple method.•The IHCs proved as anti-inflammatory and antidiabetic agents at in vitro level.•Hydrazone-salicylate complex forms 5 hydrogen bonding interaction with 1HNY.•Electrophilicity index of hydrazone-salicylate complex is higher than others.•FMO studies showed the electron cloud localized in the benzoate and pyridinium.
•The synthesized BHCs showed very good antidiabetic activity.•The BHB showed 5 hydrogen bonding interaction with α-amylase.•The BHS showed 5 hydrogen bonding interaction with α-glucosidase.•The BHA ...showed highest α-amylase inhibition than others.•The BHS showed highest α-glucosidase inhibition than others.
Bis-hydrazone of terephthalic dihydrazide was designed and synthesized using terephthalic dihydrazide and picolinaldehyde. Various bioactive benzoic acids such as benzoic acid, aspirin and salicylic acid were selected as a counter ion moiety for preparing bis-hydrazone complexes (BHCs). The prepared BHCs were well characterized using spectroscopic techniques like 1H NMR, 13C NMR and FT-IR. The BHCs showed very good in vitro antidiabetic activity in the α-amylase enzyme inhibitory method and moderate activity in the α-glucosidase inhibitory method. The molecular docking interactions of BHCs were performed against the human pancreatic α-amylase enzyme (1HNY.pdb) and homology model of α-glucosidase (3A4A.pdb) to prove the enzyme inhibitory activity. The BHCs showed very good binding energy, the complex BHB showed 5 numbers of hydrogen bonding interactions with amino acid residues of 1HNY.pdb and BHS showed 5 numbers of hydrogen bonding interactions with 3A4A.pdb. Further, the molecular orbital studies were performed using density functional theory calculations in order to support the docking study.
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This study reports the synthesis and characterization of a novel compound, a chalcone-based Schiff base (SBC), with potential applications in anti-inflammatory and anti-diabetic treatments. ...Chalcones, known for their diverse biological activities, are combined with Schiff bases, versatile compounds, to create the SBC. The synthesis process involves aldol condensation and Schiff base formation. The compound's structure is confirmed through NMR, FT-IR, and mass spectroscopic analyses. The UV–visible spectroscopy reveals the compound's electronic properties, and molecular docking experiments indicate its potential to interact with enzymes related to inflammation and diabetes. Anti-inflammatory activity is evaluated through a protein denaturation assay using bovine serum albumin. SBC demonstrates significant anti-inflammatory activity, outperforming standard drug molecules, and exhibits concentration-dependent effects. In an α-amylase inhibitory assay, a vital enzyme in the digestive process related to diabetes, SBC shows remarkable inhibition, surpassing standard drug performance, especially at higher concentrations. Molecular docking studies suggest the compound's potential interactions with enzymes responsible for inflammation and diabetes. SBC displays strong binding energies and inhibition constants with α-amylase, indicating its suitability for diabetes-related studies. The synthesis and characterization of SBC, combined with its excellent anti-inflammatory and anti-diabetic activities, underscore its potential as a promising candidate for further biomedical research and therapeutic development.
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An efficient method is developed to prepare copolymer of Poly(styrene-co-methylacrylate) using silver nanoparticle decorated reduced graphene oxide (Ag-rGO) under photocatalytic conditions using blue ...LED as light source. We have successfully utilised the prepared poly(styrene-co-methylacrylate) copolymer-based Ag-rGO nanocomposite (Ag-rGO/(P(S-co-MA) as a filler for reinforcing epoxy composite. Better dispersibility of the hybrid nanocomposite in diglycidyl ether of bisphenol A (DGEBA) over Ag-rGO helped in enhancing the mechanical properties of epoxy. The synthesis of P(S-co-MA)-Ag-rGO was confirmed using various characterization techniques like
1
H NMR,
13
C-NMR, FTIR etc. The particle size distribution and surface morphology were investigated using Field emission scanning electron microscopy (FE-SEM). The mechanical properties of P(S-co-MA)-Ag-rGO based epoxy composites showed a significant 104% of improvement in fracture toughness when compared to neat epoxy. Antibacterial performance and thermal characteristic of the fabricated epoxy composites also were investigated.
Recent years have visualized the entry of various new life-threatening diseases in the form of epidemic and pandemic and hence the introduction of novel drug delivery systems is highly vital for ...saving the lives of people. Recent research in this area portrays a relentless search for overcoming the disadvantages of older systems and replacing them with novel systems. Polymer based drug delivery systems and nanoparticles-based systems are two such developing areas that are discussed in this review. Recent studies have also shown a surge in the application of polymer lipid hybrid nanoparticles in drug delivery systems and also bioorthogonal catalytic reactions for the release of drugs at target site by unmasking reaction of prodrugs. This review highlights the various developments and innovations in the drug delivery field in the recent years with respect to these systems and throws light on the advances in the treatment of diseases in different areas accomplished by means of these systems.
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•Smart coatings auto-respond in synergy with inhibitors during damage occurrences.•Self-repairing action enhances the durability of smart coatings.•Nanoparticle dispersions contribute ...to tougher and more reliable coatings.•Multifunctionality of coatings relies on the stability of the reactive groups.
Smart coatings are innovative coatings that can react spontaneously, due to inbuilt stimuli-responsive mechanisms. The functionality obtained from these class of coatings at the metal-solution interface in aggressive environments has led to advances in anticorrosion studies and applications. This review emphasizes the effects of corrosion sensing, self-healing, anti-fouling, and self-cleaning coatings for corrosion inhibition of metallic materials. However, in keeping with the theme, novel coating designs with anticorrosive characteristics that outweigh the limitations in the use of conventional coatings have been discussed. Noting that the presence of high-quality nanoparticles in coating formulations has outweighed the effects of the microparticles. These have triggered unprecedented functionalities in the smart coatings. The smart coatings respond to single/multiple external stimuli such as light, dirt, pH changes, temperature, aggressive liquids, bio-foulant, impact, fatigue etc; and have demonstrated outstanding, barrier properties with scratch resistance, in-situ healing, superhydrophobicity, superoleophilicity, high optical transmission, thermal stability, and resistance to strong acids etc., resulting in extended service life of the coatings and the protected metallic materials. The utilization of smart coatings in complex, real-time conditions, effectively controls the triggers of metallic degradation, structural failures, and resource depletion.
A simple methodology for the reduction of acid chlorides to their corresponding alcohols has been developed. Various carboxylic acids were converted to alcohols in excellent yields using NaBH
4
-K
2
...CO
3
in a mixed solvent system of dichloromethane and water (1:1) in the presence of a phase-transfer catalyst at low temperature. The importance of the work is its simplicity, selectivity, excellent yield, and very short reaction time. This new reduction condition has proved to be an excellent chemoselective method for a range of acid chlorides in the presence of various functional groups.
Background and aim: The author created a dynamic elbow brace for a 48-year-old lady who had suffered a brachial plexus injury following surgery. The device was developed with therapeutic ...rehabilitation in consideration while being cost-effective. This design was distinct because it made use of low-cost items that were easily sourced and maintained.
Technique: Device with mechanical parts such as DC motor, DPDT switch, pulleys, belts and MS bar were conceptualized and manufactured. The design work in the pulley system.
Discussion: This device allowed the individual to do therapeutic exercise which help in the motion rehabilitation after brachial plexus injury. To meet economical limits, low-cost and conveniently accessible materials were used.
Key words: dynamic elbow brace, brachial plexus injury, cost effective, therapeutic rehabilitation, post operative brace.
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Novel imidazole-based ketene dithioacetals show impressive in planta activity against the economically important plant pathogens Alternaria solani, Botryotinia fuckeliana, Erysiphe ...necator and Zymoseptoria tritici. Especially derivatives of the topical antifungal lanoconazole, which bear an alkynyloxy or a heteroaryl group in the para-position of the phenyl ring, exhibit excellent control of the mentioned phytopathogens. These compounds inhibit 14α -demethylase in the sterol biosynthesis pathway of the fungi. Synthesis routes starting from either benzaldehydes or acetophenones as well as structure-activity relationships are discussed in detail.
