Due to the excellent physical properties and advantages in the field of tumor therapy, lutetium 177 has attracted extensive attention in the field of internal radiation therapy in nuclear medicine. ...The carrier free radionuclide lutetium 177 can be used for targeted treatment of neuroendocrine tumor and prostate tumor. The carrier free radionuclide lutetium 177 can be prepared by irradiating high abundance ytterbium 176 isotope in reactor. The experimental study result found that the abundance of ytterbium 176 isotope directly affects the activity of lutetium 177. In order to meet the requirement of high abundance of ytterbium 176 isotope, in view of the characteristics of high primary separation coefficient and good universality of electromagnetic method, the key process parameters of electromagnetic separation and preparation of high abundance ytterbium 176 isotopes were studied. Ultra dry YbCl3 with purity of 99.99% was selected as the separation raw material according to the requirements of electromagnetic isotope separation on raw materials. The trajectory of ytterbium ion beam in magnetic field was simulated, and the effects of magnetic induction intensity and beam opening angle on the dispersion of ytterbium isotope separation were given. The results are the same as the theoretical analysis. The design of nonuniform field will increase the dispersion between isotopes, reduce the sputtering contamination between isotopes, and then improve the abundance of isotopes. The emission angle of ytterbium ion beam is 11°, the seven isotopes of ytterbium can be separated completely, and the dispersion of ytterbium 176 and ytterbium 174 is large. The effects of ion source parameter on the beam intensity and focusing ability of ytterbium isotopes were obtained by ytterbium isotope electromagnetic separation experiment. The main basis for judging whether the discharge parameters of the ion source are appropriate is the current intensity of the ytterbium 176 ion beam and the focusing ability Q of the ion beam. In this experiment, the ratio of the current intensity of the ytterbium 176 to the panel current intensity was taken as the embodiment of the focusing ability Q. This experiment was carried out by controlling the variable method, and the optimal combination of separation parameters was given. Finally, ytterbium 176 isotope sample with high abundance was prepared by electromagnetic separation. After separation, the ytterbium isotope in the receiver is chemically purified to obtain ytterbium 176 isotope, which is detected by mass spectrometer. The abundance of the sample reaches 9816%. The high abundance ytterbium 176 isotope prepared in this study is chemically treated to form Yb2O3 compound, which is used as the target of nuclear reactor irradiation to supply the demander.
Background Seventeen million births occur in China each year. Neonatal mortality is the leading cause of under 5-year-old child deaths, and intrapartum-related injury accounts for much of mental ...retardation in young children. The Chinese Ministry of Health sought to improve infant and child survival through a nationwide initiative to have at least one person trained in neonatal resuscitation at every birth. The aim of the current study was to evaluate the impact of China Neonatal Resuscitation Program （NRP） on policy and infrastructure changes and its effectiveness in decreasing the incidence of mortality among newborn infants. Methods The Chinese NRP incorporated policy change, professional education, and creation of a sustainable health system infrastructure for resuscitation. Multidisciplinary teams from all 31 provinces and municipal states disseminated NRP in a train-the-trainer cascade. The intervention targeted 20 provinces with high neonatal mortality and programs to reduce maternal mortality. Program evaluation data came from 322 representative hospitals in those provinces. Results Changes in policy permitted midwives to initiate resuscitation and required resuscitation training for licensure. From 2004 through 2009 more than 110 659 professionals received NRP training in the 20 target provinces, with 94% of delivery facilities and 99% of counties reached. Intrapartum-related deaths in the delivery room decreased from 7.5 to 3.4 per 10 000 from 2003 to 2008, and the incidence of Apgar 〈7 at 1 minute decreased from 6.3% to 2.9%. Conclusions The Chinese NRP achieved policy changes promoting resuscitation, trained large numbers of professionals, and contributed to reduction in delivery room mortality. Improved adherence to the resuscitation algorithm, extension of training to the township level, and coverage of births now occurring outside health facilities can further increase the number of lives saved.
AIM To assess the feasibility and safety of a novel enteroscope,negative-pressure suction endoscope in examining the small intestine of a porcine model.METHODS In vitro experiments in small ...intestinal loops from 20pigs and in vivo experiments in 20 living pigs were conducted.RESULTS In in vitro experiments,a negative pressure of>0.06MPa was necessary for optimal visualization of the intestine,and this pressure did not cause gross or histological damage to the mucosa.For satisfactory examination of the small intestine in vivo,higher negative pressure(>1.00 MPa)was required.Despite this higher pressure,the small intestine did not show any gross or microscopic damage in the suctioned areas.The average time of examination in the living animals was 60±7.67 min.The animals did not experience any apparent ill effects from the procedure.CONCLUSION Small intestine endoscope was safely performed within a reasonable time period and enabled complete visualization of the intestine in most cases.
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