We review the relevant 10+ parameters associated with inflation and matter content; the relation between LSS and primary and secondary CMB anisotropy probes; COBE constraints on energy injection; ...current anisotropy band-powers which strongly support the gravitational instability theory and suggest the universe could not have reionized too early. We use Bayesian analysis methods to determine what current CMB and CMB+LSS data imply for inflation-based Gaussian fluctuations in tilted \(\Lambda\)CDM, \(\Lambda\)hCDM and oCDM model sequences with age 11-15 Gyr, consisting of mixtures of baryons, cold (and possibly hot) dark matter, vacuum energy, and curvature energy in open cosmologies. For example, we find the slope of the initial spectrum is within about 5% of the (preferred) scale invariant form when just the CMB data is used, and for \(\Lambda\)CDM when LSS data is combined with CMB; with both, a nonzero value of \(\Omega_\Lambda\) is strongly preferred (\(\approx 2/3\) for a 13 Gyr sequence, similar to the value from SNIa). The \(o\)CDM sequence prefers \(\Omega_{tot}<1 \), but is overall much less likely than the flat \(\Omega_\Lambda \ne 0\) sequence with CMB+LSS. We also review the rosy forecasts of angular power spectra and parameter estimates from future balloon and satellite experiments when foreground and systematic effects are ignored.
The measurements of CMB anisotropy have opened up a window for probing the global topology of the universe on length scales comparable to and beyond the Hubble radius. For compact topologies, the two ...main effects on the CMB are: (1) the breaking of statistical isotropy in characteristic patterns determined by the photon geodesic structure of the manifold and (2) an infrared cutoff in the power spectrum of perturbations imposed by the finite spatial extent. We present a completely general scheme using the regularized method of images for calculating CMB anisotropy in models with nontrivial topology, and apply it to the computationally challenging compact hyperbolic topologies. This new technique eliminates the need for the difficult task of spatial eigenmode decomposition on these spaces. We estimate a Bayesian probability for a selection of models by confronting the theoretical pixel-pixel temperature correlation function with the COBE-DMR data. Our results demonstrate that strong constraints on compactness arise: if the universe is small compared to the `horizon' size, correlations appear in the maps that are irreconcilable with the observations. If the universe is of comparable size, the likelihood function is very dependent upon orientation of the manifold wrt the sky. While most orientations may be strongly ruled out, it sometimes happens that for a specific orientation the predicted correlation patterns are preferred over the conventional infinite models.
Our understanding of the Lyman-\(\alpha\) forest has received a great boost with the advent of the Keck Telescope and large 3D hydrodynamical simulations. We present new simulations using the SPH ...technique with a P^3MG (Particle-Particle Particle-MultiGrid) non-periodic gravity solver. Our method employs a high resolution (1 kpc) inner volume, essential for capturing the complex gas physics, a larger low resolution volume, essential for correct larger scale tidal fields and a self-consistently applied, uniform tidal field to model the influence of ultra long waves. We include a photoionizing UV flux and relevant atomic cooling processes. We use constrained field realisations to probe a selection of environments and construct a statistical sample representative of the wider universe. We generate artificial Lyman-\(\alpha\) spectra and fit Voigt profiles. We examine the importance of (1) the photoionizing flux level and history, (2) tidal environment and (3) differing cosmologies, including CDM and CDM+{\(\Lambda\)}. With an appropriate choice for the UV flux, we find that the data is fit quite well if the rms density contrast is \(\sim\) 1 at \(z\sim 3\) on galaxy scales.
Abstract
Background
Medicines management in care homes requires significant improvement. CHIPPS was a cluster randomised controlled trial to determine the effectiveness of integrating pharmacist ...independent prescribers into care homes to assume central responsibility for medicines management. This paper reports the parallel mixed-methods process evaluation.
Method
Intervention arm consisted of 25 triads: Care homes (staff and up to 24 residents), General Practitioner (GP) and Pharmacist Independent Prescriber (PIP). Data sources were pharmaceutical care plans (PCPs), pharmacist activity logs, online questionnaires and semi-structured interviews. Quantitative data were analysed descriptively. Qualitative data were analysed thematically. Results were mapped to the process evaluation objectives following the Medical Research Council framework.
Results
PCPs and activity logs were available from 22 PIPs. Questionnaires were returned by 16 PIPs, eight GPs, and two care home managers. Interviews were completed with 14 PIPs, eight GPs, nine care home managers, six care home staff, and one resident. All stakeholders reported some benefits from PIPs having responsibility for medicine management and identified no safety concerns. PIPs reported an increase in their knowledge and identified the value of having time to engage with care home staff and residents during reviews. The research paperwork was identified as least useful by many PIPs. PIPs conducted medication reviews on residents, recording 566 clinical interventions, many involving deprescribing; 93.8% of changes were sustained at 6 months. For 284 (50.2%) residents a medicine was stopped, and for a quarter of residents, changes involved a medicine linked to increased falls risk. Qualitative data indicated participants noted increased medication safety and improved resident quality of life. Contextual barriers to implementation were apparent in the few triads where PIP was not known previously to the GP and care home before the trial. In three triads, PIPs did not deliver the intervention.
Conclusions
The intervention was generally implemented as intended, and well-received by most stakeholders. Whilst there was widespread deprescribing, contextual factors effected opportunity for PIP engagement in care homes. Implementation was most effective when communication pathways between PIP and GP had been previously well-established.
Trial registration
The definitive RCT was registered with the ISRCTN registry (registration number
ISRCTN 17847169
).
The measurements of CMB anisotropy have opened up a window for probing the global topology of the universe on length scales comparable to and beyond the Hubble radius. We have developed a new method ...for calculating the CMB anisotropy in models with nontrivial topology and apply it to open universe models with compact spatial topology. We conduct a Bayesian probability analysis for a selection of models which confronts the theoretical pixel-pixel temperature correlation function with the COBE-DMR data. Our results demonstrate that strong constraints on compactness arise: if the universe is small compared to the `horizon' size, correlations appear in the maps that are irreconcilable with the observations.
We present a description of the data reduction and mapmaking pipeline used for the 2008 observing season of the Atacama Cosmology Telescope (ACT). The data presented here at 148 GHz represent 12% or ...the 90 TB collected by ACT from 2007 to 2010. In 2008 we observed for 136 days, producing a total of 142h of data (11 TB for the 148 GHz band only), with a daily average of 10.5 h of observation. From these, 108.5 h were devoted to 850 sq deg stripe (11.2 h by 9 deg.1) centered on a declination of -52 deg.7, while 175 h were devoted to a 280 square deg stripe (4.5 h by 4 deg.8) centered at the celestial equator. We discuss sources of statistical and systematic noise, calibration, telescope pointing and data selection. Out of 1260 survey hours and 1024 detectors per array, 816 h and 593 effective detectors remain after data selection for this frequency band, yielding a 38 % survey efficiency. The total sensitivity in 2008, determined from the noise level between 5 Hz and 20 Hz in the time-ordered data stream (TOD), is 32 muK square root of s in CMB units. Atmospheric brightness fluctuations constitute the main contaminant in the data and dominate the detector and noise covariance at low frequencies in the TOD. The maps were made by solving the lease squares problem using the Preconditioned Conjugate Gradient method, incorporating the details of the detector and noise correlations. Cross-correlation with WMAP sky maps as well as analysis from simulations reveal the our maps are unbiased at l > 300. This paper accompanies the public release of the 148 GHz southern stripe maps from 2008. The techniques described here will be applied to future maps and data releases.
We present the measured Sunyaev-Zel'dovich (SZ) flux from 474 optically-selected MaxBCG clusters that fall within the Atacama Cosmology Telescope (ACT) Equatorial survey region. The ACT Equatorial ...region used in this analysis covers 510 square degrees and overlaps Stripe 82 of the Sloan Digital Sky Survey. We also present the measured SZ flux stacked on 52 X-ray-selected MCXC clusters that fall within the ACT Equatorial region and an ACT Southern survey region covering 455 square degrees. We find that the measured SZ flux from the X-ray-selected clusters is consistent with expectations. However, we find that the measured SZ flux from the optically-selected clusters is both significantly lower than expectations and lower than the recovered SZ flux measured by the Planck satellite. Since we find a lower recovered SZ signal than Planck, we investigate the possibility that there is a significant offset between the optically-selected brightest cluster galaxies (BCGs) and the SZ centers, to which ACT is more sensitive due to its finer resolution. Such offsets can arise due to either an intrinsic physical separation between the BCG and the center of the gas concentration or from misidentification of the cluster BCG. We find that the entire discrepancy for both ACT and Planck can be explained by assuming that the BCGs are offset from the SZ maxima with a uniform random distribution between 0 and 1.5 Mpc. In contrast, the physical separation between BCGs and X-ray peaks for an X-ray-selected subsample of MaxBCG clusters shows a much narrower distribution that peaks within 0.2 Mpc. We conclude that while offsets between BCGs and SZ peaks may be an important component in explaining the discrepancy, it is likely that a combination of factors is responsible for the ACT and Planck measurements. Several effects that can lower the SZ signal equally for both ACT and Planck, but not explain the difference in measured signals, include a larger percentage of false detections in the MaxBCG sample, a lower normalization of the mass-richness relation, radio or infrared galaxy contamination of the SZ flux, and a low intrinsic SZ signal. In the latter two cases, the effects would need to be preferentially more significant in the optically-selected MaxBCG sample than in the MCXC X-ray sample.
We present the first calculation of the kinetic Sunyaev-Zel'dovich (kSZ) effect due to the inhomogeneous reionization of the universe based on detailed large-scale radiative transfer simulations of ...reionization. The resulting sky power spectra peak at l=2000-8000 with maximum values of l^2C_l~1\times10^{-12}. The peak scale is determined by the typical size of the ionized regions and roughly corresponds to the ionized bubble sizes observed in our simulations, ~5-20 Mpc. The kSZ anisotropy signal from reionization dominates the primary CMB signal above l=3000. This predicted kSZ signal at arcminute scales is sufficiently strong to be detectable by upcoming experiments, like the Atacama Cosmology Telescope and South Pole Telescope which are expected to have ~1' resolution and ~muK sensitivity. The extended and patchy nature of the reionization process results in a boost of the peak signal in power by approximately one order of magnitude compared to a uniform reionization scenario, while roughly tripling the signal compared with that based upon the assumption of gradual but spatially uniform reionization. At large scales the patchy kSZ signal depends largely on the ionizing source efficiencies and the large-scale velocity fields: sources which produce photons more efficiently yield correspondingly higher signals. The introduction of sub-grid gas clumping in the radiative transfer simulations produces significantly more power at small scales, and more non-Gaussian features, but has little effect at large scales. The patchy nature of the reionization process roughly doubles the total observed kSZ signal for l~3000-10^4 compared to non-patchy scenarios with the same total electron-scattering optical depth.
We show that the perturbation at the peak of the light curve of microlensing event KMT-2019-BLG-0371 is explained by a model with a mass ratio between the host star and planet of q ∼ 0.08. Due to the ...short event duration (t(sub E) ∼ 6.5 days), the secondary object in this system could potentially be a massive giant planet. A Bayesian analysis shows that the system most likely consists of a host star with a mass M(sub h) = 0.09(+0.14/-0.05) M⨀ and a massive giant planet with a mass = M(sub h) = 7.70(+11.34/-3.90) M(sub Jup). However, the interpretation of the secondary as a planet (i.e., as having M(sub p) < 13M(sub Jup)) rests entirely on the Bayesian analysis. Motivated by this event, we conduct an investigation to determine which constraints meaningfully affect Bayesian analyses for microlensing events. We find that the masses inferred from such a Bayesian analysis are determined almost entirely by the measured value of θ(sub E) and are relatively insensitive to other factors such as the direction of the event (l,b), the lens–source relative proper motion μ(sub rel), or the specific Galactic model prior.
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